NCM Medicine

NCM MEDICINE
M.AMBAGA, A.TUMEN-ULZII
Socrates: there is only one good: knowledge and the only evil: ignorance. INTRODUCTION It is time to solve all problems of medicine, relating to the normal existence, disturbance of normal existence of human body, their diagnosis and treatmen by using fully membered equition 8 which include a G knowledge + X knowledge + S - knowledge + s-NCM knowledge. Definition of NCM-newly coded medicine. NCM-newly coded medicine is triple medical system, composed of Traditional Medicine (TM) in the full form, also Modern medicine (MM) in the full form and in addition s-NCM new knowledge based medicine (NKBM), implemented a every day diagnostic and treatment functions by using a three kind approaches as TM, MM, NKBM together, and their scientific-theoretical basis is strongly connected with s-NCM new knowledge as new definition of living cells, completely explaining the essence of normal existence of living cells and simultaneously revealing and discovering the essence of basic theoretical aspects of Traditional Medicine and Modern medicine, not allowing the mixing and neutralizing theoretical aspects of both medicine, preserving the unique specificity of their theoretico-practical aspects and therminological specifics, meanwhile not separating each other. In recent years, a renewed interest and attention by many scientists of our and foreign countries are directed towards the establishment of scientific essence of theoretical problems of Tibetan-Mongolian Traditional Medicine /TMTM/ in strong connection with theory of Contemporary Biology and Medicine by proposing the new knowledge based model of living cells. A number of these theoretical problems belongs the theory of five element and the theory rlung, Mkhris, Badgan. In this connection a question rises what interorganism's microstructure related morpho-functional unit i.e. new knowledge based model of living cells plays the role of real material, objective substance, which leads to the appearance of universal theory of five elements and rlung, mkhris badgan. i.e. the external properties formed in which morpho-functional unit, structure, revealed by new knowledge, had perceived and summarized as general characteristics of rlung, mkhris, badgan (so named X- knowledge), so named 20 external patterns (so named G- knowledge) in traditional medicine 3000 years ago. And so, recently scientists from many countries are remained, not able to find this whole organisms unique functional - structural bioequivalents, to propose the new model of living cells, which was reflected in the theory of rlung, Mkhris, Badgan, which in three forms of existence can be show all the external signs as hot, cold, heavy, mobile summarized and abstractized by wind like rlung, fire-sun like mkhris and water-moon like Badgan thermin. There are reasons to say that the appearing of abstract theory of Rlung, Mkhris, Badgan in Tradititional medicine 3 thousand years ago - follow from the functioning of membrane -redoxy potentials three state line systems in the first compartment with close relationship with fourth and second, third compartments in human body, revealed by s-NCM new knowledge based model of living cells. To decide a main logical cognitive key points of research works, directed to find the scientificomethodological basis of Newly Coded Medicine (NCM) was planned to conduct the our study in such interconnectable ways: 1. The first principally important step of our works was a detection of evolutionary very importantconstantly developed general characteristics of living cells, which may be reflected in the theory of rlung, mkhris, badgan of Tibetan Mongolian Traditional medicine. 2. The second principally important step of our works was a revealing the functional and structural unit of living cells, which may be reflected in the theory of Tibetian - Mongolian Traditional medicine in the following philosophical context as wind - like mobile, unoilly, light nature-external characteristics of human body, symbolized by rlung abstract thermin, sun-like hot, hot oilly nature-external characteristics
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of human body, symbolized by mkhris abstract thermin, moon-like cool, heavy, cold oily nature-external characteristics of human body, symbolized by badgan abstract thermin. 3. The next principally important step of our works was establish a scientific basis of new enriched definition of living cells, which are included the functional and structural unit of living cells of human body, which may be expressed in the theory of Tibetan Mongolian Traditional medicine by abstract thermins as rlung, mkhris, badgan. Considering the above mentioned general line of wide scale investigations and difficulties in the studying of theory of Traditional Medicine, we are setting the following concrete goals: - To reveal this material substances, which existed inside of human body and conditioned all external signs of "rlung, Mkhris, Badgan" according to theory of Traditional Medicine /TM/, revealed by s-NCM new knowledge based model of living cells To establish scientific matter of abstract notion of (rlung, Mkhris, Badgan), regarding to the age, season, diets, signs and causes of disease, 'specificity of solid organs and individuals in close connection with the functional properties, which formed on the level of "such material substances", revealed by sNCM new knowledge based model of living cells. To elaborate the new principles of prevention and treatment of obesity, ageing and cancer within s-NCM new knowledge based model of living cells, which are existed as "central cognitive-knowledge bridge" between theoretical, diagnostic and treatment aspects of Traditional and Modern medicine. Results of investigation: By using comparative analytical methods, we demonstrated in 1990 for the first time and eventually confirmed that whole body's membrane-redoxy potentials 3 state line system, which existed in the three basic states as: 1. Fluid alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, with high level of proton leak, proton conductance, with middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation. 2. Solid betta - state of membrane structures with high level of reduction potential with middle level of heat energy formation, with low level of proton leak, proton conductance, with high intensity of high energy phosphate-ATP generation, of high energy electrons - NADPH generation. 3. Intermediate gamma state of membrane structures with low level of oxidation-reduction potential with low level of proton gradient generation, low level of heat energy formation, with low intensity of high energy phosphate - ATP generation, with low intensity of high energy electrons - NADPH generation could play the role of such a biological substance, relating to theory of 5 element and theory of rlung, mkhris, badgan. A. Fluid - alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, with high level of proton leak, proton conductance, with middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation, it's hot, hot oil, acute external functional properties corresponds to the fire element related - sun like mkhris abstract notion. B. Solid betta - state of membrane structures with high level of reduction potential with high middle level of heat energy formation, with low level of proton leak, proton conductance, with high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation, it's cool, cold oil, heavy, stupid external functional properties summarized under the water-earth elements related-moon like badgan abstract notion of badgan. C. Intermediate gamma state of membrane structures with low level of oxidation-reduction potential with low level of proton gradient generation, low level of heat energy formation, with low intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation and heat
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energy, its mobile, unoilly, light external functional properties is symbolized under the wind element related - wind like rlung abstract notion. Scientic essence of our new suggestion lies in discovering "those material subjects" and revealing this secrets of theory of Rlung-Mkhris-Badgan, why under only similar thermin of rlung-Mkhris-Badgan in Oriental and Mongolian traditional medicine had expressed more different things, including the whole organism's regulatory function, seasonal, age and daily changes, specific appearance of R.M.B in individuals and five sold organs, signs of disease, causes of disease, provocation's and dietary factors. Abovementioned discovery summarized within s-NCM new knowledge was the scientificomethodological basis to laid foundation of new integrated triple medical system-NCM medicine. What is specificity of new integrated triple medical system-NCM which at first developed by us: a. Consisted of of traditional (X and G - knowledge based) and modern medical system (S-knowledge based) integrated through s-NCM new knowledge. b. Decided all diagnostic and treatment problems using triple approaches as tradinal (X and Gknowledge based) and modern medical system (S-knowledge based) integrated through s-NCM new knowledge. What is specificity of membrane - redoxy potentials three state line systems, which at first revealed by us: Consisted of H,e donators as foods and H,e acceptors as oxygens a.Ensured normal flow of protons and electrons from donators to acceptors with generation of high energy phosphate-ATP, high energy electrons NADPH and heat energy b.Functioned with using a glycolysis, Krebs cycle, oxidative deamination and betta oxidation reaction to generate normal flow of protons and electrons. c.Provided the normal maintainance of living processes. d. Existed in three interconvertible states: - fluid alpha state, consisting of mainly unsaturated fatty acids, conditioning a high levels of oxy potentials and with high levels of proton, electrons conductance and high levels of heat energy release, middle degree of energy accumulation and middle degree of high energy phosphate-ATP, high energy electrons NADPH, with middle ratio of donators : accceptors. - solid betta state, consisting of mainly saturated fatty acids, conditioning a high levels of red potentials and with slow levels of proton, electrons conductance and low levels of heat energy release, high degree of energy accumulation and high degree of high energy phosphate -ATP, high energy electrons NADPH, with increased ratio of donators : acceptors - gamma state, consisting of decreased contents of saturated-unsaturated fatty acids, conditioning a decreased levels of redoxy potentials and with slow levels of proton, electrons conductance and low levels of heat energy release and energy accumulation and low degree of high energy phosphate - ATP, high energy electrons NADPH, with decreased contents of donators: accceptors, increased significance of proton, electrons prior to generation of proton gradients, prevailed slip mecchanism. D. What is specificity of abstract theory of Rlung, Mkhris, Badgan: a. Described a general pattern of maintainance of normal living processes with participation of membrane-redoxy potentials three state line systems, ensuring normal flow of protons and electrons from donators to acceptors with generation of high energy phosphate - ATP, high energy electrons NADPH and heat energy through carbohydrate glycolysis, Krebs cycle, oxidative deamination of aminoacids and betta oxidation of fatty acids . b. Described a general pattern of normal functioning of living system with participation of 5 membrane structures-5 function systems, ensuring normal genetic-cell devision, information -response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems.
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E.What is coincidence between abstract theory of Rlung, Mkhris, Badgan and membrane - redoxy potentials three state line systems in the first compartment, which at first revealed by us: a. Fluid alpha states, consisting of unsaturated fatty acids with high levels of oxy potentials and with high levels of proton, electrons conductance and high levels heat energy release, middle degree of energy accumulation and middle degree of high energy phosphate-ATP, high energy electrons NADPH, with middle ratio of donators: accceptors are associated with abstract theory of Mkhris, which is distinguished by hot, hot oil, acute external characteristics. b. Solid betta state, consisting of mainly saturated fatty acids, conditioning a high levels of red potentials and with slow levels of proton, electrons conductance and low levels of heat energy release, high degree of energy accumulation and high degree of high energy phosphate-ATP, high energy electrons NADPH, with increased ratio of donators : accceptors are associated with abstract theory of Badgan, which is distinguished by cool, cold oil, stupid external characteristics. c. Gamma state, consisting of decreased contents of saturated - unsaturated fatty acids, conditioning a decreased levels of redoxy potentials and with slow levels of proton, electrons conductance and low levels of heat energy release and energy accumulation and low degree of high energy phosphate-ATP, high energy electrons NADPH, with decreased contents of donators: accceptors, increased significance of proton, electrons prior to generation of proton gradients, prevailed slip mecchanism are associated with abstract theory of rlung, which is distinguished by light, mobile , nonoil, cool external characteristics. The scientifico-methodological basis of newly coded medicine (NCM) is characterized by following novelty: 1. In the result of proposing the new enriched definition of living cells within s-NCM new knowledge, which clarified that main key regulating mechanism of living cells are a three states of membraneredoxy potentials, providing a normal flow of protons and electrons, by us has been established that between the quantative proportion of abstractized first compartment related rlung, mkhris, badgan code and some parameters of cell membrane redoxy potentials, located intercellularly in first compartment are existed the more strong correlation as: the elevated quantative proportion of abstractized by mkhris diagnostic parameters is associated with high oxy potentials (first compartment), the increased quantative proportion of abstractized by rlung diagnostic parameters is accompanied with slow redoxy potentials (first compartnent), the elevated quantative proportion of abstractized by badgan diagnostic parameters is associated with high red potentials (first compartnent) in the healthy persons 2. It has been revealed that between the quantative proportion of of abstractized second compartment related rlung, mkhris, badgan code and some parameters of of cell membrane redoxy potentials, located extracellularly in second compartment are existed the more strong correlation as: a.the elevated quantative proportion of abstractized by rlung code, located outside of cells is associated with low redoxy potentials (second compartment), expressed as a low internal and external adipocyte tissues, Rid formula, urine and serum oxidase enzyme activity, urine ph, resistance of membrane structures, high concentration of deprotonizid products in the membrane structures, low level of serum cholesterol, triglycerids in the Healthy persons. An all above mentioned code correlation as abstract thermins as rlung, mkhris, badgan - a three states of membrane- redoxy potentials of living cells serves the main scientifico-methodological basis of Newly Coded Medicine (NCM), which originated in the integration of traditional and recent medicine, but principally distinguished from traditional and recent medicine, taken separately.
NCM MEDICINE
Picture 1
ABSTRACTION IN THE FORM OF APPEARANCE OF THEORY OF RLUNG, MKHRIS, BADGAN (YANG-YIN)
FIRE ELEMENT
RLUNG ELEMENT
WATER, EARTH ELEMENT
Acute, hot
Unoilly characreistics
Cold, heavy characteristics
The intensification of the thermogenesis and activation of whole organisms functional level
The prevalence of gamma state of MS with low redoxy potentials
The relatively limitation of the thermogenesis, intensification of energy accumulation, decrease of functional activity of human body
Whole organisms level
Organs level
Tissues level
Alpha
Gamma
Betta state
The basic three states of membrane redoxy potential 3 state system
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New integrated triple medical system (NCM)
Picture 2
A.What is specificity of new cognitive steps as: Really existed substance - revealing of external patterns - intelectually transformation of these to the first variant of abstraction as 5 elements, transformation of these to the second variant of abstraction as Rlung, Mkhris, Badgan. According to the new cognitive steps, formulated by us as: Really existed substance (S) - revealing of 20 external patterns (EP) - abstractized transformation of these to the first variant of abstraction as 5 elements (A-1), abstractized transformation of these to the second variant of abstraction as Rlung, Mkhris, Badgan (A-2) when within membrane - redoxy potentials 3 state line system, that provide the normal existence of all cells by ensuring normal flow of electrons, protons with generating the proton gradient have been prevailed : 1. The fluid alpha state of membrane structures with high oxidation potential, high level of proton conductance and high level of proton leak play role of Really existed substance (S), because of this among 20 external patterns (EP) prevailed 7 patterns as hot, hot oil, acute et all, which at first were abstractized by hot - fire element among 5 elements (A-1), at second were abstractized by fire element related moon like mkhris (A-2). 2. The solid betta state of membrane structures with high reduction potential, middle level of proton conductance and middle level of proton leak play role of Really existed substance (S), because of this among 20 external patterns (EP) dominated 7 patterns as cold, cold oil, heavy, stupid et all, which at first were abstractized by cold-heavy earth, water elements among 5 elements (A-1), at second were abstractized by earth, water element related moon like badgan (A-2). 3. The solid betta state of membrane structures with high reduction potential, middle level of proton conductance and middle level of proton leak play role of Really existed substance (S), because of this among 20 external patterns (EP) dominated 7 patterns as cold, cold oil, heavy, stupid et all, which at first were abstractized by light, mobole wind element among 5 elements (A-1), at second were abstractized by wind element related rlung (A-2). B. What is specificity of s-NCM new knowledge, which at first proposed by us: a. Described a living cells and living organism as complex system, consisting of 4 basic compartments. b.1. First compartment, named as membrane-redoxy potentials three state line systems, ensuring normal flow of protons and electrons from donators to acceptors with generation of high energy phosphate-ATP, high energy electrons NADPH and heat energy through glycolysis reaction, Krebs cycle, oxidative deamination and betta oxidation reactions. b. 2. Fourth compartment, named as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems. c. Second compartment consists of serum and extracellular system, where donators, acceptors and some metabolites formed in the result of functioning of 5 of membrane structures-5 function systems,
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including biosynthetic, bioenergy, biotransformation functions, also products of AO-SPOL system temporarely existed. d. Third compartment consists visceral and under skin fatty acids, where donators, acceptors, products of AO-SPOL system are existed relatively constant. Developing by us the new knowledge as s-NCM new knowledge gives the possibility a integration of traditional and modern medicicne through it. C. What is specificity of membrane - redoxy potentials three state line systems, which at first revealed by us: Consisted of H,e donators as foods and H,e acceptors as oxygens a.Ensured normal flow of protons and electrons from donators to acceptors with generation of high energy phosphate-ATP, high energy electrons NADPH and heat energy b.Functioned with using a glycolysis, Krebs cycle, oxidative deamination and betta oxidation reaction to generate normal flow of protons and electrons. c.Provided the normal maintainance of living processes. d. Existed in three interconvertible states: - fluid alpha state, consisting of mainly unsaturated fatty acids, conditioning a high levels of oxy potentials and with high levels of proton, electrons conductance and high levels of heat energy release, middle degree of energy accumulation and middle degree of high energy phosphate-ATP, high energy electrons NADPH, with middle ratio of donators : accceptors. - solid betta state, consisting of mainly saturated fatty acids, conditioning a high levels of red potentials and with slow levels of proton, electrons conductance and low levels of heat energy release, high degree of energy accumulation and high degree of high energy phosphate -ATP, high energy electrons NADPH, with increased ratio of donators : acceptors - gamma state, consisting of decreased contents of saturated-unsaturated fatty acids, conditioning a decreased levels of redoxy potentials and with slow levels of proton, electrons conductance and low levels of heat energy release and energy accumulation and low degree of high energy phosphate - ATP, high energy electrons NADPH, with decreased contents of donators: accceptors, increased significance of proton, electrons prior to generation of proton gradients, prevailed slip mecchanism. D. What is specificity of abstract theory of Rlung, Mkhris, Badgan: a. Described a general pattern of maintainance of normal living processes with participation of membrane-redoxy potentials three state line systems, ensuring normal flow of protons and electrons from donators to acceptors with generation of high energy phosphate - ATP, high energy electrons NADPH and heat energy through carbohydrate glycolysis, Krebs cycle, oxidative deamination of aminoacids and betta oxidation of fatty acids . b. Described a general pattern of normal functioning of living system with participation of 5 membrane structures-5 function systems, ensuring normal genetic-cell devision, information -response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems. E.What is coincidence between abstract theory of Rlung, Mkhris, Badgan and membrane - redoxy potentials three state line systems in the first compartment, which at first revealed by us: a. Fluid alpha states, consisting of unsaturated fatty acids with high levels of oxy potentials and with high levels of proton, electrons conductance and high levels heat energy release, middle degree of energy accumulation and middle degree of high energy phosphate-ATP, high energy electrons NADPH, with middle ratio of donators: accceptors are associated with abstract theory of Mkhris, which is distinguished by hot, hot oil, acute external characteristics.
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b. Solid betta state, consisting of mainly saturated fatty acids, conditioning a high levels of red potentials and with slow levels of proton, electrons conductance and low levels of heat energy release, high degree of energy accumulation and high degree of high energy phosphate-ATP, high energy electrons NADPH, with increased ratio of donators : accceptors are associated with abstract theory of Badgan, which is distinguished by cool, cold oil, stupid external characteristics. c. Gamma state, consisting of decreased contents of saturated - unsaturated fatty acids, conditioning a decreased levels of redoxy potentials and with slow levels of proton, electrons conductance and low levels of heat energy release and energy accumulation and low degree of high energy phosphate-ATP, high energy electrons NADPH, with decreased contents of donators: accceptors, increased significance of proton, electrons prior to generation of proton gradients, prevailed slip mecchanism are associated with abstract theory of rlung, which is distinguished by light, mobile , nonoil, cool external characteristics. I. What is coincidence between abstract theory of Rlung, Mkhris, Badgan and Fourth compartments parameters, which at first revealed by us: a. Change of fourth compartment parameters, named as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate - ATP, high energy electrons NADPH and heat energy, generated in membrane - redoxy potentials three state line systems in the form of decrease of synthetic, bioenergy, biotransformation functions and of unregulated disturbance of informationresponse functions are coded by abstract Rlung code in the Tibetian Mongolian Traditional medicine. b. Change of fourth compartment parameters, named as 5 membrane structures - 5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems in the form of unregulated intensification of information-response functions are coded by abstract Mkhris code. c. Change of fourth compartment parameters, named as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems in the form of slowing of information-response functions are coded by abstract Mkhris code in the Tibetian Mongolian Traditional medicine. L.What is coincidence between abstract theory of Rlung, Mkhris, Badgan and second compartments parameters, which at first revealed by us: a. Change of second compartment parameters, consisting of serum and extracellular system, where donators, acceptors and some metabolites formed in the result of functioning of 5 membrane structures 5 function systems, ensuring normal genetic - cell division, information - response, biosynthetical, bioenergetical, biotransformation functions in the form of decrease of contents of donators, acceptors and some metabolites formed in the result of functioning of 5 of membrane structures-5 function systems, including synthetic, bioenergy, biotransformation functions are coded by abstract Rlung code in the Tibetian Mongolian Traditional medicine. b. Change of second compartment parameters consisting of serum and extracellular system, where donators, acceptors and some metabolites formed in the result of functioning of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions in the form of increase of contents of donators, decrease of acceptors and increase of AO - decrease of SPOL system are coded by abstract Badgan code in the Tibetian Mongolian Traditional medicine.
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c. Change of second compartment parameters consisting of serum and extracellular system, where donators, acceptors and some metabolites formed in the result of functioning of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions in the form of decrease of contents of donators, increase of acceptors and decrease of AO - increase of SPOL system are coded by abstract Badgan code in the Tibetian Mongolian Traditional medicine. L. What is coincidence between abstract theory of Rlung, Mkhris, Badgan and Third compartments parameters, which at first revealed by us: a. Change of Third compartment parameters in the form of decrease of visceral and external under skin fatty acids, also donators, acceptors are coded by abstract Rlung code in the Tibetian Mongolian Traditional medicine. b. Change of Third compartment parameters in the form of increase of saturated class of visceral and external under skin fatty acids, also increase of donators, decrease of acceptors are coded by abstract Badgan code in the Tibetian Mongolian Traditional medicine. c. Change of Third compartment parameters in the form of increase of unsaturated class of visceral and external under skin fatty acids, also decrease of donators, increase of acceptors are coded by abstract Mkhris code in the Tibetian Mongolian Traditional medicine. In such way we should recognize that appearing of abstract theory of Rlung, Mkhris, Badgan in Tradititional medicine 3 thousand years ago - follow from the functioning of membrane-redoxy potentials three state line systems in the first compartment with close relationship with fourth and second, third compartments in human body M. What is life process according to new integrated triple medical system - NCM which at first developed by us: Life is specific process, occurred in living cells, appeared as normal conductance of electrons and protons with participation of electrons and protons donators (food intake) - acceptors (breathihg-oxygens), which needs membrane-redoxy potentials three state line systems, which leads to formation of ATP, NADPH, heat energy, which creates the basis to formation of action potential-nervous impulse generation-propagation and cell division, bioenergetical, biotransformation functions. N. What is lifekeeping rlung according to new integrated triple medical system - NCM which at first developed by us: Life keeping rlung is specific notion of theory of Traditional medicine formed in result of imagination of ancient philosophers indicating a how human body works and regulate, ensure the normal conductance of electrons and protons with participation of electrons and protons donators (food intake) -acceptors (breathihg-oxygens), which needs membrane-redoxy potentials three state line systems inside of living cells, which leads to formation of ATP, NADPH, heat energy, which would create the basis to formation of action potential-nervous impulse generation-propogation and cell division, bioenergetical, biotransformation functions. O. New definition of living cells according to new integrated triple medical system - NCM which at first developed by us: Living cells are functional - structural unit of human body, consisting from membrane - redoxy potentials three state line systems, which ensure constant flow of electrons and protons between Donators and Acceptors with producing high energy phosphate - ATP, high energy electrons - NADPH, heat energy, thereby able to maintain normal occuring of information - response function in plasmic membrane, genetic - cell division function in nucleus membrane, biotransformation function in microsomal membrane and biosynthetic - rebiosynthetic function in ribosomo-microsomal and lisosomo-pereoxisamal membrane, bioenergetical function in mitochondrial membrane, beside all their important molecules have general nucleoside + phosphate structures.
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U. What is x, g, S, s-NCM stage of developing of medical thinking of humanity according to new integrated triple medical system - NCM which at first developed by us: In the framework of NCM medicine we also untroduce the therminology as x, g, S, s-NCM period time stage of developing of medical thinking of humanity, which made of chronology of appearing a more important time interval of developing and foundation of traditional and modern, also NCM medicine much clearer than it have been before. G-period is time of appearing of theory of 20 external patterns of Traditional medicine, X- period is time of appearing of theory of 5 elements and abstract theory of Rlung, Mkhris, Badgan of Traditional medicine, when yet not formed knowledge as s - NCM knowledge, also Modern medical knowledge as S. S-period is time of appearing and developing of Modern medicine, which are not used knowledge as X and G knowledge. S-NCM period is time of developing and establishing of NCM medicine, which used Tradiditional medical knowledge as X, G, Modern medical knowledge as S and new s - NCM knowledge all together, through it have been integrated all medical knowledge, formed during all time of developing of medical systems. U. What is definition of Traditional medicine. Owing to foundation of NCM medicine became clear that such very important regulations as gene in the one side, Rlung, Mkhris, Badgan in the another side, also such scientific knowledge as genetics and Traditional medicine existed in the one unseparable cognitive chains, consisting of whole 6 steps, started by gene regulation in the 1 step - ended by Rlung, Mkhris, Badgan coding in the therminal 6 step. Traditional medicine is medical system originated by abstractizing and transforming a different external patterns, appeared in outside of human body because of variety of enzyme - substrates relationship in the living cell level, manufactured under information - instruction - signalling functions of corresponding genes, in the first case by 5 elements as fire, water, earth, wind, in the second case by moon like badgan coding, sun like Mkhris coding, wind like Rlung coding. Picture 2
The theory rlung, Mkhris, Badgan
General characteristics Solid organs Season Age Constitution type of individuals Dietary factors Medicaments
The all recent informations, regarding to regulation function of membrane redoxy potential 3 state regulation of human body
In the frame work of new conception of the "rlung, Mkhris, Badgan-membrane structure-redoxy potentials 3 states "we have managed to explain the membrane-redoxy potential based mechanism of
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theory of TMTM in relation to taste and power, property of old medicaments and pulse diagnostic methods. According to the new cognitive steps, formulated by us as: Really existed substance (S) - revealing of 20 external patterns (EP) - intelectually transformation of these to the first variant of abstraction as 5 elements (A-1), transformation of these to the second variant of abstraction as Rlung, Mkhris, Badgan(A2) when within membrane - redoxy potentials 3 state line system, that provided the normal existence of all cells by ensuring normal flow of electrons, protons with generating the proton gradient have been prevailed : 1. The fluid alpha state of membrane structures with high oxidation potential, high level of proton conductance and high level of proton leak play role of Really existed substance (S), because of this among 20 external patterns (EP) prevailed 7 patterns as hot, hot oil, acute et all, which at first were abstractized by fire element among 5 elements (A-1), at second were abstractized by mkhris (A-2). 2. The solid betta state of membrane structures with high reduction potential, middle level of proton conductance and middle level of proton leak play role of Really existed substance (S), because of this among 20 external patterns (EP) dominated 7 patterns as cold, cold oil, heavy, stupid et all, which at first were abstractized by earth, water elements among 5 elements (A-1), at second were abstractized by badgan (A-2). 3. The solid betta state of membrane structures with high reduction potential, middle level of proton conductance and middle level of proton leak play role of Really existed substance (S), because of this among 20 external patterns (EP) dominated 7 patterns as cold, cold oil, heavy, stupid et all, which at first were abstractized by wind element among 5 elements (A-1), at second were abstractized by rlung (A2). Besides, the new conception "rlung, Mkhris, Badgan membrane - redoxy potentials 3 state line system "allows the possibility to explain following general notions of TMTM in accordance to suggested by us new conception: 1. General characteristics of rlung, Mkhris, Badgan as hot, cold, acute, stupid, motile, light 2. Division of Human Constitution specificity to Mkhris. rlung. Badgan. 3. Classification of five solid organs in relation to rlung. Mkhris. Badgan 4. Classification of Diet factors in relation to rlung. Mkhris. Badgan 5. Classification of Medicines in relation to rlung. Mkhris. Badgan (increasing and decreasing) 6. Seasonal changes of functional activity of Solid organs.
