11) 2) 3) 4) 5) 21) 2) 3) 4) 5) 31) 2) 3) 4) 5) 41) 2) 3) 4)

Hypokalemia isnt a side effect of : Spiranalactone Amiloride Triamterene Enalapril All of the above All are nitrate effects except : Bradycardia Headache Cyanosis Flushing Tolerance All are morphine effects except : Miosis Vomiting Constipation Cough Hyposis One is selective B2 agonist : Isoprinaline Noradrenaline Salbutamole Timolol

5) 51) 2) 3) 4) 5) 61) 2) 3) 4) 5)

Amphetamine Carbacol (cholinergic agonist) : Used in enuresis among children Antagonized by neostigmine Relax skeletal and smooth muscle Increase BP Decrease IOP (intraocular pressure ) One matched correctly with its source : Sulfonamide / synthetic Insulin / plants Erythropoietin / microbes Digoxin / synthetic None of them

7- All increase drug concentration in blood except : 1) Given parentally 2) Liver and kidney disease 3) c-p 450 inhibitors 4) Combined with drug displace it from its receptor and having low VD 5) All of the above 81) 2) Potency : The ability of drug to bind a receptor The maximum effect of a drug

3) 4) 5)

The effect of drug per unit of weight The dose needed to reach the maximum effect of the drug None of them

91) 2) 3) 4) 5)

All are side effect of frusemide except : Hyperlipidemia Hyperglycemia Hyperuricemia Hyperkalemia Hyponatremia

10-Hair growth is noticed in which drug used in hypertension : 1) Methyldopa 2) Na nitroprusside 3) Minoxidil 4) Hydralazine 5) Nifedipine 11- Pethidine compared to morphine : 1) Produces sedation more than restlessness 2) Less antimuscarinic effect 3) More potent 4) Has negative inotropic effect 5) More antitussive action

12-Adrenalin used in all except : 1) Asthma 2) Heart block 3) Glaucoma 4) Local bleeding 5) Angina

13-The drug reactivate inhibited Ach esterase : 1) Atropine 2) Neostigmine 3) Thiosulphate 4) Adrenaline 5) PAM 14-Succinylcholine used in : 1) Malignant hyperthermia 2) Intestinal and biliary colic 3) Rapid endotracheal intubation 4) Motion sickness 5) Glaucoma 15-1st pass effect definition : 1) Drug metabolism when given by IV route 2) Drug metabolism when not bounded to plasma albumin 3) Drug metabolism in the liver before distribution when given internally

4) 5)

Drug metabolism outside the liver Drug elimination upon manipulating urine PH

16-The half life of a drug : 1) The time needed for a drug to change concentration by 50% 2) The time needed for a drug to bind to its receptor 3) The time needed for a drug to excreted completely from the body 4) The time needed to reach the maximum concentration

17-Zero order kinetic : 1) Few drug follow it 2) Kinetic at high drug concentration 3) Fixed amount of drug metabolized per unit time 4) Rate of metabolism is time independent 5) All of the above 18-All are uses of digoxin except : 1) Heart failure 2) Atrial flutter 3) Atrial fibrillation 4) Ventricular ectopic 5) Used for all of them 19- All true regarding digoxin except :

1) 2) 3) 4) 5)

Negative inotropic agent Negative chronotropic agent Na /K pump inhibitor Given enterally and parentally Characterized by all of them

20-One anti-arrhythmic drug acts by inhibiting ventricular excitation : 1) Digoxin 2) Adenosine 3) Metoprolol 4) Verapamil 5) Lignocaine

21-About morphine : 1) Safe to be given in pregnant and lactating women 2) Respiratory center stimulants , useful in asthmatics 3) Mydriatic agent 4) Indicated in post partum urinary retention 5) Contraindicated in acute undiagnosed abdominal pain 22-NE primary terminated by : 1) Reuptake to neurons 2) Metabolized by MAO 3) Metabolized by Ach-esterase

4) 5)

Passively diffused out of synapses Metabolized by COMT

23-Prazosin : 1) The 1st choice in glaucoma management 2) Used in migraine treatment and prophylaxis 3) Contraindicated in hypertension management 4) Used in benign prostate hyperplasia BPH 5) Partial opioid agonist 24-Digoxin toxicity in increase in which of the following conditions : 1) Hypothyroidism {myxedema} 2) Thiazide diuretics 3) Renal failure 4) Hypokalemia 5) All of them

25-Angina is best managed by : 1) Oral propranolol 2) Oral isosorbid dinitrate 3) GTN patches 4) Chewed isosorbid mononitrate 5) GTN sublingually

26-Acute morphine toxicity is best managed by : 1) naltrexone 2) methadone 3) mepridine 4) Na thiosulpate 5) naloxone 27-all are side effects of B blockers except : 1) hyperglycemia 2) arrhythmias 3) bradykardia 4) sexual dysfunction 5) cold extremities 28-anticholinergic best used for mydriasis : 1) homatropine 2) benzatropine 3) pirenzpine 4) ipratropium 5) probanthine

29-the name of drug given by the manufacturers is the : 1) chemical name 2) generic name 3) official name

4) 5)

trade name approved name

30-drug absorption depends in all except : 1) blood flow at absorption site 2) contact time at absorption site 3) lipid solubility 4) volume of distribution 5) all of the above 31-therapeutic effects of a drug increase when : 1) displaced from albumin 2) bound strongly to plasma protein 3) dissociate from its receptor 4) ionized in liver set of metabolism 5) become water soluble 32-drug enters CNS readily are : 1) lipid soluble 2) highly bound to albumin 3) hydrophilic 4) polar 5) large in weight

33-one is calcium channel blocker : 1) varapamil 2) clonidine 3) timolol 4) pentazocin 5) minoxidil 34-B blockers used in all except : 1) Angina 2) Hyperthyroidism 3) Glaucoma 4) Migraine 5) Asthma 35-Neostigmine indicated in all except : 1) Organophosphate poisoning 2) Post operative urinary retention 3) Tubocurarine poisoning 4) Mysthena gravis 5) All of the above 36- Atropine indicated in all of the following except : 1) Vomiting 2) Pyloric stenosis 3) Insecticide poisoning 4) Urine retention 5) Preanesthesia

37-Drug of wide therapeutic index : 1) Toxic at low doses 2) Variation in patient response occur at the same dose 3) Minimally bound to plasma protein 4) Safe drug 5) 2 and 4 38-Bioavilability describes : 1) Percentage of drug dose not bind plasma proteins 2) Percentage of drug bind to the intracellular receptor 3) Percentage of drug reaches the plasma unchanged 4) Volume of blood containing drug excreted per unit of time 5) Percentage of drug not metabolized in the cp-450 system 39-Rectal form of drugs include : 1) Ointment 2) Suspension 3) Bolus 4) Patches 5) Suppository 40-All used in hypertension management except : 1) Alpha adrenergic antagonists 2) Vasodilator

3) 4) 5)

ACE inhibitor Cholinesterase inhibitor Calcium channel blockers