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FUNCTIONS:
o Response to stress or injury
o Growth and development
o Reproduction
o Fluid and electrolyte balance
HORMONES
GENERAL CHARACTERISTICS:
o Specific rates and rhythms of secretion
o Operate within feedback systems
o Affect only cells with appropriate receptors for that hormone
o Renal excretion
REGULATION OF RELEASE:
o Hormones are released
Negative Feedback!
HORMONES cont.
Patho Wk 7: Endocrine
o
o
NEUROENDOCRINE GLANDS
HYPOTHALAMUS
o TRH (Thyrotropin-Releasing Hormone) stimulates production of the thyroid hormone, which in turn
controls the cardiovascular system, brain development, muscle control, digestive health and metabolism
o GnRH (Gonadotropin-Releasing Hormone) stimulates the release of hormones connected to reproductive
function, puberty and sexual maturation
o Somatostatin inhibits GH and TSH
o GHRH (Growth Hormone-Releasing Hormone) controls growth and physical development in children as
well as metabolism in adults
o CRH (Corticotropin-Releasing Hormone) controls the body's response to physical and emotional stress,
and is responsible for suppressing the appetite and stimulating anxiety
o Substance P
o PIF (Prolactin-inhibiting factor)
PITUITARY GLAND
o Anterior pituitary
Melanocyte-stimulating hormone
Growth hormone
Prolactin
Thyroid-stimulating hormone
Luteinizing hormone
Follicle-stimulating hormone
-lipotropin
-endorphins
o
Posterior pituitary
NOTE: both of these hormones are synthesized in hypothalamus and secreted by post.pituitary
PINEAL GLAND
o Melatonin sleep, immune fxn, aging
Patho Wk 7: Endocrine
ENDOCRINE GLANDS
ENDOCRINE PANCREAS
Pancreas = both endocrine (producing hormones glucagon, insulin) & exocrine gland (producing digestive enzymes)
Alphaglucagon
Betainsulin
F cellspancreatic polypeptide
INSULIN
o Regulated by chemical, hormonal, neural mechanisms; negative feedback loop
o Synthesized from proinsulin
o Secreted in response to INCd blood glucose levels
o FXN: Facilitates rate of glucose uptake into bodys cells
o INSULIN RESISTANCE = Sensitivity of the insulin receptor is a key component in maintaining normal
cellular function
o Facilitates the intracellular transport of K+
o Anabolic hormone
Somatostatin
o Produced by delta cells of the pancreas
o Essential for carbohydrate, fat, and protein metabolism
o Hypothalmic and Pancreatic
Grehlin
o Stimulates GH secretion
o Controls appetite
o Regulation of insulin sensitivity
Pancreatic polypeptide
o Released by F cells in response to hypoglycemia and protein-rich foods
o Signals satiety!
o Inhibits gallbladder contraction and exocrine pancreas secretion
o s gastric acid secretion
Patho Wk 7: Endocrine
ADRENAL CORTEX
o Stimulated by adrenocorticotropic hormone (ACTH secreted by anterior pituitary gland)
o
The endocrine system reacts with the nervous system to respond to stressors
Thyroid gland
o Glandular atrophy, fibrosis, nodularity, and INCd inflammatory infiltrates
Parathyroid glands
o R/t alterations in calcium balance
Adrenal glands
o DECd clearance of cortisol