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KEISER UNIVERSITY
Master of Heath Science in Physician Assistant Course Syllabus
COURSE TITLE: COURSE NUMBER: CREDIT HOURS: PREREQUISITES: Microbiology MPA 521 3.0 graduate semester credit hours Successful Completion of MPA 514, MPA 513, MPA 511, MPA 512, MPA 510

INSTRUCTOR Pirouz Daftarian PhD pdaftarian@keiseruniversity.edu

COURSE DESCRIPTION This course provides an overview of infectious organisms, pathogenic mechanisms by which microbes and parasites cause disease, antimicrobial agents that are used to treat such infections, mechanisms by which organisms develop resistance against antimicrobials, and epidemiologic patterns of common infections. Students learn how to apply the classification and characteristics of microorganisms to determine which types of antimicrobial drugs might be most efficacious in treating a given infection, as well as how to predict which pathogens are most likely to have caused a specific infection. Course material also covers the physiologic mechanisms of humoral and cellular immunity, processes by which immune deficiencies exacerbate infectious conditions, and applications of biotechnology in creating diagnostic and therapeutic immune agents. RELATED PROGRAM OBJECTIVES Effectively demonstrate core knowledge and application in daily practice. Demonstrate analytic and investigatory thinking in clinical situations. Demonstrate a medical knowledge of pathophysiology, patient management, surgical principles and health promotion and disease prevention. COURSE OBJECTIVES
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2 Upon completion of this course, the student will demonstrate emerging competency in the following learning domains: 1. Demonstrate an accurate understanding of those aspects of medical microbiology that are of particular significance in the fields of clinical infections and chemotherapy. 2. Demonstrate comprehensive knowledge of the principles of diagnostic microbiology and their clinical correlation. 3. Demonstrate an understanding of disease pathogenesis, epidemiology, manifestation, diagnosis and antimicrobial treatments 4. Define and differentiate the bodys innate and adaptive immune responses. 5. Describe the normal processes of cellular and humoral immunity to pathogens, including the functions and properties of different cell types and organs of the immune system. 6. Describe the regulatory controls of the immune system. 7. Predict the consequences of deficiency in a particular component of the immune system. 8. Identify techniques used by biotechnology to create diagnostic and therapeutic agents. 9. Describe techniques used to make biological inferences from protein and nucleic acid sequences. 10. Utilize appropriate medical terminology to describe the epidemiology, etiology, and pathophysiology of discussed infectious diseases. Notes on Assessment/Course Evaluation: 1. The maximum grade of an 80% will apply to any late assignment or to an exam taken at a different time than scheduled. All work, including the final exam, must be completed by the ending date and time of the course. 2. Failure to obtain an overall grade of 80%, but not less than 70% will result in the student taking the Comprehensive re-examination, in which the student will receive a grade of pass or fail. If the student passes the Comprehensive exam they will receive a maximum course grade of a C. 3. Failure to pass the comprehensive re-examination will result in dismissal from the Physician Assistant program. 4. Students are responsible for all readings assigned and may be tested on material in the chapter, although not covered in lecture. 5. Cheating is not tolerated and may result in an exam grade of zero at the course directors discretion. COURSE MATERIALS

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3 MPA521 Microbiology, Sherris Medical Microbiology, 5th Ed. Ryan, Ray, Ahmad,k Drew & Plorde. McGraw-Hill 9780071604024 Ryan, Ray, Ahmad,k Drew & Plorde McGraw-Hill 9780071604024 Class Time Tuesday 3 6pm GRADING SYSTEM 90-100% 80-89% 70-79% Less than 70% A B C F

NOTES ON ASSESSMENTS/COURSE EVALUATION 1. A 10% late penalty may apply to any late assignment or to an exam taken at a different time than scheduled. All work, including the final exam, must be completed by the ending date and time of the course. ASSESSMENTS/COURSE EVALUATION Grading Events Exam 1 Exam 2 Exam 3 Exam 4 Date
Feb. 05, 2013 March 05, 2013 April 02, 2013 April 23, 2013

