‘Schematic Diagram
Predisposing
Geographical
Paci Phippinee) and Asia
area ~ tropical lands inthe
Precipitating
Enyrenmenalcondons open spaces wth waler
pats, and pans)
Irmunocompremise
Mosque caring dengue vius
Seaer
‘Sweaty skin
v
‘Aedes aegypti (dengue virus cari):
{12 days of viel replication on
‘mosquitos salivary glands
Bite from mosquito Portal of Entry in
the Skin)
towards the cirelation/biood
‘incubation Period: 3-14 days
+
Virus disseminated rapidly into the blood
and stimulates WBCs including B
Iymphocytes that produces and secretes
jmmunoglobulins (antibodies), and
monocytesimacrophiges, neutrophils
|
‘toes aaah te wal angers.
td tsun mance rcragnasts
rerm phageyiois theugh Fe receptor
(FoR) wisn the els and dengue as
peste int et
‘Revegniton of dengue viral antigen on
feted monocyte
Ent to the
spleen
oleae of eokines which consist of vascucive
agents suchas Hirlcukns, tenor WOT! ators
‘urokinase ae platelet activating facies which
stimltes WBCs and pyrogen release
Dengue‘Virus ultimately targets liver
and spleen parenchymal ells
where infection produces
spoptasivcell death
Cellular dire destruction and
infection of ret hone marrow
precursor cells as well as
fmmwinolagical shortened platelet
|
Hepatosplenomezaly
7
Dengue Hemerrhagie
Tacreaxe number and size ofthe pores in the
capillaries whieh leads to a leakage of
fui from the blood tothe imerstitial Paid
{capillary Feakage) of the different
‘Complications:
Incense bleeding
‘Pulmonary Fader
‘Shock
“Very law bio
presure
Liver cirthosis
Dea