Loss on drying

Test substance: Donepezil Hydrochloride 5 mg and 10 mg film-coated tablets

grinded in a mortar finely.

Weigh accurately about 1 g of the test supstance and transfer it to a weighing bottle
of weight W1 with a stopper, previously dried at 105 ± 2oC for 30 minutes. Note down
the weight of the weighing bottle with the sample (W2). Distribute the sample evenly
in the weighing bottle by sidewise shaking to a height of 5 mm. Place the weighing
bottle uncovered at 105 ± 2oC in an oven for 3 hours. After 3 hours, open the oven
and immediately place the stopper on the weighing bottle. Place the the weighing
bottle in a desiccator to reduce the temperature to room temperature. Determine the
weight of weighing bottle with the contents. Note down the weight (W3). Calculate loss
on drying with the following formula.

(W2 − W3 ) ×100
Loss on drying =
(W2 − W1 )