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MEMBRANE - REDOXY POTENTIAL 3 STATE MECHANISM OF THEORY OF TRADITIONAL MEDICINE ABOUT INTERRELATIONSHIP AND INTEROPPOSITION OF RLUNG, MKHRIS, BADGAN Picture 3 The intermediate gamma state of membrane structure with low redoxy potentials The increase Decrease of The The decrease The low level of induction of generation of intensification of ATP, of thermo the action ATP, NADPH, of nerve protein, genesis potential heat energy impulse NADPH, from proton conduction lipoproteid gradients (conductivity) synthesis Mobile Light Thin (narrow) Rough Cool
l.General characteristics of rlung, Mkhris. Badgan their unterrelation, interopposition and property of membrane-redoxy potentials 3 state line system. According to theory of Traditional medicine the general characteristics of Mkhris, Badgan, Rlung are as follows: "... Mkhris is characteristically hot, oily, acrid (acute-), light ... Badgan is characteristically cool, oily, stupid, heavy ... Rlung is characteristically motile, unoilly, rough, light..." More quantity of unsaturated fatty acids (UFA) as main part of fluid alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation have Tsmelting + 15- + 18C i.e possessed the most "hot" property and easily undergoes to structural changes,
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coupling with formation of "thermogenic, protonophore phore" (Ya.Musil 1984) which are accompanied by dispersion of many quantity "heat energy" (V.P.Skulacher 1972). As regards to "acute" characteristic of Mkhris may be connected with very high reactivity of UFA (ocstate) of membrane structures (Yu.A.Vladimirov et all 1972). Addition of "one unsaturated bind" leads to 11-fold increase of "coefficient of reactivity", while 4-6 unsaturated binds resulted to 1739-3478 fold increase of reactivity (A.N.Detsina et all 1990, V.N.Ushkalova 1986). In close connection with this in solid organs, where predominated a-state of membrane-redoxy potentials 3 state line system extent of damage and disturbances of membrane structures following the onset of disease proceeds in more intensive range (Ya.A.Vladimirov et all 1972) while (3-state of MS (badgan) showed slow reactivity (Ya.M.lopukhin et all 1983), which coincided with "stupid" characteristic of "Badgan". In such way in framework of the new conception we are explaining that "hot", "acute", "oily" characteristics of "Mkhris" has connected with "thermogenic", "protonophore". "activatining" action of astate (unsaturated fatty acids) of MS MEMBRANE REDOXY POTENTIAL 3 STATE MECHANISM OF APPEARANCE OF THEORY OF TRADITIONAL MEDICINE ABOUT INTERRELATIONSHIP AND INTEROPPOSITION OF RLUNG, MKHRIS, BADGAN Picture 4 The gamma state of membrane structure with low redoxy potentials The increase Decrease of The The decrease The low level of of induction of generation of intensification of ATP, thermo genesis the action ATP, NADPH, of nerve protein, potential heat energy impulse NADPH, from proton conduction lipoproteid gradients (conductivity) synthesis Mobile Light Thin (narrow) Rough Cool The solid betta state of membrane structure with high red potentials The prevalence The limitation The decrease The decrease The increase of of saturated of thermo of activity of of reception activity of fatty acids in genesis by O/P membrane activity of cholinoreceptors MS (transmechanism binding action of and the decrease configuration), enzymes, Medicaments, of cholinesterase which easily receptors and hormones activity subjected to the increase of external freezing ATP-synthesis factors Cool-oily Cold Heavy, strong Stupid Mucous (mucus) The fluid alpha state of Membrane structure with high oxy potentials Theprevalence of The high The The increase of activity of unsaturated fatty thermogenic intensification adrenoreceptors and reception acids in MS activity by of activity of activity of action of Medicaments (cisconfiguration) uncoupling membrane hormones, external factors which easily mechanism binding subjected to O/P enzymes and melting receptors Hot-oily Hot Light Acute
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While "cold", "heavy", "stupid" characteristics of "Badgan" has coincided with "energy accumulating", heat limiting, "stabilizing" effects of (betta - state - saturated fatty acids) of MS i.e solid betta - state of membrane structures with high level of reduction potential with high middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons NADPH generation, containing more quantity of cholesterol, and saturated fatty acids (SFA), which according to our new suggestion conditioned the abstraction notion "Badgan" also possessed "cold" property, having T-of smelting + 53 - + 69C (Ua.Kagava 1985, U.Strier 1984). Apart from this solid betta - state of membrane structures with high level of reduction potential with high middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation (cholesterol, and SFA) possessed more resistence to action of various "protonophore" factors (Yu.M.Lopukhin et all 1983, G.I.Klebanov et all 1986), which is conditioned less thermogenic activity (V.P.Skulachev 1971) and resulted to limitation of thermogenesis. Also, "motile", "light" characteristics of rlung are due to nerve impulse generating and impulse conducting activity of intermediate gamma state of membrane structures with low level of oxidationreduction potential of excitable membranes (excitable cells), which for their normal functioning are required a high level of proton gradient generation, high level of intensity of high energy phosphate ATP generation, high level of high energy electrons - NADPH generation, but the intermediate gamma state of membrane structures with low level of oxidation-reduction potential can not provide this in the sufficient level. In case of shortage of proton gradient generation and deficiency of high energy phosphate - ATP generation, high level of high energy electrons - NADPH generation, which more easily provocated when dominated the intermediate gamma state of membrane structures with low level of oxidation-reduction potential are resulted to appearance of "motile", "light" characteristics, coded by abstract rlung thermin. At normal condition, basic 3 states of MS existed in mutual transition and mutual oppression which connected with theory of TMTM about interrelation-interposition property of rlung, Mkhris, Badgan. Theory of Mongolian traditional medicine considered that ". . . cool character of Badgan decreases hot character of Mkhris . . , Hot-oilness of Mkhris prevents excessively increase of cold (cool)-oilness of Badgan i.e Mkhris and Badgan existed in interrelations and interopposition ... ".
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THE BASIC PERIOD OF APPEARENCE OF THE THEORY OF FIVE ELEMENTS AND THEORY OF RLUNG, MKHRIS, BADGAN, YANG-YIN Picture 5
THE SUBSTAN
EXTERN AL SIGNS
ABSTRACTI ON Hot Acute
The three states of MS with 3 state of redoxypotentials
} }
Fire element
Hot Cold Fluid Acute Heav Light Motile
Fluid Cold Heavy Stupid
} Water element
Earth element
}
}
Mkhris (yang) Badgan (yin)
Substance Stupid UnoillyLi Rlung g element Motile
Rlung
Fire, water, earth, rlung, space, wood, iron elements
The step of cognition by the direct sensation
The step of abstract cognition
By our opinion, above mentioned theoretical expression of Traditional Medicine had been appeared in the result of reflection "transitional processes", which take place as follows : 1. The intermediate gamma state of membrane structures with low level of oxidation - reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate - ATP generation, low intensity of of high energy electrons - NADPH generation supressed the excess prevalence of solid betta - state of membrane structures with high level of reduction potential with middle level of heat energy formation, high intensity of high energy phosphate-ATP generation, of high energy electrons-NADPH generation. 2. The fluid - alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation,middle intensity of high energy phosphate-ATP generation, of high energy electrons - NADPH generation supressed the excess prevalence of solid betta -state of membrane structures with high level of reduction potential with middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation. 3. The solid betta - state of membrane structures with high level of reduction potential with middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation supressed the excess prevalence of the fluid alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation. 4. The intermediate gamma state of membrane structures with low level of oxidation-reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate - ATP generation, low intensity of of high energy electrons - NADPH generation supressed the excess prevalence of the fluid - alpha state of membrane structures with high level of
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oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate ATP generation, of high energy electrons - NADPH generation 5. The fluid - alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation supressed the excess prevalence of the intermediate gamma state of membrane structures with low level of oxidation - reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate - ATP generation, low intensity of of high energy electrons - NADPH generation 6. The solid betta - state of membrane structures with high level of reduction potential with middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation supressed the excess prevalence of the intermediate gamma state of membrane structures with low level of oxidation - reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate - ATP generation, low intensity of of high energy electrons - NADPH generation Besides this, the solid betta - state of membrane structures with high level of reduction potential with middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation served the role of precondition of normal existence and normal formation and reformation of the intermediate gamma state of membrane structures with low level of oxidation-reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate - ATP generation, low intensity of of high energy electrons - NADPH generation, meanwhile the fluid - alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation served the role of precondition of normal existence and normal formation and reformation of the intermediate gamma state of membrane structures with low level of oxidation - reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy electrons - NADPH generation. The fluid - alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation served the role of precondition of normal existence and normal formation and reformation of the solid betta - state of membrane structures with high level of reduction potential with middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation i.e in favour of this suggestion recently has been established that unsaturated fatty acids of alpha state (fluidity) of membrane structures prevents excessive increase of saturated fatty acids of betta state of MS (solid), while betta state of MS (solid) decreases and maintaines the normal alpha - state of MS /L.Strier 1985, E.Kreps 1981, Ya,Kagava 1985/ (Picture N 4) One simple example of such processes is addition of one unsaturated bind of a-state of MS to p-state of MS accompanied with decrease of T of smelting from + 39.5-to + 14C, which may be serve as one of the proofs of Traditional medicine's conception: ". . . hot of Mkhris decreases cold of Badgan. . . " (Picture N 4). 2. Whole organism's regulatory function of Rlung. Mkhris. Badgan. their thermodinamical basis and participation of membrane-redoxy potentials 3 state line system. In old sutars of Traditional medicine it was stressed that ". . . If mkhris existed in adequate equal forms, which forms the "heat energy" of organism, it provides the nutrition and substrates, necessary to function of all organism ... If badgan is existed in equal balanced state, which adds the weight and fat, protects the losses of nutrient substrates, ensuring the longevity of life . . . ".
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In basis of theory of Traditional Medicine we came to conclusion, that such formulation on whole organism's regulatory function of rlung, mkris, badgan is closely connected with thermodynamical process, which constantly takes place within living organism (M.Ambaga, B.Sarantsetseg 1990), including membrane-redoxy potentials 3 state line system. Fluidity alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons NADPH generation, having more cis - configuration (L.Strier 1985) is created unorderly thermodynamic state, in same system of MS (E.A.Borodin et all 1981, 1985) unavoidly increased the probability of transition all usefull energy (U) to useless unreversible heat energy (Q) with more lossess of free energy (F). In such way, in thermodynamical system, where is prevailed alpha state of membrane structures with high oxidation potential of membrane-redoxy potentials 3 state line system, when created the condition of transferring of proton gradient to heat energy, not to generation of of high energy phosphate - ATP, of high energy electrons - NADPH "thermodynamic process is going in direction to more losses of useful free energy (F), and to more dispersion of useless "heat" energy (Q) i.e thermodynamic process of transition F-TS is directed to decrease of F, and gradually increase of Q, TS, which probably may serve the guidelines of right interpretation of theory of Traditional medicine "... mkhris forms "heat" and provides the necessary energy to normal function of organism . . . But excessively increase of mkhris burnes the all the energy and the nutritients of all organism . . . ". While betta state of membrane structures with high reduction potential of organism creates more stabile "thermodynamic" system, in such system due to trans - configuration of saturated fatty acids and cholesterol (L.Strier 1985), when created the condition of transferring of proton gradient not to heat energy, to generation of of high energy phosphate - ATP, of high energy electrons - NADPH, thermodynamic processes accompanied with more reservation of free energy (F) and less dispersion of heat (Q, TS) energy i.e thermodynamic reaction proceeds in direction: to gradually increase of F, and to decrease of Q, which are expressed in Traditional Medicine as ". . . Badgan addes the weight of organism, protectes the nutrient from burning and gives possibility to long life ... ". As regads to intermediate gamma state, when created the condition of less generation of proton gradient, thereby formation of heat energy, and generation of high energy phosphate -ATP, of high energy electrons - NADPH became diminished "which by our openion, conditioned the all external patterns of rlung abstract theoretical expression is unstable "thermodynamic system" where "thermodynamic reaction is proceeded in minimum level of free energy /F/ and maximum level of enthropy /TS/ ". Apart from this there can be reasons to say that theory of MTM on whole organism's regulatiory role of "rlung, Mkhris, Badgan" has close connection with action of symphatic /SNS/ and parasymphatic /PNS/ nervous system, because of recruitment the fluid state of MS with high oxidation potential created precondition of activation of SNS, while recruitment betta - state of MS with high reduction potential and high viscosity created precondition of activation of PNS, while formation of betta - state of MS leads to activation of PNS, external signs of which has more similarity with appearance of cold, stupid, heavy mucus characteristics Badgan /M.Ambaga 1991/.
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Picture 6
T
Q-2
40
Q-1
30
Q M K
20
F+S
L
L-1
10
L-2
Unsaturated Fatty acids ratio (%)
Saturated
The occurrence of solidization and fluidization process in MS F - the melting fluid alpha state of MS (K-III) F+S-the intermediate gamma state (M-D) S-Solid betta state (D-L) Q-L, L-1, L-2- the boundary of transforming the fluid alpha state to solid betta state. L-Q, Q1, Q2 -the boundary of transforming the solid betta state to fluid alpha state Q-the point of fluidization of MS L-the point of solidization in MS M-the alpha part of gamma - state of MS
The comparative theoretical analysis of philosophical basis of fiveelements theory of Oriental Medicine In connection with this principle that theory of five elements of Oriental medicine expressed by thermins as fire, water , earth , rlung, cosmos, wood iron had been formed as abstracted, not really existing elements, it would be more interesting, if clarify these following guestions: When, how had appeared the theory of five elements in the result of revealing which thing and identifying it with what thihgs. In appearing the theory of five elements what thing had been played the role of material, really substance, existing in side of human body. We, by using the new methodological approach Substance external properties abstraction, taking in attention the such principle that . . . five elements such as fire, water, earth, rlung, are not the really existed elements . . . five elements are abstracted symbols, which appeared in order to make easy to understand to people and in the result of perceiving the following external forms, colours . . . came to conclusion that: 1. The theory of five elements in Oriental medicine had formed in the basis of common philosophical views i.e. it had differentiated each other by that, what thermins had been used, and had not differentiated what thing to be symbolized, abstracted. 2. Between five elements theory Traditional Medicine did not existed such sharp differences, but among researchers existed many controversial views in this regard. 3. The reason, why in Oriental Chinese medicine used thermins as "wood", "iron" and in Traditional medicine used such thermins as "water", "rlung", "fire" may be explained by this circumstances, that thinkers of this time had resort to identify own recognized things with such things, with which had been encountered (faced with) in every day life. By using the methodological approach and new conception as "substance - external properties abstraction", "rlung, Mkhris, Badgan abstract thermin - membrane - redoxy potentials 3 state line system "we are managed to reveal that the role of "material substance" leading to appearance of abstracted five elements theory in Oriental Medicine and which had been secretly existed behind such external signs-
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patterns as: hot, cold, cool, sharp, fullness, emptiness, activated, slow, dampness may be played the membrane-redoxy potentials 3 state line system of human body and their 3 basic states: fluid alpha state of membrane structures with high oxidation potential, solid betta state of membrane structures with high reduction potential, gamma state of membrane structures with slow redoxy potentials i.e. behind hot, sharp, acrid, activated external properties of abstracted elements "fire", "wood" had existed the thermogenic, "enzyme-receptor" activated fluid alpha state with high oxidation potential, belonging to membrane-redoxy potentials 3 state line system, while, behind cold, cool, heavy, passive, slow, dampness external signs of abstracted elements "water", "earth", "wood" had been existed the ATP - syntethizing energyaccumulating, thermolimited solid betta state with high reduction potential belonging to membrane-redoxy potentials 3 state line system of human body (Picture N 5). To questions of explaining the identity and difference of theory Yang-Yin and theory rlung. Mkhris. Badgan in the framework of new conception "rlung. Mkhris, Badgan membrane redoxy potentials 3 state line system " During comparative theoretical investigation, which has been conducted by using the new methodological approach "External patterns - theory of five elements", "Substance - external patterns - abstraction" we came to conclusion that the theory of Yang - Yin and the theory of rlung, Mkhris, Badgan in Mongolian and Korean Traditional Medicine had formed in the result of converting the theory of five elements to specific object of thinking i.e. theory of five elements and theory Yang -Yin, rlung - Mkhris, Badgan are two unseparately steps of recognition of one things-one substance. The this our conclusion has been confirmed by theoretical expressions, written in the "The yellow emperor's classic of Medicine" (1995) as, ". . . The elements of fire and water are categorized into yang and yin, the fire being yang and the water being yin". Also, we had revealed such close relationship, which can be expressed as: Yang-Mkhris- fluid alpha state of membrane structures with high oxidation potential, Yin Badgan - solid betta state of membrane structures with high reduction potential. In order to confirm this close relationship we are drawing the below evidence: A.Theoretical expression on whole organism's regulatory role of Yang-Yin and rlung. Mkhris. Badgan and their membrane - redoxy potentials 3 state line system. equivalents The whole organisms regulatory role of Yang, Yin and Mkhris, Badgan had expressed in theory of CKTM (The yellow emperor's classic of medicine, 1995), as: ". . . energy requirement of human body compensated by increasing of Yang, while energy preservation had ensured by increasing of Yin. . .Yang is the energy, the vital force, the potential, while yin is the substance, the foundation, the mother that gives rise to all this potential. . . ", in theory of MTM as: ". . . If Mkhris existed in equal forms, which forms the "heat" of human body, provides the energy, nutrition and substrates, necessary to function of all organism ... If badgan is existed in equal state, which adds the weight and fat, protects the losses of substrates, ensuring the longevity of life. . . " i.e. it was became appearant that the theoretical expression of MKTM on the whole organisms regulatory role of Yang - Yin and Mkhris, Badgan had more similarity, in otherwise, by abstract thermins of Yang, Mkhris in MKTM considered the situation, how in human body has been occurred the process of energy consumption, while by abstract notion of Yin, and Badgan in MKTM has been showed the general feature of energy preservation process inside of human body. What about membrane mechanism and thermodynamic equivalents of theoretical expressions of KMTM on the whole organisms regulatory role of Yang - Yin, and rlung, Mkhris, badgan we are concluded that the prevalence of fluid alpha state of membrane structures with high oxidation potential in energysynthetizing membrane structure leads to increase of bind energy - enthropy /TS/, decrease of free energy /F/ by O/ P mechanism (oxydation : phosphorylation), accompanying with more heat energy
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formation and external signs of these above mentioned membrane based process summarized in the theory of KMTM as "hot", "sharp", "activating" external properties of Yang, Mkhris and as increase of Yang, Mkhris hot, thi decreaie of Yin, Badgan cool and increase of body heat. In other case, the predominance of solid betta state of membrane structures with high reduction potential in the energy - synthetizing membrane structure of human body, associated with excessive formation of free energy - ATP and less formation of bind, heat energy /TS/, and this membrane based process conditioned the more energy preservation and limitation of heat energy formation, which may be expressed in the theory of KMTM as increase of Yin cold and Badgan cool characteristics. The results of all above mentioned theoretical comparative analysis has been showed that the membrane redoxy mechanism of theory of KMTM on whole organism's regulatory role of Yang -Yin, rlung, Badgan, Mkhris can be explained by following close relationship as: "Yang, Mkhris - fluid, alpha state of MS with high oxidation potential - decrease of ATP synthesis - increase of heat energy formation decrease of energypreservation - appearance of "hot", "sharp" external patterns of Yang, Mkhris", and "Badgan, Yin - solid betta state of membrane structure with high reduction potential - increase of ATP synthesis - increase of energy preservation decrease of energy losses and thermogenesis - appearance of "cold", "cool" external patterns of Yin, Badgan" and so the first way of increase of solid betta - state of all membrane structures with high reduction potential in winter gives the possibility to discover the matte r of theory of Traditional Medicine ". . . in winter, under action of cold badgan to be stored, but concealed by cold.. . " (BJigmed 1988). The second way of increase of betta state of membrane structure with high reduction potential directly connected with the thermin of Traditional medicine ". . . warmth of the sun in spring causes "Badgan" to arise . . ". But if excessively increase of betta - state (trans - configuration) in spring potentiated by low temperature and saturated fatty acids, cholesterol (Y.A.Vladimirov 1983) leads to "cold - depending phasic transition of membranes with high reduction potential" with following abruptly losses of activity of membrane binding enzymes and receptors (M.E.Kreps 1981), which had expressed in MTM by following notion: ". . . if in spring heavy and oily qualities combined with coolness stored, arises "Badgan" ailment . . .". And so measurements of prevention from disease due to "cold-depending phasic transition" must be directed to establishment of proper membrane states by rationale use of foods and clothes in spring and autumn. B.The similarity og theoretical expressions of KMTM on general characteristics of Yang-Yin and rlung. Mkhris. Badgan and membrane structures. During our comparative investigation we had revealed that hot, sharp, hot-oil, fullness, activated, light external characteristics of Yang-Mkhris are closely connected with hot, sharp, hot oil, fullness, activated, light external properties of abstracted elements "fire", "wood", and behind such general characteristics of Yang, Mkhris, abstracted elements "fire", "wood" had existed the process of intensification of heat energy formation and activation of "enzyme - substrates", "hormone-receptor" interaction, which had been carried out in the background of predominating the fluid-alpha state of membrane structure with high oxidation potential . Also, it can be say that "cold", "cool", "passive", "slow", "dampness" general properties of Yin, Badgan had existed in close relationship with "cold", "cool", "passive", "slow", "dampness" general characteristics of abstracted elements "water", "earth", "iron", the molecular, membrane mechanism of appearance of such general characteristics of Yang, Badgan and abstracted elements "water", "earth", "iron" would be explained by activation of ATP-energy synthesis, energy accumulation limitation of heat energy formation and inhibition of activity of membrane binding enzymes and receptors, owing to prevailing of solid betta state of membrane structures with high reduction potential (Picture N5).
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In such way the results of our comparative investigation allows to conclude that theoretical expressions of KMTM on external signs of Yang - Yin and Mkhris, Badgan did not distinguished by philosophical basis and inner substance level i.e. the unique role of inner substance in regarding lo externally distinguished general characteristics of Yang-Yin, Mkhris - Badgau played the solid betta state of membrane structures with high reduction potential and of fluid alpha state of membrane structures with high oxidation potential. G General characteristics of human body regulation,when established the normal status coded by abstract Mkhris thermin Mkhris 1.Hot 2.Sharp 3.Hot oily 4.Light 5.Bad smelling 6.Quality 7.Moist G General characteristics of human body regulation,when established the normal status coded by abstract Yang thermin Yang l. Hot 2. Fullness 3.Quickly 4. High functionalactivity Ac 5.Powerfull 6.Light mobile 7.Positive 8.Transparent G General characteristics of human body regulation,when established the normal status coded by abstract Yin thermin Yin l. Cold 2. Heavy 3.Passive 4.Low functional a 5.Slow 6.Negative 7. Sticky 8.Dark
G General characteristics of human body regulation, when established the normal status coded by abstract Badgan thermin Badgan l.Cool 2.Heavy 3.Cool oily 4.stupid 5. Gen tie 6. Firm 7.Sticky
The appearance of such pathological signs: as high temperature, thirst, acute intensive pain, acute attacks of disease during excessive pathological increase of general characteristics of Yang, Mkhris are associated with intensive release of pyrogenic prostaglandin Fl, presentation of "antigen" in the membrane surface of macrophages and lymphocytes, activation "antigen-antibody" interaction and release of many inflammation mediators in background of excessive increase of fluid alpha state of membrane structures with high oxidation potential.While decrease of Body heat, feeling of cold, slow indigestion, more sleeping , chronic duration of disease which had been observed during excessive pathological increase of general characteristics of Badgan, Yin are explained by inhibition of heat energy formation /by O/P mechanism/, chronic shortage of heat energy, decrease of H+-gcneration and HCLsynthesis , inactivation of "antigen" presentation on macrophage membrane structure anddecrease of-excitability of excitable membranes in the background of solid betta state of membrane structures with high reduction potential.
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A. Ge neral characteristics of human body regulation, when established pathological status coded by abstract Mkhris thermin 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. High temperature Great thirst Shooting pains Quicly subjects to treatment Yellowing of the Urine Much vapor Yellowing of tongue Sees white objects as yellow Fast pulse Attaction to cold Bitter taste in the mouth Illness is strongest at noon A. General characteristics of human body regulation, when established the pathological status coded by abstract Badgan thermin Diminishing of Bodily warmth Inability to digest food Bodily heaviness Abundance of Saliva and Mucus Much sleep, loss resistance to cold Frequent chronisation of Disease Poor appetite Less odour and vapor of Urine Attaction to warmth, wants hot place Weak, slow pulse Diarrhea Pale tongue
Ge gneral characteristics of human body regulation, when established pathological status coded by abstract Yang thermin 1. High temperature 2. Thirst 3. S Sharp attack of disease 4. Feeling of heat 5. Darkening of urine 6. Attaction to cold 7. Talkativeness 8. Bitter taste in the mouth 9. Yellowing of tongue 10. Quicly undergoes to treatment
Gen General characteristics of human body regulation, when Esta established the pathological status coded by abstract Badganthermin 1. Constant coldness of body 2. Cold feeling 3. Wants to hot place, food 4. Frequent urination 5. Loss resistance to cold 6. Loss of appetite 7. Physical and Mental heaviness 8. Weak digestion 9. Swelling of Body 10. Slow, weak pulse
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11 12.
