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Age:neonates: too

young; too old

low defendse against

C. tetani

entrance of C. t
to the body

C. tetani transform
rod-shaped bacter

produces neurotoxin c
tetanospasmism (inact

bacteria dies and re



toxin is carried to
stem and spinal c

binds to gangliosides
of nerve synapses

block the release of

inhibitory transmitter

spasm of various
parts of the body

facial muscles spinchters abdominal neck muscles


risus sardonicus
urinary constipation
not immunized enivironmental factors
with tetanus ( agricultural regions)

soil is a good habitat for

no good defendse the C. tetani
against C. tetani

open wound
entrance of C. tetani (burn, gunshot wound, anim
to the body bites/scratch), complex fractu
puncture wound

C. tetani transformes into a

rod-shaped bacteria

produces neurotoxin called

tetanospasmism (inactivatd form)

bacteria dies and release the


tetanospasmism is proteases

toxin is carried to brain retrograde axonal

stem and spinal cord transport

binds to gangliosides membrabes

of nerve synapses

loss of control of adrenal disinhibition o

catecholamine release autonomic neuro

generalized tonic hypersympathetic autonomic

spasticity state instability

chest wall glottal

rigidity spasm

cyanosis can't cry & talk

can't cry & talk

can't cry & talk
ronmental factors Drug abuse (with the
cultural regions) use of unsterile

s a good habitat for

. tetani puncture wound

open wound
gunshot wound, animal
cratch), complex fractures,
puncture wound

disinhibition of
autonomic neurons