Pathophysiology of Dengue Hemorrhagic Fever

Predisposing Precipitating
Geographical area – tropical
Environmental conditions (open spaces
with water)
Mosquito carrying dengue virus

Aedes aegypti - dengue virus carrier

Bite from mosquito

(Portal of Entry through
Skin)

Allows dengue virus to be Diagnostic:

immunized towards the Hematology :
Increased WBC:
circulation/blood
Virus disseminated rapidly into the blood 12,900/cumm
and stimulated WBCs including B (5,000-
lymphocytes that produces and secretes 10,000/cumm)
immunoglobulins (antibodies), and Increased
monocyte. Lymphocytes: 49%
(20-
Diagnostic:
Hematology :
Decreased Antibodies attach to the viral
Monocytes: antigens, and then
monocytes/macrophages will
4%(8-14%)
perform phagocytosis through
receptor within the cells and
Decreased
dengue virus replicates in the
Neutrophils:
47%(50-70% cells

Detection of dengue viral

antigen on infected monocytes

Signs/ symptoms: Release of cytokines which consist of

Febrile: 38.2C vasoactive agents such as interleukins,
Warm skin, DENGU
tumor necrosis factor, urokinase and
stomach ache E
platelet activating factors which
5/10 pain scale;
stimulates WBCs and pyrogen release

Diagnostic:
Cellular direct destruction and
Hematology
infection of red bone marrow :
precursor cells as well as Decreased
immunological shortened platelet Platelet:
68,000/cum
 Thrombocytopeni
a

Dengue Hemorrhagic
Fever