% of Grade 25% 25% 25% 25% 100%*

TOTAL *A web base assignment and presentation on either of the following topics: has 10 score.
Sterilization and Infection Control Web base assignment: Fungal and parasitic infections in Florida / tropical regions

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COURSE OUTLINE Jan 15, 2013/ WEEK 2

Class 1. The Nature of Infection. Immune system. Infection. Immune Response to Infection. Sterilization, Disinfection and Infection Control. Chapter 1 and 2 and class notes
Reading: Chapters 1 and 2 Infection and Immune Responses to Infections Lectures: Introduction to Medical Microbiology Normal Flora An Overview of Immunology Elements of Innate & Acquired Immunity

Jan 22, 2013/ WEEK 3

Class 2. Immunogens, antibody and vaccines Class notes and Pages 45-56 with focus on i) margin notes and ii) tables 3-1, 3-2, and 33, and
chapters 6 and 7. Immunogens and Antigens Antibody Structure & Function Vaccines Pages 45-56 with focus on i) margin notes and ii) tables 3-1, 3-2, and 33 Chapter 6 and 7 Examination: None Assignment: Read: Chapter 8, 9, and 10. Review Notes/Lecture http://www.cdc.gov/vaccines/ Jan 29, 2013 / WEEK 4

Class 3. Antiviral Antimicrobics and Resistance. Influenza, Parainfluenza, Respiratory Syncytial Virus, Adenovirus and Other Respiratory Viruses. Mumps Virus, Measles, Rubella and Other Childhood Exanthems. Read chapters 11-14
Lectures: Chapter 6, 7, 8, 9, and 10 Common routes of transmission of infection: (pages 89-93 table 5-1)

Pathogenesis of Viral Infection. Antiviral Antimicrobics and Resistance. Influenza, Parainfluenza, Respiratory Syncytial Virus, Adenovirus and Other Respiratory Viruses. Mumps Virus, Measles, Rubella and Other Childhood Exanthems.

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Assignment: Read: Chapters 11-14 Review Notes/Lecture Feb 05, 2013/ WEEK 5

Class 4. Poxviruses. Enteroviruses. Hepatitis Viruses. Herpesviruses.

Lectures: Chapters 11-14 Poxviruses Enteroviruses Hepatistis Viruses Hepesviruses

Read chapters 15-17 Exam 1: Notes and PowerPoint presentations of the classes 1-3 plus Chapters 1, 2, 5-10 Exam 1: Lecture notes and chapters 1, 2, 6, 7, 8, 9, and 10
Some of the important Topics Major characteristics of Viruses, Bacteria, Fungi and Parasites Examples of normal Flora of different sites and their roles in health and disease Features of Innate Immunity (what cells, receptors etc) Features of adaptive immunity How immune system and vaccines work Cells involved in immunoresponsive Complement system (also read the presentation) Cells of adaptive Immune System CD8 and CD4 T cells B cell and antibody responses pages 1-12 Pages 14-15 as related to Figure 1-6 Pages 19-43

Feb. 12, 2013/ WEEK 6

Class 5. Viruses of Diarrhea. Arthropod-Borne and Other Zoonotic Viruses. Rabies Read chapters 18-19

Lectures: Chapters 15-17: Viruses of Diarrhea. Arthropod-Borne and Other Zoonotic

Viruses. Rabies
Assignment: Read: CHAPTERS 18-19 Review Notes/Lecture

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Feb. 19, 2013 WEEK 7

Class 6. Retroviruses: Human T-Lymphotropic Virus, Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome. Papilloma and Polyoma Viruses. Read chapters 21-23
Lecture: 18-19

Retroviruses: Human T-Lymphotropic Virus, Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome. Papilloma and Polyoma Viruses.

