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BICO 212

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..

~41=-~~
~~
. ut ...,;,14

Final Questions
..

~fo ~~l
~~l.J

1 ....

'

i ~t

~) ;1-JJ, ~'-'-'d ~,~ '~.J.& ~~ ,

.., 4J'

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FromA2 Z
Maktbt 7amed

Learn More
Study Less ..

01284164340 ~\jill
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.-.,

..

:.;;

.-
;;.-.

MUST

i
J _...,_'\.......\JL 1. .1.

.:

--:.~---.-

...

'-J,_

A. .li.,_~..l'.L'A..l"l..'-' .&.

Final Examination ofBiochemistry }OJ


Fbll Semester 2004
----~----------------~~~~~----------

(a) ATGCCTTGC

(2Crcdits)

one hour

(b) AUCGGUUCG
e

,.~-

(~) C~d-ingstrand

(c) Tcrniination site

!
i

;,

I.

.J-r)..ll

'

~-~+-:

J.VI1Vt1&&&E; '41\..-

~a&t6''"""'""""'"...,. v ~ ... ,.,..

l"""J ............. w

.........

~ .... ..._..,.__,..-

'
1

f'@It
fii l~ the g~ps betw~en
qkazaki d-agme~ts.
.
t:l-. .
. ..

:.~,
;,
.. ~:

~-,

....:';

. _,

Wiynls\5'-3' exonuciease. ac_tivity to remove the pri~er~

l.~~:~e.s ~~-RNA post1transciptionlly. ::


.
.

/4- Wh:cn

rcs~dts

a single base change


in replacement or' one amino acid .
with an6}her. this mutation called ....................................... .

~s:~~l)se-nh~tatio~;

L (c) S1lcnf mutation


../

i,

..

(b)

Non-se~se n;iutation

(~I) Frame sh}ft mutation

-.

,.c

-- --- ---- ------ -----

---------~-

!'

-------

__________________________ .:__ ________


-~-----

-----

_.:_ ___ _

--------------

--

---~

J ___ :;..-:.':-"~:

! :~.

--------

-- -----

., L__ .. ----

!i : ..

---------

--}(I
~--)

'------ ---

.,

CJ '..,.e.)'

cimlno -oa~frc:Jno_fh-n, 1h,5@~1!fj--eaited-.n

. ---orre

@ Ff/l -se-nrr- mvfzrfn;-rr- - ... .() !'lbn --:s-~rr.r&" r/1uh:r#-o~r'""T"""J- - - ....

-t-F@'~"---s-;.t-:errf-nnrfaf/on

.fi'arnr> -.s-:fr+-F-F--,n-u-1--a+r-orr-.- -

----------------------'-------li'K~41-fe

tJrrflh/o f,e---HuJf /n h , bifs- prqft:~7r --s-yrr--fh-~:5. /n PZJ r-}~,

la ~

o-cplvift---or-#rr--rn-r-}fr;rf,?Jrr -co me'-e-x- -is--


--@ ref ro ry cl in
v- (f) \5]rttjik ~ ~iqrr ( W~ z~un7n:r$1ti~s '-~~
--@J--c-h-~-z>rt::/711 p-h t'illT:-t>l-@--Err+Jrr-a-;r;-rcfrr -- _g_~~~---------

-- -

~~-trrjt H1 ('
.

7 -- -

--

------------------

--------~----

--- -------------- -----------------

::-:--.-:-.--.-

________

._,____

__ ..... -----------------

t<JF. Th-~--m-o-sf-z:la,, q ~~-j~-;.,-d--v-f p1ziiz:rh-:o-rr-is-=-~--

. {fJ 1'1t3

@ Sile,,} mulof,-orr
---@)-._ffa-,-r-:-s-h-/f-J.
------------------

O>e~-~nor:.n;oy----

711 ofr:rlrrrr-g)-,dzr7t-=-s-nr.r~u-h:rft?nr-=--- . (
.
.

-~:dl .. J.,~----

-- ------ -----------------

. ----- -- --------

lAI,..:"'..;
.
.
~_,..i'
-+--~r:rh-~:--5-cr -Ctrf--~s-rfr-a+--777rr,-c:J--c:nJfo-c~n-f---f"o- --e--a-c-h--o-1-fn:-~rr-:-

Jf.~' getrtJmt?

aJrcf-z:tr7 z:;;,,trzrrrrl ~

--~eo.F
-+.{,H'~'""""'2o,..,_/-=-=.... =-=~------- - - .L, , ,1\"i

....:._~.,

>' I

ihr

5.o7771!' Czrrrffo-~~r~
-------

- - - - - - - - - ..

-7@- -~~----------tt-e;y-ulot-~ry---g-(!"rt ~ s---------- ----.- - - - - - - ----@-~-;n-zrf-p--r------@\of'~/'0 -1-crr-------------

------ ---------

--

____

--~-----

-------

_______ .,._________

----

..

--

...

--.----------

---

----

..

--------------------

.. ___________________________

...

- --- @-o J-cuzz:rk-i- f"to!J m e-rrF----- ----- @---sTtt.:rt-r--s-ff(:J .,zl-e-d - {)-,J-11--- - --


------@--bo:-!J--:J--l7tj____ -sttanzl--------------:,@}-b-e-ocJrny-sfi?Jfn-d- -------- - --.

---'*":f.l-tf--rh-r --fpt17rtt1-ftrq-- - cnz..rm-r:r . -zrrr--uS?zi---i-rr--rh--rpfi;z:'l:'r.s--o-F-----

.._

franJ lo- f-i on , exc:ro t- ----- -_~__ :_?:.-.:-~~~-. if ' ,


..
{:. ,------.
--~pf-r-cJ.y-1 fr-a.,.s-fe'ra s ~
@ P'm t"n tJ-t.J-tjl -- l fC1;1fJ- syrr=ffri!7us-~---

'

----'---ll@P-1-~&~leas ~

@)

J}ol7 of'

fh t!'

