Beruflich Dokumente
Kultur Dokumente
Prototype Quinidine
Effects on the Heart Blocks sodium channels Slows impulse conduction Delays repolarization Blocks vagal input to the heart
Class IB
Lidocaine
Slows conduction in the atria, ventricles, His Reduces automaticity in the ventricles, His Accelerates repolarization Block Na+ channels Delay repolarization Decreasing atrial conduction velocity Exacerbate existing dysrhytmias
Class IC
Flecainide
Class II
Propanol Decreased automaticity of the SA node (non-selective Beta) Decreased AV conduction velocity Decreased myocardial contractility
Class III
Amiodarone
Reduced automaticity in the SA node .Reduced contractility .Reduced conduction velocity .QRS widening .Prolongation of the PR and QT intervals .Also promotes coronary and peripheral vasodilation Reduce SA nodal automaticity Delay AV nodal conduction Reduce myocardial contractility
Class IV
Verapamil Diltiazem
NO CLASS
Adenosine
Decreases automaticity in the SA node Slows conduction through the AV node Prolongation of PR interval
Effects on the ECG Therapeutic Uses Widens the QRS complex Long-term suppression of Prolongs the QT interval Atrial fibrillation Atrial flutter SVT Sustained vent. Tachy
Same as heart effects Sympathetic stimulation dysrhythmias Heart block Exercise-induced tachydysrhythmias .Heart failure Supraventricular tachydysrhythmias .AV block Suppression of excessive discharge .Sinus arrest Slowing of ventricular rate .Hypotension Persistent sinus tachycardia .Bronchospasm Recurrent ventricular tachycardia Same as heart effects Recurrent ventricular fibrillation Unstable ventricular tachycardia Pulmonary toxicity Cardiotoxicity Pregnancy Corneal microdeposits Breast feeding
T intervals peripheral vasodilation Same as heart effects Terminate SVT Atrial flutter Atrial fibrillation Slow ventricular rate
Bradycardia .Hypotension .AV block .Heart failure .Peripheral edema .Constipation Increase digoxin Do not use w/ beta blk Sinus bradycardia .Dyspnea .Hypotension .Facial flushing .Chest discomfort Adminster as close to heart; short 1/2 life
and GI upset
toxicity
crodeposits
w/ beta blk