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ImplementingaGUIplatformtostudy

linearviscoelasticmaterials
John Caughman and Dillon Rutland
Advisor:PaulaAVasquez

The11thAnnualUNCGRegionalMathematicsandStatisticsConference
Saturday,November7,2015

ViscoelasticFluids
Whatareviscoelasticfluids?
Fluidsthatexhibitbothviscousandelastic
characteristicswhenundergoingdeformations
Viscousfluids:
Characterizedbytheirresistanceto
deformation:Viscosity
Elasticmaterials:
Deformandreturntooriginalconformation
(unlessitexceedstheelasticlimit).
Characterizedbytheirmodulus
Examplesofviscoelastic
fluids:
Mayonnaise
Milk
Paints
Shampoo

http://www.3girlsholistic.com/wp-content/uploads/2013/01/honey.jpg

Examplesofbiological
viscoelasticfluids:
Blood
Saliva
Mucus
https://picturesplace.files.wordpress.com/2010/04/wpid-elastic-material-at-salone-internazionale-delmobile-elastic-wood-chairs-by-gilli-kuchik-2.jpg

LungMucus
Healthyindividualshavecilia(tinyhairs
withintherespiratorysystem)clearthelung
mucusfromtherespiratorytract
helppreventbacterialinfectionsand
disposeofharmfulinhaleparticulates
Someproducethickmucusthatisdifficult
toclearfromtherespiratorytract
Causedbygeneticorenvironmental
factors
COPDandcysticfibrosisaretwodisorders
thatcausesomehumanstoproducethicker
mucus
mucusoftenbecomestrappedinthe
lungsbecauseciliaareunabletomove
itduetoitshigherviscosity
Biophysicalpropertiesoflungmucus
changedaround4wt%
Biomarkerofmucussolid
concentration

http://www.pulmozyme.com/hcp/images/hcp-content/mucus_transport_800.png

http://www.drugs.com/health-guide/images/205362.jpg

ResearchQuestionandObjectives
ResearchQuestion:
Canmodelsbuilttosimulateviscoelasticmaterialsbeexpandedtoaccurately
modellungmucusonhealthypatientsaswellasinpatientswithcysticfibrosis
andchronicobstructivepulmonarydisease(COPD)?

Objectives:
1. Tocreateauser-friendlyGraphicalUserInterface(GUI)inMATLABthat
allowsuserstoinputdataandhavetheprogramoutputfractionalmodel(s)
thataccuratelycapturestheviscoelasticpropertiesofthematerial.
2. Tounderstandtheextentinwhichhumanlungmucusviscoelastic
propertiescandiagnoseandusetodesigntreatmentsforCysticFibrosisand
COPD.

SimpleViscoelasticModels

Stressproportionaltoderivativeofthestrain

Viscous

SimpleViscoelasticModels

Stressproportionaltostrain

Elastic

SimpleViscoelasticModels

Series

Viscoelastic
G

Parallel

SimpleViscoelasticModels
MaxwellModel

Stressisforceper
unitarea

SimpleViscoelasticModels
MaxwellModel

Stressisforceper
unitarea
Strainrefersto
thedeformation

SimpleViscoelasticModels
MaxwellModel

Stressisforceper
unitarea
Strainrefersto
thedeformation

Inseries,thestressesinthedashpotandthe
springarethesame.Andthetotalstrainisthe
sumoftheindividualstrains
Constitutive equation
fortheMaxwellmodel

SimpleViscoelasticModels
VoigtModel

Inparallel,thestrainsinthedashpotandthe
springarethesame.Andthetotalstressisthe
sumoftheindividualstrains
Constitutive equation
fortheVoigtmodel

SimpleViscoelasticModels
Differentmodelscanbeobtainedbycombiningspringsanddashpotsinseries
andparallelandfollowingthesamerules

Spring-Pots
Newmodelscanbeimplementedbyadding
spring-pots,acombinationofspringand
dashpot

V,
d
Theequationforthespring-potis: V
dt

isavaluerangefrom0to1
where=0isaspringand=1isadashpot

Viscous

Visquasi-property
differsfrommaterialtomaterialandhasunits[Pas]

2
Elastic

CreepExperiments
0

Output
Strain,[-]

Stress,[Pa]

Input

Elastic

Time,[t]

Time,[t]
Compliance,[1/Pa]

Compliance,[1/Pa]

Time,[t]

Compliance

J
0

Viscous

Time,[t]

GraphicalUserInterface(GUI)

References
HillDB,VasquezPA,MellnikJ,McKinleySA,VoseA,etal."ABiophysicalBasisfor
MucusSolidsConcentrationasaCandidateBiomarkerforAirwaysDisease."PloSone
9.2(2014):e87681.

Jaishankar,Aditya,andGarethH.McKinley."Power-lawrheologyinthebulkandatthe
interface:quasi-propertiesandfractionalconstitutiveequations."Proceedingsofthe
RoyalSocietyA:Mathematical,PhysicalandEngineeringScience(2012):
rspa20120284.

Acknowledgments
UNCG-RMSC
MagellanScholarshipUSC
InterdisciplinaryMathInstituteUSC
GroupsofGregForestandDavidHill
UniversityofNorthCarolinaatChapelHill
NSFDMS1410047

PaulaVasquezGroup
MathematicsDepartment
USC
paula@math.sc.edu

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