P.Po~

~ ~~,..,- - -

-------------- - - - - - - - - - - - - --------------- -------- ----- ---------~~


DuYitt9 :Sra:e-s---u{-f-t-tJ7fslo.F.Jzr,---d-o~s J+, ~ -rt-b-~:7orn~dirr-oc,tJ,:-

"*' .

jn-f:rr-i-k- ,$;E"bpn'f!. "=-!_;;_


? ',~.:.J.~ -------~=~=------@ fn/h. o fio71--(f)-fl-,-rrprh7m-~orr-@-ftt~trl-Jir~~'
- - - - - - - - - - - - - - - - ---------------'----------- ---

- -+{icn-e--+r-a-~sc.,-lpfi-prr-- ;s---a-ch:.Vo-/Z!-zf --JFr -P-Tn-cJ-r'llj"-- q-t>-1- fC pfJ-pvJy~ra-:s


@-orz-n:rto~?rr~J or

--@-fn-bcer-------(fj-pplfftPTf'

.-

-----2~--

_ -.i'

------ ----- --- --- ---- - -------- --- -------- - . ---

~fff!!r:c;--h'wr -~---p:ffuJti

~~---,1ZJ71 --: Sen>-r jlfP.fafJon

@
-

__. ,biru:Jip9 !'lf#zl7l

2F

f'Yl'~!'fnk

-------@--tft$ - -sens ~ . ?fflTfe:r-f'e>n

p('(J;-,r~5h 11f 711Uh1 /4~>11

+-l*tr~i-J,.i-,fic1 fh of

-@-s-ifen I mu-fu}lPr~ .

frtlti-J,i-f~kir1~)'11 JhrJf,s

enrz~ In

ft'-P71:r/t-t'llse-

---rs-=-------------~----------

In_

,....;'----}~t:xc-fe-r-ht-- ......1.7

~T rlbr/Sotndl sub~n:'l-

___. ________ --------- --------

----Sfr-~/=OIIi1 Cin -~---{f)-fQr-J1710na ~---

-- --(j;--6h-hfn::t7Pipl;-p~l co i @- ~rlro ry ~lin


I

:..______ -e:a 11

~ - {!T-7frr-~crfJ'~- ---@1;-uplr-Co r.

---------- ---------- ---------------- - ----------- --------.. ------ --------

-~--- . ---------~---

- - ----------..- .

--@--ppff-H'o-,r&1'-T/im -@-'FI'i:t7':> h:th'on;


--------- ----------- _____ .._ --- ----._ _
.

..

.i:Th~ ~a~"ki;o~~;ruN:A,'.a_gpleeu!c :is~-;.;,~


(a) ribose an'[~ pbosl:>h-~tc.. _ '
- _.
\..{:b(D.e~xyribose aiui :pt10sphntc. .
, . <.

"(~) ~co"xyl~if.?o,~e o)ltd-_:~ibose _.

-~. I .
. >'
,

._-,_.-

. _

:rc:. _

,...-. _: .:.:.:

\_

-~---

>. ~-------..,;,f t: /~.:pii-c' c():i~r~ex btwcen et~knr;O~'ic J>.NA. :~~d:j;t~,tei~- :1s:_cuU;e4~<:,. ,.-----,.,.{.. :. . ,;,~~!!:~~ct~ . .. .. .. . ' . :~~, ., : .' .' ,) ',j>
~,w~~~::Ltt;.;:r-~. : :: ,~ , ...:\t;:~.::&t:~,;;:,; ,@f
/ (ii) Puri~!:~:~~~l:(l pyd~nldin~-~ . . . .

-------,.f

......:.::.

------------

--------------

. :..

____________,

.,~-.

or ll_~A_ t~Hlt.!~;lllSQ2ftS amino


--------~~;**'~!i~~~~!"'t~~:}r,':rc,:;~'''''~~~~~g~'~~'z'~ ~rx~w ~-,,

r---- ---------

' _~-t>air)itl!J prtiltin s-ynmt;l?iS, th~ type

-I

_. ~ (S):hRMA.

-, . --- -. ,

., ..~_j-iJ~n~ofth~:ibt.rv.c.
.''i

..

----------lr:;~--:"'~'-'Wll;d
i.s ihe
SCI
(
'
. .
. .
. ..
.

_____ ---

.'.

.,, .

---------

, - ;_,

On
the. .com lcmClltnlc
: sh~an.d
-of
DNA. .. . -----------.
.
. .
. .
.
. .
_ inu:leculc :tha-t lui:s--,tJfc n ucle,otjde seq uenc.e;. Aq;r ,: CC~T '!
ueilCC

. Ji)_~:AKGCCJ'CA .

---~;:;\~{;~ ~~B~~~~

..

. .

;> _ ._. .

. .

. . :') ;_ _._.-'. ~.- - - -

r .. ''A;~.~;?MF~\.ift;:r;t;; :~:------

------~; ;: .. :,UP1~.9=t~qG?lr~A .
. ..
. . . .---- ---------tid~~-:>-,;_~~:;::~::;:,. ~\~aJ.:/t.~~} :.,_ ,,~>:. J-: --i_-~~1,.~:;_:~~:':",~;~i-~Li: h-~~~ _.'::~-,,:_:-.-.>-::.:.;:!f.<-{/
-------f~.ii'if.i{,~~!l'U~

lit.ans1fra p'h:Oif/Hl'~tetk;t~u~ni'-cl!.sqisg;/;;J~!if~;ft'.{j_"i, ;~_ ;>!,.,.:.'{r_y~( 1------- ____

-~----j~~~~=~~1f!~~l:~:".'1~.1.~11~:\i:''~~~~i~~~t~LJr! -----------~'

:-~.> ffl-:~C,)~-~~~~f:}gu:~J;t'l. i~~:~v.lr~.: lk~f-.~~~~-: fo-lf.QW.~~J~p~e5~p:~;~4~I~ic;,.~eMJ!~~~-~-----


' l~rl>N'A.
: . .
. ". 'i(J!Y:!:"Rfi:N -~,.. "~' r ,.~
. _.

