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NEGATIVE /POSITIVE FEEDBACK . ( ( ' 2-3 ) ) .4 , , .3 , .2 .1 : 4

THE MASTER GLAND - HYPOPHYSIS ,BUT TODAY - ALSO HYPOTHALAMUS , ACTH ,PROLACTIN ,TSH ,LH ,FSH ,GH , . . , . , 2 ,( , ) -

ADH-PREVENTS WATER EXCRETION ,ALDOSTERONE - PREVENTS NA EXCREATION DIABETES INSIFIDUSTHE URINE WASN T SWEET - THAT S WHY INSIFIDUS , , SIADH . , , , -

SELLA TURCICA,

OPTIC CHIASM CAUSING- BILATERAL HEMIANOPIA ( . ) , , , , : ,

SHEEHAN SYN -INFARCTION OF THE HYPOPHYSIS , ) -( ) . . !! , 70% , ? . CT , -

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MRI

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GH ,GH INHIBITORY - SOMATOSTATIN IGF 1SOMATOMEDIN C , -( ) , . ( ,( , ) , , , , 3, , , , ) 3< , , -

IGF1, , CT/MRI . -

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IGF1 40 , ,80-90%( , . , , , ( ( , , -42% -28% . . , . -( , ) , , , . ? , , ) )

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-PERIPHERAL VASCULAR DISEASE , , . 20% 70 ( ) , ) , , . TYPE1 DIABETES , . , ,( ) , (40:100,000 - 14 TYPE 1A -IMMUNE MEDIATED - IN THE TIME OF DIAGNOSIS -WE CAN FIND IN BLOOD ANTI ISLET CELLS / INSULIN AUTOANTIBODIES/ ANTI GLUTAMIC ACID . , 90% 5% , , 10% ) , ,10% - 60 , , , , 600,000 - 6-8% , -

LATENT AUTOIMMUNE DIABETES OF ADULTHOOD LADA- 10-25% -1 , , " ,25 . TYPE 2 DIABETES MELLITUS , 80-90% 60 , !!17 2 , ,

OTHER SPECIFIC TYPES 3% MATURITY ONSET DIABETES OF THE YOUNG AUTOSOMAL DOMINANT GENETIC DEFECTS OF PANCREATIC CELLS 6 ) ,2 , ,2 ,25 55% .(

CMV ,COCKSACKIE ,ADENOVIRUS ,MEASLES 1 GDN -GASTATIONAL DIABETES MELLITUS " , 2-4% , , -

5-15 ,

2 , ,

40-60% , , .2 CRITERIA FOR DIAGNOSIS HbA1c>6.5 ( 200< , 8 )FPG>126mg/dl

Or classic symptoms of hyperglycemia and a random plasma glucose of >200- this one is absolute, in the other 3 situation, u need to prove, no symptoms ,( 7) ?126 -

CATAGORIES OF INCREASED RISK FOR DIABETES -PREDIABETES, -

-140> -

,100-125

IFG -IMPAIRED FASTING GLUCOSE IGT -IMPAIRED GLUCOSE TOLERANCE - 140-199 , HbA1c- 5.7-6.4% , , . HbA1c( ) , TARGET ORGAN DAMAGE ? BMI>25 , ( , , ) , " ," 4 + -

TYPE 2 DIABETES MELLITUS 90 .. 60 , 10 , ) . . + . ( ) + " -200 , 50% 2 , , ,( ,

- 180 )

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: 300 -

EXCEEDS TUBULAR REABSORPTION -ESCAPES IN URINE) ( ) , = HbA1C<6.7 160 7% 135 6% 150 -( 8% + , , -( ) , 20-40 -( ) ,150 / ) ,100 ,120 : -

!! (' .. , ) ,7 !!! . , , + -

-2011 ,

SULPHONYLUREA- GLIBENCLAMIDE, GLIPIZIDE, GLIMEPIRIDE

0.8% , , , " 70

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10% -

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METFORMIN -BIGUANIDE -SUPRESSES GLUCONEOGENESIS ,TAKEN IN THE EVENING ,REDUCES ABSORPTION OF B 12 AA AND CARBOHYDRATES ,ANOREXIC DRUG -AT 1ST ,THEN THEY FOUND ITS WILL NOT CAUSE HYPOGLYCEMIA ,WILL CAUSE WEIGHT LOSS 5% - GIT DISTUBANCES DECREASES TG ,INCREASES HDL ,A VERY GOOD DRUG - THE STAR1 ST DRUG AFTER LIFESTYLE CHANGES ACARBOSE -DECREASES ABSORPTION OF CARBOHYDRATES , , ) , , , ( ' ,

THIAZOLIDINEDINONES -PIOGLITAZONE , , , INCRETINS , ( !! SITAGLIPTIN )!!!

BYETTA AND VICTOZA '

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!!