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Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
TABLET
HARDNESS TEST
Presented by:
Calingasan, Ana Theresa U.
Cortuna, Nadia Czarina Mae S.
De Guzman, Liza Marie C.
BSP4A
Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
TABLET
A solid dosage form of medicinal substances
usually prepared with the aid of suitable
pharmaceutical adjuncts
BSP4A
Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
HARDNESS
Is the measure of how resistant solid matter is
to the various kinds of permanent shape
change when a force is applied
BSP4A
Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
TABLET HARDNESS
AKA Breaking strength/force
Defined as the pressure force required to
break a tablet in a diametric compression test
BSP4A
Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
BSP4A
Definition
Group 3
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
tableting machine
BSP4A
Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
ADVANTAGES:
-to determine the need for pressure adjustments on the tableting
APPLICATIONS & USES:
machine
and storage
ofpower
the toformulation
--indicates
the resistance
damage its intactness and reflects
the internal bonding strength of granules/powders which can able to
hold composite structure under applied external force
BSP4A
Definition
Group 3
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
DISADVANTAGE:
-to check the hardness conformity
hard may
disintegrate
requiredcapping
period
1. *too
Unable
tonot
give
idea atabout
and
*too
soft may not behavior
withstand handling
during
subsequent
lamination
of the
tablet
processing
BSP4A
Group 3
Definition
Applications/
Uses
Advantages/
Disadvantages
Instrumentation
TabletDISADVANTAGES:
hardness tester models:
-to determine the need for pressure adjustments on the tableting
APPLICATIONS & USES:
1.
The Monsanto Tester
machine
So what are
these
instruments
being used in
tablet hardness
testing?
Rule of Thumb
- Most primitive way and practical test for
hardness of tablets
-rule of thumb described a tablet to be of
proper hardness if it was firm enough to break with a
sharp snap when it was held between the 2nd and 3rd
fingers using thumb as fulcrum, yet didnt break
when it fell on the floor.
WINTER
Template
-also
called as
the plunger
- adapted to
engage the tablet
WINTER
BARREL Template
plunger
stirrup
Knurled knob
WINTER
Template
WINTER
WINTER
WINTER
DISADVANTAGES:
Template
Low priced
Convenient
WINTER
ACCEPTABLE RANGE:
Template
Plunger as the
pressure increases,
plunger is forced
against the tablet
1.4 SC = 1 Kg
DISADVANTAGES:
Did
not
depend
on
the
mechanical properties of a metal
spring, and therefore did not
suffer from metal fatigue through
prolonged use
- Patented under US
2,975,630 around 1960
Patent
No.
1
3
2
2
5
Disadvantages
operator variability in
rates of loading and
difficulties in proper
setup and calibration
3
1
3 Motor the
sliding mass
which
is
driven along
by means of
this
electric
motor
Disadvantages
of Linear
sliding
mechanisms of high
quality
are usually
quite expensive and
are relatively difficult to
seal against abrasive
particles.
Powerized
platens
it
presses
the
tablet
against
the measuring
jaw
6
2
7 Drag contact
as drag contact
moves to the
right, it contacts a
pointer,
which
shows the force
applied to the
tablet on a linear
scale.
6
2
Advantages
Summary
Apparatus
Stokes-Monsanto
Strong-Cobb
Pfizer
Erweka
Schleuniger
Mechanism
Spring
Air pump
Hard pliers
Suspended weight
Platens
ADDITIONAL INFORMATION:
Factors affecting strength
(hardness) of tablets:
-Speed
of compression
-Solid state structure
-Particle Size
-Solid bridges
-Mechanical Interlocking
-distance force
-Bonding Mechanisms
-Volume reduction mechanisms of powder
-Surface Area change
REMINDERS!!!
Hardness can affect the disintegration. So if the
tablet is too hard, it may not disintegrate in the
required period of time. And if the tablet is too
soft, it will not withstand the handling during
subsequent processing such as coating or
packaging.
In general, if the tablet hardness is too high, we
first check its disintegration before rejecting the
batch . And if the disintegration is within limit,
we accept the batch.
END