Papich, Mark, DVM, MS

Professor, Department of Molecular Biomedical Sciences DVM: Colorado State University M.S.: University of Illinois (Clinical Pharmacology)

Phone: 919-513-6221 Fax: 919-513-6465 Email: mark_papich@ncsu.edu

Links:
Clinical Pharmacology Laboratory -VTH Pharmacology Analytical Laboratory

Research Program in Veterinary Clinical Pharmacology Program Description

The research program in veterinary clinical pharmacology at North Carolina State University College of Veterinary Medicine consists of studies designed to define and improve rational drug therapy in animals. The research focus consists of studies in a wide variety of animal species, including dogs, cats, horses, ruminants, zoo animals, reptiles, fish, and birds. Current studies focus on the disposition of antibiotics, antifungal drugs, anti-inflammatory drugs, gastrointestinal

drugs, and analgesic drugs in a variety of animal species. Studies originate from our laboratory, or are performed in collaboration with investigators at NCSU, other veterinary colleges, zoos, or pharmaceutical companies. For a descripton of the NCSU Graduate Program in Pharmacology, go to: Comparative Biomedical Sciences (CBS). The clinical pharmacology residency at NCSU is in compliance with the requirements for board certification by the American College of Veterinary Clinical Pharmacology (www.ACVCP.org). For a description of the NCSU Residency Program in Veterinary Clinical Pharmacology.

Program Supervisor
Mark G. Papich, DVM, MS, Professor of Clinical Pharmacology, Molecular Biomedical Sciences Department, College of Veterinary Medicine. Dr. Papich is a Past-President and Chairman of the Board of the American College of Veterinary Clinical Pharmacology. He also is a Fellow in the American Academy of Veterinary Pharmacology and Therapeutics and a member of the American Society of Clinical Pharmacology and Therapeutics (ASCPT). He was elected to the Council of Experts for the USP and is Chairman of the Veterinary Drug USP Expert Committee. He is a voting member of the Veterinary Antimicrobial Susceptibility Testing (VAST) subcommittee for the NCCLS and on the editorial board of three journals. He has given hundreds of invited lectures and is author or co-author of over 200 publications. His interests and expertise: pharmacokinetics, antimicrobial therapy, analgesic drugs, and analytical methodology.

Representative Publications
Schnabel LV, Papich MG, Watts AE, Fortier LA. Orally administered doxycycline accumulates in synovial fluid compared to plasma. Equine Vet J. 2010 Apr;42(3):208-12.PMID: 20486976

Sanchez-Migallon Guzman D, Flammer K, Papich MG, Grooters AM, Shaw S, Applegate J, Tully TN. Pharmacokinetics of voriconazole after oral administration of single and multiple doses in Hispaniolan Amazon parrots (Amazona ventralis). Am J Vet Res. 2010 Apr;71(4):460-7.PMID: 20367055 Moore SA, Muana KR, Papich MG, Nettifee-Osborne J. Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses. J Am Vet Med Assoc. 2010 Mar 15;236(6):656.PMID: 20225977 Moore SA, Muana KR, Papich MG, Nettifee-Osborne J. Levetiracetam pharmacokinetics in healthy dogs following oral administration of single and multiple doses. Am J Vet Res. 2010 Mar;71(3):337-41.PMID: 20187836 [PubM Papich MG. Proposed changes to Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs. J Vet Diagn Invest. 2010 Jan;22(1):160. No abstract available. PMID: 20093710 CLSI VAST subcommittee, Papich MG. Thoughts on testing methods for bacterial isolates. J Am Vet Med Assoc. 2010 Jan 15;236(2):162. No abstract available. PMID: 20074004 Biswas S, Maggi RG, Papich MG, Breitschwerdt EB.Molecular mechanisms of Bartonella henselae resistance to azithromycin, pradofloxacin and enrofloxacin. J Antimicrob Chemother. 2010 Mar;65(3):581-2. Epub 2009 Dec 18. No abstract available. PMID: 20022937 Biswas S, Maggi RG, Papich MG, Keil D, Breitschwerdt EB.

