Curriculum Vitae

Name: Address: Adjunct Professor (Rtd) Department of Pediatrics, 0830 UCSD School of Medicine University of California, San Diego La Jolla, CA- 92093-0830 Phone: 858-442-7135 Fax: 619-643-5642 E-mail: mmr@ucsd.edu Citizenship: U.S. Citizen M.M. Reddy, Ph.D

__________________________________________________________________ Education:
1979 1978-1980: Ph.D. Zoology/Physiology, Osmania University (O.U), India. Long-term postgraduate course in "Electrophysiology of Central Nervous System." Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia. M.Sc. Zoology, Comparative Animal Physiology, O.U, India. B.Sc. Biology and Chemistry, O.U, India.

1976 1974

Special Professional Training:

-Oct 1978-Sep 1980 Worked on synaptic plasticity, Spreading depression of the EEG in the central Nervous system. -Sept. 15-30, 1980: Attended a workshop on the "In vitro brain slice as a model for investigating synaptic transmission in the mammalian central nervous system", Institute of Neurophysiology, University of Oslo, Oslo, Norway. Worked on synaptic transmission in Hippocampul slice of guinea pig. -Sept. 6-10, 1990: Participant in the NIH sponsored workshop on "Epithelial cell growth and transformation." Cardiovascular Research Institute, San Francisco, CA, USA. -June- 2009. Nasal Potential Difference Measurements in Clinical Trials, Denver Colorado, Cystic Fibrosis Foundation sponsored Training. -Dec-08-2009. NPD Qualified Operator Certification, (Fromm CCD Manager) UAB/ USCF Foundation

Main Research Interest: Epithelial ion transport in health and disease

Work Experience:

Research-July 2004 October, 2012, Adjunct dProfessor, Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, CA-92093-0831. -July 2001- June 2004, Scientist, Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, CA-92093-0831. -Jan 1987- June 2001. Associate Research Physiologist, Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, CA-92093-0831. -Jan 1987. Associate Research Physiologist, Division of Biomedical Sciences (DBS), University of California, Riverside (UCR), Riverside, CA, USA -June 1985 -1986: Assistant Research Physiologist, DBS, UCR, Riverside, CA, and USA -Jan. 1984 - 1985: Postgraduate Research Electrophysiologist, DBS, UCR. -Sept. 1980 -Dec. 1983: Assistant in Physiology, Institute of Physiology, Ludwig Maxmillians University of Munich, Munich, West Germany. -Oct. 1983 -Jan. 1984, Visiting Scientist, Osmania University, India. Teaching-2006 till present G.I Physiology. BE 140B, Biomedical Engineering /Physiology, Jacobs School of Engineering, University of California, San Diego -2005. Metabolic Regulation. BE 140B September 2005, Biomedical Engineering/ Physiology, Jacobs School of Engineering, University of California, San Diego -2003 and 2004. Gastrointestinal physiology, BE140B, Biomedical Engineering/ Physiology, Jacobs School of Engineering, University of California, San Diego -1998. Microanatomy of Gastrointestinal tract. BMSC 210A. Div. of Biomedical Sciences (DBS); UCRUCLA 1st year Medical students. Special Lecturer In Physiology; Riverside, CA, USA -1995. Human Physiology; Membrane phenomena and ion transport. BMSC 210B; DBS, UCR-UCLA 1st year Medical Students, Riverside, CA, USA -1986 1994: Human Physiology, BMSC 210A, Clinical Gastrointestinal Physiology (4 units), DBS, UCR-UCLA 1st year Medical Students, UC Riverside. -1994 -95: Special Topics Course, BMSC 222E "Basic Epitheliology." (2 Units), DBS, UCR, Riverside. -1994: Advanced Placement Biology Class from Villa Park High School (Orange County, CA) on "Some Facts about Cystic Fibrosis" -1976-78: Comparative physiology: Strategies of biochemical adaptation, Water and solute problems in living cells, Biochemical adaptations to temperature and pressure, Neurophysiology to graduate students at Osmania University, India.

Research Grants:
-P.I. Title: HC03 Conductive function of CFTR: Implications to Oral Health and Cystic Fibrosis, 9-01-2009- 08-31-2012 ($927000.00 Total Costs), 1R01HL096732-01. -P.I. Regulation of CFTR bicarbonate transport in cystic fibrosis. CFRI, Inc., 2009. ($ 75000.00). -P.I. ENaC & CFTR: Molecular interactions in health and disease. 1RO1DE14352-01. 01-01-01 to 1230-06 ($ 1,520,000.00 total costs) -Co- P.I. Molecular Pathophysiology of Cystic Fibrosis. (P.I. T.C. Hwang, University of Missouri), 9/01/08 - 8/31/13 ($1,436,968.00 total Cost). Co.P.I. 10%. 2R01DK055835-09A1 -Co-P.I. NIH 1RO1HL084042-01: Electrolyte transport in small airways. 2006-2010 (250K/Year, P.I. P.M. Quinton) -P.I. "Role of CFTR in the regulation of ENaC Na+ channels in sweat ducts". May 2000-April 2001 ($65000) -P.I. "Role of CFTR in the regulation of ENaC Na+ channels in sweat ducts". May 1998-April 2000 ($129,600/ 2 years) -P.I. Activation of endogenous DF508 CFTR GCl of native sweat duct. The U.S. CF Foundation research grant, 1997-1999 ($ 64,800 / 2years). -P.I. "New mechanisms of fluid secretion for cystic fibrosis". Cystic Fibrosis Research Inc. (CFRI) grant, 1994-97, Palo Alto, CA (~$150,000 /3years). Co P.I. G-Protein activation of CFTR. CF Foundation Research Grant (CFF QUINT099PO) 20002001. -Co.P.I. Cl-/HCO3- Exchange in Cystic Fibrosis Sweat Glands Research Grant: USPHS R01 DK 51889. -P.I. "Control of sweating by Ca2+ activated K+ and Cl- channel blockers". Procter and Gamble Co. U.S.A. 1997 ($ 5000.00). -Co.P.I. Cl-/HCO3- exchange in cystic fibrosis sweat glands" The U.S. CF Foundation research grant, 1997-1999 ($ 300,000 /3years). -Co-P.I. "Nucleotide regulation of CFTR- chloride conductance". U.SCF foundation grant, 1990-93 ($162,000/year, P.M. Quinton, P.I.). -Co-P.I. "Intracellular potentials of microperfused human reabsorptive sweat duct", U.S. CF foundation grant, 1985- 90 ($ 200,000, P.M. Quinton, P.I.). Awards and Honors:

-U.S. CF foundation travel grant to present a paper at world CF conference, Verona, Italy, 1987 ($1200). -U.S. CF foundation travel grant to give a seminar at the North American CF conference, Dallas, Texas, 1991 ($ 850) -UNESCO and WHO Travel grants to Prague, Czechoslovakia and Oslo, Norway, 1978 (~$ 2,500). -UNESCO and WHO postdoctoral award, 1978-80. -University grants commission (UGC) junior research fellowship, New Delhi, India, 1976-78. -University Bursar's award for academic achievement, Free tuition for 2 years M.Sc. Program Osmania University, India, 1975. -Student of Distinction, M.Sc; 1975 and 1976.