..,fhl,~t\NA_. -

f-A~"J4lfmf"RNJ;

.!.

. I.

.... .-.oJ!. :

===

L-- - - - - - -

___ . __;, :*~~-~{~~~i~~~~G~~~,~~~~;g;;.t~ ~~~1i~t)_.~J-~(:~;:.~&:.~s--~ :;~ l<L/~:f-,:,-~>,; :~;;: -.~;;.,.-

. ,. .Q ~14~-,p\)ly~~;r;~.s~ 1:c;~ogui~~s.~l~~ p~om~tcr

; ,_, .... _ ._., :.. .) ~ -.

------- .... _------ -

.---- ~-'t0,.1')!~~?!~~~f(~!~E~~1~*;~~~:' t\'?f:~~~,; .:- ____ . -. . .:-; ~,...;:- .::--7

........... ,__

.. -~~,.- ...... :.. ..... ~--~'-.....:.--.~~-~-----'-----

----.a. . .,.,.,.t~--.-ez,~--~-/t~-...~--oJ---- -------@J


1

-------------------------

-:xl'-"-which

t>f

fh t:

mP l#t-.""'vl-e

------------------ - - - - - - - - - ' - - - - - - -

*"' .e-ttr7:rrg-pt?Jrcrrr --sy-rrl/1r5JS --uJ-/r-r?;k --z,;r-#f-t!'""-rP""/1-~~~'-~.s-n-~t- &rr~cl


nw

ami~C)'I ;..,. R.~t:::re!rr-r~fn:--.#-s4e---at Hrzr-rl/J":SZ>MF

--- ----()-5-zr-.S- yi-/FZ)J'~RI of $o/;o,.r,t- --z#J-a-clr.r---Tff.s-/:

_--@)---prr-haly/
~t

h(:;l~s-/cn:r.J If"

f2'lyppf'dc

@!; f~")71Jjtuh"zm
.-..;~\' ~_)

y'

~71 t_ph"t' Z21f:oJ"";rur--#r~-fo-~T?Jn- -

---------

tfl

~77' ;://boz;/p~ ,#~-.1~..-------------

~ 141-~$:)~,/?rhJ- -,-rr---zr-e:PJ=ei!:i37!'"---ca-vyec:/--lr7

Hl17rl#

---------- -----

Sl11ff 7/TtlfP/iP71 -- --<!} :5//e:nf ~h:tl-1 :,.,.-- - - - - - -

@ /1ff-:Sen.J~ JnV-hr}~i!1r1

...

;,--pr--,-p-;J- -- ------------

{g)~-~~.?~~~,-----

~~- .--~~-:--\cr(~~~n-.. o~~~~w~~cn RNApulymcras~- c)J~y_ri~e binl~ -~~ :~:-~~~H: :_at


.:

.'

. ..

_.:

'

./~

-------------

....

....... , ,

/
i .d)' ll! t't':! ''',:.
_,~-r.rr;r\"".

tiJ'Ji ra IISI~Ii bl'~i ........... , ............... , ...


..../

----~-.,..:

I J;ii,~,isl

::~f"lt\

(;.:) ::;l.,:d . r-iUL\


\:(dl ~-tUl .md :inl:tll r-ar'I/A
,..

'Jo----

--------

'i -l.l tu'i U;: I tH: -i>us.i-1 l'~i u:-:4: 1i p t ion

process souw j 11 tnw.s lu ve :;~.If-.


~ ~ 1:'' jrtn y. 1 u esc 111 uous ,callctl ............................ ..
~

:: i 1:. n ll ~~

./

.'l''....L} ..';. ,1. ".'ll


I

':,,

--:--::--:----:----:---

'

,' ;" ;;6"_~ . ...' ,i '.' ,; . :f


L.~-;::
(' .
/P"",'
. :~.. :\ily /-. ,:,jl
.=

(.
.. i-'
.
"- u~ ~l ~ >. ~ i !'~~.:; 1.rc wh :ch
.. -~ ...:\" ::: ;
.

L;i:->C Jl~air

"

has the rig II [ cumplcmeu ia t i uJl.


~

ltki} '.
v

= ,!
: 1 ' ~ :.:: , I

i_jj

..../

\_,/ .

c~ ~

icnuinaLio.t
.. )

~J .\ ....

. ''.,'
. ... '. .,'.\ ,~ l,'

,--.

~~Ju:.: .

,..

\.

_ _.A!i}Enhancers ell use decrease in the mte of m-RNA fo'rmat[()n.


v ~oxins bloc)\ translation by modifying the elongation factors.
- nJ )Antibioffcs>a ffc'ct. and inhibit mito'clhnunia I )'Wot.ein sysn th csis .

. 11-Circle (True ) or ( False ) (2 degrees each): .

. . ~r-.~\ ~~~~C

t-lh'J-\ I.S.IUfiUCll'V.l t.!UtiiJIC UC.ll\:cll

~lJciUli.!!,J

tllldU;UfJJJU:SllC Uli'Cl:lllHI!)

from 5' to 3' cnd ......................_:_ .... .'....... {0':': .. :..........{ T-rOC.~))
!'::,(.\.
. : .
.
~

..II>....J

~-

.J-

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . - . . . . .......

.... ...... . . .

.. ..... ..

................................... "-'

.......

.. ............. 14...... ..... ... ..... .. .....

b ... - ._....

,,

dena turing than DNA rich in gua'nine and cytosinc.;i.( Tnte- al'sc\
.

'

"'-The- fee din~ sWand ofON.~ renllcatton caUed


-~~-\p_ . .

