Beruflich Dokumente
Kultur Dokumente
linearviscoelasticmaterials
John Caughman and Dillon Rutland
Advisor:PaulaAVasquez
The11thAnnualUNCGRegionalMathematicsandStatisticsConference
Saturday,November7,2015
ViscoelasticFluids
Whatareviscoelasticfluids?
Fluidsthatexhibitbothviscousandelastic
characteristicswhenundergoingdeformations
Viscousfluids:
Characterizedbytheirresistanceto
deformation:Viscosity
Elasticmaterials:
Deformandreturntooriginalconformation
(unlessitexceedstheelasticlimit).
Characterizedbytheirmodulus
Examplesofviscoelastic
fluids:
Mayonnaise
Milk
Paints
Shampoo
http://www.3girlsholistic.com/wp-content/uploads/2013/01/honey.jpg
Examplesofbiological
viscoelasticfluids:
Blood
Saliva
Mucus
https://picturesplace.files.wordpress.com/2010/04/wpid-elastic-material-at-salone-internazionale-delmobile-elastic-wood-chairs-by-gilli-kuchik-2.jpg
LungMucus
Healthyindividualshavecilia(tinyhairs
withintherespiratorysystem)clearthelung
mucusfromtherespiratorytract
helppreventbacterialinfectionsand
disposeofharmfulinhaleparticulates
Someproducethickmucusthatisdifficult
toclearfromtherespiratorytract
Causedbygeneticorenvironmental
factors
COPDandcysticfibrosisaretwodisorders
thatcausesomehumanstoproducethicker
mucus
mucusoftenbecomestrappedinthe
lungsbecauseciliaareunabletomove
itduetoitshigherviscosity
Biophysicalpropertiesoflungmucus
changedaround4wt%
Biomarkerofmucussolid
concentration
http://www.pulmozyme.com/hcp/images/hcp-content/mucus_transport_800.png
http://www.drugs.com/health-guide/images/205362.jpg
ResearchQuestionandObjectives
ResearchQuestion:
Canmodelsbuilttosimulateviscoelasticmaterialsbeexpandedtoaccurately
modellungmucusonhealthypatientsaswellasinpatientswithcysticfibrosis
andchronicobstructivepulmonarydisease(COPD)?
Objectives:
1. Tocreateauser-friendlyGraphicalUserInterface(GUI)inMATLABthat
allowsuserstoinputdataandhavetheprogramoutputfractionalmodel(s)
thataccuratelycapturestheviscoelasticpropertiesofthematerial.
2. Tounderstandtheextentinwhichhumanlungmucusviscoelastic
propertiescandiagnoseandusetodesigntreatmentsforCysticFibrosisand
COPD.
SimpleViscoelasticModels
Stressproportionaltoderivativeofthestrain
Viscous
SimpleViscoelasticModels
Stressproportionaltostrain
Elastic
SimpleViscoelasticModels
Series
Viscoelastic
G
Parallel
SimpleViscoelasticModels
MaxwellModel
Stressisforceper
unitarea
SimpleViscoelasticModels
MaxwellModel
Stressisforceper
unitarea
Strainrefersto
thedeformation
SimpleViscoelasticModels
MaxwellModel
Stressisforceper
unitarea
Strainrefersto
thedeformation
Inseries,thestressesinthedashpotandthe
springarethesame.Andthetotalstrainisthe
sumoftheindividualstrains
Constitutive equation
fortheMaxwellmodel
SimpleViscoelasticModels
VoigtModel
Inparallel,thestrainsinthedashpotandthe
springarethesame.Andthetotalstressisthe
sumoftheindividualstrains
Constitutive equation
fortheVoigtmodel
SimpleViscoelasticModels
Differentmodelscanbeobtainedbycombiningspringsanddashpotsinseries
andparallelandfollowingthesamerules
Spring-Pots
Newmodelscanbeimplementedbyadding
spring-pots,acombinationofspringand
dashpot
V,
d
Theequationforthespring-potis: V
dt
isavaluerangefrom0to1
where=0isaspringand=1isadashpot
Viscous
Visquasi-property
differsfrommaterialtomaterialandhasunits[Pas]
2
Elastic
CreepExperiments
0
Output
Strain,[-]
Stress,[Pa]
Input
Elastic
Time,[t]
Time,[t]
Compliance,[1/Pa]
Compliance,[1/Pa]
Time,[t]
Compliance
J
0
Viscous
Time,[t]
GraphicalUserInterface(GUI)
References
HillDB,VasquezPA,MellnikJ,McKinleySA,VoseA,etal."ABiophysicalBasisfor
MucusSolidsConcentrationasaCandidateBiomarkerforAirwaysDisease."PloSone
9.2(2014):e87681.
Jaishankar,Aditya,andGarethH.McKinley."Power-lawrheologyinthebulkandatthe
interface:quasi-propertiesandfractionalconstitutiveequations."Proceedingsofthe
RoyalSocietyA:Mathematical,PhysicalandEngineeringScience(2012):
rspa20120284.
Acknowledgments
UNCG-RMSC
MagellanScholarshipUSC
InterdisciplinaryMathInstituteUSC
GroupsofGregForestandDavidHill
UniversityofNorthCarolinaatChapelHill
NSFDMS1410047
PaulaVasquezGroup
MathematicsDepartment
USC
paula@math.sc.edu