ENZYMES

1) Enzymes increase the rate of reaction by a) Increasing the free energy og activation b) Decreasing the free energy of activation c) Changing the equilibrium constant of the reaction d) None of the above 2) LDH 5 level is increased in a) Stroke b) Myocardial infarction c) Acute pancreatitis d) Acute viral hepatitis 3) Pepsin is classified as a) Hydrolase b) Lyase c) Ligase d) Oxidoreductase 4) Lactate dehydrogenase is classified as a) Oxidoreductase b) Transferase c) Hydrolase d) Ligase 5) The optimum pH for most enzymes is in the range of a) 2 to 5 b) 4 to 9 c) 9 to 11 d) None of the above 6) The enzyme xanthine oxidase is competitively inhibited by a) Dicoumarol b) Succinylcholine c) Allopurinol d) Methotrexate 7) The enzyme streptokinase is used in the treatment of a) Acute leukemia b) Myocardial infarction c) Pancreatitis d) Severe infection 8) The enzyme lipase is used in which case a) Following pancreatectomy b) Lymphoma c) Pulmonary embolism d) Thrombosis 9) The enzyme used in the diagnosis of prostate cancer a) Alkaline phosphatise b) AST c) ALT d) Acid phosphatise 10) The enzyme elevated earliest in myocardial infarction a) CPK b) AST c)ALT d) LDH 11) Serum lipase concentration is elevated in a) Myocardial infarction b) Muscular dystrophy c) Pancreatitis d) Hepatitis 12) The enzyme elevated in muscular dystrophy a) Acid phosphatise b) CPK c) Amylase d) ALT 13) The enzyme used in the diagnosis of urinary bladder cancer a) Glucuronidase b) Acid phosphatise v) Alkaline phosphatise d) LDH 14) Estimation of serum amylase is used in the diagnosis of a) Hepatitis b) Pancreatitis c) Myocardial infarction d) All of the above

15) Which enzyme is diagnostic of obstructive jaundice a) Alkaline phosphatise b) AST c) ALT d) Lactate dehydrogenase 16) How many isoenzymes does LDH have a) 2 b)3 c)4 d)5 17) All of the following aare oxidoreductases except a) Amino acid oxidase b) Glucokinase c) Glutathione reductase d) Glutamate dehydrogenase 18) Which of the following is a ligase a) Pepsin b) Glucose 6 phosphatase c) Alanine amino transferase d) Delta ALA synthetase 19) The protein moiety of an enzyme is known as a) Holoenzyme b) Apoenzyme c) Coenzyme d) None of the above 20) Folloeing are characteristics of enzymes except a) Protein in nature b) Colloidal and thermolabile c) Specific in action d) Emit radioactivity 21) Which of the following anti cancer drugs is a competitive inhibitor of the enzyme dihydro folate reductase a) Allopurinol b) Amphetamine c) Ephedrine d) Amethopterin 22) The coenzyme required for transamination reactions a) B6 b) B12 c) B1 d) B3 23) The coenzyme required for carboxylation reactions a) Pyridoxine b) Cobalamine c) Biotin d) Thiamine 24) The enzyme hexokinase is a a) Hydrolase b) Oxidoreductase c) Transferase d) Ligase 25) Allosteric inhibition is known as a) Competitive inhibition b) Non competitive inhibition c) Feedback inhibition d) None of the above 26) IN competitive inhibition the inhibitor a) Competes with the enzyme b) Binds with the substrate c) Competes with the substrate d) irreversibly binds with the enzyme 27) Competitive inhibition can be reversed by raising the a) Enzyme concentration b) Substrate concentration c) Inhibitor concentration d) none of the above

28) Creatine kinase is found in a) Myocardium b) Brain c) Muscle d) All of the above 29) Alkaline phosphatise level is elevated in a) Bone diseases b) muscle diseases c) Myocardial infarction d) Pancreatitis 30) Which isoenzyme of CPK is elevated in myocardial infarction a) CPK 2(MB) b) CPK 3 (MM) c) CPK3(BB) d) None of the above 31) Inactive precursor of an enzyme is known as a) Apoenzyme b) Coenzyme c) Proenzyme d) Holoenzyme 32) Which of the following is a coenzyme a) Carboxypeptidase b) Aminopeptidase c) Pepsinogen d) Chymotrypsin 33) Biotin is a coenzyme for a) Pyruvate dehydrogenase b) Pyruvate carboxylase c) Aspartate transaminase d) Amino acid oxidase 34) Most of the coenzymes are derivatives of a) Water soluble vitamins b) Fat soluble vitamins c) Amino acids d) Nucleic acids 35) The rate of enzymatic reaction is inversely proportional to a) Substrate concentration b) Temperature c) Product concentration d) Enzyme concentration

KEY FOR ENZYMES

1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. B D A A B C B A D A C B A B A D B D B D D A C C C C B D A A C C B A C