*Points Awarded* *47.00* *Points Missed* *3.00* *Percentage* *94.0%* Correct Incorrect Ungraded 1.

Which would be a useful way to compare two methods of creatinine? A) Levey Jennings chart B) Westgard square C) linear regression D) standard deviation of f-test Points Earned: 1.0/1.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 2. A "trend" occurs when the quality control results are all below 2 SD for 3 days in a row and is most often caused by random error A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* False

Correct Incorrect Ungraded 3. Your laboratory result reads 1006. The upper limit of linearity is 975. What is the BEST dilution to make in this case? (do NOT need to consider a limited sample volume-just the range of the instrument) A) x2 B) x20 C) x50 D) x100 Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 4. What would be the final result of this test? 200 uL sample diluted with 800 uL saline , then 100 uL of that is diluted with 900uL saline. Instrument reading is 110 mg/dL. A) 110 mg/dL B) 1100 mg/dL C) 550 mg/dL D) 5500 mg/dL E) 55500 mg/dL Points Earned: 2.0/2.0 *Correct Answer(s):* D

Correct Incorrect Ungraded 5.

The student's t test is useful for determining the presence of _________ between the means of two methods. A) precision B) hypothesis C) bias D) sensitivity Points Earned: 1.0/1.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 6. Bias is defined as the difference between the observed mean and the reference mean. A) True B) False Points Earned: 0.0/1.0 *Correct Answer(s):* True

Correct Incorrect Ungraded 7. A 95% confidence range for a glucose assay abnormal control is set at 275-325 mg/dL. The following values are obtained during the past week. Day 1 279, Day 2 332, Day 3 330, Day 4 295, Day 5 296, Day 6 279, Day 7 280. Which Westgard Rule has been violated, if any? A) none of the rules has been violated B) 2 2s C) R 4s D) 1 3s Points Earned: 2.0/2.0 *Correct Answer(s):* B

Correct Incorrect Ungraded 8. The dilution factor is the reciprocal of the dilution that was performed. A) true B) false Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 9. The CV is calculated by dividing the mode/2SD x 100% A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* False

Correct Incorrect Ungraded 10. Which of the following Westgard Rules does NOT require a rejection of

the run? (warning only) A) 2 2s B) R 4s C) 10x D) 1 2s *Feedback: *see Math book page 288 (1st ed.) or page 323 (2nd ed.) this is just a warning - do NOT reject the run at this point. Points Earned: 1.0/1.0 *Correct Answer(s):* D

Correct Incorrect Ungraded 11. If a serial dilution is performed, and the instrument reports the concentration of the sample as 75 mg/dL with a dilution factor of 150, what is the final concentration result? A) 7500 mg/dL B) 225 mg/dL C) 11250 mg/dL D) 112500 mg/dL Points Earned: 1.0/1.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 12. In addition to QC, labs are required to participate in external proficiency testing programs such as CAP, AAB or API. A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* True

Correct Incorrect Ungraded 13. About 99% of QC values will fall within +/- 3 SD A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* True

Correct Incorrect Ungraded 14. To compare a new method to another method of calcium, Westgard and CLIA recommend a lab should run at least 200 samples in parallel for 30 days. A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* False

Correct Incorrect Ungraded

15. Fifty ul of sample diluted with Fifty ul of diluent is a ________ dilution. A) 1 to 4 B) 1 to 2 C) 1 to 1 D) 1 to 3 Points Earned: 1.0/1.0 *Correct Answer(s):* B

Correct Incorrect Ungraded 16. A chart used in the clinical laboratory that reflects plotted QC values for tracking on a daily basis is referred to as: A) Levey-Jennings Chart B) Quality Statistics Management Chart C) Westgard Chart D) none of the answers applies Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 17. The percentage of values that will fall between +/- 2 SD in a normal distribution is A) 34% B) 68% C) 95% *Feedback: * right D) 99% Points Earned: 1.0/1.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 18. A serum AST is diluted 1 to 100 with a result of 89.0 U/L. What is the patient's actual AST result? A) 890.0 U/L B) 8.9 U.L C) 87.2 U/L D) 8900 U/L Points Earned: 1.0/1.0 *Correct Answer(s):* D

Correct Incorrect Ungraded 19. The "performance standards" (expected tolerance or variation for target value) for all laboratory testing is +/- 15% of the target value, as set by CLIA. A) True B) False

Points Earned: 1.0/1.0 *Correct Answer(s):* False

Correct Incorrect Ungraded 20. Key indicators of Quality would include which of the following? A) Safety incidents, needle sticks, and other injuries B) Blood culture contamination rates C) Critical values reported and notified (time and accurate information recorded) D) Blood component utilization and Transfusion reactions/ documentation E) All of these Points Earned: 1.0/1.0 *Correct Answer(s):* E

Correct Incorrect Ungraded 21. A serial dilution is performed. Tube 1 has 50 microliters of patient serum and 200 microliters of diluent placed in the tube. Tube 2 has 10 microliters of tube 1 and 190 microliters of diluent. What is the dilution in tube #2? A) 250 x B) 700 x C) 100 x D) 400 x E) 350 x Points Earned: 2.0/2.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 22. The 10 x rule is violated when 10 consecutive QC runs are on the same side of the mean. A) True B) False Points Earned: 2.0/2.0 *Correct Answer(s):* True