Feb. 26, 2013/ WEEK 8

Class 7. Chapters 21-23. Pathogenic Bacteria. The Nature of Bacteria. Pathogenesis of Bacterial Infection. Antibacterial Agents and Resistance. Read chapters 24-26 Lecture: Chapters 21-23 Pathogenic Bacteria. The Nature of Bacteria. Pathogenesis of Bacterial Infection. Antibacterial Agents and Resistance.
Assignment:

Read chapters 24-26

March 05, 2013/ WEEK 9

Class 8. Chapters 24-26. Staphylococci. Streptococci and Enterococci. Corynebacterium, Listeria and Bacillus. Read chapters 27-30 Exam 2 Exam 2: CHAPTERS 15-24 and related notes
Lectures: CHAPTERS 24-26

Staphylococci. Streptococci and Enterococci. Corynebacterium, Listeria and Bacillus.

Assignment: Read: Chapters 27-30 March 12, 2013/ WEEK 10

Class 9. Chapters 27-30: Mycobacteria. Actinomyces and Nocardia. Clostridium, Peptostreptococcus, Bacteroides and Other Anaerobes. Neisseria. Read chapters 31-34
Lectures: CHAPTERS 27-30

Mycobacteria. Actinomyces and Nocardia. Clostridium, Peptostreptococcus, Bacteroides and Other Anaerobes. Neisseria.
Assignment: Chapters 31- 34 Review Notes/Lecture

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March 19, 2013/ WEEK 11

Class 10. Chapters 31-34: Haemophilus and Bordetella. Vibrio, Campylobacter, and Helicobacter. Enterobacteriaceae. Legionella. Read chapters 35-37
Lecture: Chapters 31-34: Haemophilus and Bordetella. Vibrio, Campylobacter, and

Helicobacter. Enterobacteriaceae. Legionella.

Assignment: Read: chapters 35-37 Review Notes/Lecture March 26, 2013/ WEEK 12

Class 11. Chapters 35-37: Pseudomonas and Other Opportunistic Gram-negative Bacilli. Plague and Other Bacterial Zoonotic Diseases. Spirochetes. Read chapters 38-40 Lecture: Chapters 35-37: Pseudomonas and Other Opportunistic Gram-negative Bacilli. Plague and Other Bacterial Zoonotic Diseases. Spirochetes.

Review Notes/Lecture and read chapters 38-40 April 02, 2013/ WEEK 13

Class 12. Chapters 38-40: Mycoplasma and Ureaplasma. Chlamydia. Rickettsia, Ehrlichia, Coxiella and Bartonella. Exam 3: chapters 24-38 Read chapters 41-46
Lectures:

Chapters 38-40: Mycoplasma and Ureaplasma. Chlamydia. Rickettsia, Ehrlichia, Coxiella and Bartonella.
Exam 4, all chapters and notes Assignment: Read : chapters 41-56 April 09, 2013/ WEEK 14

Class 13. Chapters 41-56 Pathogenic Fungi. The Nature of Fungi. Pathogenesis of Fungal Infection. Antifungal Agents and Resistance. Dermatophytes, Sporothrix, and Other Superficial and Subcutaneous Fungi. Candida, Aspergillus, Pneumocystis and Other Opportunistic Fungi. Cryptococcus, Histoplasma, Coccidiodes and Other Systemic Fungal Pathogens.

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8 Pathogenic Parasites. The Nature of Parasites. General Principles of Pathogenesis, Immunology of Parasitic Infection. Antiparasitic Antimicrobics and Resistance. Sporozoa. Rhizopods. Flagellates. Intestinal Nematodes. Tissue Nematodes. Cestodes. Trematodes. Read chapters: 57-65
April 16, 2013/ WEEK 15

Class 14. Chapters 57-65. Clinical Aspects of Infection. Skin and Wound Infections. Bone and Joint Infections. Eye, Ear, and Sinus Infections. Dental and Periodontal Infections. Respiratory Tract Infections. Enteric Infections and Food Poisoning. Urinary Tract Infections. Genital Infections. Central Nervous System Infections. Intravascular Infections, Bacteremia and Endotoxemia.
April 23, 2013/ WEEK 16

Exam 4: chapters 38-56 75% and entire class 25%

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