Other Experience:
-2008 to Present, Member of Pediatrics Review and Appraisal Committee. -September, 2005 to present. Recruitment and Admissions committee(RAC), University of California School of Medicine. -2002 to 2005, Member of Pediatrics Review and Appraisal Committee. -2004-. Student advisor UCSD School of Medicine -1998-2002 Co-Organizer Journal club meetings for Epithelial ion transport group at Hill Crest, Dept. of Pediatrics. - Columbia University: External examiner for Hindi language proficiency test (03-02-05)

Review services:
Early Review services before 2001: American Journal of Respiratory and Critical Care Medicine FEBS Letters J. Investigative Dermatology Ashley Publications, London:(Book Chapter New England J. Medicine Cystic fibrosis Research Inc: Research grants Welcome trust Australian National Academy of Sciences The Lancet Nature Medicine The Lancet Italian CF foundation grants American Journal of Physiology Clinical and Investigative Medicine Chest Life Sciences Journal of Clinical Investigation

Proc. Nat'l. Acad. Of Sci; USA Journal of Membrane Biology Cystic Fibrosis Research Inc. Research Grants J. Invest. Dermatology J.Applied Physiol.

Recent Review services Chest (2) (date: 05-07-02) Life Sciences (2) Journal of Clinical Investigation (1) Proc. Nat'l. Acad. Of Sci; USA (1) Journal of Membrane Biology (1) Cystic Fibrosis Research Inc. Research Grants (4) (Dates: 04-14-99, 07-12-02) J. Invest. Dermatology (1)
J.Applied Physiol. (1)

Ashley Publications, London:(Book Chapter (1), (Dated: 08-13-2003) Nature Medicine (1) (date:06-30-03) The Lancet (1) (Dates:06-11-03) Italian CF foundation grants (2) (dates: 05-04-03) American Journal of Physiology (10) (Dates:10-04-01, 03-20-03, 11-29-99) Clinical and Investigative Medicine (1) American J. Physiology(1) (dated 6-21-04) Welcome trust (1) Australian National Academy of Sciences (1)
J. Inv. Dermatology, 2-08-05 J. Inv. Dermatology, 3-16-05 New England J. Medicine, 3-30-05 FEBS Letters, 4-11-05 CFRI Research Grants, 7-06-05 New England J. Medicine, 8-31-05 Am J. Resp. Crit. Care Med., 8-15-05 J. Physiol., 10-25-05

FEBS Letters (4-11-05) J. Investigative Dermatology (3-16-05) Cystic fibrosis Research Inc: Research grants (6) (3-31-2005) Experimental and Molecular Pathology, 10-20-2006 Experimental and Molecular Pathology (10- 12- 2006) Am. J. Physiol (Cell Physiol. (03-27-2006) Veterinary Dermatology (11-15-2006) Cell Biology, International (10-10-2007) J. Physiol. (06-18-2007) J. Applied Physiology (11-19-2008) European Journal of Physiology (01-9-2009) J. Applied Physiol (06-19-2009) Am. J. Physiology (Regulatory, Integrative and Comp. Physiology(05-19-2009) Journal of Exp. Physiol. (04-03-2009) J. Biochemistry (04-10-2009) Italian CF Foundation Research Grants Two grants (05-25-2009) J. Exp. Physiol. 12-08-2009 J. Physiol. 11-29-2009 J. Physiol, 10-28-2009

Am. J. Physiol. Regulatory

Am. J. Physiol. Lung Cellular and Molecular Physiology, 01-16, 2009 Integrative and Comparative Physiology, 10-28-2009 Pflugers Arch. European J. Physiol. 01-09-2009 J. Exp. Physiol. 12-25-2009 Am. J. Physiol. Lung Cellular and Molecular Physiology, 02-16, 2009 Exp. Physiol. 01-15-2010 Am. J. Physiol. Lung Cellular and Molecular Physiol. 01-13-2010 J. Physiol. 01-10-2010 Italian CF Foundation Research Grants (3), 03-15-2010 Am.J. Physiol. 01-02-2010 Am.J. Physiol. 03-04-2010 Am.J. Physiol. Lung Cell Physiol. 04-01-2011 Am.J. Physiol. Cell Physiol. 02-10-2011 Am.J.Physiol. 04-18-2011 Am.J.Physiol. 09-26-2010 Am.J.Physiol. 10-26-2011 Chest 04-12-2012 Chest 04-24-2012 J.Exp.Physiol. 08-22-2011 J.Exp. Physiol. 09-04-2011 Frontiers in Physiol. And Biophys. 09-11-2011 Frontiers in Physiol. And Biophys. 03-11-2011 Frontiers In Physiol. Biophys. 09-06-2011 Canadian Cystic Fibrosis Foundation Research grant 04-24-2010 Fundazone: Italian Cystic Fibrosis Foundation Research Grant. 05-24-2012 Chest 06-11-2012

Membership in Professional Organizations:

The American Physiological Society Biophysical Society of America

Invited Seminars and Conference Talks:

1. Relationship between the stimulation induced increase in K+ efflux and blockage of spreading depression in the cerebral cortex of rats. Czechoslovak Physiological Society Meetings, Charles University, Prague, Czechoslovakia, 1978 (Conference). Bumetanide Inhibition of chloride transport in human reabsorptive sweat duct. Anaheim, California, 1985 (Conference). FASEB Meetings,

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Intracellular microelectrode analysis of chloride transport in normal and cystic fibrosis human reabsorptive sweat duct. Biophysical Society meetings, San Francisco, California, 1986 (Conference). Mechanism of chloride transport in human reabsorptive sweat duct from normal and cystic fibrosis subjects. Cardiovascular Research Institute, School of Medicine, University of California San Francisco, California, April 6, 1987 (Seminar) Cl impermeability in the apical and basolateral membranes of human reabsorptive sweat ducts from cystic fibrosis subjects. Department of Psychology, University of Stanford, Palo Alto, California, April 7, 1987 (Seminar).

