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Mid-semester examination

GENETICS
Biology 3513C

Mar. 25, 2015

Part I: Complete the following questions without the use of books or notes. You will
receive Part II when you hand in the answers to Part I.
1. Match the following terms in the first column with the definitions in the second
column:
a. pattern baldness
A type of allelic interaction____
b. crossing over
Also known as amyotrophic lateral sclerosis____
c. Punnett square
An example of sex-influenced inheritance____
d. dominance
Percent of twin pairs in which both twins share a trait____
e. telomere
A result of X-chromosome non-disjunction____
f. ABO blood group
An example of codominance____
g. Lou Gehrigs Disease
The basis for intrachromosomal recombination____
h. phenocopy
An environmentally-induced change in phenotype____
i. epistasis
One gene affecting multiple characteristics____
j. sister chromatids A method of determining the outcome of a genetic cross____
k. pleiotropy
Shows incomplete penetrance AND variable expression____
l. Prader-Willi syndrome
Caused by a mutation in the lamin A gene____
m. Leber hereditary optic neuropathy
A late onset lethal disease____
n. Turner syndrome
An example of genetic imprinting____
o. Huntington disease
An example of maternal inheritance____
p. pangenesis
The masking of the effect of one gene by another____
q. Hutchinson-Gilford Progeria
The natural ends of chromosomes____
r. concordance
An early concept of inheritance____
s. polydactyly
Contains exact copies of the DNA ____
t. map units
Measured by recombination frequency____

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Mar. 25, 2015

Part II: THE FOLLOWING QUESTIONS ARE FROM THE BOOK AND ARE PART
OF THE CLOSED BOOK PORTION OF THE EXAM.
ANSWER Both OF THE FOLLOWING QUESTIONS.
2. In Drosophila melanogaster, forked bristles are caused by an allele (Xf) that is X
linked and recessive to an allele for normal bristles (X+). Brown eyes are caused
by an allele (b) that is autosomal and recessive to an allele for red eyes (b+). A
female fly that is homozygous for normal bristles and red eyes mates with a male
fly that has forked bristles and brown eyes. The F1 are intercrossed to produce the
F2. What will the phenotypes and proportions of the F2 flies be from this cross?
3. Alkaptonuria is a metabolic disorder in which affected persons produce black
urine. Alkaptonuria results from an allele (a) that is recessive to the allele for
normal metabolism (A). Sally has normal metabolism, but her brother has
alkaptonuria. Sally's father has alkaptonuria, and her mother has normal
metabolism.
a. Give the genotypes of Sally, her mother, her father, and her brother.
b. If Sally's parents have another child, what is the probability that this child will
have alkaptonuria?
c. If Sally marries a man with alkaptonuria, what is the probability that their first
child will have alkaptonuria?

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Mar. 25, 2015

Part IIIa: You may not use notes or the textbook for this part of the examination.
Calculators ARE allowed. Answer the following question.
4. The allele b gives Drosophila flies a black body, and b+ gives brown, the wild-type
phenotype. The allele wx of a separate gene gives waxy wings, and wx+ gives nonwaxy,
the wild-type phenotype. The allele cn of a third gene gives cinnabar eyes, and cn+ gives
red, the wild-type phenotype. A female heterozygous for these three genes is test-crossed,
and 1000 progeny are classified as follows: 5 wild type; 6 black, waxy, cinnabar; 69
waxy, cinnabar; 67 black; 382 cinnabar; 379 black, waxy; 48 waxy; and 44 black,
cinnabar. Note that each progeny group is specified by listing only the mutant
phenotypes.
a. Explain these numbers and show the appropriate map with the relative positions of
each gene and the map distances that separate them.
b. Draw the alleles in their proper positions on the chromosomes of the triple
heterozygote.
c. If it is appropriate according to your explanation, calculate interference

a)

b_______10.3_________cn__________14.7__________ wx

b)

b+__________________cn_________________________wx+
b

c)

interference=27.4%

cn+

wx

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Mar. 25, 2015

Part IIIb: You may use notes or the textbook for this part of the examination. Answer both
questions 5 and 6.
5. The following pedigree shows the inheritance of a rare human disease. Unless there is
evidence to the contrary, assume that the individuals who have married into the family do
not carry the mutant allele.
a. What is the most likely inheritance pattern for this pedigree?
b. What is the chance the offspring of the following matings will have the disease
(a) III-l X III-12; (b) III-4 X III-14; (c) III-6 X III-13 (d) IV-1 x IV-2?

a)1/2x1x1/4=1/8 b)1/2x1/2x1/4=1/16 c)2/3x1x1/4=1/6 d)2/3x1/2x1/2x1/4=2/48=1/24

6. Two Drosophila flies that had normal (transparent, long) wings were mated. In the
progeny, two new phenotypes appeared: dusky wings (having a semi-opaque appearance)
and clipped wings (with squared ends). The progeny were as follows:
Females 179 transparent, long
58 transparent, clipped
Males

92 transparent, long
89 dusky, long
28 transparent, clipped
31 dusky, clipped

a. Provide a chromosomal explanation for these results, showing chromosomal


genotypes of parents and of all progeny classes under your model.
Wing transparency is sex-linked; wing shape is autosomal
Parents: female= D/d;L/l male=D/y;L/l
Progeny:
Females:

transparent, long = D/-; L/- (3/4)


transparent, clipped= D/-;l/l (1/4)

Males:

transparent, long= D/y;L/- (3/8)


dusky, long= d/y; L/- (3/8)
transparent, clipped= D/y; l/l (1/8)
dusky, clipped= d/y;l/l (1/8)

b. Design a test for your model.


Cross D/d;L/l female parent to d/y;l/l son

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Mar. 25, 2015

Part IIIc: You may use notes or the textbook for this part of the examination. Answer two
of the following three questions. If you answer all three, the highest grades will count.
7. In Drosophila, an autosomal gene determines the shape of the hair, with B giving
straight and b bent hairs. On another autosome, there is a gene of which a dominant allele
I inhibits hair formation so that the fly is hairless (i has no known phenotypic effect).
a. If a straight-haired fly from a pure line is crossed with a fly from a pure-breeding
hairless line known to have a hidden bent genotype, what will the genotypes and
phenotypes of the F1 and the F2 be?
F1= B/b;I/I hairless
F2=

9 B/-; I/- hairless


3 B/-;i/i straight
3 b/b; I/- hairless
1 b/b; i/i bent
12:3:1 (hairless:straight:bent

b. What genetic phenomenon is involved here?


c. What cross would give the ratio 4 hairless: 3 straight: 1 bent?
(Hint: use a Punnett Square after determining the necessary genotypes of each parent)
8. In a large metropolitan hospital, cells from newborn babies are collected and examined
microscopically over a 5-year period. Among approximately 7500 newborn males, one
Barr body is seen in the nuclei of six babies. All other newborn males have none. Among
7500 female infants, four have two Barr bodies in each nucleus, two have no Barr bodies,
and the rest have one. What is the cause of the unusual number of Barr bodies in a small
number of male and female infants?
Non-disjunction
9. A couple, neither of whom has phenylketonuria have a child with phenylketonuria as
their first child. They plan to have three more children. What is probability that at least
one of these additional three children will have phenylketonuria?
37/64 or 0.578125