The theory of Yang-Yin and rlung. Mkhris. Badgan in regarding to healthy existing of human body and membrane-redoxy potentials 3 state line system. The theory of Tibetan - Mongolian, Korean Traditional Medicine in regarding to healthy existing condition of human body had more similarity i.e. in the theory of KTM this question is expressed as ". . . precondition of healthy existing of human organism is preservation of normal balance between Yang and Yin . . . ", in the theory of MTM as: " . . . precondition of healthy existing of human organism is equality which established between rlung, mkhris, badgan . . . ". It can be say the membrane-redoxy mechanism of above mentioned theoretical expression may be explained by establishing the normal balance between three basic states as fluid alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation and solid betta - state of membrane structures with high level of reduction potential with high middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation, as well as intermediate
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gamma state of membrane structures with low level of oxidation - reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate - ATP generation, low intensity of of high energy electrons - NADPH generation under various unpleasant actions, environmental influence, resulting to gain useful adaptation reactions. C.Theory of Yang-Yin and rlung, Mkhris, Badgan about reason, provocating the disease and membrane-redoxy potentials 3 state line system According to the theory of KTM ". . . Every disease has been provocated in the basis of disturbance of balance between Yang and Yin . . . ", while according to theory of TMTM ". . . The reason of disease is losses of balance (disbalance) between rlung, mkhris, badgan . . . ". The membrane mechanism of such similarity of theoretical formulations of KMTM in regarding to main reason of disease is associated with disturbance of balanced equality between basic three states as fluid -alpha state of membrane structures with high level of oxidation potential with high level of heat energy formation, middle intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation, solid betta - state of membrane structures with high level of reduction potential with high middle level of heat energy formation, high intensity of high energy phosphate - ATP generation, of high energy electrons - NADPH generation, intermediate gamma state of membrane structures with low level of oxidation - reduction potential with low level of proton gradient generation, low level of heat energy formation, low intensity of high energy phosphate-ATP generation, low intensity of of high energy electrons - NADPH generation under action of pathogenic environmental factors, which at last, leads to unability of human organism to conduct the normal adaptive reaction. The principle "Fullness and emptiness" of Korean-Chinese traditional medicine and membraneredoxy potentials 3 state line system Two of eight diagnostic and Treatment principle of Korean Chinese Traditional Medicine are principle "fullness and emptiness" (Shin. Min Kyu 1995). It can be say that, the principle "fullness and emptiness" shows the intensity of response of human body to pathogenic factors and to action of medicinal preparations. When in human organism prevails the "emptiness" it is demonstrated the signs of slowing of response reaction to pathogenic factors and to action of Medicinal preparations, while increase of "fullness" is accompanied with stimulating the over response reactions. During comparative investigation we are revealed that "fullness" of Korean Traditional Medicine corresponds to "sharp" characteristic of Mkhris, while "emptiness" is existed in close relationship with "stupid" characteristic of "Badgan", because according to theory of Tibetan Mongolian Traditional Medicine the "sharp" characteristic of Mkhris leads to suddenly attack of disease, shooting pains in all parts of a body, high sensitivity to pathogenic factors and fast end of disease, the "stupid" characteristic of badgan is contributed to frequent chronisation of disease, slow response reaction to Medical treatment, Disease often got hidden, atypical forms. In the result of comparative analysis we have find such close relationship, which can describe as follows: "fullness - sharp characteristic of Mkhris - fluid alpha state of membrane structures with high oxidation potential of immunocytes, accompanied with over response reactions" "emptiness -stupid characteristics of badgan - solid betta state of MS with high reduction potentials of immunocytes, accompanied with suppressed response reactions". ur experimental data has been demonstrated that increase of solid betta state of membrane structure with high reduction potential on immunocytes after administration of cholesterol in dose 250 mg/kg in mices leads to decrease quantity of immunocytes in 1.27 fold, antibody titer -1.38 fold, immunostimulator effects of medicinal preparations in 1.2-1.42 fold (P<0.05) in comparison to animals, in which induced the prevalence of alpha fluid state of MS in immunocytes. Basing on above mentioned experimental data we came to conclusion that decrease of immune reaction intensity in connection with prevalence of betta state of MS with high reduction potential on
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immunocytes leads to an appearance of external patterns, which in Korean traditional Medicine is described under thermin "emptiness", in Mongolian traditional Medicine under thermin "stupid" characteristic of badgan. The intensification of immune reaction intensity is due to increase of fluid alpha state of MS with high oxidation potential on immunocytes accompanied with appearance of some external patterns, which is expressed in theory of KTM by thermin "fullness", in theory of Mongolian Traditional Medicine by thermin "sharp" characteristics of Mkhris. Our new suggestion /M.Ambaga, Kim Ki Chang 1996/ relating to close coincidence of "emptiness" and "stupid" characteristics with "betta state of MS with high reduction potential -dependent immune deficiency state" has confirmed by the results of investigation of other authors /Li Song Hyo 1991, Kim Chang Gol 1991, Ching Tae Uong 1991, Rak Uong Hun 1991/ during which they had established that the appearance of "emptiness" is connected with decrease of immunocytes and antibody synthesis, also Rehmannice glutinosae Epimedium sagitatum, Glycyrrhiazae uralensis, which used for treatment of "emptiness" - like disease had possessed the immunostimulator effects in the form of increasing the cell - mediated and humoral immunity. Such interpretation of principle "emptiness and fullness" gives us possibility to increase immune reaction of a human body by using medicaments, which is used in traditional Medicine for converting emptiness to fullness, "stupid" characteristic of Badganto "sharp" characteristic of Mkhris. The principle "exterior" and interior of Korean Traditional Medicine and membrane-redoxy potentials 3 state line system. Our studies have been showed that the principle "exterior and interior" of Korean - Chinese Traditional Medicine corresponds to philosophic category "external patterns and inner essence". If considered the principle "exterior and interior" in accordance with new conception "Substance - external patterns abstract notion " proposed by professor M.Ambaga (1994) the principle "interior" corresponds to substances-inner material secretive objects, while "exterior" is connected with external properties of Ying, Yin. Judging by theory of Korean-Chinese Traditional Medicine in majority case exterior and interior had identical origin i.e. interior hot-exterior hot, interior cold-exterior cold, in this case establishment of right Diagnosis is very easy. But there are such cases, when exterior is not corresponded to interior, in this case establishment of right Diagnosis would become more difficulty /Kim Ki Chang 1996/. We are attempted to explain the scientific essence of accordance and unaccordance of "interior" and "exterior" In Korean Traditional Medicine by using the new conception "Substance External patternsAbstract notion" and "rlung, Mkhris, Badgan abstract theory and membrane-redoxy potentials 3 state line system. "In the result of conducting the comparative anal ysi s we are revealed that the principle of accordance of exterior with interior corresponds to this situation, when external patterns of human normal existence and disease are coincided with to this process, which are initiated (occurred) in membrane-redoxy potentials 3 state line system level (3 morpho-functional states of MS) i.e. hot, sharp, light characteristics "Mkhris" and alpha state of MS with high oxidation potential. But there are situations when external characteristics - outwardly manifested signs of mkhris, badgan and Yin, Yang did not corresponded to this process, which is inwardly initiated in membrane-redoxy potentials 3 state line system level i.e. externally hot, light, sharp characteristics of Mkhris and internally solid betta state of MS with high reduction potential. Such uncorrespondance of external patterns with inner substances are described in Korean Traditional Medicine as exterior cold-interior hot, Exterior hot-Interior cold. Such scientific interpretation of "Exterior and Interior" principle of Korean Traditional Medicine shows that in case of appearance of unaccordance of "Exterior and Interior", the medical treatment should be directed to correct of Disturbances, occurred in basic morpho-functional states of membrane-redoxy
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potentials 3 state line system. Classification of five solid organs in relation to rlung, Mkhris,Badgan and their membrane-redoxy potentials 3 state line system specifics. According to theory of MTM ". . . solid organ liver-is the Mkhris dominated organ, because it locates in the residence of general Mkhris becoming the path of movement of normal and form changed Mkhris. Results of our comparative investigation has been showed, that in membrane-redoxy potentials 3 state line system of liver is accumulated the products of FROL more intensively under direct action of high temperature (37C, 47C, 57C, 67C, 77C, 87C,) than other solid organs (4.2-7.5 fold P<0.05), which at last comfirmed the prevalence of alpha-state of MS with high oxidation potentials in liver cells. In conditions of such experiments we revealed very less formation of products of FROL in Badgan dominated organs as: lung and spleen (M.Ambaga 1990), which served as one proof of prevailance of betta-state of MS with reduction potentials in their membrane-redoxy potentials 3 state line system. In favour of our suggestions the results of other foreing authors showed more content of unsaturated fatty acids in liver membrane-redoxy potentials 3 state line system (L.N.Bogatchkaj 1990, A.I.Dimitrieva 1984), which is more powerfull modificator of alpha-state of MS with high oxidation. And so, predominance of alpha-state (UFA) in membrane-redoxy potentials 3 state line system of liver cells in one hands conditioned more functional activity of liver cells in connection with formation of more fluidity, less viscosity state (L.Strier 1985) but in other hands which can be serve as the reasons of more sensitivity of membrane structures of hepatocytes to various pathogenic factors (A.F.Bluger 1985, 1986, Y.A.Bladimirov 1984) in the form of provocation of cytolysis. On the results of our investigation we established that peroral administration of UFA (alpha-state of MS) on doze of 0,l ml/gr led to activation of antitoxical function of liver by 2.4 fold (P<0.05) as compared to animals with administration of cholestrol (betta-state of MS) on doze of 250mg/kg. But long time administration of UFA in mice (beginning from two weeks) accompanied by 1.31 fold increase of end products of FROL in membrane structure of liver cells, which are the proof of those, that more prevalence of alpha-state of membrane structure in liver's membrane-redoxy potentials 3 state line syste, which, sometimes will be entail the pathogenic consequences. Theory of MTM on hot, acute disease of liver and alpha-state of MS of liver Can be say that any form of pathology of liver cells proceeded in direct and unavoidly involvement of Membrane disturbance in liver's membrane-redoxy potentials 3 state line system, (A.S.Loginov 1985, M.Ambaga 1990, 1991). And so, we came to conclusion, that prevalence of alpha-state of membrane structures in liver's membrane-redoxy potentials 3 state line system unavoidly leds to appearance of "hot, acute" signs of liver disease, matter of which connected with intensive disturbance of MS coupling with formation of thermogenic, protonophor phorc on liver cell s membrane under pathogenic factors (Y.A.Lopukhin 1983, A.S.Loginov 1986, A.F.Bluger 1986) and emergence of local rise of temperature in projection zone to liver on body surface (VJ.Tariban 1986,1.N.Antonov 1989). Results of our investigation showed that in first 0-3 days after acute toxic hepatit (CCL4) in MS of liver increased the number of all products of FROL (alpha-state) of membrane of liver cells in 1.62- 6.2 fold (P<0.05), which possessed more "thermogenic" and protonophore activity (J.Musil 1984, Y.A.Lopukhin 1985, A.A.Linchevskaya 1989). Such disturbance of MS was also demonstrated by our observation, which accompained with specific pattern of cytolysis as: serum activity of ALAT and ACAT increased in 2 fold (P<0.05), decreased antitoxication function in 1.47 fold (P<0.05), bilesyntethizing activity in 1.8 fold (P<0.05).
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Replaccmanl of alpha-state of MS of liver cells by betta state during chronisalion of it s pathology and theory of MTM on cold badgan disease of liver During our experimental works we revealed that the first 0-3 days activation of FROL in MS of liver cell after poisoning by CCL4 has been replaced by their decrease during 7-28 days of experiments and all products of FROL decreased 1.16-4.8 fold (P<0.05). Basing on this results we came to conclusion that towards chronisation of liver pathology in it's MS, fluid alpha-state of MS with high oxidation activity was replaced by solid betta-state of MS with high reduction activity, which is expressed in theory of MTM as cold-badgan disease of liver. Our such suggestion was also confirmed by results of other investigators /N.Decina 1990/ according to that the process of chronisation of liver pathology accompanied by decreasing of index of unsaturation with high oxidation activity of MS and number of UFA in 1.2-1.4 fold, and increasing cholestrol and stearic acids (more viscosity betta-state of MS with high reduction activity), lowering the activity of antitoxic, proteinsynthetic function (O.P.Greek 1988) and membrane-binding enzymes (cytochroma-P-450, monoxygenasa, aminopyridinmethylasa). Also, we revealed more interesting fact, that such increase of solid betta-state with high reduction activity in MS of liver cells coupled with the process of malignization /cancer/ (L.Ivanova 1983, A.P.Chohlov 1988) which often appeared as consequence of acute disease of liver and described in MTM under thermin of cold - badgan disease of liver. Apart from this, our new suggestion, related with the explanation of hot acute disease of liver in connection with alpha - state, exhibiting the high oxidation activity of MS of liver cells gives possibility to discover the secret formulation of MFM on hot, acute property of bile. By our opinion, this is connected with detergent and destabilization effect of bile on alpha-state, exhibiting the high oxidation activity of MS of liver cells (B.R.Gedullina 1986), which is coupled with formation of protonophor, thermogenic phore of MS of liver cells /M.Ambaga, B.Sarantsetseg 1991/. Structural specifity of Badgan dominated organ-lung and theory of MTM on cold badgan disease of lung According to our investag'ation's results the intensity of induction of FROL on MS of lung under action of high temrepature was 1.5 - 2.4 fold lower than other organs, which served as the main proof of prevalence of betta-state, exhibiting the high reduction activity on it's membrane structure. By our suggestion, predominance of solid betta - state with the high reduction activity on MS of lung played on important pole in increasing it's resistance to harmful external factors /M.Ambaga 1991/. Our results coincided with results of other scientist's, which has been demonstrated more content of palmitic and stearinic fatty acids with the high reduction activity (betta-state), less number of UFA on MS of lung /E.G.Serebrennikova 1989, V.I.Kulitchkaya 1984/ and less intensity of FROL /P.Z.Meerson 1984/. On these basis we came to conclusion that theory of MTM about ". . . lung as badgan organ . . ." directly linked with it's betta-state of MS in connection with this cold badgan disease of lung also due to excessively of solid betta - state of MS of lung. Our such suggestion appeared in basis of results of our investigation, where we revealed that excessively increase of betta state of all organism's membrane structures by peroral administration of cholestrol in dose of 250 mg/kg resulted to decrease of pulmonary resistance to toxic action of adrenalin in form of increase of index of lung swelling, on the contrary, administration of UFA (alpha-state of MS) leads to 1.3-3.6 fold decrease of such pathogenic parameters, i.e. improved pulmonary resistance. Our results and suggestion were also confirmed by the investigation of other scientists, who found more decrease in number of UFA, more increase in number of cholestrol, palminitiv acid, sphingomyelin during lung disease /P.A.Kazaryan 1984, M.A.Chasina,1987, A.M.Masuev 1991/, and excessive quantity of cholestrol leading to disturbance of capillary vessel of lung, a formation oi microform of atelectasis. Owing to revealing the process of subsequent, pathogenic changes of basic states on MS of liver cells as: when increased because of pathology the fluid alpha state of membrane structures with high oxidation
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potential, high level of proton conductance and high level of within membrane-redoxy potentials 3 state line system, that provided the normal existence of all cells by ensuring normal flow of electrons, protons with generating the proton gradient were substituted by the solid betta state of membrane structures with high reduction potential, middle level of proton conductance and middle level of proton leak, during transition from acute stages of disease to chronisation, malignisation of liver's pathology and also it's relation to theory of MTM on "acute hot" and chronic "cold badgan" disease of liver and other organs we suggested new principle of prevention from chronisation and malignisation (cancer) by preservation of normal alpha-state of whole organism's membrane structures within membrane - redoxy potentials 3 state line system. Theory of MTM on seasonal changes of function of five solid organs and their relationship with seasonal changes of all organism's membrane-redoxy potentials 3 state line system. Autumn. According to theory of MTM: ". . . in autumn, the functional activity of liver is deteriorated, which yet complicated by "enemy acts" of lung in attitude towards them . . . ". The scientific essence of abovementioned process may be explained by intensifying of FROL because of the excessive, liquid phase transition within membrane-redoxy potentials 3 state line system, which occured in MS of liver cells as (1 + 2) i.e (1-means the excessive contents of unsaturatedfatty acids in MS of liver cells, (2- means the autumn season depending increase of alpha-state of MS transition with high thermogen and oxidation activity, protective against cold provocated solid phase transition action within membrane - redoxy potentials 3 state line system by homeoviscous adaptation reaction. What about enemy action of lung, this is connected with increase of active form of oxyden through respiration - oxygen acceptor functions of lung. During our observation we revealed that in autumn season in all organism's membrane-redoxy potentials 3 state line system, coefficient growth of FROL is increased in 1.28-1.63 fold (P<0.05), also "acceptor property" of MS in relation to cholestrol in 3 fold (P<0.05) as compared to spring, which shows increase in number of UFA (alpha - state of MS with high oxidation activity). Can be say that such change in number of UFA (alpha-state of MS with high oxidation activity) might exert various effect an all solid organs, depending on their specifity of membrane-redoxy potentials 3 state line system. As to liver cells MS threatened the probability of attack of "heat-depending phasic transition" due to mechanisms "alpha + alpha form increase of fluidity of membrane structures ". Such suggestion confirmed by the results of our investigation that in membrane-redoxy potentials 3 state line system of liver cells in summer the coefficient growth of FROL is increased in 1.1-2.3 times (P<0.05) under action of high temperature as compared to spring; in direct connection with this the resistance of membrane structures of liver cells to toxic prooxidant action of CCL4 and H202 decreased to 1.66-2.1 time (P<0.05), deteriorating it's antitoxic and bilesynthetized function in 1.13-1.5 fold (P<0.05). Also in favour of our these propoasals we demonstrated in autumn more decrease of bilesynthetizirrg, antitoxic activity of liver cells in 1.81, 1.32 times (P<0.05) more increase in number of products of FROL in membrane-redoxy potentials 3 state line system of liver cells (in 1.52-3.47 times) in animals, when overloaded by unsaturated fatty acids (P<0.05) in dose of 0.1 ml/20 gr; scientific matter of such pathologic process lies in more increase of alpha-state of MS /more fluidity/ by mechanisms /alpha + alpha / in autumn. Apart from this we discovered scientific matter of theory of MTM on ". . . in autumn the activity of lung is increased which is connected with changes, proceeding in membrane-redoxy potentials 3 state line system of lungs as follows: alpha against betta i.e. seasonal increase of alpha-state of MS with high oxidation, high proton conductance, high proton leak in autumn prevents the excessive rise of betta - state of membrane - redoxy potentials 3 state line system with high reduction, low proton conductance, low proton leak in lungs with following improvement of their function, because we demonstrated that administration to animals of UFA (alpha-state of MS with high oxidation, high proton conductance) increase the pulmonary resistence to toxic effect of adrenalin (in 1.3-1.7 time
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P<0.05), and such rise of pulmonary resistance (P<0.05) to toxic effect of adrenalin is found in summer, as compared to other seasons (winter and spring). As regards to enemy acts of increased function of lung to deteriorated function of liver in autumn, which is connected with prooxidant effects of oxygens, bringing through activated lungs in attitude to alphastate of MS(UFA) of liver cells, accompanied with distruction of it's membrane structures by mechanisms: RH+02T= R'+0+OH-. And so, seasonal change of alpha - state of MS in autumn can be exerted negative action to MS (alphastate) of liver, by mechanism (alpha + alpha states ), from which could be protected with the help of stopping the excessive fluidization of liver's MS and low temperature. THE INFLUENCE OF SOME FACTORS, WHICH INCREASE THE ABSTRACTED MKHRIS (YANG), AND THE BADGAN (YIN) CODE ON THE PHASE TRANSITION OF MEMBRANE REDOXY 3 STATE SYSTEM OF HUMAN BODY. Picture 7
T 40
state+oxy potential The factors, which expressed under abstract thermin Mkhris (yang) and alpha state of MS with high oxy potentials . Hot Hot oily medicaments, foods (horse, marmot meats and oils) Spring season Sun heat Middle age Liver
state+low redoxy potential
30
20
The factors, which expressed under abstract thermin Badgan (yin) and betta state of MS with high red potentials . Cold Cold oily medicaments, foods (beef, goat meats, milks) Spring season Low temperature effect Young age Lung, spleen, kidney
10
state+red potential
Unsaturated Fatty acids ratio (%)
Saturated
Spring. Judging by theory of TMTM ". . .in spring the functional activity of lung is deteriorated and increased the function of liver. Can be say that the deterioration of liver cells in spring has connected with excessive Solid phase transition of MS in this season in the form (1+2) i.e. (1-means the excessive contents of saturated fatty acids in MS of lung, (2-season depending increase of betta - state of MS in spring in according to adaptation-loss reaction. Our new conception Mkhris, Rlung, Badgan- membrane-redoxy potentials 3 state line system gives the possibility to explain the essence of theoretical expresson of TMTM ". . . if cold combined with heavy oily which leads accumulation of the Badgan. . . " in close connection with solid phase transition of MS membrane-redoxy potentials 3 state line system In such way the theoretical expression of TMTM... if hot and hot oily combined, which leads to accumulation of Mkhris... . may be interpreted in close connection with liquid phase transition of MS.
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Also should be emphasize that the all things such as hot, hot oily food, medicine, horse, marmot meat, autumn season, direct effect of Sun, middle age, liver organ, which expressed in TMTM by thermins the Mkhris had effect to increase the alpha-state of MS membrane-redoxy potentials 3 state line system, while the all things such as cold, cold oily food, medicine, beef-goat meat, spring season, cold effect of weather, young age, which expressed in TMTM by thermins the Badgan, had effect to increase the bettastate of MS membrane-redoxy potentials 3 state line system. Our investigation results showed the increase of intensity of FROL in all membrane structures within membrane-redoxy potentials 3 state line system in 1.46 fold (P<0.05) and decrease of cholesterol acceptor activity of MS in 3.1 fold (P<0.05) in spring as compared to autumn, which served as one proof of increase of betta - state of MS in the same season. Such increase of betta - state of MS has exerted negative effect on functional activity of lung by mechanism (betta+betta)-i.e by excessively solidating of MS within membrane -redoxy potentials 3 state line system, which was confirmed by our observations as: in spring the pulmonary resistence to toxic effect of adrenalin decreased in 1.3-1.7 fold (P<0.05), also tolerance to prooxidant action of CCL4, H20, deteriorated by 1.2-1.6 time (P<0.05) and administration of cholestrol in dose 250mg/kg decreased the pulmonary resistance to adrenalin in 1.16-1.46 time as compared to other seasons. Results of our investigation, conducted in spring served the basis of explaining the theory of Mongolian Traditional Medicine ". . . in spring the functional activity of lung is deteriorated ..." in close connection with membranedepending process within membrane-redoxy potentials 3 state line system. A contrary to this the such seasonal increase of betta-state of all organism's within membrane-redoxy potentials 3 state line system in spring leads to increase of functional activity of liver cells, which is linked with decrease of vulnerable alpha-state of MS in liver cells i.e stabilization the MS of liver thanks to the increase of betta-state (Yu.M.Lopukhin et all 1983, G.I.Klebanov et all 1986) of MS in spring. Such suggestion confirmed by the results of our investigation: in spring tolerance of membrane-redoxy potentials 3 state line system of liver to prooxidant action of CCL4 H202 in 1.95-2.1 fold (P<0.05) and also*intensity of accumulation of products of FROL on MS of liver decreased in 2.23 time (P<0.05) in spring. Basing on the results of such experiments we came to conclusion that theory of Mongolian Traditional medicine on ". . .increase of function of liver in spring . . . can be explained by mechanism of change of MS, which proceeds in within membrane-redoxy potentials 3 state line system of liver cells in the from as: betta - against-alpha states. Relationship between the theory of Rlung. Mkhris. Badgan and "FROL(free radical oxidation of lipids)-AO(antioxidants) systems" During interpretation of the theory of rlung-mkhris-badgan in framework of our new conception "rlung, Mkhris, Badgan - membrane-redoxy potentials 3 state line system" we revealed the close relationship between abstract notions of rlung, Mkhris, Badgan of MTM and systems of "AO-FROL", which exerted direct effect on normal regulation of three basic states of MS (Yu.A.Vladimirov 1971, 1987, E.B.Burlakova et all 1989). All things, which is expressed by thermin of Badgan (by our opinion connected with betta-state of MS within membrane-redoxy potentials 3 state line system), regarding to human age, organs, seasons, dietary factors, function (lung, young age, spring) corresponds to middle level of AO systems. While things, which expressed in MTM by thermin of Mk hris (by our opinion is linked to alpha-state of MS), regarding to age, season, all organism's regulatory function, solid organs (liver, autumn, middle age) and corresponds to high level of AO systems. The things, which expressed on MTM by thermin of rlung (by our opinion-gamma-statc of MS within membrane-redoxy potentials 3 state line system) regarding to heart, juncture of spring and summer, old process, and corresponds to unstable low levels of AO defence systems.