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Electrical properties of cultured reabsorptive sweat duct cells from normal and cystic fibrosis subjects: Intracellular microelectrode analysis. International conference on "Cellular and Molecular Basis of Cystic Fibrosis", Verona, Italy, June 15, 1987 (Seminar). Conductive Phenomenon. Second North American Cystic Fibrosis Conference, Session III, Orlando, Florida, Sept. 29, 1988 (Moderator). Functional characterization of cultured epithelial cells. Workshop on "Epithelial Cell Growth and Transformation held at the Cardiovascular Research Institute, University of California, San Francisco, sponsored by National Institute of Digestive and Kidney diseases (NIDDK), Sept. 6, 1990 (Seminar). Mechanism of stimulus response coupling in the human sweat gland secretory coil (Cystic Fibrosis Relationship). Department of Anatomy and Physiology, California State University, Long Beach, California, March 22, 1991 (Seminar). Selective impairment of cellular secretory function cystic fibrosis. North American Cystic Fibrosis Conference, Dallas, Texas, Oct. 2-5, 1991 (Symposium). cAMP and Ca2+ regulate ion transport in the human reabsorptive sweat duct. Sixth North American Cystic Fibrosis Conference, Dallas, Texas, Oct. 2-5, 1991 (Conference). Anion selectivity of Cl- conductance affected in cystic fibrosis as an in vitro diagnostic tool. Sixth North American Cystic Fibrosis Conference, Dallas, Texas, Oct. 2-5, 1991 (Conference). Cellular energy levels as a regulator of CFTR-GCl in T-84 cells. North American Cystic Fibrosis Conference, Washington, D.C; Oct. 16, 1992 (Conference). Regulation of CFTR -Cl- conductance in human reabsorptive sweat duct. Department of Internal Medicine, Howard Hughes Institute of Physiology, University of Iowa, Iowa, Jan. 22, 1993 (Seminar). Is endogenous CFTR expressed in vivo? North American Cystic Fibrosis Conference, Dallas, Texas, Oct. 12, 1993 (Conference). pH modulation of CFTR -Cl- conductance in sweat duct. North American Cystic Fibrosis Conference, Dallas, Texas, Oct. 13, 1993 (Conference). Regulation of CFTR -Cl- conductance in sweat duct. Graduate student seminar, Division of Biomedical Sciences, University of California, Riverside, California, Oct. 8, 1993 (Seminar). Endogenous phosphatases in the regulation of CFTR -Cl- conductance in the native sweat duct. West Coast Water and Salt Club, Moro Bay, California, Feb. 11-12, 1994 (Conference). Hydrolytic and non-hydrolytic interactions in the regulation of CFTR -Cl- conductance in the sweat duct. North American Cystic Fibrosis Conference, Orlando, Florida, Oct. 1994 (Conference). Mg2+ independent regulation of CFTR -Cl- conductance in the native sweat duct. West Coast Water and Salt Club, Moro Bay, California, Feb. 10-12, 1995 (Conference).

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Loop diuretic bumetanide blocks endogenous normal and mutant CFTR Cl- conductance in the apical membranes of basolaterally permeabilized human sweat duct. Williamsburg Conference on "CFTRElectrolyte Transport"; Williamsburg, Virginia, June 2-4, 1995 (Conference). Novel regulation of electrolyte absorption through CFTR-GCl in human sweat duct. Tulane University School of Medicine, New Orleans, June 12th, 1995 (Seminar). Distinctly separate cellular mechanisms of cholinergic and b-adrenergic sweat secretion. American Cystic Fibrosis Conference, Orlando, Dallas, Texas, Oct.11, 1995 (Conference). North

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Cytoplasmic pH control of CFTR GCl through phosphorylation states. West Coast Water and Salt Club, Moro Bay, California, March. 10-11, 1996 (Conference). Significance and Regulation of CFTR GCl by Cytosolic pH in the Native Sweat Duct. Dept. of Pulmonary Medicine, USC Medical School, CA. June 21, 1996. CFTR dependent regulation of amiloride sensitive Na+ conductance in sweat duct. West Coast Water and Salt Club, Moro Bay, California, March. 15-16, 1997 (Conference). Pharmacology of CFTR Cl- conductance in sweat duct. Eleventh Annual North American CF Conference on "CFTR and Transport Physiology"; Tennessee, October 23-26; 1997. CFTR a regulator of transepithelial salt transport?. Oakland Children's Hospital Research Center. April 28th, 1997 (Seminar). CFTR dependent PKA regulation of amiloride sensitive Na+ conductance in sweat duct. Department of Psychology, University of Stanford, Palo Alto, California, April 29, 1997 (Seminar). Chair: Workshop session on "CFTR- Electrolyte transport". North American CF Conference, October 23-2, 1997; Nashville, Tennessee. Regulation of ENaC in the apical membranes of native sweat duct. West Coast Water and Salt Club, Moro Bay, California, March. 14-16, 1998 (Conference). CFTR Permits ENaC Activation. West Coast Water and Salt Club, Moro Bay, California, April 10-11, 1999 (Conference). cAMP independent phosphorylation activation of CFTR in the sweat duct. April 13, 2000, West Coast Water and Salt Club, Moro Bay, California, April 10-11, 1999 (Conference). Activation of ENaC requires CFTR Cl- channel function in the sweat duct. Williamsburg Conference on Cystic Fibrosis; Williamsburg, Virginia, May 20th 2000 (Conference). Chair: HCO3- and Cystic Fibrosis, Session. 1V. Conference on HCO3- and cystic Fibrosis, International conference, March 405, 2001, San Diego CA. Selectively activating CFTR HCO3- and Cl- conductances. Conference on HCO3- and cystic Fibrosis, International conference, March 405, 2001, San Diego CA.

