Half-Life Solubility Oral Bioavailability Tmax Cmax Theraputic Index PCT FCT CRT Resistance in India Antimalarial activity

AUC Volume of Distribution mean residence time

ARTESUNTAE ARTEMETHER MEFLOQUINE LUMAFANTRINE 1.31 2.98 2-3.5 weeks 4-6 Days Water soluble Lipid Soluble Comparitively Needs to be less. taken with fat High 1.5 hr 2 hr 8088 nmol/l 3454 nmol/l High Medium

Not yet Not yet 0.7 0.3 188867nmol/l hr 11129 nmol/l hr 1.31l/kg 4.37 l/kg 2.52 hr 3.97 hr

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Artemether antimalarial bioavailability is reduced in acute malaria

Ref

J Clin Pharmacol,52,655-661 MJA 2005;182:181-185

Combination therapy reduced gametocytaemia eight fold among patients with recrudescent infetions.-Bulletin of WHO 2000,78(12) EIR= Entomological inoculation rate expressed as the number of infective mosquito bites per person per time per period.