A NDEL

Andel BiosaC
A RANGE OF VERSATILE, HIGH PERFORMANCE LABSCALE, PILOT FERMENTOR FROM 5L-500L FERMENTOR SYSTEMS WITH EASY-TO-USE TOUCHSCREEN CONTROLS

TM

Spearheading into Biofuture

Inplace Sterilizable Fermentor Bioreactor System

ANDEL BIOSAC True Value For Money....

In-place Sterilzable Fermentor|Bioreactor

5L/10L/25L/50L/100L/ 200L/500L Capacities

BiosaC Fermentors/ Bioreactors are in-place sterilizable systems ideal for pilot through production applications. Compact design allows the system to fit on the bench or on optional mobile skid. A modular design and wide variety of standard and optional components provide the flexibility to customize these systems to meet your process requirements. Standard Features Process control software Top-Mounted Magnetically coupled drive for 5L and direct coupled provided with a single mechanical seal for other capacities. ASME/CE Electropolished Vessel Baffles (removable type) Bright,5.6 Industrial Color Touchscreen Controller 4 3-Fixed Speed Pumps User-Definable, Pressure Hold Sequence User-Definable, Sterilization Sequence Program Control System Security Temperature Control Resterilizable Harvest Port Ring Sparger Inlet/Exhaust Filters Analog Inputs and Analog Outputs The BiosaC Fermentors are designed for closed aseptic operation. Air is sterilized using 0.2 sterilizable grade air filters to provide spurge and overlay aeration to the Fermentor. The BiosaC comes along with all necessary piping, valves and instruments. The skid holds all the piping and all utilities need to be connected only at one point of the each skid. Inner surface finish of 220 grit Finished & electropolished Ra0.5m External surface finish of 180 grit Matt finishing. All the wetted parts will be of Stainless steel-316L and non wetted parts of Stainless Steel-304. Temperature Control System The jacket is provided with automated secondary loop temperature control system. A PT 100 temperature sensor is provided on the lower sidewall of the fermentor through a 25 mm, inclined port. The secondary loop consists of a circulation line with temperature sensors, heat exchangers, safety relief valve, pressure gauge, flow switch, circulation pump for heating and cooling the circulating fluid. The external loop is provided with valves for steam inlet, chilled water inlet, normal water inlet, chilled water outlet, normal water outlet, drain valve and jacket condensate drain valve. Steam is automatically introduced into the jacket for full vessel sterilization. Raising temperature during process using steam is regulated by limpet and vessel temperature sensors. The chilled water inlet and outlet valves are automatically operated for cooling the vessel after empty or full vessel sterilization or for reducing temperature during process. Empty vessel sterilization is achieved by direct clean steam introduction into the fermentor through automated diaphragm valve. A temperature sensor is provided at the bottom outlet line above steam trap to monitor and control the empty vessel sterilization temperature by operating the clean steam inlet valve for a particular time cycle.

General Description The sterilizable-in-place (SIP) BiosaC fermentor is a fully automated fermentor system operated by a single PLC control system. It utilizes robust, industry- standard components and a latest version of industrial color touch screen programmable-logic controller (PLC) for its smart control and operation with increased throughput at a reasonable price. The head plate is provided with pneumatic lifting facility to lift the top lid without any effort.

Ports - In the head plate for Feeding- Acid, base, antifoam and nutrients. Inoculation-Septum port, extra septum ports. Instruments -Pressure gauge, pressure transmitter. Safety- Safety valve, Air exhaust. Utility-view glass, light glass. In Side Wall for Temperature Sensor, pH Sensor, DO sensor & Sampling Valve. In Bottom- Bottom flush valve with steam lock. Impellers: Fermentor includes three Rushton-type impellers, with pitchedblade and marine-blade, option. Bioreactor offers choice of pitched-blade, marine-blade, etc.. Gas flow control - Sparge gas with a rotometer with flow control valves, pressure regulator is standard. Replace the rotometer with TMFC for upgradation. The air inlet port(s) of the Fermentor is connected to the air line through a prefilter 1.0 micron filter and sterilizable grade 0.2 air filters.

pH Control System - pH sensor is provided on the fermentor for monitoring and controlling the pH of the contents of fermentor system. The Fermentor is provided with 2 No.s peristaltic pumps for dosing acid and alkali stock solutions through individual SIP able valve group assembly, responding to signal from online gel-filled pH sensor based on the pH set point. Addition of acid and alkali stock solutions achieves pH control in the fermentor. Do2 Control - System-Cascaded RPM- The Dissolved Oxygen level in the fermentor is indicated and controlled by an online DO2 Sensor. The sensor conveys signal to variable frequency drive of the agitator according to the DO2 set point. Foam Control System - The BiosaC is provided with 1 No. Fixed speed peristaltic for dosing antifoam solution into the Fermentor, responding to signal from foam sensor.