O~ta{<i strand .------- :


.. . ~o( f rr.u) 4 F~~ls~h:-

~~~~
4-N_Qn-sense m-utation results from a change _i.n a s.i.ng_lg'basc developing
a

t C J' H 1111 a liU II t.:UU C J~ 1 ,Ill o/ 1'

---

S~m-Rl~A
:,j"

...

~~

.~

---

-~

\~

<li:SCJ

always binds to 30S. ribosoma' sub-unit t9J~rm m_1)11itiation


1 "T'

. .

....

J..

r...... , \ ...

..............

./

~'----"'
I.

'

(2degiees each)

, Ill-Complete:
l-In protcin,synthcsis, the enzy:me :which.binds a
n~NA =s
calle(l
a. spcc~c
Ill t - 1.~
1
.

sp~cific-amino

acid to

R 1\.' .v
\-:.'\/ S-ti'
,:J it ..:-;

,...., ...LJ. '\:, ~ N


~.-..~.
\

2-The basic structnrnlunit of chromatin is ..... ,:\.v..C~.('.Q_S~:r.y.:: ...... .


.,.

{""' . . ,

. . . l ~.

. f" I

J.

,. ~ .

!"' '1\! -\

. I

" ....

J 1 , . , , '''"D-o J,.,.

P~.\. ;r. , . . . r

. ev'j~-.~- ...t;('~ '1 ~ i,...J ....-.,.- -~~h~: (c~.Q._ .


.,_.
-~
4- ...... o.tn\r.\Cl \)~~:~'.~\~~c.~ ... _.. j)-Hd .. , ... ~C~C~J)I~..;c.v7 ......... a rc
~\ \ (-, ."V'._.r.-~....
e(
mtibiotics that interferc with eJong~tion ot polypcptilll' chains by
inhibiting pcptidyl transfcraseenzyme. _

. /'

..

---:--

--. s~RNA is a single stranded molecuie

camp0s'~d

of ribonucleotides tJtat

.r. 't.

~yribose sugo;r

(a) Puri,te and pyriinidine bases


fr) Phosnhodi('stPr bonds

lllVUl.il\..<lllVU V.I. lU-..t.'-l.

,.~

.I.J~'-.L...A.

(fl)

Glveosidic honds

A.

(a)7-methyl
is added to the 5'
end. C~}-.PfJi:)
. . . GTP
.
.-..
:"!...'

J-During protein
~

synth~sis.whi~h

of the following is NOT CORRECT.

~~-{~ew anunoacy1 r-l"U'IA ~anacns to rue A ~Hear me noosomc.


~-~!('50S ribosomal subunit attachs first to m-RNA.

r/
~

(c~ Pcptidyl transferase e_nzyme caWyzes the. formation of polypeptid~

..

'!

---~----

-~ ' "..., "{P)At icnniua i.ivu ~' i'iuuSvii'ie dissociates into two subunits,

v-,, .....

c...~

./

8,:: pralassemia is.a disease caused by................................


,
,.. @Frame shift mutation
(b) Silent mutation
L./ (c) Mis-sense mutation
. " (d}-Non~sense-;mutation

J.9-During regulation of gate expression in prolmryotes, which senten~


1

'

.,

.... , ...

r'r"\.nnnrT

..

r .....................

~-!~,...

~1WJJ.e.n...a r~pressor bind; to opetator it turn_s the gene~~..


~ ~\Vhen ~o enhanc{"r binds to yepressor it turns the

-~~)RNA pol.y,m~r~~~-~-~~~~t~_tl~.d__!_C?._Promo_t~r

gene off.

tor. transct:tpnou ..QI. m-J<.L'4A.


(c!)~eprcssor and enhancer are pro(fiicts ;or the same regulatory g~ne.

......

//j

...........

',

L~~/.~/-I

'5-t"ht c.otrn01 regio\'\ of a ge_ne cohsi~-:s of .. :.-:>.~~';~~"-:':-: tf:J;~-; ... " ...

1v- \i'l'\~

",... Ln

'

:.Ill I J ...... J1,'-.;\J (... \

-~ ~ ;.:.
r.., .....-' :

IV-Pi1t ( ...J ) or- ( X-) !One degnc eadt):u.-- -- ....


-~

I-!hc 6~l'sife in a riboson1c accepts the fitst :a minoacyl t-RNA fo!:

p~otein syn~hesis ............................................................. ~)


!

~'\Y

nucl~ns

.!..i I ranslation occuts m the

while' transcription occms in the


C);tophlSill ..................................................................................... ~)
I

....

. --

..._ ...

---'""''-'-'"'"--

oJ"-"'o4-'

!-'" .... '"'""'"''--'

....

,~

.... _-..J...J.._, ..

.....

.....

....,~_

... '" ........ b

~..v

1......... ""''-"'

,,, .... , . . ,.b

the g~............................................................................................(v/)
-

-t .. 9-f~rrn

hefi~ urith rc h~s~


pai~hfrn .. :.......... ~ ............._........... ~ ..... :..... :.~ ...._. ......... :.~.:.:.:............ .-=:-.. ( 'A.)

of

Dl'l ~

de~ub1o

hoi;X ;s Q left hdnded

..

."

i") j'-

r:...

5-Introns are the coding sequence on the ctuornosome ........... :........... (~ )

- t

"'l

.\

6-Amin~gly:otia~s

;uch as streptomycin inhibit protein synthrsis in


bacteria by jllo-cldn.g the. activity_of ~h_c _3,0Si_~!ti_nti_c~m complex .._~-

7- Chapcons me ptoteins that facilitate fold_ing of polyp~ptide chains


in to-3-d imen tioita ,, con iorma tio n ........................................................... (

v)

'

S- Silent-mutation-is a result of a change inthc \Vobbling position (third


base of codon) ... : .......................... : ................ : ..................... ( v1
