Oral Solution: 100mg/ml
Mechanism of Action:
CYCLOSPORIN
E psoriasis.
Brand name:
Sandimmune
Cyclosporine lowers your body's
immune system. The immune
system helps your body fight
infections. The immune system can
also fight or "reject" a transplanted
organ such as a liver or kidney.
This is because the immune system
treats the new organ as an invader.
Pharmacologic
class:Polypeptide antibiotic
Pregnancy risk:
Category C
Available Forms:
Capsules: 25mg, 50mg, 100mg
Injection: 50mg/ml
Skin: hirsutism, acne
It inhibits proliferation and function
of T lymphocytes and inhibit
production and release of
lymphokines.
Indications:
• Is used to prevent organ
rejection after a kidney, liver, or
heart transplant.
• Is also used to treat severe
• Is also used to treat severe
rheumatoid arthritis.
Contraindications:
• Hypersensitive to drug
• Contraindicated with patients
with RA or psoriasis with
abnormal renal function
• Any type of cancer
• Untreated or uncontrolled high
blood pressure
Side Effects:
CNS: tremor, headache, confusion,
paresthesia
CV: hypertension, flushing
EENT: gum hyperplasia, sinusitis
GI: nausea, vomiting, diarrhea, oral
thrush, abdominal discomfort
GU: nephrotoxicity
Hematologic: leucopenia,
thrombocytopenia
Metabolic: hyperglycemia
Principle of Care:
• Encourage patient to take drug
at same time each day
• Instruct patient to fill glass with
water after dose
• Advise patient to take drug with
meals
• Advise patient to take Neoral or
Gengraf on an empty stomach
• Tell patient not to take drug
with grapefruit juice
Treatment:
• Instruct patient to avoid
crowded places
• Warn patient to wear protection
in the sun
• Tell patient to avoid person with
infections because drug lowers
resistance to infection
• Advise patient to perform
careful oral care and to see
dentist regularly because drug
can cause gum disease
• Tell patient to wear mask to
prevent infection
• Tell patient to avoid contact
sports like basketball, football
Members:
Carreon, Olga
Montesclaros, Julia
Pepito, Joseph
Serion, Steven
BSN 2 - A