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Chair: Session on Epithelial Transport Phenomena. West Coast Salt Water Club Meetings, March 9-10, 2001, Moro Bay, CA. HCO3- Transport in human sweat duct. West Coast Salt Water Club Meetings, March 9-10, 2001, Moro Bay, CA. Abnormal HCO3- Transport: A basic defect in Cystic Fibrosis. University of California Davis, School of Medicine, Davis CA. September 14th, 2001. CFTR and ENaC: Ion Channel Interactions. Cystic Fibrosis Seminar Series, UCSD Medical Center, San Diego, CA. March 25th, 2002. CFTR and ENaC in Sweat Glands. Invited speaker at International Conference on ABC Cassette Proteins in Epithelial Physiology, April 20th-25th, 2002, Ascona, Monte Verita/ Switzerland, April 22nd, 2002. CFTR gHCO3- is spared in R117H mutations of CFTR. North American CF conference, Oct, 2002, New Orleans, Louisiana, USA. Selective activation of Cl- and HCO3- conductances of CFTR by cytosolic glutamate, FASEB Conference, San Diego, CA, April, 15,2003 CFTR-The unlikely ion channel triggers mass destruction in Cystic Fibrosis. University of Cincinnati School of Medicine, Cincinnati, OH, USA; October, 3rd, 2003 Glutamate metabolites regulate dynamic CFTR anion selectivity in epithelial cells. North American CF conference, Oct, 17th, 2003, Anaheim, CA, USA Novel regulation of CFTR function by cytoplasmic glutamate in epithelial cells. Cystic fibrosis seminar series, UCSD School of Medicine, UCSD, San Diego, CA, Oct, 27th, 2003. Regulation of CFTR phosphorylation. West Coast Salt and Water Club. March 9, 2004, Moro Bay, CA. ENaC activity requires CFTR Cl- channel function regardless of phosphorylation. North American CF conference, St Luis, Oct. 13th-17th, 2004. CFTR regulation in human sweat duct. West Coast Salt and Water Club. March 12, 2005, Moro Bay, CA. In Vivo Nasal potential measurements in CF drug discovery. Preliminary report. Childrens Hospital, San Diego. August, 20th, 2007. Synergistic regulation of CFTR- bicarbonate conductance by protein kinases and glutamate in the human sweat duct, FASEB Annual Meetings, San Diego, April, 8th, 2008 Inspiration from Perspiration: Ion transport in sweat ducts in health and disease. Faculty Research Seminar Series. Rady Childrens Hospital, UCSD. March 18th, 2008. Regulation of CFTR in human sweat duct: Current update. Lab presentation. May, 13th, 2008

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How is bicarbonate is secreted in Airways ? Moderator: for Two sessions of Round Table Discussions. North American Cystic Fibrosis Conference, Orlando, Florida, Oct. 23-25, 2008. Epithelial electrolyte transport in health and disease: Lessons learned from the Sweat Gland. Osmania University, Hyderabad, India. March. 12th 2009 Distinct cell types regulate absorption and secretion of Airway Surface Liquid (ASL) in the small airways. CF interest group online. UCSD. March 17th, 2010 Electrolyte Transport in Cystic Fibrosis. Osmania University, Department of Zology and Molecular Physiology. 12-05-2011

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Bibliography
Published Papers: 1. Reddy, M.M; and J. Bures. Cortical K+ efflux and the stimulation induced blockage of spreading depression in the cerebral cortex. Neurosci. Lett. 17: 243-247, 1980. Krivanek, J; and M.M. Reddy. Does vanadate participate in the response of cerebral Na+ + K+ ATPase to electrical stimulation? Brain Res. 195: 506-510, 1980. Reddy, M.M; and J. Bures. Unit activity changes elicited in amygdala and neocortex of anesthetized rats by intraperitoneal injection of lithium chloride. Neurosci. Lett. 22: 169-172, 1981. Grafe, P; J. Rimpel, M.M. Reddy and G. Ten Bruggencate. Transmembrane lithium distribution across the membrane of motoneurones of isolated frog spinal cord studied with intra- and extracellular Lisensitive microelectrodes. Pflugers Arch. 393: 297-301, 1981. Grafe, P; J. Rimpel, M.M. Reddy and G. Ten Bruggencate. Changes in intracellular sodium and potassium ion concentrations in frog spinal motoneurones induced by repetitive synaptic stimulation. Neuroscience 7: 3213-3220, 1981. Grafe, P; M.M. Reddy, H. Emmert and G. Ten Bruggencate. Effects of lithium on electrical activity and potassium ion distribution in the vertebrate central nervous system. Brain Res. 279: 65-76, 1983. Chitra, T; M.M. Reddy and J.V. Ramana Rao. Levels of muscle and liver tissue enzymes in Channa punctatus bloch on exposure to sodium fluoride. Fluoride 16: 48-51, 1983. Chitra, T; M.M. Reddy and J.V. Ramana Rao. Ionic variations in tissues of Channa punctatus bloch on exposure to sodium fluoride. Fluoride 16: 60-63, 1983. Ballanyi, K; P. Grafe, M.M. Reddy and G. Ten Bruggencate. Different types of potassium transport liked to carbachol and g-amino butyric acid actions in rat sympathetic neurons. Neuroscience 12: 917927, 1984. M.M. Reddy K. Shankaraiah, S.L.N. Reddy, V.V. Ganathay and J.V. Ramana Rao. Nitrate induced carbohydrate metabolism in the tissues of a frsh water teleost Channa punctatus. J. Aqua. Biol. 4:(4) 138-140, 1986. Reddy, M.M; and P.M. Quinton. Effects of bumetanide on chloride transport in human eccrine sweat ducts. Isr. J. Med. Sci. 23(12): 1210-1213, 1987. Reddy, M.M; and P.M. Quinton. Intracellular potentials of microperfused human sweat duct cells. Pflugers Arch. 410: 471-475, 1987. Reddy, M.M; and P.M. Quinton. The retention of basic electrophysiologic properties by human sweat duct cells in primary culture. In Vitro 24(9): 905-910, 1988. Quinton, P.M; C.J. Jones and M.M. Reddy. Acid secretion by the human sweat gland. In: Exocrine Secretion, pp. 151-153. Eds. P.V.D. Wong and J.A. Young, Hong Kong University Press; 1988.

