VI.

PATHOPHYSIOLOGY

Predisposing
Factors:
Etiology: Age – 54 years
Idiopathic old
Gender - female

Primary tumor originates most

likely from a single cell at the
surface of the ovary

Mutation damaged the cell

system control mechanism

The cell proliferates

constantly

Cell divides therefore to produce two

cells, which then divide to produce a total
of four, with the next division eight cells
are to be produced then 16 and so forth

Through success cell division Rich supply of nutrients

delivered to the tumor,
Causes an exponential growth
the other formation of the
of the tumor at the expense
new blood vessels
of the ovary

Favors the uncontrolled growth

Tumors larger than

10 cm in diameter
stimulates with myxoid
component to the
stroma

Irritation of the
Associated with ascites peritoneal surfaces

Favored secretion of fluid

from the tumor as the Production of
source of the ascites peritoneal fluid

It can also be stimulated through

Direct pressure on Obstruction of
surrounding lymphatic
lymphatics or system
vessels
Large molecules can’t
reabsorb back in the
circulation
 Hormonal
stimulation
Tumor
torsion Leading to Accumulation of fluid

May be due to Suprapubic pain

Release of mediators like It will pass to

histamines, activated the abdominal
components and fibrin cavity
degradation products
Production of ascites
Leading to

Increased
capillary
permeability

Due to continuous production

Increase in
Weight gain occurs
abdominal girth
Which may lead to

Made possible
through

Lung compression

Route of transfer via

transdiaphragmatic
lymphatic channels

Difficulty of breathing