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Significance of such interpretation of theory of MTM on "rlung, mkhris, Badgan" in connection with antioxidant (AO) defence systems directed to elaborate new principle of prevention and treatment of various disease of solid organs and obesity, ageing process by the using of antioxidant preparation of natural origin strongly regarding the age, seasons, and organ's specificity. In favour of our new suggestion "rlung, Mkhris, Badgan - membrane - redoxy potentials 3 state line system" showed all results of investigations conducted by us with peroral administration of cholesterol and unsaturated fatty acids, first of which are creator of alpha - state of membrane structures while second (SFA) are the main parts of betta - state of MS within membrane - redoxy potentials 3 state line system (Ya.Kagava 1985, L.Strier 1985); and so, whole organim's external signs of peroral administrated cholesterol (betta - state of MS with high reduction activity ) in animals are expressed as follows: decrease of resistance of animals to coldris to add the weight of animals, more intensively accumulation of cholesterol in spring (probably by mechanism: (betta + betta); increase the resistance of MS of liver cells to action of pathogenic factors (by mechanism (betta + betta); deterioration of the resistance of MS of lung to action of pathogenic factors; decrease the level of functional activity of spleen; increase in number of exsecreted urine. These all had very similarity with external expressions of badgan, which are described in Oriental and Mongolian Traditional Medicine. While all organism's external signs of peroral administration of unsaturated ' fatty acids (alpha-state of MS within membrane - redoxy potentials 3 state line system) in animals are characterized: by increase of resistance of animals to cold; less addition of weight of animals, less accumulation of cholestrol in autumn, probably by mechanisms as alpha - againist-betta; increase the functional activity of lung and spleen by mechanism's alpha - againist betta states of membrane structures within membrane - redoxy potentials 3 state line system; decrease the functional activity of liver i.e by mechanism's alpha+alpha decreased the resistance of MS of hepatocytes to harmfull action of external pathogenic factors; decrease quantity of urine. These all had very similarity with external expressions of Mkhris, which arc described in Oriental and Mongolian Traditional Medicine. In such ways can be draw interesting conclusion, that three basic state (alpha, betta, gamma) of MS within membrane-redoxy potentials 3 state line system of all organism, outside of which could be impossible for any appearance of functional regulation of all organs and cells at the end led to creation of wonderfull abstract theory of rlung, Mkhris, Badgan. The seasonal changes of "rlung. Mkhris. Badgan" and the membrane - redoxy potentials 3 state line system of human body According to theory of MTM the seasonal changes of "rlung, Mkhris, Badgan" are described in following forms: ". . . "Mkhris" are stored in late summer, arised in autumn with it's qualities of oiliness and warmth, and are pacified by the coolness of early winter . . .The cool, oily heavy qualities of late winter cause "Badgan" to be stored, but they are concealed by the cold and thus do not arise. The warmth of the sun in spring causes them to arise, and the light and rough qualities of early summer pacify them . .. ".
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THE SEASONAL DEPENDING CHANGE OF ABSTRACTED RLUNG, MKHRIS, BADGAN CODE AND CHANGE INDUCED IN THE MEMBRANE REDOXY POTENTIAL 3 STATE SYSTEM OF HUMAN BODY. Picture 8
Winter
Membrane
Autumn Mkhris
Spring Badgan
Redoxy system
Summer rlung
It should be emphasized that if used our new suggestion "rlung, Mkhris, Badgan-membrane structures" to explain this above mentioned fomulation of Traditional medicine could be easely understand that such seasonal changes of "rlung, Mkhris, Badgan" literally coincided with seasonal adaptation changes of basic three state (alpha, betta, gamma) of membrane structures within membrane-redoxy potentials 3 state line system. The human and animal's organism from beginning of summer started to prepare to winter cold by increasihg fluidity alpha - state (unsaturated fatty acids) of MS, but in contrary case will be occurred "cold - depending phasic transition" on all membrane structures of organism with following abruptly lossess of their functional activity (M.E.Kreps 1981) i.e will be appeared signs of various disease caused by cold /M.Ambaga 1990/. Indeed, the results of investigation conducted by V.Ivanov et all (1984) showed that the quantity of unsaturated fatty acids (alpha - state) were increased in 1.35 fold and number of saturated fatty acids (p-state) decreased in 1.5 fold towards autumn and winter. We also revealed, that the administration of cholesterol - (betta -state) of MS in mice in dose of 250 mg/kg in winter leads to 1.2 fold decrease (P<0.05) the resistence of animals by parameters of pulmonory insistence to acute loxic effect of adrenalin, while administration of UFA (alpha-state) in dose of 0.1 ml/gr decreased this pathogenic parameter in 1.4 fold (P<0.05) i.e. improved the to endurance of organism to cold. In other hands, increase of alpha -state of MS (UFA) towards winter.through autumn ensured "thermogenic function" of MS, which is very necessary to adaptation to cold (G.Suchova 1990, E.Z.Emirkov 1991). Infortunately, if in autumn (juncture of summer and winter) preparatory increase of a-state (UFA) to winter cold provoked by such supplement factors, as high temperature, and UFA, which increased the fluidity (alpha - state) of MS within membrane-redoxy potentials 3 state line system and leads to "heat-depending phasic transition" on membranes with following lossess of all organism's membranebinding enzymes and receptors (Y.A.Vladimirov 1983, L.Strier 1985). It is of great interest,
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that our such suggestion confirmed truth of the theory of MTM ". . .hot and oily qualities combined with warmth leads to arise Mkhris in autumn ..." (Picture N 6, N 7). Towards spring in all organism's MS created precondition of increase of solid betta -state of membrane structures (saturated fatty acids and cholestrol), which by our opinion proceeded in following two ways: 1. Way of losses of alpha - state of MS within membrane-redoxy potentials 3 state line system. In winter more quantity of alpha -state (UFA) with high oxidation activity within membrane-redoxy potentials 3 state line system spended to production of heat energy againist cold, which unavoidly leads to its decrease replacing by solid betta - state of MS with high reduction activity within membrane redoxy potentials 3 state line system (G.Suchova 1990). 2. Wav of adaptation The prevalence of solid betta - state with high reduction activity within membrane -redoxy potentials 3 state line system in spring serves as protective mechanism from becoming excessively "fluidization" of MS (excessively increase of alpha - state) under direct action of summer's warmth and on other hands, ensured the mechanism of decrease of general metabolic activity of organism to comparative high temperature of spring and summer (V.I.Smolyar 1987), which is very vital to adaptation to warmth action of environmental temperature (Picture 9) THE EXPLANATION OF SCIENTIFIC ESSENCE OF DIETOTHERAPY METHODS OF MONGOLIAN TRADITIONAL MEDICINE According to theory of Mongolian Traditional Medicine (MTM): ". . . Acute (acrid) and hot oily foods (horse and marmot meat) increases "Mkhris" and contributes to "Mkhris" disorders . . . Heavy, cold oily foods (beef and goat meat) increases "Badgan", contributing to "Badgan" disease . . . ". Undoubtly, that quality and composition of all organism's membrane-redoxy potentials 3 state line system undergo to constant changes under direct action of received foods (M.M.Levachev 1980, 1986, L.M.Yazeva 1980, 1981). Number of investigation showed that Horse and marmot meat, which according to theory of MTM increased "Mkhris", contained 61-68% unsaturated fatty acid (UFA)-mainly components of alpha - state of membrane structure (MS) within membrane-redoxy potentials 3 state line system (S.Masigsuren 1978, N.Jamsranjav 1978, T.A.Valieva 1985, P.Dorjderem 1991). While Beef and goat meat, which judging by theory of MTM increases "Badgan" contained more quantity of saturated fatty acids (SFA) (59-60%)-mainly components of betta - state of MS (P.Dorjderem 1991, B.Suchbaatar 1991). Our suggestion, relating to that foods, increasing "Mkhris", contained more quantity of UFA (alpha -state of MS) increased the resistance of human organism to cold; while foods, increasing "Badgan", included more quantity of SFA (betta - state of MS) increased the resistance of human organisms to hot has comfirmed by investigations of other scientists who revealed that administration of UFA decreased the susceptibility of animals to cold by decreasing the temperature of heart arrest from + 120C (by cholestrol) to 70 C (N.Kalabukhov 1985). On the basis of abovementioned explanation of membrane mechanism of Dietotherapy of MTM we have suggested the new principle of treatment, the essence of which directed to use the foods, containing more quantity of UFA in winter cold season and to use the foods containing SFA in summer hot season. THE MEMBRANE MECHANISM OF ACTION OF FOOD FACTORS, WHICH INCREASED THE RLUNG, MKHRIS, BADGAN By our opinion, the membrane - redoxy mechanism of using beef, goat meat, oils for treatment of hot Yang-Mkhris Disease, also using horse meat, oils during Yin, Badgan Cold Disease may be explained by decreasing the excessive pathological increased during Mkhris Disease fluid alpha state of MS within
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membrane-redoxy potentials 3 state line system under saturated fatty acids, contained in goat, beef meat, oils and by diminishing the excessive pathological increased during Badgan Disease solid betta state of MS under direct influence of unsaturated fatty acids, contained in horse meat, oils. In this connection, we are putting before as the goals to carry out the comparative study, directed to establish the influence of various ratio of " unsaturated: saturated fatty acids" of horse, goat, beef meat, oils, possessing hot and cold taste, power, property on the membrane state transition, membrane permeability and stability within membrane-redoxy potentials 3 state line system.
THE MEMBRANE-REDOXY POTENTIAL 3 STATE MECHANISM OF ACTION OF FOOD FACTORS, WHICH INCREASED THE ABSTRACTED RLUNG, MKHRIS, BADGAN CODE. Picture 9
MEAT, OILS, MILKS
Alpha state of MS with high oxy potentials
Betta state of MS with high red potentials
Betta state of MS with high red potentials
Alpha state of MS with high oxy potentials
The result of our investigation shows that under action of horse oils, possessing hot power, property according to theory of KMTM, containing more quantity of unsaturated fatty acids (P.Dorjderem 1991) has been occurred the transition from bette state with high reduction activity to alpha state with high oxidation activity in membrane - redoxy potentials 3 state line system, increased the accumulation of deprotonized products as MDA in 1.2 times /P<0.05/, the membrane permeability in 1.22 times /P<0.05/, contents of deprotonized products and conjugated products as MDA, DK in the membrane structures in 1.21 times /P<0.05/ i.e. in such way the increase of proton leak, thermogenic, protonophore activity of membrane structure under direct effects of horse meat, oils may be expressed in theory of KMTM as "hot", "hot oil", "sharp" power and property of foods /horse meat, milk/. Also during our investigation we are revealed that under influence of goat, beef oils, possessing cold, cool, cold-oil property, power according to theory of KMTM, containing more quantity of saturated fatty acids (P.Dorjderem 1991) had occurred the transition from alpha state with high oxidation activity to betta state with high reduction activity in MS, increased the membrane stability in 2.01 times /P<0.05/, decreased the deprotonized products and conjugated products as MDA, DK contents in membrane
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structure in 1.8-2.12 times /P<0.05/, in otherwise the decrease of membrane permeability, limitation of proton leak, thermogenic, protonophore function of MS under direct effect of goat, beef oils may be expressed in the theory of KMTM as cold, cool, cold oil power, property of foods /goat, beef meat, oils/. During our comparative investigation have been observed by us such interesting facts i.e. the essence of the principle of using the horse meat and oils possessing hot, hot oil, taste, power, quality in KMTM to ensure the transition from "emptiness" to "fullness " may be explained by occurring the transition from gamma state of MS with low redoxypotentials to alpha state with high oxidation activity in MS under direct effect of more quantity of unsaturated fatty acids, containing in horse meat, oils, which, at last, resulted to activation of membrane binding enzymes and receptors and intensification of immune response reaction and increase of "antigen" presentation in immunocyte's membrane structures. It would be interesting, if explain how use the membrane - redoxy potentials 3 state line system related mechanism of provocation of hot-Mkhris (yang) and Cold-Badgan (Yin) disease under direct effect of foods in every day treatment practice. According to philosophical view points of oriental Medicine, the normal balance between hot and cold is ensured the precondition of normal healthy existence of human body. If normal balance between hot and cold has been disturbed by unpleasant influence of Dietary, behavioural, seasonal factors, which resulted to provocation of Disease, therefore, in this case it should be take the treatment measure by using Dietary factors, medicaments, which possessed the opposite taste, power, quality, regarding to excessive pathogenic factors. One of conditions of the provocation hot-Mkhris (yang) disease is excessive use of hot, salty, acrid taste power possessing foods, drinks such as horse , marmot, donkey, mutton, chicken meats, alcohol drinks, garlic, onion et al. The membrane-redoxy potentials 3 state line system related mechanism of provocation of this pathological process is explained by inducing the excessive fluid phase transition in membrane structure within membrane-redoxy potentials 3 state line system under direct effect of unsaturated fatty acids, contained in horse, marmot, chicken meats. In this case, for treatment, should be use beef, goat and fresh meat of hybrid yak, calf, cold water from rocky and snow mountain, which blocked the excessive predominance of fluid alpha state of MS within membrane-redoxy potentials 3 state line system by increasing the solid betta state in MS within membrane-redoxy potentials 3 state line system owing to containing the more quantity of saturated fatty acids, cholesterol and limiting the local thermogenesis, proton leak process around bioenergetic cell membranes. The main reasons of provocation of cold disease because of long time use of beef, goat, camel, yak meats, cold drinks, goat milk, fruit, vegetables, which contained the more quantity of saturated fatty acids, cholesterols-main modificator of solid betta state of MS and possessed the cold, bitter, sweet taste, power and quality are remained more interesting. The membrane-redoxy potentials 3 state line system related mechanism of provocation of cold disease under cold foods is explained by provocating the excessive solid betta state with high reduction activity under direct effect of saturated fatty acids, contained in beef, goat meat. In order to eliminate such pathological situation, according to the theory of Oriental medicine had been recommended the use of horse, marmot, sheep meats, alcohol, hot water, which decreased the solid betta state of MS with high reduction activity by increasing the fluid alpha state of MS with high oxidation activity. On the basis of above mentioned explanation of membrane - redoxy potentials 3 state line system related mechanism of dietotherapy methods of Oriental Traditional Medicine we have suggested the new principle of treatment, which essence has been directed to use the foods, containing the more quantity of unsaturated fatty acids - main modificator of alpha state of MS with high oxidation activity winter cold season, and the use of foods, containing the more quantity of saturated fatty acids - main modificator of solid betta state of MS with high reduction activity in summer - autumn hot season.
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To study the membrane - redoxy potentials 3 state line system - dependent mechanism of theory Traditional Medicine on constitution types of Individuals Judging by the theory of Traditional medicine ". . . Those, influenced by nature of Mkhris have great thirst and hunger, yellow hair and bodies, a medum of wealth, life span and bodily size . . . Those having the nature of Badgan have cool bodies, obesity, pale complexion and the ability to endure the disease. They have large bodies, long life and much wealth . . . People, who are influenced by rlung have stooped - over form, are thin and of dark complexion, unable to endure cold or warm . . .have few possessions and a short life span. They are light sleepers and have small bodies, they enjoy singing and laughing . . .". Can be say, that such classification of human constitution types in MTM may be explained by "inborn" difference of membrane-redoxy potentials 3 state line system of human body, which are expressed in predominating of any one of three basic state i.e. in "Badgan" persons has been dominated the betta - state of MS (more energy - syntethizing)with high reduction activity within all organism's membrane redoxy potentials 3 state line system which conditioned more preservation of free energy (F) in the form of ATP, NADPH and fats in the third compartment of human body with less dispersion of heat energy /Q, TS/, /B.P.Skulachev 1987, D.Nikols 1985/. THE MEMBRANE MECHANISM OF CONSTITUTION DIFFERENCE OF INDIVIDUALS While in energy synthetizing membrane structure of "Mkhris" dominated individuals in connection with prevailing of a - state of MS with high oxidation activity within all organism's membrane-redoxy potentials 3 state line system created precondition of more transition of electrochemical gradient /H2+/ to "heat energy" /Q/ with middle synthesis of high energy phosphate as ATP, high energy electrons as NADPH because of "high proton leak and proton conductance" /Y.A.Bladimirov/. Basing on such theoretical explanation we suggested the new principle of prevention and treatment of obesity, which matter lies in transferring of betta - state of MS with high reduction activity to alpha state of MS with high oxidation activity by forming of "artifical" protonophore phore i.e transferring the "Badgan" coded people to the "Mkhris" coded people. . .1989, Y.M.Lopuchin 1983, B.P.Skulachev 1987/. Prevailance of gamma - state of MS /intermediate, unstable/ leads to less energyaccumulating, energysynthetizing and low thermogenic activity, which are expressed by thermins of nature of "rlung" coded people. The results of our investigations A.In the result of comparative investigation conducted in many groups of people we are revealed that first group of people are distinguished by 1.3 fold increase of external patterns of general characteristics of Mkhris type coded constition in comparision to second group people of Badgan type coded constition such as:fast pulse, hot feeling in the body surface, heat of the body (<36.8C), much vapour, perspirations, intolerable in hot place and hot room, desire for only cold place and food. Body temperature (TS) of this group of people, was high by + Q.7-0.9C (36.8C) than second group of people. In connection with this body weight (F) was 1.8 fold low than second group of people (SGP) and also low gaining of weight in the background of good appetite and great thirst, little sleep at night anxious. Basing in obtained result we are regarded that people of first group are more similar to Mfthris dominating individuals according to theory of Tibetan Medicine. Besides, biochemical and biophysical studies shows that first group of people i.e Mkhris dominating coded people are characterized by low level of resistance membrane structure to lipid pereoxidation damage effect and the low Ch: LPOP ratio and high contents of lipid Pereoxidation, deprotonized products such as MDA, DK, shiff Base in membrane structures within all organism's membrane redoxy potentials 3 state line system.
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In first group of people the resistance of MS within all organism's membrane - redoxy potentials 3 state line system to damage effect of H202 was 1.3 fold low than SGP, the ratio Chr.LPOP was 1.4 fold less than SGP, while the quantity of MDA, Shiff base, DK in membrane structures were 1.32 fold high than SGP, respectively. In such way, results of our investigation shows that first group of people i.e Mkhris dominating coded people with high percentage of Mkhris constition type are distinquised by prevailence of fluid alpha state with high oxidation activity within whole organism's membrane structures. Also we are revealed that in people dominatly coded by Mkhris abstract thermin between body temperature and Ch: LPOP ratio existed negative correlation (r = 0.97), between body weight and Ch: LPOP ratio r = + 0.89 correlation, between body temperature and LPOP products r = + 0.78 correlation, between body temperature and permeability of MS + 0.88 correlation, between body weight and permeability of MS - 0.93 correlation. The existence of such close correlations demonstrated that in people dominatly coded by Mkhris abstract thermin the increase of fluid alpha state of MS, increase of lipid pereoxidation products and permeability of MS (decrease of Ch: LPOP ratio) leads to increase of body temperature (TS) and decrease of body weight F). Comparative analysis gives the possibilty to reveal that the second group of people is characterized by 1.8 fold increasing of external patterns of general characteristics of abstract Badgan type constitution than Mkhris abstract code dominated first group of people (FGP), such as: slow pulse, constant coldness of the body (>35.5C), low bodily heat, physical mental heaviness, poor appetite, weak digestion, rapid gaining of weight (obesity), unclear awareness, abundance of Mucus, much sleep et all. Body temperature of this group of people was low by 1.3C, body weight was high by 10-20 kg than first group of people. Our data demonstrated that second group of people are more similar to individuals, who according to theory of Traditional Medicine belongs to so called " abstract badgan-dominating people". Also, data, obtained by experimental works revealed that people of second group arc characterized by low concentration of lipid pereoxidation products. In second group of people the resistance of membrane structures to prooxidant effect of H202, was 1.3 fold high than FGP and the quantity of lipid pereoxidation products (Dien konjugat, MDA, Shiff Base) were 1.4 fold lower than FGP. In such way the results of our investigation revealed that in Badgan dominating second group of people is prevailed the solid betta state of MS within all organism's membrane - redoxy potentials 3 state line system. Also, we are finding out the positive strong correlation between increase of body weight and increase of resistance of MS within all organism's membrane - redoxy potentials 3 state line system to prooxidant damaging factors (r = + 0.9), between body weight and Ch: LPOP ratio (r = + 0.9), negative correlation between body temperature and resistance of MS (r = - 0.89), between body temperature and Ch: LPOP ratio (r = - 0.96). In second group of people (abstract badgan dominated people). In the result of establishing such strong positive and negative correlation between some biochemical and biophysical parameters in abstract Badgan dominated people we came to conclusion that decreasing the membrane permeability and lipid pereoxidation products and increasing Ch: LPOP ratio in whole organism's membrane structures accompanied with increase of free energy (body weight - ATP synthesis - F) and decrease of enthropy TS-body temperature - heat emission. This suggestion confirmed by results of our investigation, when we revealed the addition of weight on 1.36 fold (<0.05) on animals with administration of cholesterol (betta - state of MS) in doze 250mg/kg . Much sleep, physical and mental heaviness of abstract Badgan-dominated people may be explained by slow depolarization process of MS of excitable cells owing to prevailance of Betta state of membranes. The above mentioned obtained results gives to us the possibility to explain the theory of MTM on constitional type of people from view point of thermodynamic laws in membrane levels within all organism's membrane - redoxy potentials 3 state line system. In the theory of Oriental Traditional
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medicine it was stressed that. . . if Mkhris existed in equal forms, which forms the "heat" of organism, it provides the nutritions and substrates necessary to function of all organism. . . if Badgan is existed in equal state which adds the weight and fat, protects the losses of substrates, ensuring the longevity of life. Basing in the results of our investigation we came to conclusion that such formulation on whole organism's regulatory function of abstractized rlung, Mkhris Badgan is closely connected with thermodynamic process, which constantly takes place in living organism within all organism's membrane - redoxy potentials 3 state line system. (M.Ambaga, B.SarantsetM 1990). In such way, in thermodynamical system, where is prevailed - alpha state of MS with high oxidation activity the thermodynamic process is going in direction to more losses or usefull free energy (F), and to more dispersion of useless "heat" energy, which by otur investigaton are observed in abstract Mkhris dominated people i.e. thermodynamic process of transition F-TS is directed to decrease of F, and to gradually increase of /TS/, which proably may serve the guidelines of right interpretation of theory Traditional medicine : as "Mkhris forms the heat energy. But excessively increase of Mkhris burnes all the energy and nutrients of all organism . . .". This is reason, why abstractized Mkhris dominated people are distinguished by hot surface of Body, low gaining of weight in background of good appetite and great thirst. Besides, prevailance of alpha fluid state of MS in the excitable cells of central nervous system in abstract Mkhris dominated people leads to rapid depolarization and increasing the excitability ol neurons by which may be explained the bad sleep, anxious, observed in this type of people. While betta -state of MS of organism creates more stabile "themodynamic system, which is due to trans-configuration of saturated fatty acids and cholestrol /L.Streir 1985/. In such system, the thermodynamic process is accompanied by more reservation of free energy /F-ATP synthesis , energy accumulation/ and less dispersion of heat /Q,TS/ energy i.e. thermodynamic reaction proceeds in direction: to gradualy increase F and to decrease of Q, which are expressed in Traditional Medicine as Badgan addes the weight of organism, decreases the heat energy, protects the substrates and gives possibility to long life . . . This is reason, why in abstract badgan dominated people, who distinguished by high level of betta state of membrane structure observed the following external patterns such as: low bodily heat and rapid gaining of weight /obesity/. Basing on such explanation we suggested /M.Ambaga 1996/ the new principle of prevention and treatment of obesity, matter of which lies in transferring of betta -state of MS with high reduction activity to a - state of MS with high oxidation activity i.e by forming the regulated "artifcial" protonophore configuration on solid state of MS through which could be lossed the excessibly free energy /F/ in the form of dispersion of heat energy /Q/, and limited the excessive energy accumulation of free energy in the form of ATP, NADPH synthesis . To question of obtaining the antiageing preparation in the theoretical basis of Traditional Medicine and all organism's membrane-redoxy potentials 3 state line system. First of all, we have the purposes to explain the theoretical and phillosophical essence of the theory of TMTM, in which the "human age", "the human ageing process","old age" has been expressed as "in the young age - prevailed badgan (water, earth element) ", "in the middle age-dominated Mkhris (fire element)", "in the old age- prevailed rlung /rlung element". According to the notions of Traditional Medicine". . .those of middle age are "Mkhris" people, in such age the clarity of the senses, complexion and strength are increased and heightened bodily heat, courage and intelligence . . .Young people are "badgan" people and in same age bodily constituents are increased . . . People advanced in age are "rlung people", when the clarity of the senses decreased and physical activity worsened".
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Scientific interpretion of above mentioned theoretical expression of Traditional Medicine could be easily made in the framework of our new conception "rlung, Mkhris, Badgan - all organism's membrane redoxy potentials 3 state line system. The results of foreign scientist's investigation (B.B.Frolikis 1986, Yu.M.Lopukhin et all 1983, A.Alesenko 1983) surely showed that all organism's membrane structures have been subjected to natural consistent, consequent changes as: betta state with high accumulative,reduction activity > alpha state with oxidation,thermogenic activity > gamma state with low redoxy potential based accumulative, reduction and oxidation activity during ontogenetic development of human organism, bringing the more specifical feature of every groups (young - middle - old). In young age accumulated more quantity of sphingomyelin and cholesterol (betta - state of MS) in membrane structure (MS) of all organisms, which served as a role of signals to increase the activity of DNA, PNA-polimerase, and mitotic activity of cells (Yu.M.Lopukhin et all 1983, B.M.Dilman 1981, V.M.Babenko 1991), which expressed in MTM by following thermins: ". . . in young age prevailes "Badgan" which ensures the maturity of body. . . ". In middle age on whole organism's membrane structure predominated alpha - state of MS (unsaturated fatty acids) by enzymatic and endocrinic mechanisms (L.N.Bogatskaj 1990, N.M.Babenko 1991), which creates the precondition of more activation of all membrane binding enzymes such as: adenylatcyclase, cyclic AMP, Na +, K +, Ca + -ATP-ase and many all receptors (D.F.Chebotarev 1990). Such changes of all organism's membrane-redoxy potentials 3 state line system, which occured in human middle age served the reason of appearance of Traditional medicine's theory ". . . middle age, when Mkhris is dominated, strength and complexion of organism are increased . . . ". In duration of ageing in MS of all organisms is increased the intensity of process of lipid free radical pereoxidation (with involvement of unsaturated fatty acids) of a-state of MS and exhausted antioxidants supplies, which is accompanied with replacing of alpha state of MS with oxidation, thermogenic activity by gamma state of MS with low redoxy potential based accumulative, reduction and oxidation activity. Such ageing changes within all organism's membrane - redoxy potentials 3 state line system leads to decrease the activity of whole organism's enzymes and thermogenic, metobolic activity of MS (Y.M.Lopukhin 1983, D.P.Chebotarev 1990). This is concided with the notion of TM ..." in old age the energy, strength and activity of organism are exhausted. . . ". In such way the theory of TM on the ageing process can be express in the framework of the new conception "rlung, mkhris, badgan - membrane structures " as "young age - Badgan-p-state of MS", "middle age Mkhris a -state of MS", " old age rlung y - state of MS". In the result of such explanation of theory of MTM on age depending changes Badgan Mkhris - rlung according to our new suggestion of " rlung, Mkhris, Badgan membrane redoxy potentials 3 state line system", we suggested the new principle of prevention of early ageing process, which essence of directed to protection of fluid a-state of all organism's MS from lipid pereoxidation process by using " unsaturated fatty acids+antioxidants" and removing the toxic lipid pereoxidation products and limiting the peredominance of gamma state of MS with low redoxy potential based accumulative, reduction and oxidation activity i.e by prevention of transferring the abstract mkhris - coded middle age to the abstract rlung coded old age . The experimental investigation, conducted by us shows that the new antiageing preparation obtained from some plants, used in TM is increased the life duration of experimental animals by inhibition of lipid pereoxidation process.