Comparative activity of pradofloxacin, enrofloxacin, and azithromycin against Bartonella henselae isolates collected from cats and a human. J Clin Microbiol. 2010 Feb;48(2):617-8. Epub 2009 Dec 9.PMID: 20007401 Lennon EM, Boyle TE, Hutchins RG, Friedenthal A, Correa MT, Bissett SA, Moses LS, Papich MG, Birkenheuer AJ. Use of basal serum or plasma cortisol concentrations to rule out a diagnosis of hypoadrenocorticism in dogs: 123 cases (2000-2005). J Am Vet Med Assoc. 2007 Aug 1;231(3):413-6. Guedes AG, Papich MG, Rude EP, Rider MA. Pharmacokinetics and physiological effects of two intravenous infusion rates of morphine in conscious dogs. J Vet Pharmacol Ther. 2007 Jun;30(3):224-33. Innis C, Papich M, Young D. Pharmacokinetics of metronidazole in the red-eared slider turtle (Trachemys scripta elegans) after single intracoelomic injection. J Vet Pharmacol Ther. 2007 Apr;30(2):168-71. No abstract available. Davis JL, Papich MG, Morton AJ, Gayle J, Bilkslager AT, Campbell NB. Pharmacokinetics of etodolac in the horse following oral and intravenous administration. J Vet Pharmacol Ther. 2007 Feb;30(1):438. Puskar M, Lemons C, Papich MG, Vaden SL, Birkenheuer A. Antibioticresistant Corynebacterium jeikeium urinary tract infection in a cat. J Am Anim Hosp Assoc. 2007 Jan-Feb;43(1):61-4 Uhrig SR, Papich MG, Kukanich B, Mama KR, Wagner AE, Chapman PL, Hellyer PW. Pharmacokinetics and pharmacodynamics of morphine in llamas. Am J Vet Res. 2007 Jan;68(1):25-34. PMID: 17199415 [PubMed - in process] Papich MG, Wolfe BA. Bone marrow hypoplasia secondary to florfenicol toxicity in a Thomson's gazelle (Gazella thomsonii). J Vet Pharmacol Ther. 2006 Aug; 29(4):317-9 Salmon JH, Papich MG,. Pharmacokinetics of voriconazole after oral and intravenous administration to horses. Am J Vet Res. 2006 Jun; 67(6):1070-5.

Copple CN, Papich MG, Poore MF, Stauffer SH, Birkenheuer AJ, Twedt DC, Levy MG. Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection. J Vet Intern Med. 2006 May-Jun; 20(3):536-43. Papich MG, Weingarten A. The pharmacokinetics of orbifloxacin in the horse following oral and intravenous administration. J Vet Pharmacol Ther. 2006 Jun; 29(3):191-7. Papich MG. In Robinson NE (Editor). Antimicrobial Therapy for Horses. Chapter 1.2 Current Therapy in Equine Medicine, 5th Edition, page 6-10, 2003. Papich MG. In Robinson NE (Editor). Once-daily Aminoglycoside Dosing Regimens. Chapter 17.11 Current Therapy in Equine Medicine, 5th Edition, page 850-853, 2003. Riviere, J.E., and Papich, M.G. Potential and problems of developing transdermal patches for veterinary applications. Advanced Drug Delivery Reviews 50: 175-203, 2001. Papich, M.G. and Riviere JE. 2001. Fluoroquinolone antimicrobial drugs, Chapter 45 (pp. 898-917). In H.R. Adams (ed) Veterinary Pharmacology and Therapeutics, 8th Edition. Ames Iowa, Iowa State University Press. Papich, M.G. and Riviere JE. 2001. Antifungal and antiviral drugs, Chapter 46 (pp. 918-946). In H.R. Adams (ed) Veterinary Pharmacology and Therapeutics, 8th Edition. Ames Iowa, Iowa State University Press. Papich, M.G. and Riviere JE. 2001. Chloramphenicol and derivatives, macrolides, lincosamides, and miscellaneous antimicrobials, Chapter 44. (pp 868-897) In H.R. Adams (ed) Veterinary Pharmacology and Therapeutics, 8th Edition. Ames Iowa, Iowa State University Press. Papich, M.G. 2000. Pharmacologic considerations for opiate analgesic and nonsteroidal anti-inflammatory drugs. Veterinary Clinics of North America (Small Animal Practice) 30: 815-837. Bidgood T, Papich MG. Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate

