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Have you previously received an FAOBMB Travel Fellowship? If yes, please indicate when. No Curriculum Vitae
RESEARCH EXPERIENCE

As Project Assistant from 1-2-08 to 31-3-08 in DST funded project Identification and characterization of mutations in cystic fibrosis transmembrane conductance regulator gene (CFTR): genetic and diagnostic implications with Dr. R Prasad, Dept. of Biochemistry, P.G.I.M.E.R, Chandigarh. As Senior research fellow (SRF) from 1-7-08 to 31-7-09 in ICMR funded project To study the prognostic value of telomere length and telomerase activity in Diabetic Retinopathy with Dr. Amod Gupta, H.O.D, Advanced Eye Centre, P.G.I.M.E.R, Chandigarh. As Senior research fellow (SRF) from 1-8-09 to 15.7.11 in DBT funded project Effects of resveratrol on the expression of factors involved in boneremodeling in surgical menopause model of rat with Dr.Thungapathra.M, Dept. of Biochemistry, P.G.I.M.E.R, Chandigarh. Registered for Ph.D from 1-1-09 till date with Dr.Thungapathra.M, Dept. of Biochemistry, P.G.I.M.E.R, Chandigarh.
Areas of Interest

Genetic Engineering, Molecular Biology, Tissue culture and Immunology.

AWARD Awarded Senior Research Fellowship by Indian Council of Medical Research.

Project Training 45 days teaching practice from Mayur school, Ajmer during B.Ed 3 months dissertation on DNA Fingerprinting of the given plant using RAPD from Indian Institute of Integrative Medicine, Jammu during M.Sc
Conferences Attended Symposium on advance technique in basic research: tools of 21 century. (2010) Participated in Thesis writing workshop held at PGIMER Chandigarh, India. (2011) Participated in Indo-US comprehensive stroke center training program held at PGIMER, Chandigarh, India. (2010) National Symposium cum workshop on experimental research and alternatives held at PGIMER, Chandigarh, India. (2012) National and International Symposium

Participation in National level symposium on Emerging Trends on Biotechnology organized by Cancer college of Life Sciences, Gwalior. (2006) Presented a poster in International Symposium on Role of Genomics in Clinical Practice and 35th Annual Conference of The Indian Society of Human Genetics, organized by Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. (2010)

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List of Publications in International Journals*


Book Review: Rajendra Kumar, Rupali Sharma. Current topics in microbiology and immunology. Annals of neurosciences. 2010, 17 (4).

Abstract Indicate below the abstract that is submitted by you for presentation at the YSP and the FAOBMB Congress in Bangkok (include all authors, affiliation(s) and the text of the abstract) Association of Telomere mean length with Diabetic Retinopathy Rupali Sharma1, Thungapathra M2, Reema Bansal1, and Amod Gupta1
Advanced Eye centre1 and Department of Biochemistry2, PGIMER Chandigarh

Background and Objective: Variations in telomere mean length (TML) of peripheral blood mononuclear cells (PBMCs) are known to have correlation with complex disorders like CAD, cancer, arthritis and SLE. The objective of this study was to determine whether there is any association between TML of PBMCs with the presence and severity of diabetic retinopathy. Methods: The study involved six groups which included - control subjects, NIDDM subjects without diabetic retinopathy, NIDDM subjects with non-proliferative diabetic retinopathy (NPDR)(3 grades Mild NPDR, Moderate NPDR and Severe NPDR) and NIDDM subjects with proliferative diabetic retinopathy(PDR). Study subjects were selected based on detailed ocular examination and diabetic retinopathy classification was based on ETDRS. Blood was collected for estimation of plasma fasting blood sugar and Hb, HbA1c, lipid profile, urea and creatinine in the serum. PBMCs were isolated for TML determination by southern hybridization using telomere probe. Results: The mean TML in the six groups was 8.19 0.64, 6.59 1.22, 5.58 .69, 5.98 .89, 5.89 1.08 and 5.69 0.92 Kbp respectively in the above mentioned order. Conclusion: There was significant difference found between the mean TML of PBMCs from diabetic individuals (with and without retinopathy) and that of control subjects, and this difference was greater for the group with retinopathy as compared to the diabetic group without retinopathy. Although short TML was strongly associated with the presence of diabetic retinopathy, any possible correlation between the degree of reduction of TML and the severity of diabetic retinopathy could not be established due to the small number of subjects under each category.

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Personal Statement Indicate briefly here your Research Interests and Career Goals, why you are interested to participate in the YSP Program (including what you will bring to the YSP and what you hope to gain from it): (no more than one page) My research interest is in specializing in the field of diabetic retinopathy. My work is based on molecular biology techniques, So I want to enhance my knowledge in molecular biology and upgrade my interest in this field by interacting with various scientists around the globe. I am interested to participate in the YSP Program as during my stay in the conference I can meet with other scientists working in the same area and one can have scientific discussions. After presentation of my data I may get valuable suggestions from the scientists to improve my work. As many local problems require a global response. I can contribute to the explanation of many problems. Conferences provide an excellent opportunity to interact with international organizations working in same area which may help in the improvement of research.

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