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THE THEORY OF TIBETAN-MONGOLIAN TRADITIONAL MEDICINE ON THE TASTE, POWER, QUALITY OF MEDICAMENTS AND all organism's membrane - redoxy potentials 3 state line system. One of many interesting theoretical problems of TMTM, which philosophical and scientific essence can be interpreted in the framework of the new conception "rlung, Mkhris, Badgan- membrane-redoxy potentials 3 state line system "is the theory about taste, power, quality of Medicaments. In this connection we are putting the goals to clarify the following questions: l. What are taste, power, quality of Medicaments, how understand these specific thermins and notions of Traditional Medicine from viewpoint of Recent Biology and Medicine. 2. What kinds of difference and similarity are existed in the theoretical notions of Traditional Medicine and Recent Medicine in regarding to the structure, action, usage of some Medicaments. What are taste, power, quality of medicaments Despite in the Universe there are many medicaments of plant, animal, mineral origin, and medicinal raw materials, which number would be estimated (counted) by several thousands, the latter according to theory of TM in generally classified in to 6 tastes: as sweet, sour, salty, bitter, hot and astringent and divided to 8 power: as heaviness, oiliness, coolness, softening, lightness, roughness, heat, acridity, to 17 qualities as: gentleness, heaviness, warmth, oiliness, firmness, coolness, softening, coldness, pliability, fluids, dryness, fatlessness, heat, lightness, acridity, roughness, motility. Besides, in generally all Medicaments of various origin classified in to three many groups as "rlung regulating", "Mkhris regulating", "Badgan regulating". The medicinal plants, animals, minerals, which have had the sweet, sour, salty, hot tastes formed by combination of two elements as "sweet taste=earth+water elements", "sour taste=earth+fire elements", "salty taste= fire+water elements", "hot taste^fire+air (rlung) elements" possessed the activity to decrease "rlung" i.e the heavy, firm (strong), oily, hot quality of "earth", "fire" elements had exerted the action to decrease (inhibit) the light, motile, cool, strong characteristics of "rlung".
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Picture 10 The membrane redoxy potential 3 state mechanism of the theory of TMTM on taste, power, quality of Medicaments
The universe
Medicaments
Healthy human body
External signs
External signs The balance of general characteristics of rlung, Mkhris, badgan Power of medicaments Diseas
The disturbance of balance between 5 elements inside human body
Taste
The interaction between five elements of medicaments and human body
External signs
The appearance of quality of medicaments by normalisation of general characteristics of rlung, mkhris, badgan associated with normalisation in membraneredoxy 3 state system.
External signs
The appearance of quality of medicaments by normalisation of general characteristics of rlung, mkhris, badgan associated with normalisation in membrane-redoxy 3 state system.
Fire element Rlung Rlung
Earth Water
Medicaments, possessing bitter (water + air), sweet (water + earth), astringent (earth + air) tastes exhibited the activity to decrease the general characteristics of "Mkhris", which theoretical basis had been explained by these lawfull rules that cold, stupid, heavy, fluid, unoily quality of earth and water elements exerted the action to decrease the hot, acrid, oilly, light general characteristics of Mkhris. Meanwhile, medicaments of plant, animal and minerals origin, possessing the hot (fire + air), salty (fire + water), sour (fire + earth) tastes had possibilty to decrease the "Badgan", because the hot, acrid, light, rough quality of "fire" element had exhibited the action to decrease the cold, stupid, heavy, smooth general characteristics of the "Badgan". From all above mentioned, it would be clear that the general characteristics of the rlung, Badgan and Mkhris and the quality, power of medicaments has been appeared in the level of similar, unique matcriall substances existing inside of human body i.e the quality of medicaments appeared outside of human body as change of general characteristics of rlung, Mkhris, Badgan. What is taste of Medicaments In the result of conducting the comparative theoretical analysis by using the new methodological approach "substance - external properties - abstraction" we came to conclusion that "taste of medicaments" is abstract notion, which demonstrated the existence (availability) of concrete chemical
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structure in Medicaments of various origin (plant, animal, minerals), which after binding, acting (interaction) with biomolecules, bioreceptors existed in plasmic membranes of cells of human body can cause the specific biologocal effect, action. The notion of "power of medicaments" of TM means the specific interaction between of five elements existing inside of human body and five elements, contained in Medicinal plants, animals, minerals, i.e according to theory of Recent Biology and Medicine the notion of power of Medicaments shows the interaction between concrete chemical structures of medicaments and specific chemical structure of Bioreceptors, biomolecules, enzymes, located in plasmic membranes inside of human body (Picture N 1 1 ) . Meanwhile, the notion "quality of Medicaments" demonstrated how externally appeared the interaction occurred between five elements of medicaments and five elements of human, body (interaction between chemical structure of medicaments and bioreceptors chemical structure according to the theory of Recent Biology occurred in molecular, submolecular levels inside of human body) through change of general characteristics of rlung, Mkhris, Badgan i.e according to the theory of Recent Biology and Medicine the notion "quality of medicaments" shows, how appeared the normalisation of pathologically changed signs of Disease in the result of "substance-receptor" interaction, occurred inside of human body. In the otherwise, can be say that it is not possible to directly recognize the "power" of medicaments outside of human body, only we have possibility to reveal this through the appearance of quality of medicaments and through the change of general characteristics of rlung, Mkhris, Badgan. In such way if apply the new methodological approach "Substance -> external patterns - abstraction" in the comparative study of theoretical expressions of TMTM on the taste, power, quality of medicaments it was became clear that the taste, power, quality of Medicaments are various sites of one process, which occurred around the one "essence" i.e the notion "taste" demonstrated the existence of concrete chemical structure in medicaments, possessing the activity to interact with bioreceptors and cause the pharmacological effect, while the notion "power of medicaments" shows the interaction of chemical structures of medicaments with bioreceptors, causing the specific pharmacological effect inside of human body in the level of hidden material, biological substance, the notion "quality of Medicaments" exhibits that how such pharmacological effect, carried out in hidden, secretly, substance level inside of human body externally appeared outside human body as change of "external patterns" of rlung, Mkhris, Badgan. In this connection raised the question-what kind of hidden, materiall, biological substance conditioned the appearance of the notion of "power and quality of medicaments" (Picture N 11). How shows the abovementioned theoretical comparative analysis, the this biological substance, which conditioned the appearance of general charactcristucs of rlung, Mkhris, Badgan, simultaneously, should be the structure, where carried out the process,leading to the appearance of the notion "quality" and "power of medicaments". In the result of conducting the comparative theoretical investigation by using the new conception "rlung, mkhris badganmembrane - redoxy potentials 3 state line system" we are revealed that the membrane structure, their basic three states (alpha state with high oxidation activity , betta state with high reduction activity, gamma state with low reduction, oxidation activity) can be play the role of such Material, Biological substance, which1 leads to appearance of general characteristics of rlung, Mkhris, Badgan and also, conditioned the appearance of notion about "power", "quality" of medicinal plants, animals, minerals. THE PULSEDIAGNOSTIC METHOD OF ORIENTAL MEDICINE AND membrane-redoxy potentials 3 state line system Pulsediagnosis is more important, because it in somr concrete case clearly shows the type of disease present in the human body, but in order to maintain a calm and continuous nondisturbed harmony of the
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rlung, mkhris, Badgan, the most attention should be paid to time, place, precondition of conducting the pulsediagnostic method. Observances to be followed by the patient so that pulse can be ascertained. A.Intake of overly nutrititions food such as meat or wine should be eliminated on the day or prior to pulse reading. B.No overeating C.No fasting D.No sexual intercourse E.No sleeplessness, no overtalking No observance of the above criteria may result in confusion. The pulse reading is to be performed in the early morning In the famous books, writting by Darmu naaramba Luvsanchoidog (1690) had been emphasized the time for taking of the pulse as, when "the sun has risen but the rays have not fallen on the mountain top". It is pre-dawn, when warm breath is neither exhaled in large quantity nor is cold air inhaled. If the pulse taken before this time stage the power of the moon (cooling or yin) is stronger and the pulse is mistaken for rlung and Badgan (phlegm). If pulse taken after this stage the heat of the sun (hot and yang) will make the pulse appear like a Mkhris (hot, blood) disorder (Yeshe Donden 1980). In this connection, has been raised the question, what kind of hidden, materiall, biological substance, existing inside human body conditioned the really external appearances of pulse and influenced by abovementioned psychological, behavorial factors and "day-night shift", food, which oftenly leads to distort the right, really appearance of pulse. By using the new methdological approach "Substance - external - patterns -> Abstraction " we proposed that this kind of Material substances should be possess the following attributes (attribute quality): 1. It influenced by human constitution type, food, age, emotion, circiad biorhytm, hot - cold temperature, all these leads to appearance either Mkhris, or rlung, badgan character of pulse. 2. 1t exerted the direct effect (influence) on the regulation of proton leak, proton conductance speed, donators utilization, acceptor delivery symphatic - parasymaphatic nervous system, adreno cholinoreceptors, activity of adenylatcylclase - cholinoesterase enzymes activity within all organism's membrane - redoxy potentials 3 state line system, actin-myosin interaction, Na, K, Ca ion channels of smooth muscles of vessels wall, aggregation - desaggregation system, blood viscosity and fluidity, which in Recent Biology and Medical science considered as main factors of pulse regulation. Our new conception "rlung, Mkhris, Badgan- membrane - redoxy potentials 3 state line system " gives the possibility to say that the membrane-redoxy potentials 3 state line ,localized in the membrane structure of smooth muscles cells (SMC) of vessel wall and cardiomyocytes can be play the role of such material, biological substances, because it possessed the above mentioned attributes. Besides, it may be that the before pre-dawn increase of solid betta state of membrane structure with high reduction activity according to normal circaid biorhytm leads to activation of parasymphatic nervous system - cholinoreceptors and appearance of cold-badgan character of pulse, while the after predawn increase of fluid alpha state of MS with high oxidation activity normal circaid biorhythm is accompanied with activation of symphatic nervous system adrenoreceptors and appearance of Hot-Mkhris character of pulse.
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Picture 11
1. (++) The normal level of Basic three states of membrane-redoxy 3 state system. 2. (1+ 2+ 3+ 4) The basic points of the occurrence of solid phase transition in membrane-redoxy 3 state system. 3. (1+ 2+ 3+ 4) The basic points of the occurrence of fluid phase transition in membrane-redoxy 3 state system. 4. (6, 7, 8, 9) The appearance of various variants of Hot pulse 5. (4, 3, 2, 1) The appearance of various variants of Cold pulse 6. (5) The appearance of healthy pulse Ratio of saturated: unsaturated fatty acids (%)
The relationship between the solid-fluid phase transition in membrane-redoxy 3 state system.
The theory of Mongolian Traditional Medicine on the hot and Cold character of pulse and membraneredoxy potentials 3 state line system It should be emphasize that the secrecy (art) of establishing the right diagnosis laid to differentiate the three types of pulse as "healthy", "hot pathological", "cold pathological". The pulse in health and disease can be determined by the rate, nature and volume of the pulse. In general the normal pulse rate is 5 times for each respiratory cycle. During inhalation, earth and water pulse beats twice. In between inhalation and exhalation on pulse beat from metal element ensues. Exhalation incorporates pulse beat from the fire and wood elements.
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In general if there is greater than 5 beats per respiratory cycle this disorder is termed a hot disorder. More specifically, in hot disorder, 6 pulse beats per respiratory circle denote a minor hot (fever), 7 to 8 a moderate hot (fever) and 9 or more (over coming the hot high points). If there are less than 5 beats per respiratory circle, the disorder is termed cold. In a cold disorder 4 pulse beats per respiratory cycles denote a minor cold illness. 2 to 3 denote a moderate cold disease and 1 or less (over coming the cold low points) denotes a severe disorder. In the framework of the new conception "rlung, Mkhris, Badgan- membrane-redoxy potential 3 state line system has been established that the scientific essence of distinguishing the healthy and cold, hot pathological pulses by conducting the pulse diagnostic methods can be explained by maintenance of normal equilibrium (balance) between alpha, betta,gamma states of MS and also induction of liquid-fluid phase transition in the MS with high reduction activity and solid phase transition in the MS with high reduction activity under pathological factors. Picture 13 The relationship between the solid-fluid phase transition in MS and the normal, pathological pulse appearance In the healthy person has been established the balanced equilibrium between alpha, betta, gamma states of membrane structure and in such way, inhibited the excessive pathological increase and decrease of three basic states by "alpha - betta - gamma" membrane state based mechanism which accompanied with normalization of the activity of membrane binding receptors, enzymes, hormones, symphatic parasymphatic nervous system, adreno - cholinoreceptor activity, all the these processes resulted to externally appearance of healthy normal pulse signs. It was interesting that how shown in the picture N 13 under figure (5), "(betta " points of MS may be expressed in the theory of MTM as "inhalation - cold air - solid state of MS - earth, water pulse beats", "gamma" point of MS determined in the theory of MTM as "between inhalation and iexhalation - Normal temperature air-metal pulse beats", "alpha " points of MS expressed in the theory of MTM as "exhalation - hot air - fluid state of MS - fire, wood elements pulse beats". But can be say that in Mkhris dominated persons, age, in Mkhris increased summer season, using Medicaments, foods which contributed to increase the general characteristics of Mkhris has been induced the fluid phase transition of MS by following subsequent points showed in figure as 6. 7. 8. 9. The such fluidphase transition, occurred in membrane structures accompanied with abruptly increase of activity of Adenylatcyclase enzyme, adrenoreceptors, pulse beating Rate, pulse tension, which externally characterized as minor hot, hot, moderate hot, overcoming the hot boundary pulses i.e. 6 point of fluid phase transition corresponds to hot pulse, 7 point corresponds to minor hot pulse, 8 point to moderate hot pulse, 9 point - to exclusive hot pulse (overcoming the hot boundary). It should be say that 6, 7, 8 points of alpha fluid phase transition of MS would taken place in the frame of normal adaptive reaction, but reaching the fluid phase transition in 9-point of MS leads to irreversible membrane fluidization, resulting to sharply loss of activity of all the membrane binding receptors enzymes, biological active compounds, at last to death.
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The membrane-redoxy potential lever mechanism of appearance of normal healthy pulse in spring season according to clockwise rules Picture 12
The appearance of specific for liver pulse as taut, fast
Normal clockwise rules
Increase of resistance of MS to action of pathogenic factors
Stabilization of MS of hepatocytes
The lever mechanism of the betta state of membrane redoxy potential 3 state system Increase of viscosity of MS of lung cells
Decrease of adrenoreceptors activity and oxygen diffusion
Comparative inhibition of functional activity of lung The limitation of appearance specific for lung pulse as sharply, rough
Concretely speaking can be say that: 1. 6 pulse beats per respiratory circle denote a minor hot (fever) corresponds to about 10-15 % increase of alpha state - increase of oxidation reaction speed - increase of proton conductance - increase of proton leak- increase of acceptor delivery with following increase of donator utilization- increase of metabolism rateincrease of pulse frequency - increase of arteial pressure - increase of breathing frequency - increase of proton gradient expenditure to heat formation , all these occurred within all organism's membrane - redoxy potentials 3 state line system, 2. 7 to 8 a moderate hot (fever) and 9 or more (over coming the hot high points) pulse beats per respiratory circle denote a minor hot (fever) corresponds to about 20-25 % increase of alpha state increase of oxidation reaction speed - increase of proton conductance - increase of proton leak - increase of acceptor delivery - with following increase of donator utilization- increase of metabolism rateincrease of pulse frequency - increase of arteial pressure - increase of breathing frequency - increase of proton gradient expenditure to heat formation, all these occurred within all organism's membrane redoxy potentials 3 state line system, 3. 9 or more (over coming the hot high points) pulse beats per respiratory circle denote a minor hot (fever) corresponds to about 30-35 % increase of alpha state - increase of oxidation reaction speed increase of proton conductance - increase of proton leak - increase of acceptor delivery - with following increase of donator utilization - increase of metabolism rate - increase of pulse frequency - increase of arteial pressure- increase of breathing frequency - increase of proton gradient expenditure to heat formation, all these occurred within all organism's membrane - redoxy potentials 3 state line system, Contrary to this, in Badgan - dominated person, age (spring) and excessive using the medicaments, foods, possessing Cold, heavy, stupid, oily property, power, quality resulted to occurrence of solid phase transition of MS by following subsequent points as 4, 3, 2, 1 (figure N 13).
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The solid phase transition, occurred in MS Leads to suddenly activation of acetylcholinesterase, cholinoreceptors and decrease of pulse tension, pulse beating Rate, which externally characterized as minor cold, cold, moderate cold, excessive cold (over coming the cold boundary) pulses. During our comparative theoretical analysis it was became clear that 4, 3, 2 points of solid phase transition (SPT) would be carried out in the frame of Normal adaptive response reaction, but SPT occurred in 1 point had accompanied with completely solidization of MS, the latter leads to abruptly increase of viscosity of membrane structures and inactivation of all membrane binding enzymes, receptors, resulting sometimes to death of patients. It may be say that: 1. 4 pulse beats per respiratory cycles denote a minor cold illness corresponds to about 10-15 % decrease of alpha state - increase of betta state of MS- decrease of oxidation reaction speed - decrease of proton conductance-increase of proton leak- decrease of acceptor delivery - with following decrease of donator utilization- decrease of metabolism rate - increase of pulse frequency - decrease of arteial pressure - decrease of breathing frequency - decrease of proton gradient expenditure to heat formation , all these occurred within all organism's membrane - redoxy potentials 3 state line system. 2. 2 to 3 denote a moderate cold disease corresponds to about 10 - 15 % decrease of alpha state increase of betta state of MS - decrease of oxidation reaction speed - decrease of proton conductanceincrease of proton leak - decrease of acceptor delivery - with following decrease of donator utilization decrease of metabolism rate - increase of pulse frequency - decrease of arteial pressure - decrease of breathing frequency - decrease of proton gradient expenditure to heat formation, all these occurred within all organism's membrane-redoxy potentials 3 state line system. 3. 1 or less (over coming the cold low points) denotes a severe disorder corresponds to about 10-15 % decrease of alpha state - increase of betta state of MS - decrease of oxidation reaction speed - decrease of proton conductance - increase of proton leak - decrease of acceptor delivery - with following decrease of donator utilization - decrease of metabolism rate - increase of pulse frequency - decrease of arteial pressure - decrease of breathing frequency - decrease of proton gradient expenditure to heat formation, all these occurred within all organism's membrane - redoxy potentials 3 state line system. Our suggestion, regarding to the existence of close coincidence as "alpha state of MS - hot character of pulse" has been confirmed by results of our joint investigation, during which we are established thai in Mkhris - dominated persons the increase of fluid state of MS (as increase of lipid pereoxidation products: cholesterol ratio) leads to appearance of hot pulse as: increase of pulse beating rate, systolic arterial pressure, and vessels peripheral resistance, while in Badgan - dominated persons the prevalence of solid betta state of MS (as decrease of lipid pereoxidation products: cholesterol ratio) are accompanied with manifestation of cold character of pulse as: decrease of pulse beating rate, systolic arterial pressure and vessels peripheral resistance (M.Ambaga, Sh.Bold, B.Saranstetseg 1998). The membrane - redoxy potentials 3 state line system based mechanism of Season depending change of pulse character The normal pulse appearance in spring season During spring the wood element is most influential and liver pulse becomes most active so a normal pulse becomes under the influence of the liver or wood element, which characterized as tense , taut or fast during the spring time. If during this spring the pulse of spleen, kidney, heart (friend, mother, son of wood element) arc also found to be taut and fast the disease of patients easily subjected to recovery. Meanwhile the enemy of wood element is metal, which is associated with the lung, if in the spring the lung pulse is not strong and not gives own character of pulse, his mission will be successful. The membrane - redoxy potentials 3 state line system based mechanism of normal pulse appearance (NPA) in spring season
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Season depending increase of betta solid state in the whole organism's membrane structure in spring season leads to decrease of excessive damage of MS of hepatocytes by betta - alpha mechanism, resulting to appearance of specific for liver pulse as: tense and taut, fast. Simultaneously, increase of betta state of MS in whole organisms level in spring season is accompanied with increase of solid betta state in lung cells membrane structure, resulting to activation of adrenoreceptors, bronchospasm, increase of tension of Bronchial smooth muscles, decrease of Surfactant synthesis and oxygen diffusion, which at last leads to depression of specific for lung pulse as sharply. rough (Picture N 14). In such way, the lung cells functional activity, oxygen diffusion, generation of toxic oxygen active forms (0'2, HO', O) in spring under influence of dominated in this time betta state of MS has been limited, prevented the damage of hepatocytes MS by lipid pereoxidation mechanism i. e limited the dangerous effect from enemy organ-lung to liver, which expressed in the theory of Traditional Medicine as "friendenemy" relationship between lung and liver in spring time. The disturbance of normal membrane-redoxy potential 3 state lever mechanism of appearance of healthy pulse in spring season Picture 13
The appearance specific for lung pulse as sharply, rough Excessive formation of oxygen reactive radicals in lung cell membrane Decrease of Adrenoreceptors activity in lung cell membrane
Pathological counter clockwise rules
The disturbance of lever mechanism of betta state and red potentials in membrane-redoxy potential 3 state system because of deficiency of Antioxidant system and pathological increase of alpha state of membrane structure
The damage of MS of hepatocytes by lipid pereoxidation mechanism The disturbance of Normal pulse appearance of liver
The disturbance of normal pulse appearance (DNPA) in spring season According to the theory of Tibetan-Mongolian Traditional Medicine "... If the lung pulse is found to be taunt and fast in spring time the patient, who exhibits this pulse will face disease because is occurred the antagonism from enemy organ-lung to liver organ". The membrane-redoxy potentials 3 state line system based mechanism of DNPA in spring season If in the spring season disturbed the "lever" mechanism of whole organisms solid betta state of membrane structures, which acted by clock-wise rules, how shown in the picture N10, by which the solid, betta state of MS is exerted the limitation effect in attitude to lung cells and to appearance of specific for lung
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pulse as sharpy, rough i.e the disturbance of regulatory function of betta state of MSin the spring season, the defect of lever mechanism of Betta state, appeared in the from of counter clockwise rules leads to decrease of the activation of adrenoreceptors, excessive oxygen diffusion and generation of toxic oxygen active forms (O2, O, H2O2, HO) within membrane-redoxy potentials 3 state line system, existed in lung, which is accompanied with intensive damage of cell membranes of hepatocytes and exhaustion of antioxdant defensive system: all these processes may be expressed in the theory of Tibetion-Mongolian Traditional Medicine as: . . .if in the spring had been appeared specific for lung pulse as sharply, rough is created the precondition of provocation of liver disease (Picture N 15). The normal pulse appearance in autumn season During autumn the metal element is most influential, Lung reverals his specific pulse as sharply, rough. In this connection, his mother organ-spleen gives smooth, short puls, son organ-kidney gives slow, smooth character of pulse, friend organ-liver shows thin, intense pulse, and his enemy organ-heart not exhibits specific for him pulse as thick, long: these all has demonstrated that human body is existed in the normal healthy state. The membrane-redoxy potentials 3 state line system related mechanism of NPA in autumn season The season depending increase of fluid alpha state of MS in whole organisms membrane-redoxy potentials 3 state line system playing the role of lever mechanism in autumn time is resulted to decrease of viscosity of MS of lung cells, activation of adrenoreceptors, increase of surfactant synthesis and oxygen diffusion, which are externally leaded to the appearance of specific for lung pulses as: sharply and rough (Picture 14)
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THE NORMAL PULSE APPEARANCE IN AUTUMN SEASON BY LEVER MECHANISM DUE TO FLUID ALPHA STATE AND OXY POTENTIALS OF MEMRANE-REDOXY 3 STATE SYSTEM Picture 14

The appearance of specific for lung pulse as sharpy, rough The increase of surfactaut synthesis and oxygen diffusion The activation of adrenoreceptors of lung The increase of viscocity of membrane structures of lung
Normal clockwise rules
The lever mechanism of fluid alpha state and oxy potentials in the membrane-redoxy 3 state system
The disturbance of NPA in autumn season
The normalizati on of excitability and contraction of cardiomyoc ytes The relatively depresson of specific for lung pulse as thick, long
Judging by the theory of TMTM in autumn time, if the heart pulse is found to be thick and long, the patient, who exhibits this pulse will face disease because is occurred the antagonism from enemy organ-heart to organ-lung. The membrane-redoxy potentials 3 state line system based mechanism of DNPA in autumn season If in the autumn time, has been disturbed the "lever" mechanism of whole organisms fluid alpha state of MS and antioxidation defense system, by which ensured the normal morpho - functional relationship between lung and heart (enemy organ to lung) according to "clock wise" rules, all these processes are resulted to loss of the normal excitability - contractility of heart cells i.e excessive excitability of cardyomyocytes has been accompanied with increase of detergent toxic lipid pereoxidation products, originated from heart cells membranes, and exhaustion of Antioxidant defense systems, uncoupling of the oxygen delivery and consumption, which at last resulted to damage of lung cells membranes, leading to disease (Picture N 17). Besides, it is raised the question: through what kind of material substances has been occurred the process of transferring the information about the normal and pathological state of functional activity of all solid and hollow organs,internally existing in various places of Human body by the appearance of "normal", "cold", "hot" character of pulse in arteria radialis, externally.
