University of Maryland Medical Center

Pediatric Antimicrobial Intravenous Dosing Guidelines

( > 2 kg and > 7 days old)

DRUG IV DOSE FREQUENCY MAX/DOSE

Amikacin* 7.5 - 10 mg/kg/dose per renal function N/A

Amphotericin B 0.3 – 1 mg/kg/24h q 24 h N/A

Ampicillin 100 – 400 mg /kg/24h q6h 3 gm

Ampicillin/Sulbactam 100 – 400 mg /kg/24h q6h 3 gm

(Unasyn) (as ampicillin component)

Azithromycin 10 mg/kg/24h Day 1 q 24 h 500 mg

5 mg/kg/ 24h Day 2 to 5

Cefazolin 50 – 100 mg /kg/24h q8h 1 gm

Cefepime* 50 mg/kg/ dose q8h 2 gm

Cefotetan 20 – 40 mg/kg/dose q 12 h 2 gm

Cefoxitin 80 – 160 mg/kg/24h q6h 2 gm

Ceftriaxone 50 – 100 mg/kg/24h q 24 h 2 gm

q 12 h (for meningitis)

Ciprofloxacin* 15 – 20 mg/kg/24h q 12 h 400 mg

Clindamycin 25 – 40 mg/kg/24h q6h–8h 900 mg

Doxycycline 2 – 4 mg/kg/24h q 12 h 100 mg

Erythromycin 20 – 50 mg/kg/24h q6h 1 gm

Fluconazole 3 – 12 mg/kg/24h q 24 h 800 mg

Gentamicin 2.5 mg/kg/dose per renal function N/A

Metronidazole 30 mg/kg/24h q6h 1 gm

Nafcillin 150 – 200 mg/kg/24h q6h 2 gm

Penicillin G 100,000–400,000 u/kg/24h q 4 h 4 mln units

Piperacillin/Tazobactam 200 – 400 mg/kg/24h q6h 4 gm

(Zosyn) (as piperacillin component)

Ticarcillin/Clavulanate 200 - 300 mg/kg/24h q6h 3 gm

(Timentin) (as ticarcillin component)

TMP/SMX 6 – 20 mg/kg/24h q 12 h – 6 h N/A

(Bactrim, Septra) (as TMP component)

Vancomycin* 10 – 15 mg/kg/24h per renal function N/A

*Requires ID approval.

Women’s and Children’s Pharmacy Central Pharmacy

Hours: Telephone Number: 8- 5644

Monday to Friday 7 am to 10 pm
Saturday & Sunday 7 am to 8 pm Fax Number: 8- 8474

Telephone Number 8 – 8950

Fax Number 8 - 7163

Beeper Numbers: 0847: S6U, S6D, FTN, L&D, MBU

8476: S5U, S5D, S5A, S5B, P4G

Clinical Specialist Beeper: 2411

Updated 8/2000
 University of Maryland Medical System

Pediatric Antimicrobial ORAL Dosing Guidelines

( > 2 kg and > 7 days old)

DRUG ORAL DOSE FREQUENCY MAX/Dose

Amoxicillin 25 - 90 mg/kg/24h q 12 h 875 mg

Amoxicillin/ 25 – 90 mg/kg/24h q 12 h 875 mg

Clavulanic Acid
(Augmentin)

Azithromycin 5- 12 mg/kg/24h q 24 h 500 mg

Cefpodoxime 10 mg/kg/24h q 12 h 400 mg

Cephalexin 25 – 100 mg/kg/24h q6h 1 gm

Ciprofloxacin 20 – 30 mg/kg/24h q 12 h 750 mg

Clarithromycin 15 mg/kg/24h q 12 h 500 mg

Clindamycin 10 – 30 mg/kg/day q6h–8h 450 mg

Doxycycline 2 – 4 mg/kg/24h q 12 h 100 mg

Erythromycin 30 – 50 mg/kg/24h q6h 800 mg

(as ethylsuccinate)

Erythromycin/ 40 – 50 mg/kg/24h q6h 500mg

Sulfisoxazole (as erythromycin component)
(Pediazole)

Fluconazole 3 – 12 mg/kg/24h q 24 h 800mg

Penicillin VK 25 – 50 mg/kg/24h q6h 500mg

TMP/SMX 6 – 10 mg/kg/24h q 12 h 160 mg

(Bactrim, Septra) (as TMP component)
Updated 9/2000