intravenous infusion in dogs. American Journal of Veterinary Research 64: 1040-1046, 2003. Bach JF, Kukanich B, Papich MG, and McKiernan BC. Bioavailability of two extended-release theophylline formulations in dogs. Journal of the American Veterinary Medical Association (in press). Stamper, M. A., M. G. Papich, G. A. Lewbart, S. B. May, D. D. Plummer and M. K. Stoskopf. Pharmacokinetics of florfenicol in Loggerhead Sea Turtles (Caretta caretta) After Single Intravenous and Intramuscular Injections. Journal of Zoo and Wildlife Medicine 34(1):38, 2003. Bermngham EC, Papich MG. Pharmacokinetics after intravenous and oral administration of enrofloxacin in sheep. American Journal of Veterinary Research 63: 1012-1017, 2002. Bidgood T, Papich MG. Plasma pharmacokinetics and tissue fluid concentrations of meropenem after intravenous and subcutaneous administration in dogs. American Journal of Veterinary Research . 2002;63(12):1622?1628. Papich, M.G., VanCamp, S.D., Cole, J., and Whitacre, M.D. Pharmacokinetics and endometrial tissue concentrations of enrofloxacin and the metabolite ciprofloxacin after IV administration of enrofloxacin to mares. Journal of Veterinary Pharmacology and Therapeutics 25: 343-350, 2002. Mallo KM, Harms CA, Lewbart GA, and Papich MG. Pharmacokinetics of fluconazole in loggerhead sea turtles (Caretta caretta) after single intravenous and subcutaneous injections, and multiple subcutaneous injections. Journal of Zoo and Wildlife Medicine 33: 29-35, 2002. Davis, J.L., Gardner, S.Y., Jones, S.L., Schwabenton, B.A., and Papich, M.G. Pharmacokinetics of azithromycin in foals after iv and oral dose and disposition into phagocytes. Journal of Veterinary Pharmacology and Therapeutics 25: 99-104, 2002. Gardner, S.Y., Papich, M.G. Comparison of cefepime pharmacokinetics in neonatal foals and adult dogs. Journal of Veterinary Pharmacology and Therapeutics 24: 187-192, 2001.

Flammer, K., Whitt-Smith, D., Papich, M.G. Plasma concentrations of doxycycline in selected Psittacine birds when administered in water for potential treatment of Chlamydophila psittaci infection. Journal of Avian Medicine and Surgery 15: 276-282, 2001. Gookin, J.L., Levy, M.G., Law, J.M., Papich, M.G., Poore, M.F., and Breitschwerdt, E.B. Experimental infection of cats with Tritrichomonas foetus. American Journal of Veterinary Research 62: 1690-1697, 2001. Latimer, F.G., Colitz, C.M.H., Campbell, N.B., Papich, M.G. Pharmacokinetics of fluconazole following intravenous and oral administration and body fluid concentrations of fluconazole following repeated oral dosing in horses. American Journal of Veterinary Research 62: 1606-1611, 2001. Levy, J.K., Crawford, P.C., Collante, W.R., and Papich, M.G. Use of adult cat serum to correct failure of passive transfer in kittens. Journal of the American Veterinary Medical Association 219: 1401-1405, 2001. Santschi, E.M., & Papich, M.G. Pharmacokinetics of gentamicin in mares in late pregnancy and early lactation. Journal of Veterinary Pharmacology and Therapeutics. 2000; 23: 359-363. Van Camp, S.D., Papich, M.G., & Whitacre, M.D. Administration of ticarcillin in combination with clavulanic acid intravenously and intrauterinely to clinically normal estrous mares. Journal of Veterinary Pharmacology and Therapeutics. 2000; 23: 373-378. Sellon, D.C., Monroe V.L., Roberts, M.C., & Papich M.G. Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses. American Journal of Veterinary Research 2001; 62: 183-189. Riddle, C., Lemons, C., Papich, M.G., and Altier, C. Evaluation of ciprofloxacin as a representative of veterinary fluoroquinolones in susceptibility testing. Journal of Clinical Microbiology. 2000; 38: 16361637. Gulland, F.M., Stoskopf, M.K. , Johnson, S.P., Riviere, J., & Papich, M.G. Amoxicillin pharmacokinetics in harbor seals (Phoca vitulina) and