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In the result of conducting the many series of experimental works by us established that the lipid metabolites, released from membrane structure of corresponding solid, hollow organs bringing in it's molecule, such vasoactive substances (molecules) as adrenalin, serotonin, acethylcholin, endothelin, bradikinin, making the ciralation by following path as: "target organ - blood serum - incorporation to membrane structure of smooth muscle's cell (SMC) of vessel's wall leads to change of Ca2++ ton permeability in sarcoplasmatic reticulum - change of interaction between action myosin - change of contraction of vessel's wall and the appearance of the normal, cold, hot character of pulse i.e. increase of lipid pereoxidation products 'and ratio of LPP/cholestrol in the lipid metabolites, released from MS of varions organs leads to increase of fluid alpha state in MS of SMC and Ca2++ ion permeability -intensification of "actin - myosin interaction", contraction - the appearance of hot character of pulse, meanwhile, decrease of lipid pereoxidation products /LPP/ and the ratio of LPP/cholesterol in the lipid metabolites resulted to increase of solid betta state in MS of SMC - increase the Ca2++ ton permeability-slowing of the "actin - myosin interaction", decrease of contraction of vessel's wall - the appearance of cold character of pulse (Picture 15) THE DISTURBANCE OF NORMAL MEMBRANE-REDOXY POTENTIAL 3 STATE DEPENDENT LEVERMECHANISM OF APPEARANCE OF HEALTHY PULSE IN AUTUMN SEASON Picture 15
Pathological counter clockwise rules
The disturbance of lever mechanism of membrane fluid alpha state and oxy potential regulation because of the deficiency of antioxidant system
The appearance of specific for heart pulse as thick, long The disturbance of excitability and contraction of cardiomyocytes The increase of Detergent toxic lipid pereoxidation products in cardiomyocytes membrane
The damage of MS of lung organ by toxic, detergent lipid pereoxidation products, originated in the membrane-redoxy 3 state system of cardiomyocytes Increase of the viscosity of MS of lung cells Decrease of adrenoreceptors activity of lung cells membraneredoxy 3 state system
Decrease of lung cells

functional limitation activity of and the
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THE PATHWAY OF TRANSFORMING THE PULSEDIAGNOSTTC INFORMATION THROUGH LIPID METABOLITES OF MEMBRANE ORIGIN
The lipid metabolites of membrane origin of solid organs Blood circulation Ca2++ permeabilityi in the MS of sarcoplasmatic reticulum actin-myosin interaction change of contractibiliry of smooth muscles of vessel's wall The appearance of various forms (the normal, hot and cold character) of pulse The membrane mechanism of Blood letting therapy and blood purifying medicaments The method of bloodletting practiced in three ways: 1.By puncturing the blood vessel 2.By sucking with the aid of a copper bowl, also known as cupping 3.By sucking with the aid of bulls horn Blood letting is allowed in cases of all kinds of ailments of the fever, blood and Mkhris disease, red sores caused by the presence of impure blood in the liver, coagulation of blood and lymph (fluid). The treatment of Blood letting is prohibited in ailments caused by the psychotic action, deficiency of body constituents, pregnancy, postnatal period, chronic diseases in a state of passivity, deficiency in digestive fire. It is strictly avoided in case caused by the disorder of rlung and Badgan. The new conception on the membrane-redoxy potentials 3 state line system related mechanism of Blood letting therapy According to the our new conception, impure blood (according to theory of Traditional Medicine) is one of parts of circulated blood, formed due to various pathology of all the solid organs, consisting of form elements such as, erythrocytes, lymphocytes, macrophages , subjected to the following pathological changes as: 1. During hot (fever) disease (according to theory of Traditional Medicine) paralled with increase of alpha state of membrane structures, accompanied with a increase of oxidation reaction speed, elevation of proton conductance, increase of proton leak, increase of acceptor oxygen molecular concentrations, elevation of donator utilization process, increase of metabolism rate, increase of pulse frequency, increase of arterial pressure, increase of breathing frequency, increase of proton gradient expenditure to heat formation, all these processes occured within all organism's membrane - redoxy potentials 3 state line system lead to that in a membrane structures of erythrocytes has been accumulated the more quantity of toxic lipid pereoxidation products and their free movement limited, became slowly and aggregated.
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2. Owing to above mentioned pathological changes the erythrocytes and another form elements have been acquired "immunosuppression" activity and also exerted the hepatotoxic, cardiatoxic and nephrotoxic action. 3. In such way, during various disease of all the solid organs has been formed the three cell population of erythrocytes in comparison with healthy state such as the population of normal erythrocytes with a normal membrane - redoxy potentials 3 state line system, the population of erythrocytes which membrane-redoxy potentials 3 state line system subjected to reversible damage process, the population of erythrocytes which membrane-redoxy potentials 3 state line system subjected to unreversible damage process, acquiring the character of "impure blood" according to theory of Traditioal medicine.
THE membrane - redoxy potentials 3 state line system related MECHANISM OF BLOODING THERAPY Picture 16
Before bloodletting therapy
After bloodletting therapy
The population of erythrocytes, which membrane-redoxy potential 3 state system subjected to unreversible damage process
The population of erythrocytes, which membrane structure subjected to reversible damage process, so named impure blood
The population of erythrocytes
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The population of erythrocytes, which membrane - redoxy potentials 3 state line system subjected to unreversible damage process The population of erythrocytes, which membrane-redoxy potentials 3 state line system subjected to reversible damage process, taking a character of so named "impure blood" The population of normal erythrocytes with a normal membrane - redoxy potentials 3 state line system In the case of not using, applying the appropriate treatment, including the blood letting therapy, blood purifying medicaments the last two population of erythrocytes has been gradually increased and the population of normal erythrocytes had subjected to lipid pereoxidation process, damaged, and converted to the population of irreversible with a character of "impure blood" and reversible damaged erythrocytes, acquiring the "immunosuppressive" activity. It can be say that under the direct of blood letting therapy and blood purifying medicaments has been removed from the human body the population of irreversible damaged by lipid pereoxidation process population of erythrocytes, not losing the population of erythrocytes, which may be converted from reversible damaged to irreversible damaged population i. e in the case of appropriate use of blood letting therapy, blood purifying medicaments during various disease of all the solid organs has been occurred the transition from three cells population (normal, reversible, irreversible) to two cells population (normal and irreversible damaged) by ensuring the sanogenetic transform of irreversible damaged population to population of normal erythrocytes with removing this population of erythrocytes, possessing immunosuppressive, organotoxic activity (Picture N 18). The experimental confirmation of the our conception In the result of experimental research works conducted in rats, mice with experimental model of "acute hepatite" induced by CCL4 (40% oil olution in dose 40%-0.5ml/kg) we are revealed that: a. The blood letting therapy, the blood purifying medicament and lheir combined use has been possessed the hepatoprotective action, which appeared in the form of decreasing the serum concentration of alat, aspartatransferase, gamma-glutamyltransferase enzymes b. The hepatoprotective action of blood letting therapy, blood purifying medicaments and their combined use has been accompanied with remarkable decrease of the concentration of toxic lipid pereoxidation products in erythrocyte membranes c. The sanogenetic process of decreasing the lipid pereoxidation products in erythrocyte membrane under direct of blood letting therapy, blood purifying medicaments and their combination resulted to intensification of immune response reaction i. e the intraperitoneal administration (injection) of erythrocyte cells, obtained from "donor" animals (rats, mice) with "acute hepatite" model, treated by blood letting therapy and blood purifying medicaments to recipient animals leads to 1.3-1.4 fold increase of antibody formation, quality of immunocytes and 1.2-1,4 fold decrease of the concentration of lipid pereoxidation products in erythrocytes membrane structures in comparison with recipient animals, received the erythrocyte population from untreated control animals. In such way the results of our investigation has been demonstrated that the membrane mechanism of treatment efficacy of blood letting therapy and blood purifying medicaments may be explained by removing, eliminating from the human body and decreasing the irreversible and reversible damaged by lipid pereoxidaation erythrocytes, lymphocytes possessing the organotoxic, immunosuppressive activity under their direct effect. Pharmacological aspects of the new conception "rlung, Mkhris, Badgan membrane - redoxy potentials 3 state line system. According to the theory of Tibetan Mongolian-Traditional Medicine "... liver, as mkhris /hot/ dominated organ is served the role of residence of general mkhris, and also is existed in the place of healthy and pathologically changed mkhris. In this connection, because of place, liver disease always has been
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provoked in the background of hot disease, conditioned by excessive hot mkhris and blood . . . ". Also, most attention should be paid to such interesting theoretical expressions of TMTM as: "... the reason of mkhris dominated hot disease of liver is the normally healthy existed Mkhris . . . ". Undoubtely, raised the question in regarding to how explain thisabovementioned theoretical expression of TMTM, relating to reason of liver disease in the basis of the new conception "rlung. Mkhris, Badganmembrane-redoxy potentials 3 state line system". In the result of conducting by us the more detailed scientific investigation in the framework of the new conception "rlung. Mkhris, liadgan membrane - redoxy potentials 3 state line system." has been revealed that, in comparison with other solid organs, in the membrane structure of hepatocytes prevailed the fluid alpha state i. e during evolution development of living organism had been formed such lawfull process that all the membrane structure, which existed in hepatocytes had created by low viscous, cis configuration, ensuring the high activity of thermogenesis, membrane binding receptors, "receptorhormon", "enzyme-substrate" interaction, besides, such fluid alpha state, cis-configuration of MS, performing, ensuring the high functional activity of liver cells easily subjected to lipd pereoxidation process, resulting to cytolysis i.e it may be say that the prevailence of fluid alpha state of MS in hepatocytes had the two basic sanogenetic and pathogenetic consequences: at first created the precondition for activation of all membrane binding molecules and receptors, thermogenesis, enzymes, at second conditioned the easy susceptibility of hepatocytes membrane structure to harmfull action of pathogenetic factors, resulting to the hot mkhris disease of liver. Therefore, according to existence of close coincidence, which appeared as "alpha state of MS - general characteristics of Mkhris" it was became clear that the scientific essence of the theory of TMTM about that ". . . the healthy existed Mkhris is the main reason of hot, mkhris disease of liver ..." should be explained by these facts, that which may be express in (he following ways as " . . . the normally existed fluid alpha state of MS with high oxidation activity of hepatocytes (according to the theory of MTM the normal Mkhris of liver), except playng the role for activation of hepatocytes, increase of deficiency of antioxidant defense system easily subjected to pathological factors, becoming the reason of disease. Such our suggestion and conclusion has been confirmed by the results of our following research works: l. In liver cells the intensity of lipid pereoxidation process, which provocated due to fluid alpha state, cisconfiguration of MS with high oxidation activity was in 1.2-7.5 times high than other solid organs. 2. The intensity of induction of lipid pereoxidation process under the prooxidant action of CCL4 was 1.64-4.21 times high than other solid organs by concentration of deprotonized MDA, DK and shiff base (P<0.05) products . 3. The intensity of provocation of lipid pereoxidation process in MS of liver cells under toxic action of CCL4 was in 1.6-1.8 times high in the case of artificial induction of predominance of fluid alpha state by using the unsaturated phospholipids than induction of solid betta state of MS by using the saturated phospholipids and cholesterol. In such way, the results of above mentioned experimental works and the new conception "rlung. Mkhris, Badgan membrane - redoxy potentials 3 state line system" and the tradition of using of Medicaments, possessing bitter taste, cool, stupid, cold power, quality for treatment of liver hot disease in TMTM gives the ground to use the medicinal plants, which possessed antioxidant, membranestabilitizing, fluid alpha state-limiting capacity and also trans - configuration containing compounds, which increased the solid betta state of MS of hepatocytes for treatment of acute form of liver disease. In this regard, by us had been selecting the some plants: as Chiazospermum erectum, Silibum marrianum, Gentianae acuta, Salsola collina for testing their hepatoprotective action. In the result of conducting the experimental research works in the model of acute hepatite, induced in mice, weighting 18-20 gr by undercutaneous injection of 40% CCL4 we are established that:
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a. The sum of alkaloids from Chiazospermum erectum, sum of flavonoids from Lomatogonum rotatum, Silibum marrinum, Gentianae acuta and their combination had been exerted the hepatoprotective action in the form of decreasing the concentration of toxic lipid pereoxidation products in MS of hepatocytes, serum Alat, aspartattransferase activity and inhibiting of excessive unregulated activation of immunoresponce reaction and increasing the intoxication, proteinsynthizing activity of hepatocytes. b. The water and Alcohol (ethanol) extraction of Salsola collina had been possessed the hepatoprotective action by antioxidant, membrane stabilizing, immunocorrecting mechanism, which has been carried out in the background of increasing the solid - betta state in MS of hepatocytes and decreasing the excessive pathological predominance of fluid alpha state of MS. In such way, in the result of establishing their hepatoprotective action we are obtaing the new hepatoprotective preparations "Barbadin", "Silodin", "Salsomon" from Chiazosperum erectum, Gentianae acuta, Lomatogonum rotatum, Silibum marrianum and Salsola collina and introduced in the Medical practice (Picture N 20). The new immunostimulator preparation and the new conception "rlung, Mkhris, Badganmembrane-redoxy potentials 3 state line system. The normal function and specifics of pathological processes of spleen, which 80-90% of cell populations consists of T-lymphocyte, T-helper, T-suppressor, T-effector (killer), B-lymphocytes and Macrophages had been described in the theory of TMTM as: "spleen is one of solid organs, playing the most important role in stomach digestion, because, spleen is existed in the way of circulation and recirculation of healthy badgan and pathologically changed badgan. The disease of spleen is caused by cold badgan. . . " In the result of conducting the research works, directed to explanation of scientific essence of above mentioned theoretical formulations, regarding to spleen function and cause of spleen disease we are revealed the following interesting lawfull phenomenons: a. In the membrane structure of spleenocytes the intensity of lipid pereoxidation process was in 2.3-4.0 times slow than other solid organs i. e it has been prevailed the solid betta state of MS within membrane - redoxy potentials 3 state line system. b. In the case of inducing the two variants of predominance of basic states of MS in the spleenocytes, such as alpha fluid state by administration of unsaturated phospholipids (0.5 ml/kg), betta-solid slate by administration of saturated phospholipids and cholesterol (250 mg/kg), the predominance of alpha fluid state in MS of spleenocytes in autumn season (alpha + alpha states of MS) has been accompanied with 1.36-1.4 fold increase of antibody titer, 1.6-1.7 fold increase of immunocytes in comparison with betta solid state of MS, in spring season (season related increase of betta states) i.e the results of our investigation shows that the increase of solid betta state in MS of spleenocytes under direct effect of saturated fatty acids, cholesterol and sprimg season, low temperature (cold) in the form of (betta + betta + betta) leads to sharply decrease of immune response reaction, which may be expressed in the theory of TMTM ". . . the spleen is subjected to disease and deficience because of cold badgan . .. ". In the result of conducting the experimental research works, which has been directed to establish the immunostimulator activity of Salsola laricifolia, Oxytropis pseudoglandulosae used in TMTM for treatment of various infectious disease and immunodeficience pathology we are revealed that: a. The sum of polysaccharids from Oxytropis pseudoglandulosae and the sum coumarins from Salsola laricifolia had been exerted the immunostimulator action in the two models of predominance of alpha fluid state or betta solid state of MS: as "alpha + alpha + alpha" and "betta + betta + betta" by increasing the antibody titer in 1.2-1.45 times, the quantity of immunocytes in 1.25-1.55 times and decreasing the concentration of lipid pereoxidation products in MS of spleenocytes in 1.3-1.52 times (p<0.05). b. The intensity of immunostimulator activity of Salsola laricifolia and Oxytropis pseudoglandulosae increased in 1.2-1.3 times by the antibody titer, and the quantity of spleenocytes in the case of
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predominance of fluid state of MS ("alpha + alpha + alpha") in comparison with the predominance of betta solid state of MS ("betta + betta + betta") i.e the results of our investigation has been demonstrated that combination use of Salsola laricifolia and Oxytropis pseudoglandulae with unsaturated fatty acids -main modificator of fluid alpha state of MS leads to magnification of their immunostimulator activity, which gives the possibility to explain the scientific essence of theoretical expressions of TMTM as ". . . warm, oily foods contributed to dispell the cold badgan from spleen and leads to amplification of immunostimulator activity of Medicaments . . . "by "alpha + alpha + alpha" mechanism, occurred in MS of immunocytes and spleenocytes. In the result of conducting the above mentioned experimental workswe are obtaining two new immunostimulator preparations "Salorid", "Ortuuzin" and introduced to medical treatment practice. (Picture N 20). The new nephroprotector preparation and the new conception "rlung, Mkhris, Badgan membrane-redoxy potentials 3 state line system. In the theory of TMTM had been emphasized that "kidney, as badgan dominated organ served the residence of healthy badgan and existsin the way of circulation of pathologically changed badgan. . . In this connection the kidney disease is conditioned by cold badgan . . . ". In the result of our comparative experimental research works has been stated by us that, the intensity of induction of lipid pereoxidation process in the MS of kidney cells was in 1.2-1.3 times slow than MS of liver cells in autumn season, but these findings were in 1.2-1.36 times high in spring season. In such way the results of our investigation demonstrated that kidney cells have the most specific character by their ability to conduct the adaptive reaction by increasing the unsaturated fatty acids fluid alpha state of MS under low temperature (cold) and by increasing the saturated fatty acids - solid betta state of MS under influence of high temperature (hot). It was very interesting that during our experimental works by us has been established that in case of inducing the predominance of solid betta state of MS by low temperature and saturated fatty acids (cholesterol) the volume of diuresis of laboratory animals increased in 1.3 times in comparison to animals with predominance of alpha-fluid state of MS. Basing in these results of our investigation we came to conclusion that the scientific essence of theoretical expressions of TMTM about ". . . increase of cold badgan in kidney and the diuresis under direct effect of low temperature and cold foods ..." would be explain by such lawfull process, which has been carried out in following consequence: as "cold food, low temperature - the predominance of solid betta state of MS in kidney cells inactivation of kidney Na+, K+ATP - ase enzyme the decrease of the K+, Na+ reabsorption - the increase of diuresis". In this way, the some date of foreign researchers (S.Rjabov 1998) who established that during acute nephrites has been accumulated the toxic lipid pereoxidation products and cholesterol on MS of kidney cells, increased the viscocity of MS, and the results of our above mentioned research experimental works gives the ground to say that the medicaments of plants origin, possesing the immunomodulator, antioxidant and membranestabilizing activity may be exhibit the nephroprotective action. In this connection we are choosen the Iris tenufolia as object of our further investigation, which had been used in TMTM for treatment of various forms of kidney disease, it was stated by us that the ethanol extraction obtained from Iris tenufolia exerted the nephroprotective action by decreasing the accumulation of toxic lipid pereoxidation products in MS of kidney cells and serum concentration of kreatinin and urea, inhibiting the excessive increase of more viscous solid betta state of MS in kidney cells and attennuating the cytotoxic immune reaction, decreasing the acute damage of kidney cells. Basing in the results of this experimental investigation we are obtained the new nephroprotective preparation "Nephromon" and introduced to medical treatment practice (Picture 20).
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The new cardioprotective preparation and the new conception "rlung, Mkhris, Badganmembrane-redoxy potentials 3 state line system. According to the theory of Traditional Medicine. ". . .The heart as rlung dominated solid organ is existed in the residence of general "rlung" way, acted under the regulation of "general rlung". In this connection, the heart is easily subjected to disease, which are accompanied with unsufficiency of high energy phosphate- ATP, high energy electrons - NADPH, provocated in the background of gamma state of membrane structure with low level of redoxy potentials ability because of excessive accumulation of abstracted by thermin rlung really existing substance . . .The accumulation of abstracted by thermin rlung really existing substance in heart has been carried out under the direct influence of using of fatless foods, /goat/ possessing light, cool power and quality. . . ", these according to the new conception "rlung, Mkhris, Badgan membrane - redoxy potentials 3 state line system lead to unsufficiency of high energy phosphate - ATP, high energy electrons - NADPH, resulting to the elevating of gamma state of membrane structure with low level of redoxy potentials. In the result of interpretation the scientific essence of theoretical formulations of TMTM regarding to function and cause of heart disease we came to conclusion that the abovementioned factors, foods, which served the role of cause of heart disease had been characterized by deficiency of antioxidant defense system and the capacity to induce the lipid pereoxidation process in membrane structures of cardiomyocytes, i.e. long term use of foods, which according to the theory of TMTM contributed to induction of heart disease leads to the accumulation of "detergent" lipid pereoxidation products in the MS of cardiomyocytes and the damage of ion /Na+, K+, CL ion conductivity, also the disturbance of "normal action potential", the defect of normal process of contraction and excitability of cardiomyocytes, all these processes may be expressed in the theory of TMTM as "pathological increase of rlung, located in the heart". In the result of conducting the experimental research works, we are established that the normal cardiac function and ion conductivity of cardiac muscles, also the resistance of cardiomyocytes to arrhytmic action of CaCI2 /in 1.3-1.4 times/ has been disturbed and alterated in the case of modifying the normal state of MS by insaturated and saturated fatty acids in the form of causing the pathological predominance of fluid alpha and solid betta states of MS.i.e. the normal function of cardiomyocytes has been influenced by balance between three basic state of MS of cardiomyocytes. In such way, on the basis of our experimental works, during which we are established that the disturbance occured in the relationship as "the heart function - normal intermediate gamma - state of MS - normal speed of excitability and contraction of cardiomyocytes" had resulted to cardiac disease, we are putting before us the goals to study the cardioprotective action of sum flavonoids from Astragalus variabillis and Astragalus galactites, containing the polyphenol complex, which possessed the antioxidant, membrane stabilizing activity. It was shown that sum flavonoids from two species of Astragalus has been possessed the cardioprotective, antiishemic action by decreasing the myocardial infarction size /in 1.5-1.8 times/, the size of nonvascularization cardiac muscles and the size of pathological dilatation of the ventricle cavity, also diminishing the ST segment elevation and the depth of necrosogenic Q waves in EKG during the acute coronaroocclusion myocardial infarction models, induced in Rats. The results of our experimental investigation gives to us the possibility to obtain the new cardioprotective preparation "Astradin", "Asvargal" and introduce these two preparations in Medical practice. The new conception "rlung, Mkhris, Badgan- membrane-redoxy potentials 3 state line system" and the pharmacological study of some anticancer preparations. In can be say that according to the theory of rlung, Mkrhis, Badgan and five elements of TMTM the cancer belongs cold-induced, abstracted by thermin badgan disease. If explain these theoretical expressions of Traditional Medicine in the framework of the new conception "rlung, Mkhris, Badgan -
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membrane - redoxy potentials 3 state line " the cancer process is caused by unregulated increasing of the solid betta state and the viscosity of MS with high reduction potential, when are elevated high energy phosphate- ATP, high energy electrons - NADPH, thereby creating a precondition of excessive activation of cell division process in cancer cells (CC) by mecchanism as active G1 Cdk - active Rb proteinactive E2F protein S - phase gene transcription-active G1/S - Cdk-active S Cdk - DNA synthesis. The above mentioned comparative theoretical analysis gives the possibility to say that one of ways of inhibition of cell division during the cancer should be directed to decrease of excessive solid betta state of MS of CC by using the medicaments, containing the unsaturated fatty acids and conjugated fatty acids, which contributed to increase of the fluid alpha state of MS with induction of phase transition in the direction of "from betta state to alpha state", "from elevated reduction potential to elevated oxidation potential "... In this connection we are studied the anticancer activity of "Ellipin" obtained from fermented bovine liver and contained the more quantity of unsaturated fatty acids and conjugated fatty acids with high oxidation ability . There have been many epidemiological and animal studies concerning dietary fatty acids related to tumors. According to literature date some fatty acids selectively suppress tumor cells, without affecting normal cells. The purpose of this investigation was to analyze the chemical composition of lipids named Ellipin (YS2H) extracted from bovine liver and to examine the antitumor effects and possible mechanisms of Ellipin (Picture N 20). Ellipin was extracted from X-ray irradiated and fermented bovine livers by Folch's modified method. The chemical composition was analyzed, using chemical methods, thin-Layer chromatography, gas chromatography and high performance lipid chromatography. The antitumor effect and its mechanisms were studied on Hela, Raji, J6.2, K562 tumor cell lines in vitro, and lymphogenous Leukemia (L615) and astrocytoma (G442) in mice in vivo. Ellipin was mainly composed of free fatty acids (FFAs), phospholipid, cholesterol and triacylglycerol. The major FFAs in Ellipin were C14:0, C16:0, C18:l, C18:2, C20:4 and conjugated linoleic acid (CLA). Ellipin significantly suppressed the growth of K562, J6.2, Raji and Hela and inhibited 3H-TdR incorporation by J6.2, and K562. The growth of G442 was significantly suppressed by oral administration of 3-0.6 g Ellipin (Kg, daily, for 14 days). The NK activities of spleen lymphocytes from Ellipin-treated mice were greatly higher than that of untreated controls. The proliferation response of T lymphocytes from spleen of mice treated with to mitogen (con A) also was obviously elevated, compared with that of untreated one. The immunization of mice with Ellipin-treated L6]5 tumor cell vaccine induced very strong effects may be the complex FFAs including CLA and other unknown substances in Ellipin. Ellipin has significant antitumor efficacy on G422 in mice by oral administration. The antitumor efficacies of Ellipin might be correlated to killing tumor cells directly and strengthening the host immunities mediated by T lymphocytes indirectly. Tumor cells of Ehrlich ascites carcinoma (EAC) and hepatoma (H22), uterine carcinoma (Uu) and sarcoma (S180) were inoculated in each. Into Kum Ming mice of weighting 182g respectively. The cells inoculated were 3xl06 for EAC and 2xl05 for H22intraperitoneally, 5xl06 for U14 and 2xl06 for S180 series subcutaneously. Twenty four hours later, the mice with each cell line series were divided into 6 of 3 experimental and 3 control groups, and heplipin of 300 to 500 mg/kg body weight was injected intraperitonelly, daily, for 7 to 14 days, Normal saline, Vehicle, another antitumor agents were used as negative and positive controls. Life span was observed by 60 days for the series of mice with EAC and H22 at 24 hours after last injection of Ellipin, mice with U14 and S80, series werekilled and observed inhibitory rates by weighting tumor. Inhibitory effects of Ellipin to tumor growth were larger enough than those of another anticancer agents used as positive controls. Life span inducated by survival rate was increased by 90% in EAC and 70% in H22 mice. LD50 was 8.0g/kg for the oral and 1.64g/kg for intraperitoneal administration.
