Beruflich Dokumente
Kultur Dokumente
FUNGI
Eukaryotic; most are nonmotile and possess a rigid wall
Nonphotosynthetic
<400 species are medically important
<50 species cause >90% of the fungal infections of humans and other animals
Reside in nature and essential in breaking down and recycling organic matter
Contribute to the production of food and spirits (cheese, bread, beer)
FUNGI
Each fungal cell has at least one nucleus with a nuclear membrane, ER,
MYCOSES
Fungal infections
Most pathogenic fungi are exogenous
MAJOR MYCOSES
CATEGORY
Superficial
Cutaneous
MYCOSIS
CAUSATIVE FUNGAL
AGENTS
Pityriasis versicolor
Tinia nigra
White piedra
Black piedra
Dermatophytosis
Malassezia species
Hortaea werneckii
Trichosporon sp.
Piedraia hortae
Microsporum species,
Trichophyton species,
Epidermophyton floccosum
Candida albicans and other
Candida species
Candidiasis of skin,
mucosa or nails
MAJOR MYCOSES
CATEGORY
Endemic
(primary,
systemic)
MYCOSIS
Sporotrichosis
Chromoblastomycosis
Mycetoma
Phaeohyphomycosis
CAUSATIVE FUNGAL
AGENTS
Sporothrix schenckii
Phialophora verrucosa
Fonsecaea pedrosoi and others
Pseudallescheria boydii,
Modurella mycetomatis, and
others
Exophiala, Bipolaris, Exserohilum,
and other dematiaceous
molds
MAJOR MYCOSES
CATEGORY
Opportunistic
MYCOSIS
Systemic candidiasis
Cryptococcosis
Aspergillosis
Hyalohyphomycosis
CAUSATIVE FUNGAL
AGENTS
MAJOR MYCOSES
CATEGORY
Opportunistic
MYCOSIS
Phaeohyphomycosis
Mucormycosis
(zygomycosis)
CAUSATIVE FUNGAL
AGENTS
Chladophialophora bantiana,
species of Alternaria,
Cladosporium, Bipolaris,
Exserohilum and other
dematiaceous molds
Species of Rhizopus,
Lichtheimia, Cunninghamella, and
other zygomycetes
MAJOR MYCOSES
CATEGORY
Opportunistic
MYCOSIS
Pneumocystis pneumonia
Penicillosis
CAUSATIVE FUNGAL
AGENTS
Pneumocystis jiroveci
Penicillum marneffei
A - coenocytic hypha
B - septate hypha
C - septum
HYPHAE
Coenocytic /aseptate vs.
Septate
Hyaline vs.
dematiaceous
Fine vs. broad
dichotomously
branching
septate hyphae
nonseptate hyphae
Microconidia
Singly or in clusters
Macroconidia
morphologic differences
YEAST CELLS
Budding yeast
cells surrounded
by clear capsules
Most fungi are obligate aerobes, some are facultative anaerobes, but
FUNGI
BACTERIA
Diameter
Nucleus
Eukaryotic
Prokaryotic
Cytoplasm
Cell Membrane
Chitin
FUNGI
BACTERIA
Spores
Sexual and asexual spores for Endospores for survival, not for
reproduction
reproduction
No
Metabolism
CRYPTOCOCCUS NEOFORMANS
ROOM TEMPERATURE
CULTURE
37oC
ASPERGILLUS SPP.
ROOM TEMPERATURE
CULTURE
37oC
CANDIDA ALBICANS
ROOM TEMPERATURE
CULTURE
37oC
Ex.
Sporothrix schenckii
Histoplasma capsulatum
Blastomyces dermatitidis
SPOROTHRIX SCHENCKII
ROOM TEMP
CULTURE
37oC
HISTOPLASMA CAPSULATUM
ROOM TEMP
CULTURE
37oC
BLASTOMYCES DERMATITIDIS
ROOM TEMP
CULTURE
37oC
TAXONOMY
TAXONOMY
PHYLUM GLOMERULOMYCOTA, ORDER MUCORALES
SPORANGIA
Vegetative hyphae sparsely septate
TAXONOMY
PHYLUM ASCOMYCOTA (Ascomycetes)
Sexual reproduction involves a sac (ascus) in which karyogamy and meiosis
DIAGNOSIS
SEXUAL SPORES:
1. zygospores single large spores with thick walls
2. ascospores formed in a sac (ascus)
imperfect
ASCOSPORES
produced within an
enlarged cell by
nuclear fusion; enclosed
in a sac called an
ASCUS or
ASCOCARP.
Typically, there may be
ASCOSPORES
ASCOCARP
ASEXUAL SPORES
arise by the differentiation of spore bearing hyphae without nuclear fission
most fungi of medical interest propagate asexually by forming asexual
1. arthrospores
2. chlamydospores
3. blastospores
4. sporangiospores
Arthroconidia
formation
CHLAMYDOSPORES
BLASTOSPORES
formed by a simple
budding process from
cells of the mycelium.
Budding may be in:
1)one cell to one spore
basis
Blastomyces dermatitidis
2) multispore basis
Paracoccidioides braziliensis
SPORANGIOSPORES
produced on a specialized
hypha, inside a round
container known as
SPORANGIUM.
When the sporangium ruptures, the sporangiospores scatter and leave the
thin walled sporangium in place or it may dissolve
MYCOTOXINS
Poisonous substances produced by fungi
Cause acute or chronic intoxication and damage
Produced by mushrooms (Amanita sp.) mycetismus
ANTIFUNGAL THERAPY
POLYENES Amphotericin B, Nystatin
Bind to ergosterol in the cell membrane
FUSIFORM spindle-shaped
CLAVATE club-shaped
conidiophore