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Age:neonates: too

young; too old

low defendse against


C. tetani

entrance of C. t
to the body

C. tetani transform
rod-shaped bacter

produces neurotoxin c
tetanospasmism (inact

bacteria dies and re


tetanospasmism

tetanospasm
actvated

toxin is carried to
stem and spinal c

binds to gangliosides
of nerve synapses

block the release of


inhibitory transmitter

spasm of various
parts of the body

facial muscles spinchters abdominal neck muscles


muscles

risus sardonicus
urinary constipation
retention
not immunized enivironmental factors
with tetanus ( agricultural regions)
vaccine

soil is a good habitat for


no good defendse the C. tetani
against C. tetani

open wound
entrance of C. tetani (burn, gunshot wound, anim
to the body bites/scratch), complex fractu
puncture wound

C. tetani transformes into a


rod-shaped bacteria

produces neurotoxin called


tetanospasmism (inactivatd form)

bacteria dies and release the


tetanospasmism

tetanospasmism is proteases
actvated

toxin is carried to brain retrograde axonal


stem and spinal cord transport

binds to gangliosides membrabes


of nerve synapses

loss of control of adrenal disinhibition o


catecholamine release autonomic neuro

generalized tonic hypersympathetic autonomic


spasticity state instability

chest wall glottal


rigidity spasm

cyanosis can't cry & talk

can't cry & talk


can't cry & talk
ronmental factors Drug abuse (with the
cultural regions) use of unsterile
technique)

s a good habitat for


. tetani puncture wound

open wound
gunshot wound, animal
cratch), complex fractures,
puncture wound

disinhibition of
autonomic neurons

autonomic
instability