./..-:-,....J~ . ~- . r '" v
J ...

..:liiii,;U\;\.:1-:t

1..&1\l.:)~-

111'-l\::&,i.:J\::

Ui

1-..11\.

\11.

lllii.:J"-li!'IIIJll

oliJ\1

lll-i'o.\,:1.

fo1~nmtion by activating the p_romotc-r..................................................


,:~.f

. ('

,t,,l\'~

fJ, .....

a;.l;.t,..j:.;\1

ir!;;.,.,;-~

~,,

, .. ~~.,~\

(M"

la!,iJ-!

con-trolled by a single contn.)I rcgi<)u: ........... :....................................... (

-~;irJ

V)

that cfompound.

(8 degrees)

--,
I

I
N

H
.

v\_1.)\.l'{\L \.._ ~...,.l.-~

Vlll-Completc:NH2

N~~I

~-.

-.

( 4 degrees)
0
II
J., L ..l. ..\

.. -.,.

boo

~>

Vlhic:h P~A. d-ena1utts ~asier

l-

DNA ~i-eh ih Gr.:= G


c:.v (f~(art>f'/ A. rieh in #. = T
...
i .:) . crr~uh.rt>N~ neh in q:: c
(a)

\1

.-~

./

(dJ

LinorbNt\ With e.qual amounts ofG= G aflu A==T

~ :,_ i'..: :nl;u:.riou o fT,-ans(!rJ pion


.

o.(curs
Wlu~n ........,. .1. ~ ........... ..
.
.
~

RNA poly:-o.erase 1_.eeoguisc!i the promoter

(:1)

. ,..

(L) 'fll.: ficsl 1:ll.JS[il11Hlicslcr bond is_fo1:mcd


~-:i:.u1:1

(rj

~:

,..- - : - ,

fill'iu: dissol'iallS froua tile core cu:ty111c


I

\.0.~JVu:,tqHn

J,!;Jl-'

iunucd

lS

:.; . --- . :. . =- ...

,./

\,_. ./

.. '1(..::.:1

~- ::~::~.".':~~.t.i~'.'. ~- ~:::~.::.I:~.':.~~~~ poly 111 c1as ccn/zy


me bind to agrH! at

.. > :'

1.'

;,;iru<.:turc I:' .:w:

t:i.J

(11) ~~~uliu:dio~t ~;ik

,....-., .--

. -.~~.) lil'IJiiWCu: :z::

'I)'

o I

o.

o 11 I

.. ,,
,';.. :.pU
,I . .i!C Ul':.!h::::i~m
:-- ..:
-

0
I

I I

1'

'J

... .............. .. :.:li .. i>l',l :i

:;ingh.:

!;:1~;.:

'
n

ch:wgc l~ads tu fun:talio.Ja cfa

~/'

'

......... .--/

/.

~ ..., "'.
r
,,,...
""""' :-....

....~ ,\:....

r~

:~~:

ESk

,; .'

~::::.:

,._
..
'

, .... i
... ,.._.

..--
......

,, .. I'

~'-.

:..

(.::::

....

' ...

I ..
I

..

,......
;

"'

i ...
,-.

IX-Wllm is th,_ compick ...-,i-.i~

,i~ ~~::.._.:-~-~i-

.t

.It
':... - .

'

J -~

..

J.

..
'

'

..... .- i

\tv-.~~1-L"'~~e\.VY'-:-G'-.~~~~v'~ ~~:~?~~t'"~~~-!;'d
.--'.::..:"-. \.

..

~..

(/

_.--...

X-Mention~:example of anisoenzyme and its,imp~rtais<:e.

c_ \)

L \.~ \-\

~r

0. -\-- \ -.:

:-X!!

-:.' ._ \. : ..

(4 degrees)

\'0...\_dv-...ce;x.t'..rG----:Q.
.

\_)

l '- \-\.LVJc_\ c._

{Lf)

. ..\.. ' @.
.;:" \"'e<-'-j.... -

.__. - :: ...

'. _,

'

..........

\-o'-q \.1..._ ~

.....

.,JoJ-

\.\_.-. -~r

~-

'.i

\_h--1 c\.Q.. 1 ~::.r( \.--

...J~

'*- j._:~c~N<=\.<"'.':.
~ C:\-t"l~_,..\
.12w':>'-'!"-C.~
T~\
_______ ..U-Q
l} ,~
L) ~

c:L~~c:Af:-.'* J\C~("w:")

c'l\

l,..,

'

~ ..::_\i\1 ...~"--~~

. Q
c \,..~~ (_~'
C'.l~ ffe. ~

GOOD LUCK

_D

<'"'

- \-;

')('.\.)

5o..rN?-- ~'\..~'-"'-

-~--- 0't\.~~\Cc:LV
,)(..:~

CV-'---

C\{'\C'\

.~.~

'i_.o

(VU..

'- ...

;~

~~-.:

,_,

i.

___l_'t~~~~-_"\.!..1!..!r~-~--II.Lfl!..iiJ..l
-- J..JI"r'-'-1t-l.I.J-.'-11.;-.,'
. .,,__. _,.,..,."
. .. !~l:. ... .;

i-f 11! \ . , -I.,..,.,,,,.


i" ,. .
' ..........
I

~...

i ._.
1-

I:-1:_-

ll-[stC'r."of f:Jlly acid.s wi;h :1lcolwl other than gl)'ccroL:hc

'

I..~V "~'\ ~ t) .1.- '')' i '

t:~dlcd ......... ? . .,; .............

12- i\'lention the

.
. . ,,." ......J
-

'

;I ..

-~

{2d cgi"ees)

of':111 uusatur:J(cd !':t1tv :1cid fnrnHr! nf' II\


1wnus :11 l.~-~i-1 1-lL
(2degrecs)

III:Jlll'

~ ... ., .-. ,. 1111 utHJrJJe

fl,, ,.,,..,

f,

\\1 c. . c.\, . c\ JI\:C.


1 ~- \Vh ~It ur

I..

i-

,.

,-.

'

1 .

t. ~ . .
.... :.,

.,. .
;

l -t - \\I r i Ic l I! c 11 a 11'1 c :lll d s ' r II t' I II !'l' u r a

re iil&l i e seX JlOr Ill ()II t'.


!1

'

1"'-.:
j
~

.__; (' s-s..


'-

'

,, ~ \.t:..<..._

r~ ,'\ J (\ c,.r.\

a._

t\~ o.C.. h',c\ 6 n <_ (~--

. :-..
... .

'.

BIOCIII~:!\liSTI{\'

Answlr tht l"ollowiuo~ lltll'Siinns:----


i- \Vri!l: Clle slrudura[ formulat~ ol':

(2degrccs e:tch)

Tyro~:inc

Thyntint

2- IVltnl if) 11

IIIII'

"I II ,. ,, r "

.. ; ,. .. : -- .

.-~-~

. ;..e:. . .~i'i.

,iht&.ii.V ;.1!\..i(i,

J.:i'c-U- L '-

,1

~l-~_,. "- _, "

(2dccrrccs)
b

Orotic acid

.
UriC

~:

drgrNs)

~--

.I

HCI(

.......-........................ 1 . . -...-... ,.,.."

\r<~~-c~,~ c::-~':-}~e.._OJl)e.:\

Multienzymc ,complex
p

,-.\. o

, ..__

r . .:~... ~- :.

1.- - .')-~f:IV ~""!(- <'-,-'lf"--\t~..ty../'1


..

'

_/

v
__ ,

MitochO~d rial-erizy-me

