PATHOPHYSIOLOGY

Precipitating Factors:
Predisposing Factor: - Environmental Condition
- Geographical Area (Tropical) - Decreased Immune System
- Presence of mosquitoes carrying dengue virus

Aedes aegypti bites the host, injecting the virus

Virus incubates in the circulation for 3-14 days

Virus rapidly disseminates into blood

Stimulation of the WBC which includes B lymphocytes which

produces and secretes Ig, monocytes/macrophages and neutrophils

Antibodies attach to the viral antigens, and then macrophages perform phagocytosis
within the cells and dengue virus replicate in the cells

Recognition of dengue viral antigen on monocyte

Release of cytokines which consist of vasoactive

agents such as interleukins, tumor necrosis Entry to bone
Entry to spleen
factor, urokinase, and platelet activating factor marrow
which stimulate WBCs and pyrogen release

DENGUE