Sampling System Sampling system consists of a zero dead leg manual sampling valve, steam lock valve, manual diaphragm type clean steam supply valve, steam trap and a sampling device. Sensors & Transmitter

ANDEL SCADA Software

Display of all parameters of all rectors in the same page with pop-up set point window Display of minute wise updates of all configured parameters. Error display and control page. Feed pump configuration page- pump calibration: pulse width: feed volume Feed lizer, etc. details. Add /alkali / antifoam pump page pump on /off and status configuration. History display of the changes effected during the batch progress password protection. Report Manager- daily/batch wise datasheet of all parameters on hourly execution basis. Alarm for all parameters/ values depends on the conditions and set point deviations. Data acquisition for all parameters Remote controlling from a Remote PC> Potting and display of up to 10 process variables for on-line values. Data Export of finished or active batches can be further processed by 3rd party software (e.g. Excel). The SCADA Software will be given with a personalization serial number (ID) for installation.

ANDEL mLERT This additional utility enables

you to receive SMS alert to multiple mobile phones (Up to 10Nos.) whenever the system generates alarm of any malfunction and hence any parameter deviation from the set value range. This feature will be more advantageous for plant managers to get to know immediately in case of any problem in the equipment irrespective of where they are. They can call the operator immediately to rectify the same.

ANDEL InstaPro This additional utility comes

along with a PDA and it enables the user to monitor all the parameters of the fermentation process at any point of time while roaming in the plant.

*Specifications may be subject to change without notice

Optional Utilities
Low to Medium Turbidity Measurement
Higher productivity- Reliable and accurate measurements prevent time consuming cross checks with offline laboratory equipment and consequently avoid process interruptions. Quick start-up and operation. On-site correlation of sensor and transmitter allows for flexible interchange-ability of system components and faster operational readiness.

Continuous Analyzer for Oxygen and Carbon Dioxide Measurement

Co2 Range 0-1, 2.5, 10, 30 or 100% : O2 Range 0-25 or 100%:10 second warm-up time.-Rugged metal case. Long life, 5 year proprietary electrochemical O2 cell. Solid state infrared CO2 sensor.-Digital display of 0.1% O2 and 0.1% CO2 range (.01% CO2 for 0-1, 0-2.5, or 0-10 ranges)-Sampling through front panel inlet port at 5 to 100 cc/min. with flowing sample; connection with plastic tubing 1/16 to 1/8 ID;also connector for syringe injection of sample gas; 60 cc syringe included. Filter supplied for inlet connection-Oxygen calibrates using room air.-includes inlet/outlet fittings, tubing, & particulate filters; splitter; 60 cc sampling syringe.-100-240 Vac, 50/60 Hz operationInternal pumpInternal battery- 0-5V DC output-Data logger (USB connection to PC-PC Software.

Chiller Circulator
ANDEL BiochIL is ideal for chilling and condensing applications in external systems such as fermentors, Rotary Vaccum Evaporators, Electrophoresis Systems, Chilling of heated water baths and general lab applications of chilling in closed loop systems. Technical Features Microprocessor based PID digital t e m p e r a t u r e i n d i c a t o r c u m controller. Ambient to 16 Degree C. With timer, alarm & over temperature protection Powerful circulation pump.

Steam Generator
ANDEL Electra, electrical heating boiler is intelligent and clean machines whose safety characteristic will meet your requirements. ANDEL Electra electrical heating boiler's power is from 6KW to 24 KW. The water tank, water pump, pressure gauges as such elements are all installed in the boiler such a way that your precious spaces will be immensely saved. The boiler is fully controlled, and all the heating elements and other electric elements are of standard make components. Small footprint enables very less space consumption in your laboratory. The boiler is delivered to site assembled, tested and ready for installation. ANDEL ElectrA is one of electrical boiler product for its nice design and technology of ANDEL. Electra steam boiler provide steady and clean steam using electrical heating system as a source of heating.

A NDEL

TM

Spearheading into Biofuture

ANDEL EQUIPMENTS PRIVATE LIMITED #298, Industrial Area, Phase-9, Mohali Punjab-160062. Email:info@andelindia.com Ph:+91-172-3198298, 2213861 www.andelindia.com