~~~,(~,,,._: -S-~-);--\~~-") (__

--

.. - .. _t ~-. ~. . '""

.:;.

~~~ j.IY'(~~:.._ ;.~ f.)\.lj(~C~L"' 'f-.. 0\"lr'-:~}U.~I.OA.,

(J\"--\\._<C'C-~i..~-- ~'v~(~\?"-uJ-~~~ ~ i-;)\(c.\.~Cdo~..:.;.\ c\~t_;:,c.\c__ ,_:.~.-'_,\-.,,,.,

<;

~\o,,..-..'.:)

1~.nzyme

11\~tc\... ~~~-dcp'r\.o':'(~~65\a.\Cl"\.

activated by

,......_
,-.
,. I'-\ '{""-.('"'1(\v. .'v'
.

.-.

l).

proteoT~tic clc~1vagc

_-,...
----'(

. 'I (_i'l("'-'

~ r_\--.~,,_~\:;' ,-~
,,J -IL.~, n e'-"'" .

I,.N...

'?'-o-\..~:)~C
C

\o;<."'-vr\.O~L

.. ...:7

":. 1f\(t(tLve

~)""~~~

\)

[/

_C\(1t.._~t:. ~ c0 'l'-'C'-7

t"v:_,. . ---

\,. ---t -i>Y\LS"\)'"''"-t

\ ...

....

:tl' ~rt!llp

J- \ll"llli<lll

-t.- i\-lcnlion

~l;l

elf

l"IIZ)'IIll'S

cx;lmple ol group
c1\

:111d

:Ill

l'X:Illlj)Je of j(.

SjWCtltnty

(2dL'grces)

ol enzyme action.

(2dcgrccs)

.-,;.

5- Enzymes

1_

i11~.:n:asc

:1divation.

--decrease- don't ch:111gc) l'nL' cnurgy of


(2dcgrccs)

6- Change or the activity of glycogen syuthnsc by phosphory\:1tion is

. I - ~ "" . --!1 j\-_..__ -t .


L:<llll:(l .-. ,, ,,,,,,,,. (

lllltllbcr ( i-:.:.- 5- G)

\..:..liCbll:l:~J

(2dcgrces)

X-,-M e11t ion ihc 11amc oC:my-mmtosaccha ridcanlLits, corn:spunding


s11gai' alt:ohol. : . . ( .. :.c _
.,
:!:.

-,,.

.:')o (

~)-i \" (

(2dcgrccs)

.....

._.J

..

;",j

")

9- M Ctll:ioll the struct II n

-t

.I

.::.,.......

-. ..

or rl'llulnsc.

(2dcgrrcs)

'\

'

ao

~-----~---------- .

.~:. ..--~=-~
_.;

"Hi-: what is the

..,.;_

c~1m;c

(2dcgrees)

uf I:Jctosc intolerance .

...

.;

?:t.:j
' .,.
-~ :~:.---~
~ ~-

. ::

:.::-.

l"J- llllC:sllll;u upaM.: '''-'"' 1111 \ .... - ...........,. - ... _~-

.. : .
. :.

(2dcgrccs)
...-

1~- Cnln:~.ynH~

\.

Q is used in .substrate level phnsphoryl:l!i:m.

:- ...
.:

( TnH -

(2tl egrccs)

F:1l..;p )

19- Amino group attached-to C2ofguaninc. is:obtainl~d l"rom


. n
.
.
..
\{!- ( ~. 'j~' '

.' .. ...... ~.....I~"NitJ!:~ ~~

..,,

II

f'..(~'\, .

.i.\1- lJI 01~11 oiiiii-.IIIJ II IIIli.. ''"" "~h'

..
.'

...
!:

.... '

..

""" "' ,., ........ .

...

( True

i.<:j

. i

False )

. I

:. f

. i

..

..~1:

,:-_: .:-:

o\.
I'll\
\

I _.,

,
1
'!

f:~

.il

. '
I

~..--.

..

,i

., .

. -.

. -.i

'

..

'

'

'~I

(7: 1"\.

.L-~~

>-! -

' '.

l ' ' , ___ , '


-i

:;{c~:.rc.J~

./

.r-'
~

[Dli<;cXD,:[~;,
~
'---I

-~.

- ----- . . . , -~..::J/j>,c
;-

1
1 . )"'

.~ (:-;.-:.,-' _.{ I .J(. ... .

.....-..~.--. ----.. ---

;-;~-~-,~/-l
. :r~.!:t-L --;,~-. r-1 ,OcJ/; .f,l},~a~. ---=--_~~:.;.
. / ..
\LA
//
-.:::::. ' '-:
v ' - f._ r

'-- u, .

..

.----------~

---

\j
~- .:~- l_ 5'/\ _.t:t.rJ c., . t--Ctc~-~\~-u
J1/k~et.
I
Ql' ___ ._ __
1 .._.-1

.. --~ ........ ;~

---------------

"-

a(\

'j

~~~\

ij(

/';:
I

>

: l;

'

"1YaV'SLat1on "pro~;n. %n:thests~~--ID~

1!!

