Pathophysiology of ischemic Stroke

Predisposing (nonmodifiable)
Gender: Female
Age
Race: White
women
Genetic
Family history
Reproductive
history

Precipitating
(modifiable)

Lifestyle
Alcohol use
Smoking
High fat diet
Obesity
Environmental
pollutants

Etiology
UNKNOW
N

Vascular spasm
Blood stasis and coagulability
Formation of blood clot/plaque
Occlusion by major vessels/arteries
Increase resistance and pressure
Vascular wall becomes weakened and fragiile
Dislodging blood clot
Emboli

Lodges and obstruct to other small vessels

of tissue

vasospasm
and arteries

Ventricles dilate to the site of obstruction

Cerebral
hypoperfusion
Increase ICP
Distribution of
O2

dizziness

and glucose
compression of tissues

A
head ache
tissue hypoxia and cellular starvation
Cerebral
A Schemia
Impaired perfusion and function
Middle Cerebral

Compression of nerves
if theres invasion of

skin & nipple retraction/dimpling

microorganism & tumor
obstruction

Inflammation
Nipple
discharges
Reddened skin, local tenderness/
pain, warmth

B
Cell breaks out & invades to
lymph nodes and blood vessels
Dissemination and entry
to lymph and blood vessels
Cancer cell lodge in lymph nodes
and grows
Lymph nodes and vessels
become obstructed
Blockage of lymph vessels draining
swelling of lymph nodes
fluids from the breast

inflammation and
Pain

Obstruction and accumulation

lymphatic of fluid
Pitting of skin (similar to the surface of
an orange Peau dorange