Correct Incorrect Ungraded 23. Quality Assurance means the same thing as Quality Control A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* False

Correct Incorrect Ungraded 24. Match the terms with the statistic A. unpaired t-test

B. paired t-test C. f-test used to compare two different groups, such as men and women using a new drug, or different samples used on different days a way to measure the precision of a new method used to compare two methods or two instruments using duplicate aliquots of sample, run on each. Used to determine if there is a difference between the 2 methods (bias) Points Earned: 3.0/3.0 *Correct Answer(s):* unpaired t-test:used to compare two different groups, such as men and women using a new drug, or different samples used on different days, f-test:a way to measure the precision of a new method, paired t-test:used to compare two methods or two instruments using duplicate aliquots of sample, run on each. Used to determine if there is a difference between the 2 methods (bias)

Correct Incorrect Ungraded 25. Calculate the coefficient of variation (percent) for a set of quality control data where the mean(X)= 100 mg/dL and the 2 standard deviations (SD) range is 80 - 120 mg/dL. (just type the number - do NOT type the percent symbol) *Feedback: *sd/mean = 10/100 (recall that the sd range of 80-120 means that 1 sd is 10, range is 100 +/- 2 x SD) great job Points Earned: 2.0/2.0 *Correct Answer(s):* 10

Correct Incorrect Ungraded 26. Sensitivity is the ability of a test method to eliminate: A) true positives B) true negatives C) false positives D) false negatives Points Earned: 1.0/1.0 *Correct Answer(s):* D

Correct Incorrect Ungraded 27. Quality Assurance is the overall process for ensuring your laboratory is performing accurate tests in a proficient manner. A) true B) false Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 28.

At the end of the SOP - the Signatures section will be signed by the author and the medical director and will list any revision dates. A) True B) False Points Earned: 1.0/1.0 *Correct Answer(s):* True

Correct Incorrect Ungraded 29. Collection, Handling, Special precautions, Volume requirements and Specimen Types will be found in the ____ section of the SOP. A) "Sample requirements" B) "Specimen" C) "Collection" D) "Principle" Points Earned: 1.0/1.0 *Correct Answer(s):* B

Correct Incorrect Ungraded 30. The coefficient of variation or the variance are measures of A) accuracy B) interference C) precision D) specificity E) sensitivity Points Earned: 1.0/1.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 31. What is the mode of the following set of numbers: 25, 24, 22, 30, 26, 23, 22, 21? A) 22 B) 24 C) 23.5 D) 30 E) 21 Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 32. A Gaussian distribution when presented in graph form will look like: A) a bell curve B) a straight line C) a representation of inverse proportionality D) none of the answers apply Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 33. A ______ occurs when the quality control results are all distributed on one side of the mean or the other for 6 to 7 consecutive days. A) trend B) shift C) random error D) leap Points Earned: 1.0/1.0 *Correct Answer(s):* B

Correct Incorrect Ungraded 34. Which section of the SOP contains step-by-step instructions for performing a test? A) IX. References B) II. Principle C) V. Procedure D) VI. Performance Characteristics Points Earned: 1.0/1.0 *Correct Answer(s):* C

Correct Incorrect Ungraded 35. When reading a new SOP, you will find all the precautions and safety information listed in Section V - which is the "MSDS" section of the SOP A) True B) False *Feedback: *MSDS is a separate document Points Earned: 1.0/1.0 *Correct Answer(s):* False

Correct Incorrect Ungraded 36. Which of these are often monitored as part of a quality assurance program? A) turn around time B) customer satisfaction C) sample refusal rates D) sample labeling error rates E) all of these Points Earned: 1.0/1.0 *Correct Answer(s):* E

Correct Incorrect Ungraded 37. The confidence interval that represents a 68.2% of a population of data or the likelihood that a result is correct 68.2% of the time refers to A) plus/minus 1 SD B) plus/minus 2 SD C) plus/minus 3 SD

D) plus/minus 4 SD Points Earned: 1.0/1.0 *Correct Answer(s):* A

Correct Incorrect Ungraded 38. Correctly match the following terms with their definitions. A. sensitivity B. standard deviation C. specificity the square root of variance ability of a test method to detect true positives ability of a test method to detect true negatives Points Earned: 1.0/3.0 *Correct Answer(s):* standard deviation:the square root of variance, sensitivity:ability of a test method to detect true positives, specificity:ability of a test method to detect true negatives

Correct Incorrect Ungraded 39. Match the following terms correctly with their definitions A. linearity B. accuracy C. reliability the reportable range (without dilution)of an assay results correctly reflect the true value measure of the test to maintain both accuracy and precision Points Earned: 3.0/3.0 *Correct Answer(s):* linearity:the reportable range (without dilution)of an assay, accuracy:results correctly reflect the true value, reliability:measure of the test to maintain both accuracy and precision