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Datasheet of (S)-Gossypol (acetic acid)

Description:
(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1M)
or Bcl-xL (IC50, 22.9M). in vitro: Gossypol-acetic acid significantly inhibited the proliferation of RAW264.7 cells in a
dose-dependent manner, and caused obvious cell apoptosis and a loss of m in RAW264.7 cells. Gossypol-acetic
acid-induced cell apoptosis was markedly inhibited by caspase inhibitors. gossypol acetate resulted in a dose- and
time-dependent inhibition of multiple myeloma cell proliferation, with an IC50 value to both U266 and Wus1 cells at 2.4, 2.2
M at 48 h after treatment. Gossypol acetate effectively induced the apoptosis of multiple myeloma cells. Colorimetric assays
showed activation of both caspase-3 and caspase-9. Bcl-2 and Bcl-xl expression was decreased by 86.5% and 35.9%, respectively,
after treatment with gossypol acetate at 25 M for 24 h [2]. Gossypol-acetic acid (5-40 M) inhibited the growth of MEC-1
cells in a dose- and time-dependent manner. Gossypol-acetic acid inhibits the proliferation of MEC-1, and DSB maybe one of the
mechanisms of inhibitory effect of Gossypol-acetic acid on the growth of tumor cells. in vivo: A growth inhibition (T/C) of 30.9%
(gossypol acetate 40 mg/kg) was obtained in Balb/C mice bearing Wus1 cells. In addition, there was no body weight loss for the
treated group in comparison with the vehicle mice. Male rats were treated with gossypol acetic acid, GSH-Px specific activity
increased in gossypol acetic acid group. gossypol acetic acid induce significant increases in the hepatic NEFA with remarkable
decrease in the total saturated fatty acids with a significant increase of PUFA. Gossypol-acetic acid has selective action on the
sperm membrane of the rats, it inhibited sperm Ca2+ influx in a dose-dependent manner, and exerts no effect on the high K+
induced contraction of smooth muscle of isolated rat.

Chemical Information
Catalog

DC9368

Purity of current batch:

>98%

Molecular Weight (MW)

578.61

Molecular Formula

C32H34O10

CAS No.

1189561-66-7

Solubility (25C)

DMSO

Storage

Store at -20C (desiccating conditions).

Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in
advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable
for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room
temperature for at least 1 hour.