GERVACIO, Siergs Smith P.

BSN IV

Patients Name: Teresita Daraman

Sex:
Female
Name of Drug
Generic Name:

Classification
Pharmacologic:

Cefoxitin

second-generation
cephalosporins

Brand Name:
Mefoxin
Cefoxin
Cefoxitina

Diagnosis: Staghorn Calculus, Left

Age: 56 years old
Mechanism of Action
Action:
Bind to bacterial cell wall membrane,
causing cell
death. Therapeutic Effects: Bactericidal
action
against susceptible bacteria. Active
against
Bacteroides fragilis.

Patients Dose:

Therapeutic:

Pharmacokinetics:

500 mg IVTT q12 hr

anti-infectives

Absorption: well absorbed following

IM administration.
Distribution: Widely distributed.
Penetration into
CSF is poor. All cross the placenta and
enter breast milk in low concentrations.
Metabolism and Excretion: Excreted
primarily
unchanged by the kidneys.

Maximum Dose:
2 g q6-24 hr

Date of Admission: January 23, 2016

Height/Weight: 39.5 kg/5 ft.
Indication
General:
Treatment of the
following infections
caused by susceptible
organisms: Respiratory
tract infections, Skin
and skin structure
infections, Bone and
joint infections, Urinary
tract infections. Intraabdominal and
gynecologic infections
Patients Indication:
Urinary tract infection

Contraindication
Hypersensitivity to
cephalosporins;
Serious hypersensitivity
to penicillins.

Side Effects
CNS: SEIZURES (high
doses).
GI:
PSEUDOMEMBRANOUS
COLITIS, diarrhea, cramps,
nausea, vomiting.
Derm: rashes, urticaria.

Precautions:
Renal impairment;
Patients with hepatic
dysfunction, poor
nutritional state, or cancer
may be at increased risk
for bleeding; History of
GI disease, especially
colitis; may also be at
increased risk for
bleeding OB, Lactation:
Have been used safely.

Hemat: agranulocytosis,
bleeding, eosinophilia,
haemolytic anemia,
neutropenia,
thrombocytopenia.
Local: pain at IM site,
phlebitis at IV site.
Misc: allergic reactions
including ANAPHYLAXIS
and SERUM SICKNESS,
superinfection.

Minimum Dose:
Ro
ute

1 g q6-8 hr
Pregnancy Category:
Availability:
Powder for injection
Premixed containers

IM
IV

On
set
Ra
pid
Ra
pid

Peak
30
min
End
of
infus
ion

Durat
ion
4-8
hr

Drug Interactions:
Probenecid decrease
excretion and increase
blood levels.
Concurrent use of
aminoglycosides or loop
diuretics may increase
risk of nephrotoxicity.

4-8
hr

Route:
IM
IV

Source:
Daviss Drug Guide
for Nurses p. 287 292

Source:
Daviss Drug Guide for Nurses
p. 287 - 292

Source:
Daviss Drug Guide for Nurses p. 287 292

Source:
Daviss Drug Guide for
Nurses p. 287 - 292

Nursing Responsibilities
Before:
Observe the 10Rs of drug
administration
Ask for drug allergies
Administer the prescribed dosage
Assess for infection
Do not confuse cefotetan with
cefoxitin

Source:
Daviss Drug Guide for
Nurses p. 287 - 292

Source:
Daviss Drug Guide for
Nurses p. 287 - 292

During:
IM: Reconstitute IM doses with
sterile or bacteriostatic water
for injection or 0.9% NaCl for
injection.
May be diluted with lidocaine to
minimize injection discomfort.
Inject deep into a well-developed
muscle mass; massage well.
IV: Change sites every 4872 hr to
prevent phlebitis.
Monitor site frequently for
thrombophlebitis (pain,
redness, swelling).
After:
Advise patient to report signs of
superinfection and allergy.
Instruct patient to notify health
care professional if fever and
diarrhea develop, especially if
stool contains blood, pus, or
mucus.
Advise patient not to treat diarrhea
without consulting health care
professional.
Alcohol and alcohol-containing
medications should be avoided
during and for several days
after therapy.
Documentation.
Source:
Daviss Drug Guide for Nurses p.
287 - 292