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The anticancer efficacy of Ellipin was excellent with wide spectrum to various cell line, Ellipin could elongated life span of the mice with cancer, and there was no serious side effects indicating acute toxicities both in oral and intaperitoneal administration, indicating a good anticancer agent for cancer. In the present studies, significant cytotoxicities of Ellipin in vitro on K562 and J612 Leukemic cell lines and very effective antitumor activities on implanted U14 and EAC were demonstrated indicating that the active constituents of if s antitumor effect may be fatty acids, in particular conjugated one, which induced in the MS of cancer cells the transition in the forms as from betta state to alpha state, resulting to decrease of cell division and DNA synthesis. Obtained results had confirmed that suggested by us new conception, according to which tumor related pathology belongs to cold Badgan Disease and should be successfully treated by preparation, containing conjugated fatty acids - main component of a - state of MS with high oxidation activity, which expressed in theory of MTM as prescription, possessing hot, oil property and power, under this action would occur the process as within membrane - redoxy potentials 3 state line of cancer cells happened the process of transformation as "from betta state to alpha state", "from elevated reduction potential to elevated oxidation potential "with lessening of high energy phosphate - ATP, high energy electrons-NADPH, thereby creating a precondition of supression of cell division process in cancer cells (CC) by mecchanism as low level of ATP, NADPH - low level of phosphorylation of Rb protein - low level of active G1-Cdk- low level of active Rb protein - low level of active E2F protein low level of S - phase gene transcription - low level of active G1/S-Cdk- low level of active S - Cdk - low level of DNA synthesis. 8. Some theoreitical and education,training aspects of NCM medicine It is raised the following questions as : a. How in our New Medicine medical institute we should improve the educational process resulting in a Traditional medical doctor competent at a basic level, to decide this problems how to change the training technology. b. How to establish in our New Medicine medical institute the appropriate foundation for further training of Traditional medical doctor in any branch of medicine, including Traditional Medical system, also, Modern Medical system with account a new world future trend of integrated Medical systems. . How to positively change the roles of Traditional Medical doctors in the health care system of our country, including Traditional Medical system, also, Modern Medical system with account a new trend of integrated Medical systems by modifying and improving the training technology in our New Medicine medical institute. We are deciding the problems of improving the educational process resulting in a Traditional medical doctor competent at a basic level by introducing the triple training technology, consisting of Traditional Medical education methods, also, Modern Medical education methods, additionally to education methods, based in s-NCM new knowledge with account a new world future trend of integrated Medical systems. As one of more appropriate way of implementation of objectives, which are determined as ensuring of educational process resulting in a medical doctor competent at a basic level we are elobarating and conducting the training technology by triple mecchanism as prepare one medical doctor, who able to conduct the diagnosis, reatment by Traditional Medical principle, simultuneously the diagnosis, reatment by Modern Medical principle, and also the diagnosis, reatment by Triple new NCM medicine principle. We are drawn the of Traditional medical doctor, graduates competency models of our institute, relating to their knowledge practice - attitude,who able to conduct the diagnosis, reatment by Traditional Medical principle, simultuneously the diagnosis, reatment by Modern Medical principle, and also the
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diagnosis, reatment by Triple new NCM medicine principle in the examples i.e.around the thematics as resting potential. The medical doctors of triple training technology at first, our graduates - Traditional medical doctors know that The resting cell is not resting at all but very busy controlling the state of its interior, and it required a continuous supply of energy to do so, at second, our graduates Traditional medical doctors know that, according to theory of Traditional medicine, the disturbance of a continuous supply of energy of the resting cells, described as rLung disease (Lobsang Rapgay) in Traditional medicine by thermins as Restlessness, Deliurum, Anger, Amnesia, Neuronic disturbances, at third, our graduates - Traditional medical doctors know that the disturbance of a continuous supply of energy of the resting cells, according to NCM medicine - s-NCM knowledge would be occurred because of predominance of gamma state of membrane structures and slowing of redoxy potentials and high level of proton leak, slip potentials and shortage of high energy phosphate - ATP, of high energy electrons - NADPH, also heat energy because of slipping in redox and ATPase H + pumps (Pietrobon D, Zoratti M, Azzone GF) with dependence of the membrane 'leak' conductance for H+. Now our New Medicine medical institute are introduced the new triple medical education technology to establish the appropriate foundation for further training of Traditional medical doctors-medical proffessionals, who are possesed knowledge practice attitude to work in the directions as Traditional Medical diagnostics and treatment system, also, Modern Medical diagnostics and treatment system, in addition to it, diagnostics and treatment system NCM medicine. What about remarkable roles of doctors in the health care system we are recognizing that only triple medical training system, consisting of Traditional and Modern medicine separately and their integration through s-NCM new knowledge gives to graduates the knowledge practice attitude competent. In order to positively change the roles of Traditional Medical doctors in the health care system of our country, including Traditional Medical system, also, Modern Medical system, integrated with NCM combined Medical system we are elobarating the appropriate variant of modificated and improved training technology in our New Medicine medical institute. Our variant of modificated and improved triple training technology are extended the roles of our graduated traditional doctors in the health care system by enabling them to perform the many functions in all sectors of medical system of Mongolia as Traditional Medical doctor, Modern Medical doctors,NCM medicine doctors, family doctor, urban doctor, social medical worker, researchers, pharmacologists, pharmaceutics et all. The mission and objectives should encompass social responsibility, research attainment, community involvement, and address readiness for postgraduate medical training. The Vision of the New Medicine medical institute is to be recognized internationally as the leading medical school in the direction of preparing of Traditional Medical doctors to deliver academically excellence medical education in close with research based, evidence based,problem based training technology, to prepare Traditional Medical doctors able to work in majority parts of health services, including Traditional Medical system, also, Modern Medical system, integrated with NCM combined Medical system et all. New Medicine medical institute mission is to be recognized as the leading national medical education organisation which prerares future graduate health care professionals, oriented in Traditional medical direction, capable of meeting the national, regional and global, healthcare demands , also capable of working in the integration of education research - health care delivery, able to compete in competency based medical education multifunctions . New Medicine medical institute mission is prepare world recognized Traditional medical doctors, trained by triple training technology, including Traditional medical knowledge, Modern medical knowledge,new s-NCM knowledge, based in the full cognitive interpretation of medical knowledge of all period.
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The full cognitive interpretation of medical knowledge of all period of humanity means the solution of a main urgent problems of medicine, consisting following 4 parameters as secret of normal existence key cause of pathological change - their diagnostics - their treatment by using sum of medical knowledges as X + G + S + s-NCM, whicn formed during of all period of developing of various medical systems of humanity. A. Traditional medical system laid a foundation of X + G knowledge and used them to solution of a main urgent problems of medicine, consisting following 4 parameters as status of normal existince of human body - key cause of pathological change - their diagnostics - their treatment but have not a S, sNCM knowledge i.e.in this connection Traditional medical education system are based X + G knowledge without using S, s-NCM knowledges to teach a main urgent problems of medicine as status of normal existince of human body - key cause of pathological change - their diagnostics - their treatment to students. During development of medical system at last 5000 years health account, health state evaluation approach of individuals has been conducted by following four parameters as at first : parameters of normal existince, at second : key cause of pathological change, at third: their diagnostics, at fourth: their treatment and contantly changed to gradually improvement. At example 2000 years ago medical thinking based only g knowledge as g knowledge = secret of normal existence - key cause of pathological change - their diagnostics - their treatment 1000 years ago medical thinking based in the g + X knowledge as g + X knowledge = secret of normal existence - key cause of pathological change - their diagnostics - their treatment since 1600 year medical thinking based S -knowledge as S - knowledge = secret of normal existence - key cause of pathological change - their diagnostics - their treatment from 1970 medical thinking based g+X knowledge disconnected with S knowledge as g + X knowledge, S - knowledge = secret of normal existince- key cause of pathological change-their diagnostics-their treatment .But since 1990 year in the medical thinking abruptly changed,acquiring completely new character because of appearing the s-NCM new knowledge and based in the g + X knowledge + S knowledge + s-NCM knowledge, decided all questions by new approach as g + X knowledge + S knowledge + s-NCM knowledge = secret of normal existence - key cause of pathological change-their diagnostics-their treatment. 1. According to Traditional medical system the balance of of normal status existing of human body are determined by balance of X + G parameters, including 20 external patterns and 5 elements, balance between rlung: mkhris: badgan. 2. According to Traditional medical system the key cause of pathological change, occurred in human body are determined by disbalance of X + G parameters, including 20 external patterns and 5 elements, disbalance between rlung: mkhris: badgan. 3. According to Traditional medical system diagnostics of pathological change, occurred in human body are based in establishing the disbalance of X + G parameters, including 20 external patterns and 5 elements, disbalance between rlung: mkhris: badgan. 4. According to Traditional medical system treatment of pathological change, occurred in human body are based in correcting of the disbalance of X + G parameters,including 20 external patterns and 5 elements, also in correcting of the disbalance between rlung: mkhris: badgan. B. Modern medical system laid a foundation of living cell level S knowledge,used them to solution of a main urgent problems of medicine, consisting following 4 parameters as secret of normal existince of human body - key cause of pathological change - their diagnostics - their treatment but is lacking of X + G knowledge, in this connection Modern medical education system are based S knowledge without using X + G, s-NCM knowledges to teach a main urgent problems of medicine as status of normal existince of human body - key cause of pathological change - their diagnostics - their treatment to students.
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1. According to Modern medical system the balance of of normal status existing of human body are determined by balance of living cell level S knowledge related parameters. 2. According to Modern medical system the key cause of pathological change, occurred in human body are determined by disbalance of living cell level S knowledge related parameters. 3. According to Modern medical system diagnostics of pathological change, occurred in human body are based in establishing the disbalance of living cell level S knowledge related parameters. 4. According to Modern medical system treatment of pathological change, occurred in human body are based in correcting of the disbalance of living cell level S S knowledge related parameters. C. What about advantage of NCM new medicine, which are used a Traditional medical X + G knowledge, addition to it, used a Modern medical system S knowledge, besideit is introducing the sNCM new knowledge, thereby laid foundation new NCM medicine able decide a main urgent problems of medicine , as status of normal existince- key cause of pathological change-their diagnostics-their treatment by using full integrated X + G + S + s-NCM knowledges , in this connection NCM new medical education system are based X + G + S + s-NCM knowledges to teach a main urgent problems of medicine as status of normal existing of human body - key cause of pathological change their diagnostics - their treatment to students. 1. According to NCM new medical system the balance of of normal status existing of human body are determined by balance of membrane - redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment, consisting of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, third compartment, representing a visceral and external fatty depositions, coded by abstract mkhriss, rlung, Badgan code in the Tibetian Mongolian Traditional medicin and in the living cell level S parameters by using full integrated X + G + S + s-NCM knowledges. 2. According to NCM new medical system status the balance of of normal status existing of human body are determined by disbalance of membrane-redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment, consisting of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, third compartment, representing a visceral and external fatty depositions, coded by abstract mkhris, rlung, Badgan code in the Tibetian Mongolian Traditional medicin and in the living cell level S parameters by using full integrated X + G + S + s-NCM knowledges. 3. According to NCM new medical system diagnostics of pathological change, occurred in human body are based in establishing the disbalance of membrane - redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment, consisting of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, third compartment, representing a visceral and external fatty depositions, coded by abstract mkhris, rlung, Badgan code in the Tibetian Mongolian Traditional medicin and in the living cell level S parameters by using full integrated X + G + S + s-NCM knowledges. 4. According to NCM new medical system treatment of pathological change, occurred in human body are based in correcting the disbalance of membrane-redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment, consisting of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, hird compartment, representing a visceral and external fatty depositions, coded by abstract mkhris, rlung, Badgan code in the Tibetian Mongolian Traditional medicin and in the living cell level S parameters by using full integrated X + G +
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S + s-NCM knowledges. In this way the cognitive uncoincidence existing between X + G medical knowledge of Traditional medicine and S knowledge of Modern medicine, relating to urgent quiestion of medicine as secret of normal existing of human body - key cause of pathological change - their diagnostics - their treatment decided through s-NCM new knowledge developed, proposed by us, thereby these barriers are demolished. The scientic based elimination of the cognitive uncoincidence-barrier existing between X+G medical knowledge ofTraditional medicine and S knowledge of Modern medicine,relating to urgent quiestion of medicine as secret of normal existence - key cause of pathological change-their diagnostics - their treatment through s-NCM new knowledge also, gives to us the possibility to correct the cognitive disruption, appeared in 6 steps of interconnectable chain parameters. A. variant before correction: A. 1-variant - Gene enzymes substrates -disrupted, nly studied by Modern medicine (alone S). A. 2-variant- 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin. Cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin) - disrupted, studied by Traditional medicine (alone X, G). B - variant after correction: B. 1-variant - Gene-enzymes-substrates-disrupted, studied by Modern medicine and integrated with Traditional medicine through s-NCM new knowledge (S+X, G through s-NCM new knowledge ). B. 2-variant- 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile)abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) -abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin . Cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin) - disrupted, studied by Traditional medicine and integrated with Modern medicine through s-NCM new knowledge (X, G+ S through s-NCM new knowledge ). C-variant in the form of integration (S + X,G through s-NCM new knowledge ): Gene enzymes - substrates + integration through s-NCM new knowledge + 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile)-abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin. Cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). By using abovementioned of integration of medical knowledges in the form as S knowledge + X, G knowledge + s-NCM new knowledge we elaborating the new triple training technology of preparing of Traditional Medical doctors within one integrated curriculum content, which are included Gene enzymes substrates approaches in relation to a main urgent problems of medicine, consisting following 4 parameters as secret of normal existence - key cause of pathological change-their
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diagnostics-their treatment, 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile )-abstraction them by 5 abstract elements - abstraction them by abstract rlung, mkhris, badgan thermin based approaches in relation to a main urgent problems of medicine, consisting following 4 parameters as secret of normal existince- key cause of pathological change-their diagnostics-their treatment, and s-NCM new knowledge based approaches in relation to a main urgent problems of medicine, consisting following 4 parameters as secret of normal existince- key cause of pathological change-their diagnostics-their treatment. The graduates -Traditional medical doctors model of New medicine (NCM) medical institute: ( ) The graduates -Traditional medical doctors model of New medicine (NCM) medical institute should possess theoretical knowledge, practical skills, thinking ability, attitude to distinguish that which pathological process initiated in which parts of membrane - redoxy 3 state line systems,representinf first compartment, in which parts serum - fluid second compartment, in which parts of fourth compartment as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, informationresponse, biosynthetical, bioenergetical, biotransformation functions, in which part of third compartment, representing a visceral and external fatty depositions, coded by abstract mkhriss, rlung, Badgan code in the Tibetian Mongolian Traditional medicine, how emerged all kinds of treatment effects in them by using Traditional Medical diagnostics and treatment system, also, Modern Medical diagnostics and treatment system, in addition to it, diagnostics and treatment system NCM medicine. The graduates-Traditional medical doctors job description, who graduated from New medicine (NCM) medical institute. The graduates - Traditional medical doctors job description, who graduated from New medicine (NCM) medical institute would be expressed as follows: 1.Traditional Medical doctors should possess the foreig language ability, ratified by state examination to translate all Tibetan materialls, written in a old sutaras and Language ability, ratified by state examination to translate all proffessional materialls, written in english language, also ability to to write History of disease, diagnostic therminology in Russian language. 2.Traditional Medical doctors should possess the theoretical knowledge, practical skills to conduct Traditional medical diagnosis, treatment of inner disease, acupuncture, to use traditional receipts, according State standartization MNS 2008. 3.Traditional Medical doctors should possess the basic theoretical knowledge, practical skills to conduct every day Diagnosis and treatment with using of integrated medical knowledges in the form as Modern medical S knowledge + Traditional medical X, G knowledge + s-NCM new knowledge in relation to a main urgent problems of medicine, as status of normal existince of human body - key cause of pathological change-their diagnostics-their treatment, with accounting the membrane-redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment, consisting of 5 membrane structures - 5 function systems, ensuring normal genetic - cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, third compartment, representing a visceral and external fatty depositions, coded by abstract mkhriss, rlung, Badgan code in the Tibetian Mongolian Traditional medicine. 4. Traditional Medical doctors should possess the basic theoretical knowledge, practical skills to understand the scientific essnce of Traditional pulse, urine, five flower diagnostic principles in the frame of the membrane-redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment, consisting of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, third compartment, representing a visceral and external fatty
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depositions, in close with abstract mkhris, rlung, Badgan coding of Tibetian Mongolian Traditional medicine. 5. In case of planning of diagnostic and treatment strategies in every patients should possess the basic theoretical knowledge, practical skills, thinking ability, attitude to distinguish that which pathological process initiated in which parts of membrane-redoxy 3 state line systems, representinf first compartment, in which parts serum-fluid second compartment, in which parts of fourth compartment as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, in which part of third compartment, representing a visceral and external fatty depositions, coded by abstract mkhriss, rlung, Badgan code in the Tibetian Mongolian Traditional medicine, how emerged all kinds of treatment effects in them by using Traditional Medical diagnostics and treatment system, also, Modern Medical diagnostics and treatment system, in addition to it, diagnostics and treatment system NCM medicine in complience with them choose a appropriate treatment decisions. 6. In case of choosing of rational use of Traditional medicaments, acupuncture, traditional massage therapy in every patients should possess the basic theoretical knowledge, practical skills, thinking ability, attitude to understand their treatment and correction effects would occure in which pathological process initiated in which parts of membrane - redoxy 3 state line systems,representinf first compartment, in which parts serum - fluid second compartment, in which parts of fourth compartment as 5 membrane structures - 5 function systems, ensuring normal genetic-cell division, informationresponse, biosynthetical, bioenergetical, biotransformation functions, in which part of third compartment, representing a visceral and external fatty depositions, coded by abstract mkhris, rlung, Badgan code in the Tibetian Mongolian Traditional medicine. 7. In case of conducting of Traditional diagnostic procedures in every patients by using of computerized Docam-1 programm should possess the basic theoretical knowledge, practical skills, thinking ability, attitude to establish the correlation between the status of membrane-redoxy 3 state line systems, representinf first compartment and their abstract mkhris, rlung, Badgan coding and the link between the status of serum-fluid second compartment and their abstract mkhris, rlung, Badgan coding, also the correlation between the status of fourth compartment as 5 membrane structures-5 function systems,ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions and their abstract mkhris, rlung, Badgan coding, in addition to it the link between the status of third compartment and their abstract mkhris, rlung, Badgan coding and the pathological influences, occuring between a first, second, third and fourth compartments. 8. Traditional Medical doctors should possess the systemized - ordered basic theoretical knowledge, practical skills to unite the content of all 80 lessons in the frame of equation as + g + S + s-NCM = the solution of a main urgent problems of medicine, as status of normal existence - key cause of pathological change - their diagnostics - their treatment, unserstand the essence of Traditional medicine lessons by using the X, G knowledges, unserstand the essence of Modern medicine lessons as biochemistry, immunology, physiology by using the S knowledges, also use them in close context with sNCM new knowledge by principle as All 80 lessons and one action moment of Diagnosis, treatment of Traditional medical doctors 9. Traditional Medical doctors should possess the systemized-ordered basic theoretical knowledge, practical skills at first to establish the pathological change of the membrane - redoxy 3 state line systems, representing the first compartment, serum-fluid second compartment, and fourth compartment ,consisting of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions, also, third compartment, representing a visceral and external fatty depositions, by using the computerized
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Traditional Medical Docam-1 programm, and at second to establish the their pathological change by using Modern medicine Diagnostic laboratory tests at third to establish the coincidence and uncoincidence of Traditional Medical and Modern medical diagnostic data, at fourth to decide the choosing of appropriate medicaments, foods, other traditional methods of therapy, basing on the s-NCM new knowledge as intermediate code between Traditional Medical and Modern medical diagnostic data, at fifth to decide the principal important quiestion, how to combined and separately use of medicaments, foods, other traditional methods of therapy and Modern medicaments, foods. Graduates-professionals Traditional medical doctors according to standarts MNS 5323 and to The job description standard model of medical professionals, Minister of Health order # 442, 2009, www.moh.mn is medical proffesiols, who are possessed the theoretical knowledge, practical skills to conduct prevention, diagnosis, treatment functions of commonly occurred disease in complience with health care policy in a first and second step hospitals by combined using Traditional and Modern Medical methods. The requirement, posed to graduate preparation of bachelor Traditional medical doctors. The requirement, posed to graduate preparation of bachelor Traditional medical doctors as follows:acquinted with basic laws of Humanitarian and Nature science, able to make scientific analysis to these and use in own every day practices, have a full imagination, relating to processess occurred in unliving and living universe - their differences and relationships, understanding the essense of modern methods of study and possessed the ability to use these in implementation of own medical duty, prone to acquire the new knowledge, new informations accumulated durin science development, able to creative selflearning, have full scientific imagination about healthy style of life. The requirement, posed to professional preparation of graduate bachelor Traditional medical doctors. The requirement, posed to professional preparation of graduate bachelor Traditional medical doctors as follows: learned in the field of normal regulation-pathological change, metabolism of human body and cause, pathogenesis, clinics, treatment aspects of commonly occurred disease The requirement, posed to graduates of bachelor Traditional medical doctors. The requirement, posed to graduates of bachelor Traditional medical doctors as follows: possess a the theoretical knowledge, practical skills to render Modern medical assistance to issue clinical decisions during commonly occurred disease in the job working place as family and urban hospitals. In such way objectives of of accredizated curriculum, the requirement, posed to graduate preparation of bachelor Traditional medical doctors, the requiremen, posed to professional preparation of graduate bachelor Traditional medical doctors, the requirement, posed to graduates of bachelor Traditional medical doctors are constantly changed and improved depending on appearance of new knowledge and new scientific interpretation, relating to answer to quiestion as what is basic scientific point of teaching of Traditional and Modern medicine subjects, in which based all kinds of training processess. The more distributed tendency of imagination, demonstrating that the basic scientific point of teaching of Traditional medical subjects should be based in the really existing inside of human body Rlung, Mkhris, Badgan and the basic scientific point of teaching of Modern medical subjects should be based in the living cell regulation serves the role serious barrier to achieve the integrated medical education system, omprising Traditional and Modern medicine. But, appeared last time our new conception as Substance - external patterns abstraction,One substance-two medicine, +g+S+s-NCM = the solution of a main urgent problems of medicine are withnessed that between basic scientific point of teaching of Traditional and Modern medicine subjects not existed any differences. These differences disappeared in case of using the principally new knowledge formulated as + g + S + s-NCM = the solution of a main urgent problems of medicine - status of normal existence - key
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cause of pathological change - their diagnostics - their treatment, understand the essence of Traditional medicine lessons by using the X,G knowledges, understand the essence of Modern medicine lessons as biochemistry, immunology, physiology by using the S knowledges, also use them in close context with sNCM new knowledge by principle as All 80 lessons and one action moment of Diagnosis, treatment of Traditional medical doctors i.e. the cognitive uncoincidence existing between X + G medical knowledge of Traditional medicine and S knowledge of Modern medicine,relating to urgent quiestion of medicine as secret of normal existing of human body - key cause of pathological change-their diagnostics-their treatment decided through s-NCM new knowledge developed, proposed by us, thereby these barriers are demolished. Such specific therminology firstly developed and proposed by us to express the essence of integrated medicine and NCM medicine, s-NCM knowledge as one cell two medicine, one cell-triple medicine, The intermediate code between Traditional and Modern medicine, Building bridge between Traditional and Modern medicine, cell related appearance of abstract theory Rlung, mkhris, badgan, The abstractized by Rlung, mkhris, badgan model of living cells, The cell morphophysiological correlates of abstract theory Rlung, mkhris, badgan, also, now started the using by forein researchers, who are working in the field of integrated medicine. It should say that the appearance of Integrated medicine, NCM medicine plays the significant role in the improving the educational process resulting in a Traditional medical doctor competent at a basic level, in the extending of appropriate foundation for their further training in any branch of medicine and in increasing the roles of Traditional medical doctors in the health care system. One of examples of increasing the roles of Traditional medical doctors in the health care system is the their participation in genetic study of Traditional medicine, conducted by Mi Kyeong Lee, Eun-Su Jang, Ho-Young, in the scientific article Investigation of Genetic Evidence for Sasang Constitution was written that types in South Korea Sasang constitution type was diagnosed by traditional doctors. Leem KH, Park HK stressed in the article Traditional Korean medicine: Now and the future ( Neurol. Res. 2007, v.29, S3-4 ) : If modern medicine provides complement of Traditional Korean Medicine, it would open up new prospect of research and clinical regimen for various diseases.... The all above mentioned things show that now are created the all condition of implementig the new trend of medical education programm Traditional medical education in the 21 century,aimed to conduct training to preparing Traditional medical doctors by using full integrated X + G + S + s-NCM knowledges i.e. the training specifics of medical education programm Traditional medical education in the 21 century is X + G + S + s-NCM full integrated knowledge relating preparing of Traditional medical doctors. The specifics of graduates- Traditional medical doctors, trained by program Traditional medical education in the 21 century as follows: a. Who able to conduct all kinds of prevention, diagnostics and treatment procedures in case of diseases of Traditional medicine b. Who able to conduct all kinds of prevention, diagnostics and treatment procedures in case of diseases of Modern medicine . c. Who able to analyze all prevention, diagnostics and treatment data of Traditional and Modern medicine by using s-NCM knowledges and X + G + S + s-NCM full integrated knowledge and make the final diagnostics and treatment clinical decisions. In such way the training specifics of medical education programm Traditional medical education in the 21 century meets the MNS 5323 standarts demand, which indicated that Graduatesprofessionals Traditional medical doctors is medical proffesiols, who are possessed the theoretical knowledge, practical skills to conduct prevention, diagnosis, treatment functions of commonly occurred
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disease in complience with health care policy in a first and second step hospitals by combined using Traditional and Modern Medical methods. The innovation and improvement of objectives of curriculum, teaching technology of Traditional medical doctors is deeply depended in progress of scientific interpretation relating to basic theory of Traditional medicine. A. Objectives of curriculum of preparing of of Traditional medical doctors - before integration, when existed disruption between X, G knowledge and S knowledge was based in the conception that rlung, mkhris, badgan is not abstract thermin, rlung, mkhris, badgan is really existindg materiall substance i.e.prevailed the imagination that it is impossible teach Traditional and Modern medicine lesson subjects within integrated links. B - Objectives of curriculum of preparing of of Traditional medical doctors - before integration, when existed disruption between X, G knowledge and S knowledge was based in the conception that rlung, mkhris, badgan is not abstract thermin, rlung, mkhris, badgan is really existindg materiall substance i.e.prevailed the imagination that it is impossible teach Traditional and Modern medicine lesson subjects within integrated links. By using abovementioned of integrated curriculum in the form as Modern medical S knowledge + Traditional medical X, G knowledge + s-NCM new knowledge we became able to conduct training processess within one integrated curriculum content, which are included Gene enzymes substrates approaches in relation to a main urgent problems of medicine, consisting following 4 parameters as secret of normal existence - key cause of pathological change - their diagnostics - their treatment, 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) -abstraction them by 5 abstract elements-abstraction them by abstract rlung, mkhris, badgan thermin based approaches in relation to a main urgent problems of medicine, consisting following 4 parameters as secret of normal existence - key cause of pathological change - their diagnostics - their treatment, and sNCM new knowledge based approaches in relation to a main urgent problems of medicine, consisting following 4 parameters as secret of normal existence - key cause of pathological change - their diagnostics - their treatment. In such way can be divide the basic periods of modification of curriculum content of Traditional medical organisation as follows: 1. First period, when prevailed the imagination that human body consists of really existing rLung, mkhris, badgan, training process of Traditional Medical doctors based in the X, G knowledge. 2. Second period, when changed the imagination that human body consists of really existing rLung, mkhris, badganconsidered that the sympathic and parasympathic regulation are connected with abstract theory of rLung, mkhris, badgan, training process of Traditional Medical doctors based in the X, G knowledge separately and S knowledge separately without connection. 3. Third period, when appeared the new conception - the coincidence of really existing living cell membrane-redoxy potentials 3 state regulation is the substance of forming the theory of rLung, mkhris, badgan, training process of Traditional Medical doctors based in the X, G knowledge, in addition to it S knowledge, integrated through s-NCM knowledge. In our New medicine (NCM) medical institute in order to conduct training function in accordince with MNS 5323, 2011 we are using combined, integrated teaching, which include: a. 1-4 courses students comprised to training based in the X, G knowledge,during which they are acquired the the knowledge about theory of 20 external patterns of human body and 17 power of medicaments, 5 element and the theory of rLung, mkhris, badgan, acquired the practical skills to use of medicaments possessing 17 power, conduct pulse, urine, five flower diagnosis, acupuncture, massage techniques during commonly occurred disease.
