vlLamln AnLloxldanLs

8eLlnol Cholecalclferol and Lrgocalclferol 8uLylaLed Pydroxyanlsole or 8uLylaLed Pydrozy

Loluene Alpha 1ocopherol and ropyle gallaLe
8 vlLamlns ropyl CallaLe
Ascorblc acld Sodlum SulphlLe propyl CallaLe
8eLa CaroLene Alpha 1ocopherol ascorbyl almlaLe
lollc Acld 8PA nordlhydrogualareLlc acld

roperLles
1 1ocopherrols 8P1 and ropyle CallaLe 1raps free radlcals
2 Sodlum SulflLe and ascorbyl palmlLaLe are reduclng agenLs or oxygen Lraps
3 Ascorblc Acld can be used as a waLer soluble anLloxldanL ln oLher producLs
4 8eLa caroLene vlLamln C and vlLamln L are consldered as physlologlcal anLloxldanL
3 lor Ascorblc acld drug formulaLlon pP and Lhe addlLlon of chelaLlng agenL ls used Lo counLer Lhe
caLalyLlc acLlon of heavy meLal on oxldaLlon Lhe absence of oxldlzlng agenLs lncludlng oxygen
SLablllzer for Ascorblc acld soluLlon ln waLer
SLorage SLablllzer 8aLlo of Ascorblc acld Lo sLablllzer
under Alr LLhylenedlamlneLeLraaceLlc acld 1001
Sodlum SulphlLe 1001
ClLrlc acld 101
Clucose 101
under nlLrogen Sodlum SulphlLe 1001
MalLose 101
ropyl CallaLe 1001

lor Ascorblc acld besL pP ls 33 63 and Sodlum 8lcarbonaLe ls besL for ad[usLlng Lo Lhls pP

ClLrlc Acld 1he essenLlal acLlon comprlses lnacLlvaLlon of Lraces of meLals by Lhe formaLlon of sLable
chelaLe rlngs eg wlLh copper or lron So lL ls an effecLlve sLablllzer for ascorblc acld soluLlons sLored
under alr
82 LlghL senslLlve heaL senslLlve pP 43 30

Lu1A used as chelaLlng agenLs Lo blnd heavy meLals ln aqueous soluLlon of vlLamlns ln order Lo
ellmlnaLe or dlmlnlsh Lhelr caLalyLlc acLlon on Lhe oxldaLlve breakdown of some vlLamlns
SLablllzaLlon by Lu1A Ascorblc Acld 1hlamlne PCl yrldoxlne PCl nlcoLlnamlde 1Ccopherol

SLerlllzaLlon
lnfluence of heaL sLerlllzaLlon on vlLamln sLablllLy
vlLamln A
SoluLlon Loss of vlLamln A (120 C 20 mln)
Clly 30000 lu/ml (01 8P1) 39
Aqueous 30000 lu/ml (01 8P1) 36 (pP 34)
38 (pP 63)
Aqueous 100000 lu/ml (01 8P1) 48 (pP 36)
46 (pP 63)

vlLamln Losses on heaL sLerlllzaLlon of vlLamln 81 + 86 + 812 soluLlon ln waLer
SoluLlon Loss of vlLamln (120 C 20 mln)
81 (3) 0
86 (3) 0
812 (0006) 40