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Reddy, M.M; and P.M. Quinton. Altered electrical potential profile of human reabsorptive sweat duct cells in cystic fibrosis. Am. J. Physiol. 26 (Cell Physiol. 4): 722-726, 1989. Reddy, M.M; and P.M. Quinton. Localization of Cl- conductance in normal and Cl- impermeability in cystic fibrosis sweat duct epithelium. Am. J. Physiol. 26 (Cell Physiol. 4): 727-735, 1989. Quinton, P.M; and M.M. Reddy. Cl- conductance and acid secretion in the human sweat duct. Ann. New York Acad. Sci. 574: 438-446, 1989. Reddy, M.M; and P.M. Quinton. Intracellular potassium activity and the role of potassium in transepithelial salt transport in human reabsorptive sweat duct. J. Membrane Biol. 119: 199-210, 1991. Quinton, P.M; and M.M. Reddy. Regulation of absorption in the human sweat duct. Advances in Exp. Med. and Biol. 290: 159-172, 1991. M.M. Reddy A.A. Anandakumar, P.S. Reddy and S.L.N. Reddy. Phenol induced metabolic alterations in the brain and muscle of fresh water fish Channa punctatus (Bloch) during sublethal toxicosis. J. of Ecotoxicol. And Environ. Monitoring (3(1): 13-17, 1992. Bell, C.L; M.M. Reddy and P.M. Quinton. Reversed anion selectivity in cultured cystic fibrosis sweat duct cells. Am. J. Physiol. 262 (Cell Physiol. 31): C32-C38, 1992. Reddy, M.M; and P.M. Quinton. Electrophysiologically distinct cell types in human sweat gland secretory coil. Am. J. Physiol. 262 (Cell Physiol. 31): C287-C232, 1992. Reddy, M.M; C.L. Bell and P.M. Quinton. Evidence of two distinct secretory cell types in primary cultures from human sweat gland secretory coil. Am. J. Physiol. 262 (Cell Physiol. 31): 891-898, 1992. Reddy, M.M; and P.M. Quinton. cAMP activation of CF affected Cl- conductance in both cell membranes of an absorptive epithelium. J. Membrane Biol. 130: 49-62, 1992. Quinton, P.M; and M.M. Reddy. Control of CFTR-Cl- conductance by energy levels and nonhydrolytic ATP- binding. Nature 360: 79-81, 1992. Quinton, P.M; and M.M. Reddy. The sweat gland. In: Cystic Fibrosis. Ed. Pamela Davis. Lung Biology in Health and Disease. Ed. Claude Lenfant. Mercel Dekker, Inc; NewYork, NY, pp.135-157, 1992. M.M. Reddy Anand Kumar, P.S. Reddy and S.L.N. Reddy. Hepatotoxic and nephrotoxic effects of phenol in a fresh water teleost Channa punctatus during sublethal toxicosis. Trends in Life Sciences. 8(2) 103-107, 1993. (Research article) Reddy, M.M; and P.M. Quinton. Membrane Biol. 140: 57-67, 1994. Rapid regulation of electrolyte absorption in sweat duct. J.

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Reddy, M.M; and P.M. Quinton. Intracellular Cl- activity: Evidence of dual mechanisms of Clabsorption in human sweat duct. Am.J.Physiol. 267 (Cell Physiol. 36): C1136-C1144, 1994. Quinton, P.M; and M.M. Reddy. Regulation of absorption by phosphorylation. Japanese J. Physiol. 44 (2): 5207-5213, 1994.

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Reddy, M.M; and P.M. Quinton. Deactivation of CFTR-GCl by endogenous phosphatases in the native sweat duct. Am.J.Physiol. 270 (Cell Physiol.39) :C474-C480, 1996. Reddy, M.M; and P.M. Quinton. Hydrolytic and non-hydrolytic interactions in the ATP regulation of CFTR-GCl in the native sweat duct. Am.J.Physiol. 271 (Cell Physiol.40):C35-C42, 1996. Reddy, M.M; and C.L. Bell. Distinct cellular mechanisms of cholinergic and b-adrenergic sweat secretion. Am.J. Physiol. 271 (Cell Physiol. 40):C486-C494, 1996. Reddy, M.M; P.M. Quinton, C. Haws, J.J. Wine, R. Grygorczyk, J.A. Tabcharani, J.W. Hanrahan, K.L. Gunderson and R.R. Kopito. Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP. Science 271: 1876-1878, 1996. Reddy, M.M; C.L. Bell, and P.M. Quinton. Cystic fibrosis affetcs specific cell type in sweat gland secretory coil. Am. J. Physiol. 273 (Cell Physiol.42): C426-C433-000; 1997 . Reddy, MM; Quinton, PM; Haws, C; Wine, JJ; and others. Cystic fibrosis transmembrane conductance regulator and adenosine triphosphate - Response. Science, 275:1325-1325,1997. Reddy,M.M. and P.M. Quinton. Cytosolic pH regulates GCl through control of phosphorylation states of CFTR. Am. J. Physiol. 275(Cell Physiol.44):C1040-C1047, 1998. Reddy,M.M; and P.M. Quinton. Bumetanide blocks CFTR GCl in the native sweat duct. Am. J. Physiol. 276 (Cell Physiol.45): C231-C237, 1999. Reddy, M.M; M. Light and P.M. Quinton. Activation of epithelial Na+ channel (ENaC) requiresCFTR Cl- channel function. Nature 402:301-304; 1999. Reddy, M.M. and P.M. Quinton. cAMP independent phosphorylation activation of CFTR by Gproteins in the native human sweat duct . Am. J. of Physiol. (Cell Physiol.) 280: C604-C613, 2001. Reddy, M.M, Duo Sun and P.M. Quinton. Apical heterotrimeric G-proteins activate CFTR in the native sweat duct. J. of Membrane Biol. 179: 51-61, 2001. Reddy, M.M and P.M. Quinton. Selective activation of CFTR Cl- and HCO3- conductances. J. Pancreas, 2 (suppl): 212-218, 2001. Reddy, M.M. and P.M. Quinton. Effect of anion transport blockers on CFTR in the human sweat duct. J. Membrane Biol. 189:15-25, 2002 Reddy,M.M. and P.M. Quinton. Functional interaction between CFTR and ENaC in sweat duct. Flugers Arch. Eur. J. Physiol. 445: 499-503, 2003

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Reddy, M.M and P.M. Quinton. Glutamate/ATP control of dynamic CFTR Cl- and HCO3- selectivity in epithelial cells, Nature, 423: 756-760, 2003 Wang, X.F., M.M. Reddy and P.M. Quinton. Effects of new CFTR inhibitor on Cl- conductance in the native human sweat duct. Experimental Physiology, 89.4:417-425, 2004.

