Chemical Ionization

In chemical ionization-mass spectrometry(CI-MS) the sample

of molecules are combined with a stream of ionized reagent gas
that is present in great excess relative to the sample.
It is found that when a sample molecules collide with the
preionized reagent gas, some of the sample molecules are ionized
by various mechanisms, including proton transfer, electron
transfer and adduct formation. It is prove that almost readily
available gas or highly volatile liquid can be used as a reagent gas
for CI-MS.