STREPTOMYCIN

Classification: anti-infectives (therapeutic), aminoglycosides (pharmacologic)

INDICATIONS ACTION CONTRAINDICATI ADVERSE & SIDE NURSING

ONS & EFFECTS IMPLICATIONS
PRECAUTIONS
o In o Inhibits protein Contraindicated in: o EENT: o Assess patient
combination synthesis in o Hypersensitivity ototoxicity for infection (VS,
with other bacteria at level o Most parenteral (vestibular & wound
agents in the of 30S ribosome products contain choclear) appearance,
management of o Most bisulfites & o GU: sputum, urine &
active aminoglycoside should be nephrotoxicity stool, WBC) at
tuberculosis s notable for avoided in o F&E: beginning of &
activity against: patients with hypomagnesemi throughout
 P. aeruginosa known a therapy.
 Klebsiella intolerance o MS: muscle o Obtain
pneumoniae o Products paralysis (high specimens for
 Escherichia containing parenteral C&S before
coli benzyl alcohol doses) initiating
 Proteus should be o Misc: therapy. First
avoided in hypersensitivity dose may be
 Serratia
neonates reactions given before
 Acinetobacter
o Cross-sensitivity receiving results.
 Staphylococc o Evaluate 8th
among
us aureus
aminoglycosides cranial nerve
o In treatment of
may occer function by
enterococcal audiometry
infections, before &
Use cautiously in:
synergy with a throughout
o Renal
penicillin is therapy. Also
impairments
required monitor for
(dosage
o Also active vestibular
adjustments
against dysfunction
necessary; blood
mycobacterium level monitoring (vertigo, ataxia,
useful in nausea &
preventing vomiting).
ototoxicity & o Monitor intake &
nephrotoxicity) output and daily
o Hearing weight to assess
impairment hydration status
o Geriatric patients & renal function.
& premature o Asess patient for
infants (difficulty signs of
in assessing superinfection.
auditory &
vestibular
function; age-
related renal
impairment)
o Neuromuscular
diseases such as
myasthenia
gravis
o Obese patients
(dosage should
be based on
ideal body
weight)
o Pregnancy (may
cause congenital
deafness)
o Neonates
(increased risk of
neuromuscular
blockade;
difficulty in
 assessing
auditory &
vestibular
function;
immature renal
function)
o Lactation,
infants, and
neonates (safety
not established)