Okuda

Parameter
Tumor size Ascites Serum albumin Bilirubin

Negative
<50% of liver Absent >3 g/dl <3 mg/dl (Radio Button) (Radio Button) (Radio Button) (Radio Button)

Positive
> 50% of liver (Radio Button) Present (Radio Button) < 3 g/dl (Radio Button) >3 mg/dl (Radio Button) Score will Calculate Automatically on the Basis of Below Parameters and Should Be Displayed in the Text box

Okuda

Text Box

Okuda I Okuda II Okuda III

if No Postive Factor is Selected if 1 OR 2 Postive Factor is Selected if 3 OR 4 Postive Factor is Selected

CLIP
Parameter Child- Pugh stage Tumour morphlogy Score 0 A (RB) Score 1 B (RB) Uninodular Multinodular and and extension extension <=50%(RB) <=50%(RB) <400 (RB) no(RB) >400(RB) Yes(RB)

AFP (ng/ml) Portal vein thrombosis

Clip Stage

Text Box

Score will Calculate Automatically on the Basis of Be Parameters and Should Be Displayed in the Text b

Early Stage Intermediate Stage Advanced stage

if Score is ZERO if score is 1-3 points if score is 4 - 6 points

Score 2 C (RB) Massive or extension >50%(RB)

only one Radio button will be selected from

and final score will be the addition of correspon will be selected in particula

(RB) Radio Button

Calculate Automatically on the Basis of Below ers and Should Be Displayed in the Text box

will be selected from each row

e addition of corresponding radio button which e selected in particular row

BCLC
Tumour status
BCLC stage
Stage A: early HCC A1 A2 A3 A4 Stage B: intermediate HCC

PST
0 0 0 0 0 0

Tumour stage

Okuda stage Liver function staus

No portal hypertension and nomal bilirubin portal hypertension and nomal bilirubin portal hypertension and abnomal bilirubin Child - pugh A-B

Single,<5 cm Single,<5 cm Single,<5 cm 3 tumours <3 cm

I I I I-II

Large multinodular I-II Child - pugh A-B Vascular invasion or Stage C: advanced HCC 1-2* extrahepatic spread* I-II Child - pugh A-B Stage D: end stage HCC 3-Apr Any III Child-Pugh C Stage A and B: all criteria should be fulfilled. Stage C: at least one criterion ; *PST 1-2 or vascular invasion /extrahepatic spread. Stage D: at least one criterion;PST 3-4 or Okuda stage III/ Child -Pugh C.

BCLC

Drop Down list

A B C D

this is for Display purpose only

and in the Last Provide a Drop Down.

ECOG
Grade
0(RB) 1(RB) 2(RB) 3(RB) 4(RB) 5(RB)

ECOG

Fully active, Able to carry on all pre-disease performance without restriction Restricted in physicallly strenuous activity but ambulatory and able to carry out work of a light or sedentary Ambulatory and capable of all selfcare but unable to carry out any work activities.Up and about more than 5 Capable of only limited selfcare, confined to bed or chair more then 50% of waking hours Completely disablesd. Cannot carry on any selfcare.Totally confined to bed or chair Dead

ECOG

Text Box

Selected Grade will Automatically Display in the Text bo

RB

Radio Button

ECOG

ECOG

n y out work of a light or sedentary nature, e.g., light house work, Office Work ivities.Up and about more than 50% of waking Hours waking hours or chair

omatically Display in the Text box.

and only one Radio Button will be Selected from the above Category

CTP Score
Measure Total bilirubin,umol/I(mg/dl) Serum albumin, g/l PT INR Ascites Hepatic encephalopathy 1 point <34(<2)(RB) >35(RB) <1.7(4)(RB) None(RB) None(RB) 2 points 34-50(2-3)(RB) 28-35(RB) 1.71-2.20(4-6)(RB) Mild (RB) Grade I-II(RB)