1 l'l
}I _ CoU"'enr.~
'I
. :

. '
I

--

------,..-l'""'!"t---.-~

I
I

s~ o.rd pm~n --=~--~~-~----t\__.-,;.: ..7 /_~-~!___ .______. .,


-

I 1--.......
:r
,. ,. . . . . --- --- _________ . :._____,i____ _. _____ ... ____ .........--:1~--,_.;: . ~< . . _... -----~.. _I-.

-- ......... I

I(

'"''

-,--.,-~-.._..---,.---,-----,.-.---~----~-.,..---

............

-.

d_~Jf~+-~s ha..re~1 b__ s<~~l--,--. ----:-.-1-..-------~ _

-.et _..
j;; --- C

...

I. - .

~-

I '
i

,;

6_ --

,)_. .to.u:JY]l~:-5q.Y.l~~-o.CCa~
.

_I

__

.J~,
,
__ 1
I
. .l... - ....!O.I..u:.~''{)5 -~--------~-" --0m-U1D-0.UCL_._ .. J.L ...... _.. -- .. - --- .:..... -

' '

h
L~..~~-'---::tf)e_
.... -J.i
0 .
cn __y:l"bcOO.me:S--~--::trz:u.~fi.
I

Ot..ut

-1---
.................
\
i

....L:

~-!Pc:;:.uc_
C)

[
--.----------j----

_______Co_a..on~'7_o(\__m.._~

r.

~----~~~--~~-------------------------------------~ . Genena'Code
. . . . l

-...~~~:bL~de: i~~-i J_m~~ ;;~~A~-~---~.


I
:

__________ .,;_~--

_.,.-t

J.L...,. ..L.,..

f'~.

-------~----------=-----

---Lne.....~-'C:I:~~Cle IS 3.

- - -- - - - - - -------

I -.lJn~
J
~---U:J_qri.l

-f ..

(V

i..,

_r)~L-

-~---

CAde ~ -

~--. ___

-----. ----------.-------_- . c------

~-~~4~~~-~~rc;y;~_jjl__mQ$~~i-~rrh~o:ffi>reru~.
.
-'- -t'\ /, t 11 tt
,.,~
. ________ f& __3__fb_oar~~-_,_u\.7.(

HA'G

..
V~- '\
-J~5:top

. . lco..c:bXL:/ .
=u+OOitl~~

~~~

.r--. -

---------~--.:The . ._Y.f.St ,&...G:d.orl"i) ~ fc.c__2~~--~-... . .


.
a.m._\:no_a.ud_ho..ve .. m6.r.:e._k0--.~--- 6:,_~-----~------.--.
____ . . ~. --Ccclo.n--=ba.L.d.~~~y:_,ts.L2___~ us he.._J:t:cqj.n.,'zed

. . . . . . . _ . . . . .s..o. .).

. . - . --41-di1ken.-t.R~UL________ '

., ]]~3h'"iinism (;\! -tronSi.ation


... 0\ \ t\L..~o'(l

'

I ----j- .7

. --:----

-.; .

'

@.ElorL~CL'O. _____.______ .@~m.io..CL-t:itJT---~

'

':

'

,.

I
~

j.

'

...

_ Q~
---

'''''"

____,_~

; '"' I f~

.....--r----... ~-...- .
I
.,.

..---~-r---------,---

.-- - - r - -

...

_ _ __,_

_,;,__

a_ ..istb- 7 -~Je... .'.. a..cL_\s_.a.ciiv.cdd._bt)---xecte:h.O@J-t.c..li:th__ _Rl!A __~J'ct:~~e-___.--.

. .a~ . . -R~A. ---hl!--.a.A.--tRt-JA


___. s~~
. ~--.
U
V
:
.

-- .

____ ---------------~,- ..... __ _


.
l
.

-.~~r -~:~=i~-~~:=~~~-:~;~J_&_~;ob~~l~~~~=~

- -_~jk:~=~-~--6n.~~-------~--~~~~L~_---.A;~-:;~~T%o-.t:-~~~th<o~-.- _::
. _. ._ _ Md. . .~-~- . ~"'P~ .Jtl___hac.e.i:~.a.~_G~_(.eaciL-f.oy:~Y.o.\.-~;
4-----I
.
I
;
.
!
.
.
.
r.
:.t..r_\...l.J~-'-~

~-

:~~~fu-_;~?---~n-~:-L~~--;=~------~==~~=
.. --- ..........~-~e.;:J~\_:1\.CL-b.CT(.\_.~-r:e.....alot'l-_a_n __ ~:~~~~d~

~~~
... ... 3. - _erd_ _ _ p{___4e ____ J6_S -~-&NA_I.1.:..-th~_S,_su.bi.Yl..l--.d.
. . r::l~~e-~-------.
i

i
. . ... . .....---------..--'----------------------.. ------------------- ... -.. --i-.--....
-...

"""-- -r.h.e_..lui:ticdio:n~:c__l.I:t1..j_I.1:..2.:1_!1;~~La.\__()__caoo.~Ll:..rb__;
::OS ...._stJ.b.w:id:_cJ_-c.ib.cctxa~te_~L~o~lf.:L~~-~rl~n4~

be.

( Tp. i1L.bi.ncL wi:lh__l_-l;_2-+.hcd-~DJ8q.~e :-!--AU~_.c:Mon..!------..\n\1io.ioa_ .

_ ___o,de__ -+_erxJJles~_mR,N_a&-Me!-- . ~.
.

'

.. p

-...... ----. ------------- _______________ . _____________iuJO-ID .. ~---COmpb-".....

_11_ ___
.

------- ....... _

'' :s .~~~~,di~~r J1.1.~_1i..J:i-~g,;-~~C'amfl"t .


