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PHR 142P- Quiz#8 - F2002
(points)

(2) 1 Ephedrineis a weakly basicdrug with Ku : 2.3 x IIa . Define intrinsic


partition coefficient for ephedrine.
, fFl
V =::3 [u: i, 6fc
f\!
[E] \o

(2) 2. Define apparentpartition coefficientfor a weak acid.

lrrn]"
K* :
t-.^-1
LA-J*
LHAJ,,n
r
'1

(2) 3. Write an equationwhich relatesKuooto pH for a weak acid. Be certain

(4) 4.Sketch a graphof Kuoovs pH for a weakacid. Indicatepredominantspecies


at variouspoints on the graphand indicatesignificant featuresjust as has
beendone in lecture.

Ko
u,.{
H.K K,7,