IAY, J. TUSZYNSKI AND ¥.K. TAM. the Area Under the Curve. The of the body and Wwe drug. from the plast ‘drug removed depends on the plasma concent Clearance can be measured as « proportion Ri, = Retnination = Ch + Cu dosage forms provides addi and intrinsic clearance. These di Physiologi of compartments representing 1g by in xy, depending on the precision and accuracy of the methods used Absorption routes of admi which involves the r y the cutaneous structure, of iv, injection. throughout the body to various organs and ing the transport of the drug between the various defined compartme movement ix xed to be limited within the blood [8] REASSESSI ‘PAI CTRACTION: 3 is homogeneous and that the phys in the compart ‘equations (ODEs) with fer approach assumes tlnued popularity of multi-compartment models of phan sticle we compare and contrast several concept of interconnected compartments. Our obje sy of providing 4 correla studied : the well-sirred, the p the Vou and Kyy 1 hepatocyte preparation. This kinetic data ‘must then be sed to predict the to st TVIVE work assumes exposed to the same drug concentr stand and work with, and produces res hat they bel siosing sinusoids, The administration I review unticles ‘We apply our technique to drugs taken from two Houston LIVER MODELS There are a substant