Overview of Antibacterial Drugs - Infectious Diseases - Merck ...

Page 1 of 3
English

Common Effects of Antibiotics on Other Drugs

Drug

Toxicity Enhanced By

No Change With

Drug

Toxicity Enhanced By

No Change With
Aminoglycosides
Cephalosporins
Clindamycin

All macrolides (eg, azithromycin, clarithromycin,

erythromycin)
Digoxin

Doxycycline

Tetracycline

Trimethoprim

Fluoroquinolones
Ketoconazole
Linezolid

Metronidazole
Penicillins

Quinulpristine/dalfopristin
Sulfonamides
Vancomycin
Phenytoin

Chloramphenicol

Azithromycin

Isoniazid

Cephalosporins

Ciprofloxacin

Some macrolides (erythromycin, clarithromycin,

telithromycin)
Rifampin (decreased phenytoin levels)
Sulfonamides

Aminoglycosides
Clindamycin
Doxycycline

Fluoroquinolones except
ciprofloxacin
Linezolid

Metronidazole
Penicillins
.
These drugs interfere with vitamin Kdependent clotting factors and, when used with antiplatelet drugs and
thrombolytics, may increase risk of bleeding.

http://www.merckmanuals.com/professional/infectious-diseases/... 05-Apr-16

Overview of Antibacterial Drugs - Infectious Diseases - Merck ... Page 2 of 3

Drug

Toxicity Enhanced By

No Change With
Quinulpristine/dalfopristin
Tetracycline

Trimethoprim
Vancomycin

Aminoglycosides
Azithromycin

Cephalosporins
Clindamycin
Ciprofloxacin
Theophylline

Clarithromycin
Erythromycin

Rifampin (decreased theophylline levels)

Doxycycline
Linezolid

Metronidazole
Penicillins

Quinulpristine/dalfopristin
Sulfonamides
Tetracycline

Trimethoprim
Vancomycin
Warfarin*

Cefoperazone

Aminoglycosides (IV)

Chloramphenicol

Cephalosporins (some)

Doxycycline

Doxycycline

Certain fluoroquinolones (ciprofloxacin, levofloxacin,

moxifloxacin, ofloxacin)

Penicillins

Cefotetan

Azithromycin

Clarithromycin

Clindamycin

Erythromycin

Linezolid

Metronidazole

Rifampin (decreased PT)

Quinulpristine/dalfopristin
Tetracycline

Trimethoprim

.
These drugs interfere with vitamin Kdependent clotting factors and, when used with antiplatelet drugs and
thrombolytics, may increase risk of bleeding.

http://www.merckmanuals.com/professional/infectious-diseases/... 05-Apr-16

Overview of Antibacterial Drugs - Infectious Diseases - Merck ... Page 3 of 3

Drug

Toxicity Enhanced By

No Change With

Sulfonamides

Vancomycin

.
These drugs interfere with vitamin Kdependent clotting factors and, when used with antiplatelet drugs and
thrombolytics, may increase risk of bleeding.

http://www.merckmanuals.com/professional/infectious-diseases/... 05-Apr-16