.: ' :S~ .'auJ>..u..nit: ;oJ r:: ~e-~'"----

.:

~.

c.Jtili--I

. -

_t1.et--.iRbJJL_.ir:L.J ~o.\YI_:tbe___ca~,?leX..----~

--------

..8t;lmSe ath--~-oJJo~~~~---~
. . . . ~--- cc'' '. ' .. '
.
. < ' .,_.,,., ..., " . : "' ,., ', . . ~~---..J~~~):re +he _cacbn__AUG_'"_. \:o.l_no.h.o:f.:l_eooJoY\~--}--- ____ _
---'---'i;:!L . .. , .,.
----------~-. . _... :..~~~- ___:_ ___ ~..:_. . .
~-----~-.

.... _EJxJJle . m RNA. &


l ;
;

- -- -~-- 4---.- -

.. .. . J: --------------------------------------

__

- --

..

-" _,_.... _.., ____ ....

----

-:-

~-----

... _

. _____ :;~-~--'=------ .. - ----- ---

------..
-----------~~---"------:------.....__

________ .... _ _ _ _ _

_ _ _. ____ ...... _____------l.__

..

...

.
-- .... ---------------:-------- ---------------- ----:--- ---------------- ----'--

----:-- ..

- - - --- . ------ -

'

'

:t; ~-,
'

. .

'

'
i

,,

~ -~3-.;
. 4~--~i 0 ~F-~
____ ... .'0 ...ta.5_1aj_n -

..

; :.~
--~---

di\ 1/

--.---,----.--t--:..-:---

I ..L~~- ' __!_\


, ~ .. -: .
,.~ -=-~-,J:.\
__J&f__m.IOa..:;n.Oi-\.--,-~uo:r--'---+--Q~....u.-v-wc...---r-;--~

-~
.

. ~~r; ~\~d.Yn.~se ..,L~P-o4)pr-tide ____a.nd___-c._JiNA__}pnd__\tL....~P---~i:\e_._-;-~---

"

- ------------

- - - - - - - - - - - - - - - - - - -.- - ------r-_;_
----

:'~'" : 5<!~1-!-lenccaLnu_c..t~~cb--~~YLoJllA-bas_o.n\Le.c:ta:.l ~--mJ_s""'~uen"'F' o..~

Jf.uL '1o~pt.p:tide.~pme"" .pnm~~-

____ -----

.-E-----

c~~; :~~-~~;__

______ ;__._~c..inc>.
~ el0 ( ~~)-~
.. --~:~ ~: _.,.:.e.bn8rll~.o~:J.~
.~-&EI,~E:~~
--- -:~: 1e:.al~- ,,

_..._e_g,~L..:...;-.-~~---"-

,.

!
-------------~---------

\i~--1.0.8. :-jf1_li~2...1r.ans.Lolecl

l[L_______5_'-

dirt=ei6Yl - - - -

,:

~--pm~:t~th~z.J i~ 4~~ ~ ~~ci~:---~ -cthttfiC~;~ .~fWA--:~-:;~~#~:~~:k-:m:--[: _-

(a)

.
i

fll.aru
!! .
.
. - DC___ ~_\L

:MJJ ... ..
-J----oCA~

-~--:------- -!-f

__________').\ ______ _u_ _________

. - . .

: __ :_______ ______
~ ____
mu.Hi- .-ir-~------- -----'~~~-----

. ::.

.. .

----~

; . . .

.
lu . .... ' j " l . () .
~ II
.
. I ,,
ol I
cp ~-lpo:J ~li~:te._ Llr.Ui1_::w.r-.m.~--~-r:\~_.;...itl CL\~_:__

~~::~.p-~~,~~--:l:ei::h~~c"~Jo- m~~-.;c-V.,tri~,~---~-- ..

__ ..:..Jc.___ ~b.H~-.l~.:_C2allS!C!_ut\.Lii
,I . ~

. I

. _.:. earn~ I

_____

:,,.~. . -~~:=?~~i_~\;~~~;J:.:_;~:gp~~-~

,. , . , ~ _. .. ,...__:.,1 . '

.,

,; .~;pct~~~----_------~------- :. . r-----~F~-"''1!
> . l,,,

l'

-'" cf'{

,.

,.<.-,.,- 'f '''"''" . ',., '

' " ' " .,. ,........ . .. .,,xi,.,..'

.. '"".

. .=

I
;
'
.
.
!i ---------.................... --;--1-------------------------- ------ ...... ------------------:-.......... --- :--------

S~-e(').,l _r.\boS:>~

.G;v.J_ ..-tra.nslcde

-----------~--.

_"PiJt'lSI! '

-.

__mRJ~A ---~~u.lLa.neo.~-er - ..

;
I
l
. .. ~-c- \f.O..~Y"\to.so.mcs ~-'---- ...... ..... -------1--- - . .... .. .... ---- . -------.. -------!- ----
; ~ ""'J
.
I
.
l
~

..... ----- --~-----.:. ________ _;,_______ ------------- -- ---. ------ .. ---- ---- r--- ---- -- --------.- -- ... -- ---- j_ - - - - - - '"----.

.;..~e ___ mw;im"--"l ___


.

...........

,::,\e,;.si:lj

-----~.1'. ---- ..... -----.. ---- ........... .. ..... .

1<;,_

o~e _rlhl .:'"me_

. . ... : .. ---------- .

-~--- -~--->-.:

-----~-- --------

p::.-LW ___n~cks ,
. . - - --~--- ----'~--------

l~t_
i

..

I
I

. !
.

(.1(?)

=: ;

----Vf!r~---

: :- "

-=-=.

s~~--.
.

Ah

---.------ ------------ -- . --------------- ---- --

_flo ~r:psides

~.

--- ... ------- --- - ----

,.. e bep toWJ~d.t\ '\

..

--+----- -- --

J-~~:~c.fiv1~~_d__iYli.tLoh_o1L_~-m.~----'o_~-~

------..-~ . o_ui_30 s. su.bu.nLt.\-o~- - - , - - - - - .! t

-- .... --- ... _....,.._.___Jl.-~------------,.


1

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