5.3. 5.4.

Response of the second order systems to various inputs Higher order systems

6. Introduction to Feedback Control Systems 6.1 Concepts of feedback control 6.2. Control Systems 6.3. Controllers and final control element 6.4. Hardware for process control 7. Dynamic Behavior of Feedback Control Processes 7.1. Block Diagrams / Algebra 7.2. Effect of proportional control 7.3. Effect of Integral control 7.4. Effect of Derivative control 7.5. Effect of Combined (PID) control 8. Stability of Feedback Control Systems 8.1. Motion of Stability 8.2. Characteristic Equation 8.3. Routh-Hurwtz Criterion 8.4. Root-Locus Criteria 9. Controller Tuning 9.1. Ziegler-Nichols Method 9.2. Cohen Coon Method

Laboratory Equipment

None

Course Name: Course Description Number of Units for Lecture and Laboratory Number of Contact Hours per week

BIOCHEMICAL ENGINEERING This course deals with the processing of biological materials and processing using biological agents such as cells and enzymes. 3 Lecture units 3 hours per week

Prerequisite

Introduction to Biotechnology, Chemical Reaction Engineering After completing this course, the student must be able to: 1. Write enzyme kinetic models and solve related problems. 2. Write biological reactions and perform elemental balance to determine growth yield 3. Demonstrate how to set up and solve enzyme and cell kinetic expressions. 4. Describe gas-liquid transfer in cellular systems 5. Determine the oxygen transfer rate in bioreactors. 6. Design and analyze bioreactors. 7. Describe mixed-microbial population interaction and their application in

Course Objectives

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industrial processes

I. ENZYME KINETICS F. Simple Enzyme Kinetics G. Michaelis Menten Type Kinetics H. Enzyme Specificity I. Enzyme Kinetics 1. Simple enzymes kinetics 2. Michaelis-Menten Type kinetics 3. Enzyme Inhibition 4. Models for more complex enzyme kinetics 5. Effect of temperature and pH II. STOICHIOMETRY OF MICROBIAL GROWTH AND PRODUCT FORMATION D. Elemental Balances E. Degree of Reduction C. Theoretical Predictions of Yield Coefficients III. KINETICS OF SUBSTRATE UTILIZATION, PRODUCT FORMATION AND BIOMASS PRODUCTION IN CELL CULTURES A. Ideal Reactors for Kinetics Measurement 1. Batch Reactors 2. Continuous-Flow Stirred-Tank Reactor (CSTR) B. Kinetics of Balanced Growth 1. Monod Growth Kinetics 2. Kinetic Implication of Endogenous and maintenance Metabolism 3. Other Forms of Growth Kinetics C. Product Formation Kinetics D. Kinetic Models of Growth and Product Formation Course Outline IV. TRANSP[ORT PHENOMENA IN BIOPROCESS SYSTEMS A. Gas-Liquid Mass Transfer in Cellular Systems B. Determination of Oxygen Transfer Rates C. Determination of KLa values D. Factors Affecting KLa values in bioreactors 1. Degree of Agitation 2. Medium and Culture Rheology 3. Effect of Foam and Anti-foam on Oxygen Transfer V. DESIGN AND ANALYSIS OF BIOREACTORS A. Ideal Reactors 1. Fed-Batch Reactors 2. Enzyme-Catalyzed Reactions in CSTRs 3. CSTR with Recycle 4. Multi-Stage CSTR 5. Plugflow Reactors B. Sterilization Reactors 1. Batch Sterilization 2. Continuous Sterilization C. Immobilized Cell Systems 1. Active Immobilization 2. Passive Immobilization: Biological Films 3. Diffusional Limitations in Immobilized Cell Systems D. Multi-Phase Bioreactors 1. Packed-Bed Reactors 2. Fluidized-Bed Reactors 3. Trickle Bed Reactors VI. BIOREACTOR INSTRUMENTATION AND CONTROL

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A. Instrumentation for Measurements of Active Fermentation B. Using the Information Obtained VII. FERMENTATION TECHNOLOGY A. Medium Formulation B. Design and Operation of a Typical Aseptic, Aerobic Fermentation Process VIII. MIXED MICROBIAL POPULATION AND THEIR APPLICATION A. Analysis of Multiple Interacting Microbial Populations B. Uses of Well-Defined Mixed Populations C. Biological Wastewater Treatment Laboratory Equipment None

Course Name:

INDUSTRIAL WASTE MANAGEMENT AND CONTROL This course covers the study of the different Environmental Management Programs applied to industry. These includes: Environmental Impact Assessment, Environmental Management System, Risk assessment, Life Cycle Analysis, Pollution Prevention and waste treatment (wastewater, air pollutants, solid and hazardous waste) 3 hours lecture

Course Description

Number of Units for Lecture and Laboratory

Number of Contact Hours 3 hours/week per week

Prerequisite/Co-requisite Biochemical Engineering After completing this course, the student must be able to: 1. Comprehend and master the principles of environmental engineering related to wastewater management, air pollution and control, solid and hazardous waste management 2. Use material and energy balances and kinetics to solve basic design parameters, needed in wastewater treatment, air pollution and control, solid and hazardous waste management using the material balances and kinetics 3. Apply basic Environmental Management Programs such as EIA, EMS, Risk Assessment, Pollution Prevention to an industry I. Fundamentals: Definitions, Sources, Composition and Properties, Generation Rates, Regulations, Treatment and Disposal: Physical, chemical, Biological Methods, Solidification and Stabilization, Thermal methods; Equipment Design 1.1. Wastewater Management 1.2. Air pollution and Control 1.3. Industrial Solid Waste Management 1.4. Hazardous Waste Management 2. Environmental Impact Assessment 3. Environmental Management Systems 4. Risk Assessment: Risk analysis, Exposure Pathways, Ecological Risk Assessment and Uncertainties 5. Pollution Prevention: Economic Incentives and Life-Cycle Analysis, Volume Reduction and Recycle None

Course Objectives

Course Outline

Laboratory Equipment

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