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Mechanism:
The glycosides are absorbed from the small intestine and re-excreted in the large intestine where they increase the motility so produce laxation. Aglycons produce griping effect so it is recommended to prescribe antispasmodic with them.
Chemistry:
Chemically these are related to anthracene.
a) Aloe
Botanical origin:
Aloe barbadensis Aloe ferox Aloe perryi Aloe vera
Family:
Asphodelaceae
Part used:
Dried juice of leaves
Collection:
Leaves are cut from 9-12 years old plant and placed in v-shaped trough which in turn is placed on incline so that juice can be collected in receiver. It is allowed to evaporate, finally thickened juice is placed in metal box for drying.
Chemistry:
Barbaloin is active ingredient. Upon hydrolysis, it yields; Aloe emodin
Uses:
Laxatives and purgatives Emollient Ingredient of benzoin tincture
b) Cascara
Botanical Origin:
Cascara sagrada Rhamnus purshiana
Family:
Rhamnaceae
Part used:
Dried bark
Collection:
Bark is collected from April to August when it can be readily separated from wood. It is dried in shade.
Chemistry:
Cascarosides Cascarosides A and B (related to Barbaloin) Cascarosides C and D (related to chrysaloin)
c) Rhubarb
Botanical Origin:
Rheum officinale Rheum emodi
Family:
Polygonaceae
Part used:
Dried rhizome and root
Collection:
Rhizome and roots are collected from 6-10 years old plant in spring or autumn. These are dried either in sunlight or by artificial heat.
Chemistry:
Active constituent is Rhein anthrone.
d) Senna
Botanical Origin:
Cassia angustifolia Cassia acutifolia
Family:
Febaceae
Part used:
Dried leaflets
Chemistry:
It contains; Sennoside A and B Sennoside C and D
e) Cochineal
Zoological Origin:
Dactylopius coccus
Family:
Dactylopidus
Part used:
Dried female insects containing eggs and larvae
Collection:
Insects are collected and killed by steam or hot water. These are dried in oven.
Chemistry:
Active constituent is Carminic acid.
Uses:
As a dye in; Fabrics Cosmetics Food Paints Colouring agent for pills etc.