Chemical Reaction of Amino Acid

N
o
1.

Chemical Reaction of Amino Acid

Reaction with HCl

Reagent : HCl

Chemical Reaction
Example :
1.

H
H3CH 2C C

NH2

HCl

COOH

2.

Reation with NaOH

Reagent : NaOH

Example :
1.

H
H3CH 2C C NH2

NaOH

COOH

3.

Reaction with alcohol in the

presence of acid catalyst

Reagent : R-OH, HCl(catalyst)

Example :
1.

H
H3CH 2C C COOH
NH2

NMS/Chap 19/sem2/2013_2014

H3C OH

H2SO4

4.

Reaction with NaNO2 and HCl

Example :

Reagent : NaNO2 and HCl

(0-5o C)

1.

H
H3C C

NH2

COOH

NaNO2 , HCl
o

0-5 C

H
H3C

C N

-N2

NMS/Chap 19/sem2/2013_2014

COOH
carbocation
H2O

H3C

COOH
diazonium salt

Formation of Peptide Bond

+Cl +

-H+

Peptides are amino acid polymers in which the individual amino acid units, are linked together by amide bonds, or peptide
bonds
More than one amino acid react together, H2O is eliminated. This is condensation reaction

Peptide Bond

Dipeptide bond

Tripeptide bond

2 amino acids form dipeptide

1.

Formation of dipeptide

When two amino acids react together, a water molecule is eliminated and dipeptide is formed. The reaction is called condensation.

Example :

O
H2N CH 2 C OH

2.

3 amino acids form tripeptide

C COOH

CH3

Formation of tripeptide

When three amino acids react together, a water molecule is eliminated and tripeptide is formed.

Example :

NMS/Chap 19/sem2/2013_2014

H2N CH 2 C OH

NMS/Chap 19/sem2/2013_2014

CH3

C COOH

CH3

COOH