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Curriculum Vitae

Department of Pharmacy, Seoul National University (SNU) (Principle investigator: Uhtaek Oh) Education 1998.02 2005.02: Bachelor of Science Department of Biological science, Ajou University (1999 - 2001: mandatory military service) 2005.02 2012.02: Unified Masters and Doctors Course Department of Pharmacy, Seoul National University 2012.03 present: Post-Doctor fellow Department of Pharmacy, Seoul National University

Patents Application title: METHOD OF IDENTIFYING AGENTS WHICH MODULATE THE ACTIVITY OF CALCIUM-ACTIVATED CHLORIDE CHANNEL Inventors: Yeon Su Jeong, Uhtaek Oh, Hawon Cho, Young Duk Yang, Min Ho Tak , Yongwoo Jang, Jae Yeon Koo, Si Young Cho Publication date: 08/19/2010 Patent application number: 20100209934 Oral presentation 12st the Korean Society for Brain and Neural Science Title: Constitutive reduction in neurite growth by TRPM2 underlies the etiology of bipolar disorder Date: 2010.12.10 Venue: Kunkuk University 3st the Seoul-Kyoto-Osaka university joint symposium Title: TRPV4 mediates neurotrophic factor-induced neuritogenesis Date: 2011.06.02 Venue: Seoul National University Awards Research Award (AKN, 2008) Excellent Poster Award (KSBNS, 2008) Distinguished Poster Award (Pharmaceutical society of Korea, 2009) Distinguished Poster Award (Pharmaceutical society of Korea, 2010)

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List of Publications in International Journals*

1. J. Y. Koo, Y. Jang, H. Cho, C. H. Lee, K. H. Jang, Y. H. Chang, J. Shin, and U. Oh. Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci, 26, 1139-47 (2007) (IF 3.631) YJs contribution to this paper was screening of ion channels 2. W. S. Shim, H. Back, S. W. Jung, J. W. Kim, Y. Jang, B. Lee, E. K. Seo, U. Oh, and C. K. Shim. An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction. J Ethnopharmacol, 132, 328-33 (2010) (IF 3.014) YJs contribution to this paper was calcium imaging to measure channel activity 3. Y. Cho, Y. Jang, Y. D. Yang, C. H. Lee, Y. Lee, and U. Oh. TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium, 48, 202-8 (2010) (IF 3.766) YJs contribution to this paper was calcium imaging to measure channel activity 4. Y. Jang, J. Jung, H. Kim, J. Oh, J. H. Jeon, S. Jung, K. T. Kim, H. Cho, D. J. Yang, S. M. Kim, I. B. Kim, M. R. Song, and Oh, U. Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. J Biol Chem, 287, 6014-24 (2012) (IF 4.773) YJs contribution to this paper was molecular, biological work and drafted and revised the manuscript. 5. H. Cho, Y. D. Yang, J. Lee, B. Lee, T. Kim, Y. Jang, S. K. Back, H. S. Na, B. D. Harfe, F. Wang, R. Raouf, J. N. Wood, and U. Oh. The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci, 15, 1015-21 (2012) (IF 15.531) YJs contribution to this paper was molecular biological work and behavioral studies 6. Y. Jang, Y. Lee, S.M. Kim, Y.D. Yang, J. Jung, and U. Oh. Quantitative analysis of TRP channel genes in mouse organs. Arch. Pharm. Res. In press (2012) (IF 1.592) YJs contribution to this paper was the statistical analysis, drafted and revised the manuscript.

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TRPM2 regulates neurite outgrowth via LPA receptor in embryonic cortical neurons

Yongwoo Jang, Mi-hyun Lee, Byeongjun Lee, Jungeun Oh, and Uhtaek Oh

Neurogenesis and plasticity of neurons are correlated with neurite outgrowth. Recently the importance of transient receptor potential (TRP) channels for the neuronal differentiation and proliferation has been exhibited. But, it is still not well understood which types of TRP channels are involved in neurite outgrowth. So we screened types of TRP channels are required for the neuronal outgrowth, using real time quantitative-PCR technique in PC12 cells. As a result, we hypothesized that TRPM2 is related to neurite outgrowth. TRPM2 is highly expressed in the brain, but its role in the nervous system is largely unknown. We report that its expression with small interfering RNA increased neurite outgrowth in live cell imaging. Its overexpression decreased the length of neurite. Also the length of neurite is increased by its inhibitors such as econazole, clotrimazole and flufenamic acid. These results suggest that TRPM2 inhibits nuerite outgrowth as negative regulator. We found that expression of TRPM2 and LPA receptor is colocalized in the neuronal cell. Actually, LPAinduced Ca2+ influx is higher in TRPM2 overexpressed in PC12 cell than those in control, using whole-cell recording and Ca2+ imaging. Furthermore, LPA-induced neurite retraction is recovered by blocking TRPM2 channel. Therefore These findings suggest that TRPM2 inhibits neurite outgrowth via LPA receptor. TRPM2 becomes a good molecular target for developing a novel drug to treat neurodegenerative disease.

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Personal Statement
First of all, its a great honor to give me change to apply this great young scientist program. My name is Yongwoo Jang who I work in Dr. Uhtaek Oh lab in Seoul National University. I got the Ph.D at last feburary in this year. Consecutively, I am now researching as a postdoctoral fellow at the same lab. Let me briefly explain my research interests. I have been studying various functions of ion channels during the neuronal differentiation. Ion carriers including in Ca2+, Na+, K+, Cl- have important roles in the process of neuronal differentiation. As you know, these ions were regulated by many kinds of ion channels and receptors. Specially, I focus on the TRP channels, non selective cation channels in the series process such as neurogenesis, axonal growth, synaptogenesis during neuronal differentiation. Recently, I have published my research result suggesting that TRPV4 regulates neurotrophic factor-derived axonal growth in the peripheral nerves. Moreover, Id like to present or share my unpublished results of the function of TRPM2 channel during axonal growth at this program. I sincerely hope to have a chance to share research results of my and other great researchers through young scientist program (YSP).

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