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  • Complement System KORDOFAN

    Hochgeladen von

    Dr. Atif Hassan Khirelsied
    19 Ansichten17 Seiten
    Complement System Co p e e ts Complements Activation and regulation of the  complement system. complement system Co p e e ts Complements The complement is a highly conserved innate  immune cascade of about 30 proteins that  interact to recognize and eliminate pathogens. i t tt i d li i t th Complement • A group of plasma proteins produced by the liver  (~30). • They are produced as pro‐enzymes which are  activated as part of an immune response p p • Pathways for activation Pathways for ac

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    Complement System Co p e e ts Complements Activation and regulation of the  complement system. complement system Co p e e ts Complements The complement is a highly conserved innate  immune cascade of about 30 proteins that  interact to recognize and eliminate pathogens. i t tt i d li i t th Complement • A group of plasma proteins produced by the liver  (~30). • They are produced as pro‐enzymes which are  activated as part of an immune response p p • Pathways for activation Pathways for ac

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    Attribution Non-Commercial (BY-NC)
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    19 Ansichten17 Seiten

    Complement System KORDOFAN

    Hochgeladen von

    Dr. Atif Hassan Khirelsied
    Complement System Co p e e ts Complements Activation and regulation of the  complement system. complement system Co p e e ts Complements The complement is a highly conserved innate  immune cascade of about 30 proteins that  interact to recognize and eliminate pathogens. i t tt i d li i t th Complement • A group of plasma proteins produced by the liver  (~30). • They are produced as pro‐enzymes which are  activated as part of an immune response p p • Pathways for activation Pathways for ac

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Als PDF, TXT herunterladen oder online auf Scribd lesen
    Markieren Sie unangemessene Inhalte
    von 17

    ComplementSystem

    Co p e e ts Complements

    Activationandregulationofthe complementsystem. complement system

    Co p e e ts Complements
    Thecomplementisahighlyconservedinnate immunecascadeofabout30proteinsthat interacttorecognizeandeliminatepathogens. i t tt i d li i t th

    Complement
    Agroupofplasmaproteinsproducedbytheliver (~30). Theyareproducedasproenzymeswhichare p p activatedaspartofanimmuneresponse Pathways for activation Pathwaysforactivation Classicalpathway Alternativepathway MBLpathway

    Complement
    Activationtakesplacebyproteolytic cleavage. Eachcomplementmoleculeiscleavedintotwo p fragmenta andb Usuallybisthelargefragmentwhichisinvolvedin thepathway. the pathway

    Complement

    Allcomplementpathwaysconvergeintheactivation p p y g ofC3whichactivatesthesubsequentstepstoward themembraneattackcomplex(MAC).

    Complement
    Theclassicalpathway isactivatedprimarilyby q theinteractionofC1qwithimmune complexesofantibodywithantigen. CanalsobeactivatedbyinteractionofC1q withnonimmunemolecules.

    Complement
    Thealternativepathway doesnotdependupon thepresenceofimmunecomplexesandleadsto thedepositionofC3fragmentsonthetarget the deposition of C3 fragments on the target cells.

    Complement
    Thelectin pathway sharesseveralmoleculeswith theclassicalpathwayandisactivatedbybinding ofMBLtocarbohydratesexpressedon of MBL to carbohydrates expressed on pathogens.

    Complement
    Theendresultofallthreepathwaysiseitherthe opsonisation orthedestruction(through formationofthelytic moleculeC5b9)ofnonself formation of the lytic molecule C5b9) of nonself cellsandtargetorganisms.

    Complement

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