Hannah Goldstein

10-11-15
IR1/3/10GT
Annotations: Week of 10/12
Key Terms:

Melanocytes
Cutaneous Malignant Melanoma (CMM)
Plasmid

Citation:
Wei, Q., J. E. Lee, J. E. Gershenwald, M. I. Ross, P. F. Mansfield, S. S. Strom, L.-E Wang, Z.
Guo, Y. Qiao, C. I. Amos, M. R. Spitz, and M. Duvic. "Repair of UV Light-Induced
DNA Damage and Risk of Cutaneous Malignant Melanoma." JNCI Journal of the
National Cancer Institute 95.4 (2003): 308-15. Web. 11 Oct. 2015.
<http://easybib.com/journal-article-citation/from-pubonline>.
Annotation:
This article discusses an experiment that was conducted to further explain how UV
radiation plays an important role in the development of CMM. Patients were observed and DRC,
DNA Repair Capacity, was concluded to play an important role in the development of CMM. UV
induced DCR was observed in all case study patients. This article provided a case study to
support the hypothesis that UV radiation causes repair gene damage, thus causing cancer. The
evidence provided will be used to further prove the DCR is affected by UV radiation.

Hannah Goldstein
10-11-15
IR1/3/10GT
Annotations: Week of 10/12
Key Terms:

Keratinocytes
Cytosine, Thymine, Guanine
Lesion

Citation:
"UV: Molecular Mechanism of Action." UV: Molecular Mechanism of Action. N.p., 2003. Web.
11 Oct. 2015.
Annotation:
This article thoroughly explained how UV radiation causes skin cancer. The UV radiation
damages various genes that encode for certain proteins. It caused a different bas to be placed
that\n the intended one. As a result, the protein sometimes cannot function, and over periods of
exposure to the light the proteins can reproduce and create more ineffective cells. This can result
in the cells becoming cancerous. This article was somewhat beneficial because its insight into
how UV radiation can cause a direct link to cancers. But, it provided minimal information on
melanoma development; and therefore, wasnt completely beneficial.