CTP Score

Text Box

Score will Calculate Automatically on the Basis of Above Selected Parameters and Should Be Displayed in the Text box

re
3 points >50(3)(RB) <28(RB) >2.20(>6)(RB) Severe(RB) Grade III-IV (or refractory)(RB)

only one Radio button will be selected from and final score will be the addition of correspon

alculate Automatically on the Basis of Above rameters and Should Be Displayed in the Text box

be selected from each row dition of corresponding radio button which

Category
Sex AP:AST(orALT)ratio y globulin or lgG level above normal

Variables
Female (RB) >3(RB) <1.5(RB) >2.0(RB) 1.5 2.0(RB) <1.0(RB) >1:80(RB) 1;80(RB) 01:40:00(RB) <1:40(RB)

Score
Plus 2 Minus2 Plus 2 Plus 3 Plus 2 0 Plus 3 Plus 2 Plus 1 0

ALH SCORE Category

HLA Immune Disease

Other markers

ANA, SMA, or LKM1 titers

Histological features

AMA Viral markers

Positve (RB) Positive(RB) Negative(RB) Yes (RB) No (RB)

Minus 4 Minus 3 Minus 3 Minus 4 Plus 1

Treatment response

Drugs

Pretreatment aggregate score: Definite Diagnosis>15 Probable Diagnosis 10 15 posttreatment aggregate score: Definite diagnosis >17 Probable diagnosis 12 17

Alcohol

<25 g/day(RB) >60 g/day(RB)

Plus 2 Minus 2

Only one will be Selected from a Parti

And Please Treat Plus as And Please Treat Minus as + Sign Sign

RB

Radio Button

Variables
DR3 Or DR4(RB) Thyroiditis, colitis, others (RB)

Score
Plus 1 Plus2

Anti SLA, anti actin, anti LC1,pANCA(RB)

Plus 2

Interface hepatitis (RB) Plasmacytic(RB) Rosettes(RB) None of above(RB) Billary changes(RB) other features(RB) Complete(RB) Relapse(RB)

Plus 3 Plus 1 Plus1 Minus5 Minus3 Minus3 Plus2 Plus 3

Text Box

Score will Calculate Automatically on the Basis of Above Parameters and Should Be Displayed in the Text box

5 Text Box Score will Calculate Automatically on the Basis of Above Parameters and Should Be Displayed in the Text box

om a Particular Category

Score will Calculate Automatically on the Basis of Above Parameters and Should Be Displayed in the Text box

Score will Calculate Automatically on the Basis of Above Parameters and Should Be Displayed in the Text box

MELD = 3.78[Ln serum bilirubin (mg/dL)] + 11.2[LnINR] +9.57[LnserumCREATININE (MG/DL)] +6.43 is given a value of 1] Maddrey's (Discriminant Function ) = 4.6* (PT in seconds prolonged ) + Total bilirubin

Lilley Model score: Text Box

erumCREATININE (MG/DL)] +6.43 [Any value less than one

Automatically Take Values from Investigation TAB and calculated the Score Automatically Take Values from Investigation TAB and calculated the Score

d ) + Total bilirubin

In the Lilley Model Score, only a text box is Required

ly Take Values from Investigation and calculated the Score

ly Take Values from Investigation and calculated the Score

Model Score, only a text box is Required

Mrecist for HCC 1 CR=Disappearance of any intratumoral arterial enhancement in all target lesions (Check Box) 2 PR =At least a 30% decrease in the sum of diameters of viable ( enhancement in the arterial phase)target lesion, taking as referen 3 SD= Any cases that do not qualigy for either partial response or progressive disease (Check Box) 4 PD = An increase of at least 20% in the sum of the diameters of viable (enhancing ) target lesions, taking as reference the smalles

only Check Box Required

mRECIST

esions (Check Box) ent in the arterial phase)target lesion, taking as reference the baseline sum of the diameters of target lesions (Check Box) e disease (Check Box) ancing ) target lesions, taking as reference the smallest sum of the diameters of viable ( enhancing ) target lesions recorded since treatment started (C

mRECIST

reference the baseline sum of the diameters of target lesions (Check Box)

mallest sum of the diameters of viable ( enhancing ) target lesions recorded since treatment started (Check Box)

ed since treatment started (Check Box)