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Reddy, M.M, X.F. Wang, M. Gottschalk, K. Jones and P.M. Quinton. Normal CFTR Activity and Reversed Skin Potentials in Pseudohypoaldosteronism. J. Membrane Biol. 203: 151-159, 2005. Reddy, M.M. and Quinton, P.M. Cytosolic K+ Regulates Deactivation of CFTR. Am. J. Physiol. Cell Physiol, 291:C122-C129, 2006 Reddy, M.M. and Quinton, P.M. ENaC Activity Requires CFTR Channel Function Independent of Phosphorylation in Sweat Duct, J. Membrane Biol. 207(1):23-33, 2006 Reddy, M.M; X.F. Wang and P.M. Quinton. Effect of cytosolic pH on ENaC in normal and CF Sweat Ducts. J. Membrane Biol. 225: 1-11, 2008. Shamsuddin, A.K.M.; M.M. Reddy and P.M. Quinton. Iontophoretic b-adrenergic stimulation of humn sweat glands: Possible assay for CFTR activity in vivo. Exp. Physiol. 93.8:969-981, 2008. M.M. Reddy and P.M. Quinton. PKA Mediates constitutive activation of CFTR in human sweat duct, J. Membrane Biology. 231:65-78, 2009.

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Book Chapters: 1. Krivanek, J; J. Bures, V.I. Karoleva, and M.M. Reddy. The mechanism and integrative role of extracellular potassium clearance in the rat brain. In: Ion Selective Microelectrodes and Their Use in Excitable Tissues, PP 278-282. Eds: E. Sykova, P. Hnik and L. Vyklicky, Plenum Press, 1981. Grafe, P; J. Rimpel, M.M. Reddy, C. Koestler and G. Ten Bruggencate. Effects of lithium on motoneurones, synaptic transmission, and extracellular potassium in the isolated frog spinal cord. In: Basic mechanisms in the Action of Lithium, PP. 92-101. Eds. H.M. Emrich, T.B. Aldenhoff and H.D. Lux; Elsevier Science Pub. Co; 1981. M.M. Reddy, S.L.N. Reddy, K. Shankaraiah, Ashok Reddy and D.D. Reddy. Influence of temperature in vivo effects of mercuric chloride on certain aspects of carbohydrate metabolism in the tissues of Channa Punctatus. Proc. of 6th Symp. Life Sciences, 17-19, Jan 1985, pp23-31, 1985. Riordan, J.R; J. Burns, L.C. Tsui, M.M. Reddy, P.M. Quinton and M. Buchwald. Utilization of cultured epithelial cells from the sweat glands of the CF defect. Prog. Clin. Biol. Res. 254: 59-71, 1987. Reddy, M.M; and P.M. Quinton. Cl- permeability of sweat duct cell membranes: Intracellular microelectrode analysis. Prog. Clin. Biol. Res 254: 45-57, 1987. Reddy, M.M; and P.M. Quinton. Chloride and bicarbonate transport in the human sweat duct. In: Cellular and Molecular Basis of Cystic Fibrosis, pp. 125-132. Eds: G. Mastella and P.M. Quinton, San Francisco Press, Inc; 1988. Reddy, M.M; J.R. Riordan and P.M. Quinton. Electrical properties of cultured reabsorptive duct cells from normal and cystic fibrosis subjects: Intracellular microelectrode analysis. In: Cellular and Molecular Basis of Cystic Fibrosis, pp. 125-132. Eds: G. Mastella and P.M. Quinton, San Francisco Press, Inc; 1988. Quinton, P.M; C.J. Jones and M.M. Reddy. Acid secretion by the human sweat gland. In: Exocrine Secretion, pp. 151-153. Eds. P.V.D. Wong and J.A. Young, Hong Kong University Press; 1988.

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Quinton, P.M; and M.M. Reddy. Cl- conductance and acid secretion in the human sweat duct. Ann. New York Acad. Sci. 574: 438-446, 1989. Quinton, P.M; and M.M. Reddy. Regulation of absorption in the human sweat duct. Advances in Exp. Med. and Biol. 290: 159-172, 1991. Reddy, M.M; and P.M. Quinton. Electrophysiological signatures for cells from the secretory coil of the sweat gland. In: Ionic Basis and Energy Metabolism of Epithelial Transport--Hot Aspects from Exocrine Secretion. Eds. M. Murakami, Y. Seo, A. Kuwahara and H. Watari; Kembun Printing Ltd, Okajaki, Japan, pp. 157-160, 1991. Reddy, M.M; and P.M. Quinton. Selective impairment of cellular secretory function in cystic fibrosis. Ped. Pulmonology, Suppl. 6: 123-124, 1991. Quinton, P.M; and M.M. Reddy. The sweat gland. In: Cystic Fibrosis. Ed. Pamela Davis. Lung Biology in Health and Disease. Ed. Claude Lenfant. Mercel Dekker, Inc; NewYork, NY, pp.135-157, 1992. Quinton, P.M. and M.M. Reddy. CFTR, a rectifying, non-rectifying anion channel? J. Korean Med Sci. 15 (Suppl):S17-20; 2000. Reddy, M.M, Andres Ponce and P.M. Quinton. Outside neurons inside epithelia: Novel activation of CFTR Cl- and HCO3- conductances. Adv. Exp.Medicine and Biology, 558: 1-21,

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16. Reddy, M.M. and J. Stutts. In: Cystic Fibrosis: Fluid and Electrolyte Transport. Cold Spring Harbor Laboratory Press. Cold Spring Harbor perspective on Cystic Fibrosis. 2012

Abstracts:

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Reddy, M.M; V.I. Karoleva and J. Bures. (1978) Relationship between stimulation induced K+ efflux and the blockage of spreading depression in the cerebral cortex of rats. Physiol. Bohemoslov 28: 466467. Reddy, M.M; and J. Brozek. (1980) Local injection of colchicine into the lateral geniculate body causes reversible blockade of signal transmission in the optic pathway of rats. Physiol. Bohemoslov. 29: 275. Rimpel, J; P. Grafe M.M. Reddy and G. Ten Bruggencate. (1981) Lithium kinetics within motoneurones and extracellular space in the isolated superfused frog spinal cord. Proceedings of the German Physiological Society meetings. Grafe, P; J. Rimpel, M.M. Reddy, C. Koestler and G. Ten Bruggencate. (1982) Intracellular sodium and membrane potential of frog spinal motoneurons during repetitive synaptic stimulation. Proceedings of the German Physiological Society meetings. Grafe, P; M.M. Reddy and G. Ten Bruggencate. (1982) Effects of lithium on potassium homeostasis in the guinea pig olfactory cortex slice. Proceedings of the German Physiological Society meetings. Grafe, P; J. Rimpel, M.M. Reddy, and G. Ten Bruggencate. (1983) Changes in intracellular potassium concentration in frog spinal motoneurons during repetitive synaptic stimulation. Proceedings of the German Physiological Society meetings. Reddy, M.M; and P.M. Quinton. (1985) Bumetanide inhibition of chloride transport in human reabsorptive sweat duct. Federation Proceedings 44: R5590. Reddy, M.M; and P.M. Quinton. (1985) Bumetanide inhibited chloride transport in human sweat duct. CF Club Abstracts, Vol. 26. Reddy, M.M; and P.M. Quinton. (1986) Intracellular potentials from microperfused human reabsorptive sweat ducts of normal and cystic fibrosis (CF) subjects. CF Club Abstracts, 27th annual meetings, Bethesda, Maryland, p.129. Reddy, M.M; J.R. Riordan and P.M. Quinton. (1986) Comparison of intracellular electrical potentials of control and cystic fibrosis (CF) sweat duct cells from primary cultures in vitro. CF Club Abstracts, 27th annual meeting, Bethesda, Maryland, p. 27. Reddy, M.M; and P.M. Quinton. (1986) Intracellular microelectrode analysis of chloride transport in normal and cystic fibrosis human reabsorptive sweat duct. Biophysical Journal 49: 157a. Reddy, M.M; and P.M. Quinton. (1987) Lack of b-adrenergic responsiveness in cells cultured from reabsorptive sweat ducts of cystic fibrosis (CF) subjects. Pediatric Pulmonology (Suppl.1): 115. Reddy, M.M; and P.M. Quinton. (1988) Intracellular potassium activity of human reabsorptive sweat duct cells. Pediatric Pulmonology (Suppl.2); 106. Reddy, M.M; and P.M. Quinton. (1988) Acid secretion by the human sweat gland. Proceedings of the Symposium on Exocrine Secretion, Hong Kong, Feb. 12-15.

