Immunohematology

Question Answer
In humans, what organ is considered
Thymus
responsible for producing T lymphocytes?
Cells that syntesize antibody are? Mature B lymphocytes
Rejection of a transplant is characteristic of Cellular immune
which of the immune response systems? system
The secondary or anamnestic response
IgG
causes proliferation of what antibodies?
The primary response causes proliferation
IgM
of what antibodies?
Immunoglobulins are part of what type of
Humoral
immunity?
Which lymphocytes are responsible for
cellular immunity, tissue graft rejection,
T lymphocytes
delayed hypersensitivity reactions and
immunologic surveillance?
A low molecular-weight substance that
rarely stimulates the production or
Hapten
antibodies, but can react with an antibody if
present.
When can hapten ilicit an immune When attached to a
response? carrier protein
An antigen that reacts with antibodies from
Alloantigen
within the same species.
An antibody produced in response to an
Autoantibody
antigen possessed by the same individual.
An antibody produced in one species that
reacts with an antigen from another Heterophile antibody
species.
What is another name for a Heterophile
xenoantibody
antibody?
What immune antibody reacts best at 37C, IgG
resistant to treatment with sulfhydryl
compounds, and often requires the
addition of antihuman globulin to produce

1
agglutination?
Which of the immune antibodies is the
largest, arranged in a pentamer, and IgM
cannot cross the placental barrier?
Which immune antibody activates the
complement cascade by way of the IgA
alternate pathway once aggregated?
Which immune antibody is a reaginic
antibody that binds to mast cells by the Fc
IgE
portion and is associated with immediate
hypersensitivity?
By their amino acids in
How are the 5 classes of immunoglobulins
the constant region of
distinguished?
their heavy classes.
Which phenomenon is due to excess of
prozone due to
antibody in relation to antigen, preventing
antibody excess.
the formation of a lattice?
Which test for syphilis is primarily used for
screening for the treponemal antibody; is RPR
sensitive but lacks specificity?
Which laboratory test is specific and is
used for a comfirmatory test when testing FTA-ABS
for the treponemal antigen?
What substance is produced by the liver in
inflammation, necrotic, and infectious CRP
diseases?
What type of test is the ASO test? neutralization test
The antistreptolysin O present in a person
with group A streptococcal infection, No lysis of the red
neutralizes the reagent streptolysin. What blood cells.
is the postive result going to show?
Which blood group antibody is mainly IgM,
reacts best at 4C, associated with atypical
Anti-I
pneumonia, and cold autoimmune
hemolytic anemia?
Which antigens should be tested for when HLA antigens
assessing histocompatibility for organ
transplantation, paternity testion, or for the

2
selection of platelet and granulocyte
donors?
What is the minimum time interval for blood
8 weeks
donation?
The blood group that reacts LEAST
A1B
strongly with anti-H lectin is?
The blood group that reacts the strongest
O
with anti-H lectin is?
Which 2 antibodies are most often naturally
occurring, react best at room temp., and anti-M and anti-N
can agglutinate cells in saline medium?
Which blood group system antigens are
primarily in the plasma and adsorbed onto Lewis
red cells.
Which type of blood group cells are used
Group O, Rh-pos
for antibody screening tests?
Cell bound IgG may
Why is it important that antiglobulin serum
detach from the red
be added immediately after washing the
cells if delayed
cells?
addition.
A patient who has repeated severe non-
hemolytic febrile transfusion reactions and
Leukocyte-Poor Red
requires transfusion of blood for oxygen-
Blood Cells
carryig capacity should be transfused with
what type of blood product?
What test is the best and quickest way to Direct antiglobulin test
determine acute hemolysis in a transfusion on the posttransfusion
reaction? specimen
Which antibody is most often associated
with delayed hemolytic transfusion Jka
reactions?
An acute hemolytic transfusion reaction is
An ABO mismatch
most commonly due to?
Be processed into
What should be done with a donor unit that components that
contains 37 degree C reacting antibodies? contain minimal
amounts of plasma.
Whole blood collected in CPDA-1 may be 35 days

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stored for how many days?
What is the only solution that can be added
to blood or components before or during a Normal Saline.
transfusion?
The temperature of a refrigerator that
contains stored blood should not exceed 6 degrees C
what temperature?
What is the term for average strength of
Avidity
binding between antigens and antibodies?
What is the term for nonspecific
attachment of substances to the surfaces Adsorption
of insoluble particles?
What is the term for the use of reagents to
remove certain antigens from a mixture by Absorption
serologic reaction?
Allergic reaction to grass pollen is an
type I hypersensitivity
example of which type of hypersensitivity
reaction
reaction?
Anaphylactic reactions that occur with in
minutes and are mediated by IgE Type I hypersensitivity
antibodies are considered which type of reaction
hypersensitivity reaction?
Autoimmune hemolytic anemias and
thrombocytopenic purpura are caused by
Type II hypersensitivity
antibodies directed against an individual's
reaction
own red cells. Which type of
hypersensitivity reaction is this?
Immune complexes are deposited in an
individuals tissues in the diseases of
Type III hypersensitivity
Systemic lupus erythematosus and post-
reaction.
streptococcal glomerulonephritis. Which
type of hypersensitivity reaction is this?
During TB skin reaction and contact
dermatitis, sensitized T cells release Type IV
lymphkines following a secondary hypersensitivity
exposure to antigen. Which type of reaction
hypersensitivity reaction is this?