page 1 of 4 pages Fall 1999 Name: Neha M mation Exam I Form A Please print Basal nuclei, cerebellum, nerve tracts, analgesia, and ANS Mall choice questions have only one correct answer unless otherwise indicated Use the Yo lowing code to indicate which of the following are associated with either Parkinson's disease or a’cerebellar malfunction: \ \ P Parkinson's disease C= Cerebellar malfiigction —7'Sqxeehn mencill “eqnbrat ne Dank if nether de epproprit RT \ Po ani of and % AE excessive it priate involuntary tor movenstns Caypeckidesia) 7 CE muscle rigidit SS \ ~ x 2 tremor during moto! \ \ migraine headaches C__ inappropriate sequencing 6: 2. Which ofthe following plays a roe in the fa inhibiting the stretch reflex? . vestibulocerebellum 5 medullary redeulospinal tract na €. cerebrocerebellum d. spinocerebellar tract as ae Researchers have found that a decline in the mitochondriahenzyme\ in the substantia nigra may asia he destfuction of. ‘evenigee neurons sen in in Parkinson’ 's disease. a. Coenzyme Q \ x » crea eatin 7 \ SN daa ‘Phosphory! Compleat 1 4. The ihuscle tremor that is seen in Parkinson's disease seems to be caused by an imbalance between ‘excitatory and inhibitory influences controlling muscle movements. This imbalance occurs because of a decline in dopamine and a relative increase in (chy Arelul daaline 5. A drug that inactivates acetylcholinesterase 7 bwals up chili * aLEty! ach inte wwonla keep & a. inhibits the release of ACh from presynaptic endings. . inhibits the attachment of ACh to its receptor protein increases the length of time that ACh remains in the synapse all of the above in from: ral (<) C-fber pathway = ~Conivospinalpathway- 5 ‘d:~Dorsat-column pathway "ey, its action potentials in which of the following pathways? Dr, 7. Why is 2 woman's blood alcohol level higher than @ man’s even though they may consume the same alcohol content? (2pts) be thay Wore less aledhel delyelrcqenase thon men. Alcohol dehyareanone bums doum oledhot to alblelysterpage 2 of 4 pages 8. Alcoholics develop a fatty liver because they eat more fried foods than the general public. & tek er use alcohol instead ot fatty acids for energy thus the fatty acids accumulate in the liver. ©. they absorb fatty acids more efficiently from the diet. 4. they smoke more than the general publi 9. Which of the following statements about catecholamitesys false? a. They include epinephrine, norepinephrine ine Their effects are increased by action of the enzyme catechol-O-methyltransferase, ©. They are inactivated by monoamine oxidase 4, They may stimulate the production of cAMP in the postsynaptic neuron. 10. Questions 1-4 below refer to the diagram below. PreGPS = preganglionic parasympathetic neuron PostGPS = postganglionic parasympathetic neuron PreGPS 3. PostGPs , 4 O-—~? CC 7 # sa roe ect 2 1. What neurotransmitter is released from the preganglionic parasympathetic neuron? (do not abbreviate) Attu ebnoline ~ 2. What neurotransmitter is released from the postganglionic parasympathetic neuron? (do not abbreviate) Aber choline Q- What type of receptor is found on the postganglionic parasympathetic neuron? (do not abbreviate) LL. of the following Neuroransmitter-receptor complexes acts directly on ion channels to cause m to open? 9 ACh on cholinergic nicotinic receptors ACh on cholinergic muscarinic receptors ¢. Catecholamines on alpha-adrenergic receptors a d. Catecholamines on beta-adrenergic receptors % Which of the following neurotransmitter-receptor complexes acts through a second messenger mechanism to influence ion channels? =. ACh on cholinergic nicotinic receptors ‘ACh on cholinergic muscarinic receptors Catecholamines on alpha-adrenergic receptors ‘@ Catecholamines on beta-adrenergic receptors — 13. What reaction does adenylyl cyclase catalyze? G points) oS cyclic AMP 499, ave 4 “\2 16 BAG page 3 of 4 pages Pim

. negra phosphate, 15. When.gcesylcholine binds to its cholinergic muscarinic receptor on the heart, G-proteins liberate their aber —P subunit to cause a__¥*_jon channel ‘ojopeni or close thus causing a decrease in heart rate. hyper polOniee, 16. Which of the following enzymes would met monoamine oxidase OR atechol-O-methyl transferase] 17,_Why is deprenyl, a monoamine oxidase inhibitor, used to treat Parkinson’s disease? Because it prevents the degradation of dopamine in substantia nigra neurons. Because it enhances the degradation of dopamine in substantia nigra neurons. ¢. Because it enhances the degradation of dopamine in striatal neurons. d. Because it prevents the degradation of GABA in substantia nigra neurons lize norepinephrine in the synapse? 18. Enkephalins inhibit pain by nereasing Ca*-influxin-AS pain fibers > b. increasing Nat influx in AS pain fibers —_— (@ increasing K* efflux in spinothalamic tract neurons - 1, SS tees increasing Na* influx in spinothalamic tract neurons yet 19. The following questions refer to the diagram below: Raphe nuclei neurons (#1) release_ S@vatonin as their neurotransmitter. Substantia gelatinosa neurons (#2) release Jing -—— SNS as their neurotransmitter ubstantia gelatinosa nev iit ENE A® pain fibers (#3) release ZAberwmce P as their neurotransmitter. Is fiecianaeebe released from the AS pain fiber (neuron 3) considered an -xcitatory inhibitory neurotransmitter? J Raphe nuclei neurons J ‘Substantia gelatinosa neurons t Ag 3 20. Visceral pain that is perceived to be coming from the body surface is called colored pain e 6 ° ® ered ¢