ulsease SympLo

ms
CL lx Screenlng ulagnosLlc 1x
Cushlng roxlmal
myopaLhy (hlp
flexor 4/3)
SLrla
8uffalo hump

Plgh
corLlsol
Low k
Plgh Clu
24h urlnary
corLlsol
Low dose
overnlghL
dexameLhasone
suppresslon LesL
(lalse poslLlve
rlfamplcln/carb
amazeplne/alco
hol)
Plgh dose
dexa LesL 48P
(wlll suppress
ln cushlng dz
/ wlll noL ln
plLulLary or
ecLoplc

Addlson Muscle
weaknes
s

PyperplgmenLaL
lon

Low na
122/
Plgh k
(7)
Low glu
ShorL
synacLhen
LesL
Adrenal
caused
CorLlsol noL
ralsed
Lxogenous
SLerold
caused
AC1P wlll
caused ralsed
corLlsol
AcuLe lv
hydrocorL
100mg sLaL
and fluld
resusc (even
b4
synacLhen
LesL)
uon'L sLarL
Lhyroxlne lf
1l1 low!!
Wlll
deLerloraLe
pL
lludrocorLls
one afLer
acuLe sLage
Conn syndrome
AldosLerone
produclng
adenoma
rlmary
hyperaldosLeron
lsm
PyperLenslon
refracLory
Alkalosls
Low k
na mlld
hlgh
AldosLerone/re
nnln raLlo
(A88) hlgh
(Aldo
lncrease/rennln
low)
C1/M8l
Adrenals





CP deflclency lnsulln
Lolerance LesL
(CP wlll only be
10 aL peak
level of lnsulln)

haechromocyL
oma
caLhecolamlne
produclng
adrenal medulla
Lumour
PyperLe
nslon
wlLh
paroxys
m
headach
a/w men 2a/b

also can be
caLhecolamlne
lnduced
cardlomyopaLhy
24 hr urlne
caLhecolamlne
elevaLed
(blochemlcal
dlagnosls)
C1/ M8l Abdo
Ml8C
chromaffln
lsoLope
scan(lf canL
locallzed)/

e
palplLaLl
on
Medullary
Lhyrold ca
A/W
Men 2
enLagasLrln
LesLlng (hlgh
calclLonln)

Clucagonoma
(glucagon
secreLlng
Lumour of
pancreas)
lncrease glucose
ln blood
necroLlslng
MlgraLory
eryLhema nML
(red bllsLer rash
from groln
spread Lo
buLLock and LL)
uM
l8S
ralsed
uS/C1
Abdo
usually
3cm
CcLreoLl
de scan
meLs
(30)
Clucagon level Surglcal
cure 3
CcLreoLlde
for
conLrolllng
rash
alllaLlve
chemo
sLrepLozocln
/flurocll
good
PepaLlc
arLery
embollzaLlo
n
vloma Severe
waLery
dlarrhoe
a
Pypokalaemla
(k 20)
Low PCC3
MeLabollc
acldosls

CasLrlc
h 63
hlgh
alkaloLlc
(achlohy
drla)
8alsed
chromograffln A
(all ralsed ln
neuroendocrlne
Lumour excepL
lnsullnoma)

lnsullnoma Plgh CepLlde


CasLrlnoma
Zolllnger Llllson
syndrome

(Ccells ln
duodenum and
pancreas)
uu
ularrhea
(blle
acld
decon[u
gaLlon)
laL
malabsorpLlon
812 deflclency
CCuS
MuL1lLL
duodenal
ulcers
esophaglLls
Macrocy
Ll
anaemla

lasLln serum
gasLrln 1000
(off l)
lf noL osL
secreLln
ln[ecLlon
CasLrln200
8adlolsoLope
scan PoL
spoL
somaLosLln
recepLor
Plgh dose
ocLreoLlde
and l
60
mallgnanL
CasLrecLom
y
Carclnold
Lumour

neuroendocrlne
Lumour
lncrease
seroLonl
n
ularrhoe
flushlng
wheezln
Abdo
paln

CvS 1rlcuspld
regurge
A/W ellagra
(nlacln/nlcoLlc
acld deflency
due Lo lack
LrypLophan)
dermaLlLls
demenLla
depresslon
Plgh urlnary 3
PlAA
(hydroxylndolea
ceLlc acld) end
producL
seroLonln
CcLreoLlde
scan (wlll go
Lo
somaLosLaLln
recepLor)
Surgery
PaemochromaL
osls
A8 lncreased
lnLesLlnal lron
absorpLlon
1anned/
SlaLe
grey
plgmenL
aLlon
Llver
dlsease
sLlgmaLa
lmpoLen
ce (no
erecLlon

Male
40s
8ronze ulabeLes
Chondrocalclno
sls (arLhralgla)
Chronlc llver
dlsease
Sparse publc
halr
CardlomyopaLh
y
AL1
ralsed
u/Aglu+
ferrlLln
ralsed
Plgh
serum
lron
Low
1l8C

Serum
Lransferrln
saLuraLlon /

Cene LesL
Chr 6p /PlL
C282?
P63u
Llver blopsy
used Lo
quanLlfy lron
buL now done
Lo see
clrrhosls and
Lo monlLor
for PCC

8egular
venesecLlon
gulded by
ferrlLln
level)
(cardlomyop
aLhy
lmprove buL
noL
arLhralgla
and uM and
hypogonado
Lroplc
Wllson's uz

A8

arklnso
nlsm ln
Lhe
young
lPx llver
dz
ALaxla
neuropsyclaLlc
lllness
LxLrapyrlmldal

a/w 81A
Lype 2
(hypokal
emla)
Serum copper
Low buL
lncrease ln
fulmlnanL dz
Low serum
caeruloplasmln
Plgh urlnary
copper
Speclflc slgn
kalser
llelsher rlng
acuLe ux
Chronlc
seLLlng llver
bx
Cene chr 13
A178
enlclllamln
e
1rlLnLlne
(less Loxlc
new Lx)
1 Zlnc 30mg
1uS