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Reddy, M.M; and P.M. Quinton. (1989) Direct demonstration of Cl- conductance in the apical and basolateral membranes of human reabsorptive duct. Pediatric Pulmonology (Suppl. 4): 129. Reddy, M.M; and P.M. Quinton. (1990) Regulation of Cl conductance in human reabsorptive sweat duct. Pediatric Pulmonology (Suppl. 5): R133. Reddy, M.M; and P.M. Quinton. (1990) Electrophysiological identification of different cell types in human sweat gland secretory coil. Pediatric Pulmonology (Suppl. 5): R135. Reddy, M.M; and P.M. Quinton. (1990) Electrophysiological characterization of human sweat gland secretory coil cells in primary culture. Pediatric Pulmonology (Suppl. 5): R136. Reddy, M.M; and P.M. Quinton. (1991) Selective impairment of cellular secretory function in cystic fibrosis. Ped. Pulmonology, Suppl. 6: 123-124. Reddy, M.M; and P.M. Quinton. (1991) cAMP and Ca2+ regulate ion transport in human sweat duct. Pediatric Pulmonology (Suppl. 6): R119. Reddy, M.M; and P.M. Quinton. (1991) Properties of Cl- conductance in the basolateral membrane of human sweat duct. Pediatric Pulmonology (Suppl. 6): R159. Reddy, M.M; C.L. Bell and P.M. Quinton. (1991) Anion selectivity of Cl - conductance affected by cystic fibrosis as an in vitro diagnostic tool. Pediatric Pulmonology (Suppl. 6): R107. Quinton, P.M; and M.M. Reddy. (1992) Cl- conductance is dependent on ATP energy levels in reabsorptive sweat duct cells. Pediatric Pulmonology (Suppl. 8): R87. Reddy, M.M; and P.M. Quinton. (1992) Intracellular Cl- activity in human sweat duct: Evidence of transient shift from conductive to carrier Cl- transport. Pediatric Pulmonology (Suppl. 8): R147. Quinton, P.M; and M.M. Reddy. Regulation of absorption by phosphorylation. In: Cl channel: Molecular and Cellular Physiology. Eds: Y. Okada, J. Oiki, S. Yamagishi and K. Hama. National Institute of Physiological Sciences, Okazaki, Japan, pp. 158-163, 1994. Reddy, M.M; and P.M. Quinton. (1993) pH modulation of CFTR- Cl- conductance in sweat duct. Pediatric Pulmonology (Suppl.9): R20. Reddy, M.M; and P.M. Quinton. (1993) HCO3- impermeability via CFTR-Cl- conductance in sweat duct. Pediatric Pulmonology (Suppl.9): R21. Reddy, M.M; and P.M. Quinton. (1993) Is endogenous mutant CFTR expressed in vivo? Pediatric Pulmonology (Suppl. 9): R5. Reddy, M.M; and P.M. Quinton. (1994) Endogenous phosphatases deactivate CFTR-Cl- conductance in the native sweat duct. FASEB J. (Proceedings of the FASEB meetings) Reddy, M.M; and P.M. Quinton. (1994) Hydrolytic and non-hydrolytic interactions of ATP in the regulation of CFTR-Cl- conductance in native sweat duct. Pediatric Pulmonology (Suppl. 10): R17.

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Reddy, M.M; and P.M. Quinton. (1994) cAMP activation of mutant CFTR-GCl in the sweat duct. Pediatric Pulmonology (suppl.10): R17.

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Reddy, M.M; and P.M. Quinton (1995) Bumetanide selectively blocks CFTR-GCl in sweat duct. Pediatric Pulmonology (suppl.11): R34. Reddy, M.M; M. Bergler and P.M. Quinton (1995) Hypotonic airway surface fluid composition measured with double barreled ion-sensitive micro-electrodes in cow trachea. Pediatric Pulmonology (Suppl.11): R256. Reddy, M.M; C.L. Bell and P.M. Quinton (1995) Distinctly separate cellular mechanisms of cholinergic and b-adrenergic sweat secretion. Pediatric Pulmonology (Suppl.11): R53. Reddy, M. M; C.L. Bell and P.M. Quinton (1996). Cell specific expression of CF defect in sweat secretory coil. Pediatric Pulmonology (Suppl 13): R116. Reddy, M. M; and P.M. Quinton (1996). Apparent lack of acute regulation of amiloride sensitive Na+ conductance by PKA in human sweat duct. Pediatric Pulmonology (Suppl 13): R117. Reddy, M.M; and P.M. Quinton (1997). Coordinated regulation of amiloride sensitive Na+ and CFTR Cl- conductances by PKA phosphorylation in the native sweat duct. Pediatric Pulmonology (Suppl 14): R00. Reddy, M.M; M. Light and P.M. Quinton (1998). G-proteins activate CFTR GCl in the native sweat duct. Pediatric Pulmonology (Suppl 14): R46. Reddy, M.M and P.M. Quinton (1998). Arylaminobenzoates, sulfonylureas, loop diuretics and disulfonic stilbenes inhibit CFTR GCl in the native sweat duct. Pediatric Pulmonology (Suppl 14): R47. Reddy,M.M; P.M. Quinton (1999). cAMP independent phosphorylation activation of CFTR by heterotrimeric G-proteins in the native sweat duct. Pediatric Pulmonology (Suppl 19): R52. Reddy. M.M; M. Light and P.M. Quinton (1999) Na+ conductance is not increased in CF absorptive epithelium. Pediatric Pulmonology (Suppl. 19): R51. Reddy, M.M, and P.M. Quinton (2000). CFTR independent cytosolic pH basic pH activation of ENaC in the native sweat duct. Pediatric Pulmonology (Suppl 20): R30 Reddy, M.M. and P.M. Quinton (2000). Is CFTR a rectifying bicarbonate anion channel? Pediatric Pulmonology (Suppl 20): R105 P.M. Quinton and Reddy, M.M. (2000). Close dancing: CFTR and ENaC. Pediatric Pulmonology (Suppl 20): 93-94. Reddy, M.M. and P.M. Quinton (2001). Glutamate activates cAMP/ATP independent Cl - conductance and ATP dependent HCO3- conductance in sweat duct. Pediatric Pulmonology (Suppl 22): R96.