northern elephant seals (Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose scaling. Journal of Veterinary Pharmacology and Therapeutics 2000; 23: 223228. Powers, L. V, Flammer, K, & Papich, M.G. Preliminary investigation of doxycycline plasma concentrations in cockatiels (Nymphicus hollandicus) after administration by injection or in water or feed. Journal of Avian Medicine and Surgery 2000; 14: 23-30. Bush, M., Stoskopf, M.K., Raath, J.P., & Papich, M.G. Serum oxytetracycline concentrations in African elephant (Loxodonta africana) calves after long-acting formulation injection. Journal of Zoo and Wildlife Medicine. 2000; 31: 41-46. Lee, D.D., Papich, M.G., Hardie, E.M. Comparison of pharmacokinetics of fentanyl after intravenous and transdermal administration in cats. American Journal of Veterinary Research 2000; 61: 672-677. Bermingham, E.C., Papich, M.G., & Vivrette, S.L. Pharmacokinetics of enrofloxacin administered intravenously and orally to foals. American Journal of Veterinary Research 2000; 61: 706-709. Powers, L.V., Flammer, K., Papich, M. Preliminary investigation of doxycycline plasma concentrations in cockatiels (Nymphicus hollandicus) after administration by injection or in water or feed. Journal of Avian Medicine and Surgery 2000; 14: 23-30. Murphey, E.D, Santschi, E.M., and Papich, M.G. Regional intravenous perfusion of the distal limb of horses with amikacin sulfate. Journal of Veterinary Pharmacology and Therapeutics 1999; 22:68-71. Breitschwerdt, E.B., Papich, M.G., Hegarty, B.C., Gilger, B., Hancock, S.I., and Davidson, M.G. Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain Spotted Fever in dogs. Antimicrobial Agents and Chemotherapy 1999; 43: 813821. Tudor, R.A., Papich, M.G., and Redding, W.R. 1999 Gentamicin disposition and dosage determination of once daily administration of

gentamicin sulfate in horses after abdominal surgery. Journal of the American Veterinary Medical Association 215(4): 503-506. Olby, N.J., Sharp, N.J.H. Munana, K.R., and Papich, M.G.. 1999. Chronic and acute compressive spinal cord lesions in dogs due to intervertebral disc herniation are associated with elevation in lumbar cerebrospinal fluid glutamate concentration. Journal of Neurotrauma 16(12): 1215-1224. Breuhaus, B.A., DeGraves, F.J., Honore, E.K. and Papich, M.G. 1999 Pharmacokinetics of ibuprofen after intravenous and oral administration and assessment of safety of administration to healthy foals. American Journal of Veterinary Research 60 (9): 1066-1073. M. A. Stamper, Papich, M.G., G.A. Lewbart, S.B. May, D. D. Plummer, and M. K. Stoskopf. (1999) Pharmacokinetics of ceftazidime in Loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections. Journal of Zoo and Wildlife Medicine 30(1):32-35. Martin-Jimenez, T., Papich M.G., and Riviere J.E. Population pharmacokinetics of gentamicin in horses. American Journal of Veterinary Research 1998; 59: 1589-1598. Kyles, A. E., Hardie, E.M., Hansen, B.D., and Papich, M.G. Comparison of transdermal fentanyl and intramuscular oxymorphone on post-operative behaviour after ovariohysterectomy in dogs. Research in Veterinary Science 1998; 65: 245-251. McFarlane, D., Sellon, D.C., Gaffney, D., Hedgepeth, V., Papich, M., and Gibbs, S. Hematologic and serum biochemical variables and plasma corticotropin concentration in healthy aged horses. American Journal of Veterinary Research 1998; 59: 1247-1251. Korsrud, G.O., Salisbury, C.D.C., Rhodes, C.S., Papich, M.G., Yates, W.D.G., Bulmer, W.S., MacNeil, J.D., Landry, D.A., Lambert, G., Yong, M.S., and Ritters, L. Depletion of penicillin G residues in tissues, plasma, and injection sites of market pigs injected intramuscularly with procaine penicillin G. Food Additives and Contaminants 1998; 15: 421-426.