Wolf-Hirschhorn syndrome

by Arely and Adrian

Who discovered WolfHirschhorn syndrome?

Wolf-Hirschhorn syndrome was
first described in 1961 by scientists
Herbert L. Cooper and Kurt Hirschhorn.
But actually gained worldwide attention
by publications from Scientists Ulrich
Wolf, and Kurt Hirschhorn.

What is Wolf-Hirschhorn
Syndrome?
Wolf Hirschhorn syndrome is an
extremely rare chromosomal disorder that
is caused by a deleted portion of
chromosome 4.
Wolf-Hirschhorn syndrome is a
condition that affects many parts of the
body. The major features of this disorder
include a characteristic facial appearance,
delayed growth and development,
intellectual disability, and seizures.

Symptoms
The features of a patient with Wolf-Hirschhorn Syndrome may include the following
extremely wide-set eyes
a broad or beaked nose
a small head
low-set malformed ears
unusual bump on the forehead above the nose
low birth weight
growth retardation and deficiency
delayed bone age
undescended testicles

Cause
Wolf-Hirschhorn Syndrome is caused by an extremely rare chromosomal
disorder that deletes a portion of chromosome 4 creating Wolf-Hirschhorn
Syndrome. This disorder can also be caused if one of the parents of the
offspring has a balanced translocation, so yes it is a mutation.

Inherited
No, Wolf-Hirschhorn Syndrome is not sex linked but is created by a
chromosomal disorder located on chromosome 4 where the disorder is caused
when a short portion of it is deleted. This Genetic Disorder is a homozygous
recessive

Treatment of Wolf Hirschhorn

Syndrome
Wolf hirschhorn syndrome can have multiple treatments such as..
Surgery. Patients with the Symptoms that we listed on the diagnosis page
can have their malformations surgical repaired
Genetic Counseling. Genetic counseling is a benefit for the families with
children that have Wolf Hirschhorn

Diagnosis
Wolf-Hirschhorn Syndrome may be determined before birth via
ultrasound
If a case is suspected, using conventional genetic techniques on cells they
will detect the disorder in about 60-70% of cases.
There is another way of diagnosis which is a more sophisticated technique
called FISH that can be used on prenatal or postnatal cells with a 95% chance
of a correct finding.
Genetic counseling is a benefit for the families with children that have
Wolf Hirschhorn Syndrome

Probability
While Wolf-Hirschhorn Syndrome doesnt have a set in the stone number
of affected people, it does have the probability of getting it. The probability of
getting this genetic disorder is 1 in 50,000 births and is more common in
females at a ratio of 2:1.

Article
1.

WHAT IS THE TITLE OF THE ARTICLE? THE TITLE OF THE ARTICLE IS WOLF HIRSCHHORN SYNDROME

2.

WHAT JOURNAL, MAGAZINE, OR WEBSITE IS THE ARTICLE FOUND IN? WE USED THE WEBSITE FOR THE
NATIONAL ORGANIZATION OF GENETIC DISORDERS

3.

How do you know it is a reliable resource?: Our source is a national organization, it cites it resources, has a donate button, it
also has ways to contact them for information, and has ways to contact them for information, and has scientific evidence to
back its claim.

4.

WHAT QUESTION OR QUESTIONS DO YOU PREDICT THE ARTICLE WILL TRY TO ANSWER?

I PREDICT THAT THE ARTICLE WILL TRY TO ANSWER HOW THE DISORDER IS CAUSED
WHAT ARE THE FIRST SIGNS OF THE DISORDER?
I THINK THE WEBSITE WILL TRY TO ANSWER WHAT SYMPTOMS
WHAT DO YOU PREDICT THE ARTICLE IS ABOUT, JUST BY LOOKING AT THE TITLE, GRAPHICS, AND THE FIRST
SENTENCE?

VERY DESCRIPTIVE EXPLANATION OF THE DIAGNOSIS AND HOW THE DISORDER IS CAUSED

I PREDICT THAT THE ARTICLE WILL SHOW SYMPTOMS OF DISORDER

I PREDICT THAT IT WILL GIVE US TREATMENTS OF THE DISORDER

Article part 2
CHECK PREDICTIONS:
1. LOOK AT THE PREDICTING SECTION. LIST THE PREDICTIONS THAT WERE CORRECT ABOUT THE ARTICLE.
.
THE ARTICLE SHOWED US HOW THE DISORDER IS CAUSED
.
THE ARTICLE SHOWED US HOW THE DISORDER IS DIAGNOSED
.
THE ARTICLE GAVE THE SYNONYMS OF THE GENETIC DISORDER
.
THE ARTICLE ANSWERED OUR QUESTION ON HOW IS THE DISEASE TREATED
.
THE ARTICLE SHOWED US WHAT CHROMOSOMES THE DISORDER IS LOCATED ON
READING:
1. READ THE ARTICLE WITH YOUR PARTNER (IF YOU HAVE ONE); TAKE TURNS HAVING ONE PERSON READ A
PARAGRAPH OUT LOUD AND WRITE DOWN NEW INFORMATION YOU LEARNED ABOUT YOUR DISORDER.

THERE ARE MORE THAN 2 SYMPTOMS THAT COME WITH THIS DISORDER

Wolf-Hirschhorn Syndrome is caused by an extremely rare chromosomal disorder that deletes a portion of chromosome 4

THERE ARE 2 VERY VISIBLE SYMPTOMS ON THE PATIENTS FACE

THIS DISORDER IS CAUSED BY A chromosomal DISORDER OF CHROMOSOME 4

ONLY 2 WAYS TO TREAT THIS DISORDER

Bibliography
https://en.wikipedia.org/wiki/Wolf%E2%80%93Hirschhorn_syndrome
http://www.ncbi.nlm.nih.gov/books/NBK1183/
http://emedicine.medscape.com/article/950480-overview
http://emedicine.medscape.com/article/950480-treatment
https://rarediseases.org/rare-diseases/wolf-hirschhorn-syndrome/
http://ghr.nlm.nih.gov/condition/wolf-hirschhorn-syndrome