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Objectivisation of antibiotic therapy practice for leptospirosis seropositive dairy cows

Bajrovi T., Eterovi T. Zvizdi ., Sarajli R.

Diagnosis of leptospirosis in dairy cows by testing blood serum is today the most frequent test method in use, weather is it about the asymptomatic or animals with the clinical manifestation of the disease , and the therapy and the therapy results are subsequently based on the results of the serotesting. Antibiotic therapy spontaneously infected cows is justified in both cases, the animals with the clinical manifestation of the disease and the asymptomatic cows, but after testing the paired sera, after which they can compare the obtained values with the MAT test.Problems due to the presence of low level persisting antibodies, the absence of high antibody tier or a slower disappearance of specific antibodies in asymptomatic seropositive cows after treatment is more difficult to interpret and to plan the repeated treatment(s). Our target population are asymptomatic dairy cows among the 14 030 we have found 145 seroreactors on one of three serovars of L. Interrogans we have used. Of the 117 cows included in the first therapy for 36 there was no need for therapy repetition, which means that the efficiency was 30,76%. The dominance of serovar hardjo, with relatively modest antibody titre (not over 1:400), we could not define precisely, except the adaptability of the strain to other or even changed locations in the host organism and even mild immunostimulation.