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Reddy, M.M. and P.M. Quinton (2002) CFTR HCO3- conductance is spared in R117H mutations of CFTR. Pediatric Pulmonology (Suppl 23): R77. Reddy, M.M. and P.M. Quinton (2002). Influence of cytoplasmic Cl- on the effect of CFTR activation on ENaC function. Pediatric Pulmonology (Suppl 23): R78. Reddy, M.M and P.M. Quinton (2003). Novel activation of independent HCO3- and Cl- conductances in CFTR FASEB. J. R 803.7 (Page 1224) Reddy, M.M and P.M. Quinton (2003). Glutamate metabolites regulate dynamic CFTR anion selectivity in epithelial cells. Pediatric Pulmonology (Suppl 25): R2 (p 186) Reddy, M.M and P.M. Quinton (2003). ENaC function is not required for PKA activation of CFTR in sweat ducts from PHA patients. Pediatric Pulmonology (Suppl 25): R3 (p 186) Wang, X.F; Reddy, M.M and P.M. Quinton (2003). Model human tissue preparation for testing experimental drugs. Pediatric Pulmonology (Suppl 25): R 41 (p 199) Wang, X.F; Reddy, M.M and P.M. Quinton (2003). Effect of new inhibitor on CFTR in the human native sweat duct. Pediatric Pulmonology (Suppl 25): R40 (p 198) M.M. Reddy and P.M. Quinton (2004). Distinctly different phosphatases deactivate PKA and gprotein activated CFTR in sweat duct. Pediatric Pulmonology (Suppl 26): R24, (p196). M.M. Reddy and P.M. Quinton (2004). Cytosolic k+ signals PP-2A deactivation of CFTR in absorptive epithelial cells. Pediatric Pulmonology (Suppl 26): R23, (p196) M.M. Reddy and P.M. Quinton (2004). ENaC activity requires CFTR chloride channel function regardless of phosphorylation in sweat duct. Pediatric Pulmonology (Suppl 26): R56, (p207). M.M. Reddy and P.M. Quinton. Potassium sensitive phosphatases distinguish different mechanisms of regulation of CFTR. Symposium Proceedings on world conference on the "anti-infective and dosing the magic bullet", Nurenberg, Germany, Aug, 8-11, 2004. M.M. Reddy, and P.M. Quinton. Physiological regulation of CFTR Cl- conductance by cGMP in sweat duct. FASEB J. IUPS Abstract 672.48. p-A1180, 2005. M.M. Reddy and P.M. Quinton. Cytosolic changes in Cl- and Na+ potentially regulate CFTR and ENaC differentially in absorption and secretion. FASEB J. IUPS Abstract 672.47. p-A1180, 2005. M.M. Reddy and P.M. Quinton. Phosphorylation dependent and phosphorylation independent mechanisms regulate CFTR bicarbonate conductance. Pediatric Pulmonology (Suppl 28): R53, (p207), 2005 M.M. Reddy and P.M. Quinton. Potassium sensitive phosphatases deactivate phosphorylation but not glutamate activated CFTR. Pediatric Pulmonology (Suppl 28): R52, (p207), 2005, M.M. Reddy and P.M. Quinton. Multiple regulatory controls determine the magnitude of CFTR HCO3- conductance. Pediatric Pulmonology (Suppl 29), 2006

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M.M. Reddy and P.M. Quinton. Endogenous Phosphorylation seems Responsible for Constitutively open CFTR Cl- channels in the Native Human Sweat Duct. Pediatric Pulmonology (Suppl 29), 2006. M.M. Reddy and P.M. Quinton. The cytosolic pH may mediate ENaC and CFTR cooperativity in the human sweat duct. Pediatric Pulmonology (Suppl. 30), 2007 M.M. Reddy and P.M. Quinton. Synergistic regulation of CFTR- bicarbonate conductance by protein kinases and glutamate in the human sweat duct. Proceedings of the Exp. Biol. 2008. M.M. Reddy and P.M. Quinton. cAMP and glutamate regulation of CFTR represents two distinct mechanisms as shown by their differential sensitivity to monovalent cations in sweat duct. Pediatric Pulmonology, Supplement 31, R 34, 2008 M.M. Reddy and P.M. Quinton. cAMP. Cytosolic pH Differentially Controls cAMP and cGMP Activation of CFTR in the Sweat Duct. R33, 2008 Shamsuddin, M.M. Reddy, C. Lytle and P.M. Quinton. Distinct secretory and absorptive system control luminal surface fluids in small airways. ATS meeting, May 15-20, 2009 Shamsuddin, M.M. Reddy, C. Lytle and P.M. Quinton. Distinct secretory and system control luminal surface fluids in small airways. ATS meeting, May absorptive 15-20, 2009

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M.M.Reddy, M. A. Garcia and P. M. Quinton. Sensitivity to monovalent cation comp[osition

distinguishes glutamate and cAMP regulation of CFTR in human sweat duct. Pediatric Pulmonology, Pediatric Pulmonology, Pediatric Pulmonology, Supplement 33: 2010

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M.M.Reddy, M. A. Garcia and P. M. Quinton. Pharmacology CFTR Cl channels in human sweat

duct. Pediatric Pulmonology, Supplement 33: 2011

_____________________________ M.M. Reddy, Ph.D.

Date: 11-26-2012