PATHOPHYSIOLOGY

AGING
Women Declining Genetic Thyrotoxicosis
Increas
whose testoster Factors Hyperthyroidism
e
ovaries have one (60- Anorexia Nervosa
acceler
stopped levels 80%) Cushing’s
ation
in functioning, syndrome
bone such as Long term use of
loss women being medication such
becaus treated for as thyroid
the hormone,
prevention anticonvulsant,
and furosemide, and
corticosteroids
History of low-
trauma fracture

Increased
Duration of Bone

Change in Aging in Accumulati

Bone Bone on of
Architectu Tissue Microdama
ge

Thinning of Bone
Cortex

Marked Weakness of
Bone

Progressive Bone Fracture Functional

Deformities Disability

Physical Immobility
Shortened Compressio
Stature n Fracture
of Vertebral
Deformities
Progressive Development of
Dorsal Decubitus Ulcers

Pain
Accompanie
Resting of d by
Skeletal
Lower ribs on
Fractures

Downwar PAIN Restricte

d d Lung
Pressure Expansio
on

Impaired
Abdom Respirati
inal
Distent
ion &
Bloatin Generaliz
ANOXIA ed
g DEATH

OSTEOPORO AGING
 Physical Decrease In Incontinen
Immobility Circulation ce

Decreased Moisture
Nutrients in
Periphery

Skin
Maceration
External Posture
Friction
Shearing Force
Skin
Breakdown
Disruption of
Blood Flow to
Capillary Beds
Decubitus
s and Arterioles
Ulcer
Stretching on
Rupture to
Blood Vessels

Edema,
Autolysis of

Tissue Ischemia

Decubitus Ulcer

Worsening of
Tissue Injury

Increased Depth
of Wound
Tunneling/

Infection

Systemic Sepsis

DEATH