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b. 1-4 courses students comprised to training based in the S knowledge, during which they are acquired the knowledge of diagnosis by determining the nature of a disease by considering the signs, symptoms, by using results of laboratory tests and X-ray examinations, the knowledge about morphology, physiology, microbiology, pathophysiology, immunology, pharmacology, internal disc c. 4-6 courses students comprised to training based in X, G knowledge + S-knowledge + s-NCM knowledge. The main objectives are connected with implementation of curriculum mission. 1. We follow the principle to be not remained below than sthe science, education development of forein developing country in the field of study of Traditional medicine. 2. We follow the principle to be not make education quality, research level, social-wellfare -service shortage, relating to students, teachers, workers. 3. We are putting the goal to be internationally ranked by achievement of elobarating the innovative training technology of preparing of Traditional medical doctors and by achievement of conducting the education, research, service related investigation. The basic principle of implementation of curriculum mission. The basic principle of implementation of curriculum mission is existed in the moving from this wrong tendency as one equation of diagnosis and treatment separately decision of this equation with participation of 4 doctors, trained in the 4 various trend as Traditional, Modern medicine, NCM medicine and biomedicine-4 various clinical conclusions to right tendency as one equation of diagnosis and treatment decision of this equation by 1 doctors, trained in integration educational system, including the Traditional, Modern medicine, NCM medicine and biomedicine - 1 clinical conclusion. The scientific - methodological basis of abovementioned new principle. The scientific - methodological basis of abovementioned new principle is based in the preparing world recognized Traditiol medical doctors by systematization and ordering of X, G knowledge (theory of 20 external patterns, 5 element, theory of rlung, mkhris, badgan) based traditional medical education system within s-NCN new knowledge, also by the systematization and ordering of S - knowledge (living cell related knowledge, but not ordered and systematized by using s-NCN new knowledge) based Modern medical education system within s-NCN new knowledge. We are dividing the very important chronical periods of appearing of integrated educational system, including the Traditional, Modern medicine, NCM medicine and Biomedicine which lasted during last 22 years in the two basic stages as 1990-2000 , 2001-2012 years. A.Main results of investigations, conducted in 1990-2000 years. The quiestion, relating to what is Rlung, Mkhris, Badgan remains unsolved untill - 1990 years, when by us proposed new conception The coincidence of Rlung, Mkhris, Badgan abstract thermin with regulation occurred in membrane - redoxy potentials 3 state systems of living. Many researchers, except us postulated that Rlung, Mkhris, Badgan are really existed materiall substance, functioned inside human body, which can see, taste and measure. Our suggestion was absolutely opposite to these and we developed working hypothesis, according to it, inside human body functioned unknown structural - functional unit, which has a following specifics: 1. In human body, during 24 hours three times subjected to absolutely opposite 3 states, in the morning existed in the state, coded by Rlung thermin, in the midday existed in the state, coded by Mkhris thermin, in the evening existed in the state, coded by Badgan thermin. 2. In human body, during whole year three times subjected to absolutely opposite 3 states coded by Rlung, Mkhris, Badgan abstract thermin, in the spring existed in the state, coded by Rlung thermin, in the autumn in the state, coded by Mkhris thermin, in the summer existed in the state, coded by Badgan thermin.
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3. The human body subjected to absolutely opposite 3 states during phylogenesis, in the child age existed in the state, coded by Badgan thermin, in young in the state, coded by Mkhris thermin, in the old existed in the state, coded by Rlung thermin. 4. The human body subjected to absolutely opposite 3 states coded by Rlung, Mkhris, Badgan abstract thermin depending the compositions of horse, sheep, goat, marmot meats. 5. The individuals are borned with excess one of three constitutions, which are coded by Rlung, Mkhris, Badgan abstract thermin . 6. The human body subjected to a absolutely opposite 3 states coded by Rlung, Mkhris, Badgan abstract thermin under influence of medicaments. 7.The general mecchanism of healthy existence of human body are due to normal balance of unknown structural-functional unit with 3 basic states, which coded by Rlung, Mkhris, Badgan abstract thermin under influence of medicaments. 8. The individuals are borned with excess one of unknown structural-functional unit with 3 basic states, which coded by Rlung, prone to loss of body weight, the individuals are borned with excess one of unknown structural-functional unit with 3 basic states, which coded by Mkhris prone to excess of body heat, the individuals are borned with excess one of unknown structural - functional unit with 3 basic states, which coded by Badgan, prone to excess gain of body weight. In this time we can not find a literature information, experimental data, describing the existence of about structural-functional unit with 3 basic states, which during 24 hours three times subjected to absolutely opposite 3 states, which during whole year three times subjected to a absolutely opposite 3 states, which during whole year three times subjected to absolutely opposite 3states, which are subjected to absolutely opposite 3 states under influence of medicaments, which are subjected to absolutely opposite 3 states during phylogenetic development of human body. Because of this we conduct investigation under isolated cell population,during which we establish that: a. The response of cells to stimulus was various in the morning coded by Rlung thermin, in the midday coded by Mkhris thermin, in the evening, coded by Badgan thermin. b. Became clear that the main structures of living cells, which subjected to daily three state change are membrane structures. 3. Also became clear that fluid alpha, solid betta and intermediate gamma state of membrane structures are subjected to daily, seasonal, phylogenetic, medicament and food depending changes. Based in theses results we came to conclusion that: 1. In human body, during 24 hours fluid alpha, solid betta and intermediate gamma state of membrane structures are three times subjected to absolutely opposite 3 states, in the morning dominated the gamma state of membrane structures, c oded by Rlung thermin, in the midday existed in the fluid alpha state, coded by Mkhris thermin, in the evening existed in the solid betta state, coded by Badgan thermin. 2. In human body, during whole year fluid alpha, solid betta and intermediate gamma state of membrane structures are three times subjected to absolutely opposite 3 states coded by Rlung, Mkhris, Badgan abstract thermin, in the spring dominated the gamma state, coded by Rlung thermin, in the autumn elevated the fluid alpha state state, coded by Mkhris thermin, in the summer increased the solid betta state state, coded by Badgan thermin. 3. The human body alpha, solid betta and intermediate gamma state of membrane structures subjected to absolutely opposite 3 states during phylogenesis, in the child age dominated the solid betta state state, coded by Badgan thermin, in young age dominated the fluid alpha state, coded by Mkhris thermin, in the old age dominated the intermediate gamma state state, coded by Rlung thermin.
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4. The human body subjected to absolutely opposite 3 states coded by Rlung, Mkhris, Badgan abstract thermin depending the compositions of horse, sheep, goat, marmot, beef meats. The eating of horse, marmot meats resulted to increase of fluid alpha state with high level of oxidation potentials, coded by Mkhris thermin, take of beef meats resulted to increase of solid betta state with high level of reduction potentials, coded by Badgan abstract thermin, take of lean goat meats resulted to increase of gamma state with low level of oxidation-reduction potentials, coded by rLung abstract thermin. 5. The individuals are borned with excess one of three constitutions, which are coded by in one case by Rlung abstract thermin, in another case by Mkhris, in third case by Badgan abstract thermin . 6. The human body subjected to absolutely opposite 3 states coded by Rlung, Mkhris, Badgan abstract thermin under influence of medicaments. 7. The general mecchanism of healthy existence of human body are due to normal balance of 3 basic states as gamma state with low level of oxidation - reduction potentials and solid betta state with high level of reduction potentials, addition to these fluid alpha state with high level of oxidation potentials, which coded by Rlung, Mkhris, Badgan abstract thermin. 8. The individuals are borned with excess of gamma state with low level of oxidation-reduction p, which coded by Rlung, prone to loss of body weight, the individuals are borned with excess of fluid alpha state with high level of oxidation potentials, which coded by Mkhris prone to excess of body heat, the individuals are borned with excess of solid betta state with high level of reduction potentials, which coded by Badgan, prone to excess gain of body weight. B. Main chronical stage of appearance of new conception The coincidence of Rlung, Mkhris, Badgan abstract thermin with regulation occurred in membrane - redoxy potentials 3 state systems of living cells 1.Basic membrane states and redoxy potentials of hemolysate, representing first compartment, containing redoxy line systems in Rlung constitution category of individuals (Rlung dominated ). All individuals, belonging to Rlung constitution category, identified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract-subjective nature of cognition have following differences : a. Low Reducing capacity of of hemolysate, determined by using the nitroblue tetrazolium test b. Low protonizing, radical scavenging activity of hemolysate,determined by using the Diphenyl picril hydrasyl radical test c. High Contents of Deprotonized products of hemolysate by concentration of TBA positive products, paralleled with low antioxidant capacity. 2. Basic membrane states and redoxy potentials of all membrane system, representing fourth compartmemt in Rlung constitution category of individuals (Rlung dominated). All individuals, belonging to Rlung constitution category, identified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition were distinguished by: a. Low Reducing capacity of of of all membrane system, representing fourth compartmemt, determined by using the nitroblue tetrazolium test b. Low protonizing, radical scavenging activity of all membrane system, representing compartmemt by using the DPPH (2, 2-diphenyl 2 picrylhydrazyl ) radical test. fourth
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c. High Contents of Deprotonized products of all membrane system,representing fourth compartmemt, determined by concentration of TBA positive products, paralleled with low antioxidant capacity. d. Low contents of saturated and low contents of unsaturated fatty acids contained in LPHD and LPLD fractions, which incorporated in integrated membrane - serum circultion system, which are evidence of prevailing of gamma state of membrane structures in these indivduals. i. Low Degree of saturated and also low concentration of unsaturated fatty acids dependant resistanse of all membrane system, representing fourth compartmemt are calculated by using osmotic and pereoxidation hemolysis causing test, which are evidence of prevailing of gamma state of membrane structures in these indivduals. 3. Basic membrane states and redoxy potentials of Redoxy potentials of second compartment in Rlung constitution category of individuals (Rlung dominated ). All individuals, belonging to Rlung constitution category, established with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition have following differences : a. Low redoxy potentials of second compartment of individuals, accounted by parameters of AO:LPO system, contents of LPHD and LPLD. b. Low reducing capacity of second compartment of individuals established by using the nitroblue tetrazolium test. c.Low protonizing, radical scavenging activity of second compartment of individuals determined by using the DPPH (2, 2-diphenyl 2 picrylhydrazyl ) radical test. d. High contents of deprotonized products of second compartment of individuals calculated by concentration of TBA positive products. e. Low level of concentration of cholesterols, triglycerids and LPHD, LPLD, which are evidence of prevailing of gamma state of membrane structures in these indivduals. 4. Basic membrane states and redoxy potentials of Redoxy potentials of third compartment in Rlung constitution category of individuals (Rlung dominated ). All individuals, belonging to Rlung constitution category, who classified according to Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition were distinguished by : a. Low contents of visceral (mainly containing LPLD fraction) and subcutaneous fatty acids (mainly containing LPHD fraction), which are indicated a prevailance of membrane - gamma state related low redoxypotentials in these individuals .
Second results: 1.Basic membrane states and redoxy potentials of hemolysate, consisting of first compartment, containing redoxy line systems in Mkhris constitution category of individuals (Mkhris dominated). All individuals, belonging to Mkhris constitution category, who classified according to Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition have a some specific characters as: a. Low reducing capacity of of hemolysate, accounted by using the nitroblue tetrazolium test b. Midlle protonizing, radical scavenging activity of hemolysate, calculated by using the DPPH (2,2diphenyl 2 picrylhydrazyl ) radical test.
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c. High Contents of Deprotonized products of hemolysate by concentration of TBA positive products, paralleled with high antioxidant capacity. 2.Basic membrane states and redoxy potentials of all membrane system, consisting of fourth compartmemt in Mkhris constitution category of individuals (Mkhris dominated ). All individuals, belonging to Mkhris constitution category, classified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition were distinguished by: a. Low Reducing capacity of of of all membrane system, representing fourth compartmemt, determined by using the nitroblue tetrazolium test b. Midlle protonizing, radical scavenging activity of all membrane system, representing fourth compartmemt, determined by using the DPPH (2,2-diphenyl 2 picrylhydrazyl ) radical test. c. High Contents of Deprotonized products of of all membrane system, consisting of fourth compartmemt by concentration of TBA positive products, paralleled with low antioxidant capacity. d. Low contents of saturated and high concentration of unsaturated fatty acids contained in LPHD and LPLD, which incorporated in integrated membrane - serum circultion system, which are evidence of prevalence of alpha state of membrane structures in these indivduals. i. Low Degree of saturated and unsaturated fatty acids dependant resistanse of all membrane system, presenting fourth compartmemt are determined by using osmotic and pereoxidation hemolysis test, which are evidence of prevalence of alpha state of membrane structures in these indivduals. 3. Basic membrane states and redoxy potentials of second compartment in Mkhris constitution category of individuals ( Mkhris dominated ). All individuals, belonging to Mkhris constitution category, identified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract-subjective nature of cognition have following differences : a. High oxy potentials of second compartment of individuals, accounted by parameters of AO:LPO system, contents of LPHD and LPLD b. Low Reducing capacity of second compartment of individuals, established by using the nitroblue tetrazolium test. c. Midlle protonizing, radical scavenging activity of second compartment of individuals, calculated by using the DPPH (2,2-diphenyl 2 picrylhydrazyl ) test. d. High Contents of Deprotonized products of second compartment of individuals determined by concentration of TBA positive products, paralleled with high antioxidant capacity. e. Low level of concentration of cholesterols, triglycerid, LPLD and high level of LPHD, which are evidence of prevailing of alpha state of membrane structures in these indivduals. 4. Basic membrane states and redoxy potentials of third compartment in Mkhris constitution category of individuals ( Mkhris dominated ). All individuals, belonging to Rlung constitution category, identified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition were distinguished by: a. Low contents of visceral (mainly containing LPLD fraction ) and high level of subcutaneous fatty acids (mainly containing LPHD fraction), which are demonstrated a prevalence of alpha state of membrane structures in these indivduals. Third results:
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1.Basic membrane states and redoxy potentials of hemolysate, representing first compartment, containing redoxy line systems in Badgan constitution category of individuals (Badgan dominated ). All individuals, belonging to Badgan constitution category, classified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition have following differences: a. High reducing capacity of of hemolysate, accounted by using the nitroblue tetrazolium test b. High protonizing, radical scavenging activity of hemolysate ,established by using the DPPH (2,2-diphenyl 2 picrylhydrazyl )test. c. Low contents of Deprotonized products of hemolysate, determined by concentration of TBA positive products, paralleled with high antioxidant capacity. 2.Basic membrane states and redoxy potentials of all membrane system, presenting fourth compartmemt in Badgan constitution category of individuals (Badgan dominated ). All individuals, belonging to Rlung constitution category, classified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract-subjective nature of cognition were distinguished by : a. High reducing capacity of all membrane system, consisting of fourth compartmemt by using the nitroblue tetrazolium test b. High protonizing, radical scavenging activity of all membrane system,representing fourth compartmemt by using the DPPH (2,2-diphenyl 2 picrylhydrazyl )test. c. Low contents of Deprotonized products of all membrane system, consisting of fourth compartmemt by concentration of TBA positive products, paralleled with high antioxidant capacity. d. High contents of saturated and low concentration of unsaturated fatty acids contained in LPHD and LPLD, which incorporated in integrated membrane - serum circultion system, which are evidence of prevailing of betta state of membrane structures in these indivduals. I. Low degree of saturated and unsaturated fatty acids dependant resistanse of all membrane system, presenting fourth compartmemt are determined by using osmotic and pereoxidation hemolysis test, which are evidence of prevailing of betta state of membrane structures in these indivduals. 3.Basic membrane states and redoxy potentials of second compartment in Badgan constitution category of individuals (Badgan dominated ). All individuals, belonging to Rlung constitution category, identified with help of Docam-1 programm parameters, obtained these by transferring to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract-subjective nature of cognition have a some specific characters as: a. High red potentials of second compartment of individuals, accounted by parameters of AO:LPO system, contents of LPHD and LPLD, which are evidence of prevailing of betta state of membrane structures in these indivduals. b. High reducing capacity of second compartment of individuals, determined by using the nitroblue tetrazolium test. c. Low oxidizing capacity of second compartment of individuals, established by using the DPPH (2,2-diphenyl 2 picrylhydrazyl) test. d. Low contents of Deprotonized products of second compartment of individuals, calculated by concentration of TBA positive products, paralleled with high antioxidant capacity.
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e. High level of concentration of cholesterols, triglycerid, LPLD and low level of LPHD, which are evidence of prevailing of betta state of membrane structures in these indivduals. 4.Basic membrane states and redoxy potentials of third compartment in Badgan constitution category of individuals (Badgan dominated). All individuals, belonging to Badgan constitution category, classified with help of Docam-1 programm parameters, obtained by transferring these to abstract thermin as as rlung, mkhris, badgan, which not really exist inside of human body, eventually have a abstract - subjective nature of cognition were distinguished by : a. Low contents of visceral (mainly containing LPLD fraction) and subcutaneous fatty acids (mainly containing LPHD fraction) which are evidence of prevailing of betta state of membrane structures in these indivduals. Basing in results of these investigations we conclude that: 1. Inside of every cells existed the regulation, which conducts electron, proton flow from donators to acceptors, resulting to producing ATP, HADPH, heat energy, ensuring the basis of normal existence of cell and we are given to them a new thermin as membrane-redoxy potentials 3 state systems 2. We observe that, one of membrane-redoxy potentials 3 state systems is fluid alpha state of membrane structures with high degree of oxidation potentials, with following middle intensity of ATP, HADPH generation and high intensity of heat energy generation. 3. We observe that, second of membrane-redoxy potentials 3 state systems is solid betta state of membrane structures with high degree of reduction potentials, with following high intensity of ATP, HADPH generation and middle intensity of heat energy generation. 4. We observe that, third of membrane-redoxy potentials 3 state systems is intermediate gamma state of membrane structures with low degree of oxidation - reduction potentials, with following low intensity of ATP,HADPH generation and low intensity of heat energy generation. 5. We establish that, the fluid alpha state of membrane structures with high degree of oxidation potentials, with following middle intensity of ATP, HADPH generation and high intensity of heat energy generates hot, hot oil external patterns and symbolized in Traditional medicine by hot-fire element and sun like mkhris abstract thermin. 6. We establish that, solid betta state of membrane structures with high degree of reduction potentials,with following high intensity of ATP, HADPH generation and middle intensity of heat energy generates cold, cold oil external patterns and symbolized in Traditional medicine by cold water, earth element and moon like badgan abstract thermin. 7. We establish that, intermediate gamma state of membrane structures with low degree of oxidationreduction potentials, with following low intensity of ATP, HADPH generation and low intensity of heat energy generates mobile, light, unoil, cool external patterns and symbolized in Traditional medicine by mobile wind element andwind like rlung abstract thermin. 8. Summarizing all these results of investigation we develop s-NCM new knowledge, which expressed as new conception The coincidence of Rlung, Mkhris, Badgan abstract thermin with regulation occurred in membrane - redoxy potentials 3 state systems of living cells. To elucidate the new knowledge as The coincidence of Rlung, Mkhris, Badgan abstract thermin with regulation occurred in membrane - redoxy potentials 3 state systems of living cells, we are drawn below examples: A-1 shows electron,protons conductance, B-2 shows proton gradient, formed during electron,protons conductance, C-3 shows the high energy phosphate-ATP, high energy electronsNADPH and heat energy generation with participation of proton gradient, formed during electron, protons conductance, D-4 shows 5 general functions, occurred in 5 membrane structure - by using of energy phosphate-ATP, high energy electrons-NADPH, E-5 shows donators as source of electron,
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protons, F-6 shows basic acceptors of electron, protons as oxygen, ox forms of NAD, ox forms of FAD molecules, G-7 shows gamma state of membrane structures with low degree of oxidation- reduction potentials, solid betta state of membrane structures with high degree of reduction potentials, fluid alpha state of membrane structures with high degree of oxidation potentials, H -8 shows high oxidation potentials state, high reduction potentials state, low reduction- oxidation potentials state, I-9 shows membrane redoxy potentials 3 state lines. By us established below lawfull processes: a. In the individuals, coded by Mkhris abstract thermin-in the G-7 point is increased the fluid alpha state of membrane structures with high degree of oxidation potentials,because of this in the A-1 point is elevated the electron, protons conductance, in the B-2 point generated high level of proton gradient, formed during electron, protons conductance, in the C-3 point occurred high level of heat energy generation with participation of proton gradient, formed during electron,protons conductance, in the D-4 point is increased the speed of information-response reaction, elevated the concentration and synthesis of biological active compounds with oxidized functional groups, increased the amount of deprotonized products in all membrane structures, intensified lysosome degradation activity, increased the quantity of oxygen active forms, observed middle level of protein synthesis, increased the synthesis of LPHD, decreased the synthesis of LPLD, in the H - 8 point predominated high oxidation potentials state, in the I-9 point prevailed the fluid alpha state of membrane structures with high degree of oxidation potentials of membrane redoxy potentials 3 state lines, coded by mkhris abstract thermin . b. In the individuals, coded by Badgan abstract thermin - in the G-7 point is increased the solid, betta state of membrane structures with high degree of reduction potentials, because of this in the A-1 point is decreased the electron, protons conductance, in the B-2 point generated high level of proton gradient, formed during electron, protons conductance, in the C-3 point occurred high intensity of high energy phosphate - ATP, high energy electrons-NADPH and middle intensity of heat energy generation with participation of proton gradient, formed during electron,protons conductance, in the D-4 point is decreased the speed of information-response reaction, elevated the concentration and synthesis of biological active compounds with reduced functional groups, increased the amount of protonized products in all membrane structures, decreased the lysosome degradation activity, decreased the quantity of oxygen active forms, observed the high level of protein synthesis, increased the synthesis of LPLD, decreased the synthesis of LPHD, in the H - 8 point predominated high reduction potentials state, in the I-9 point prevailed the solid 8 betta state of membrane structures with high degree of reduction potentials of membrane redoxy potentials 3 state lines, coded by Badgan abstract thermin . c. In the individuals, coded by rLung abstract thermin - in the G-7 point is increased the intermediate gamma state of membrane structures with low degree of oxidation-reduction potentials, because of this in the A-1 point is increased the electron, protons leak and prevalence of slip potentials ,in the B-2 point generated low level of proton gradient, formed during electron, protons conductance, in the C-3 point occurred low intensity of formation of high energy phosphate-ATP, high energy electrons-NADPH and low intensity of heat energy generation with participation of proton gradient, formed during electron, protons conductance, in the D-4 point is occurred the hypersensitivity of information-response reaction, decreased the concentration and synthesis of biological active compounds with oxidized-reduced functional groups, increased the amount of deprotonized products in all membrane structures, paralleled with low antioxidant activity, decreased the lysosome degradation activity, decreased the quantity of oxygen active forms, observed the low level of protein synthesis, decreased the synthesis of LPLD, decreased the synthesis of LPHD, in the H -8 point decreased the oxidation and reduction potentials state, in the I-9 point prevailed the intermediate, gamma state of membrane structures
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with low degree of oxidation-reduction potentials of membrane redoxy potentials 3 state lines, coded by rLung abstract thermin. d. In the patients with hyperthyreosis, coded by Mkhris abstract thermin - in the G-7 point is increased the fluid alpha state of membrane structures with high degree of oxidation potentials, because of this in the A-1 point is elevated the electron, protons conductance, in the B-2 point generated high level of proton gradient, formed during electron, protons conductance, in the D-4 point is increased the speed of information-response reaction, decreased the concentration of cholesteols, LPLD, increased the concentration of LPHD synthetized here, accumulated in the second compartment, increased the membrane leakage of all membrane structures, increased the quantity of deprotonized products in all membrane structures intensified lysosome degradation activity, increased the quantity of oxygen active forms, in the H - 8 point predominated high oxidation potentials state, in the I-9 point prevailed the fluid alpha state of membrane structures with high degree of oxidation potentials of membrane redoxy potentials 3 state lines, coded by mkhris abstract thermin . e. In the patients with hyperthyreosis, coded by Badgan abstract thermin- in the G-7 point is increased the solid, betta state of membrane structures with high degree of reduction potentials, because of this in the A-1 point is decreased the electron,protons conductance, in the B-2 point generated high level of proton gradient, formed during electron, protons conductance, in the D-4 point is decreased the speed of information - response reaction, elevated the concentration of cholesteols, protein, LPLD, decreased the concentration of LPHD synthetized here, accumulated in the second compartment, decreased the membrane leakage of all membrane structures, increased the quantity of protonized products in all membrane structures, decreased the lysosome degradation activity, decreased the quantity of oxygen active forms, in the H-8 point predominated high reduction potentials state, in the I-9 point prevailed the solid, alpha state of membrane structures with high degree of reduction potentials of membrane redoxy potentials 3 state lines, coded by Badgan abstract thermin . f. In the patients with after hyperthyreosis hypothrophy, coded by rLung abstract thermin - in the G-7 point is increased the intermediate, gamma state of membrane structures with low degree of reduction - oxidation potentials, because of this in the A-1 point is decreased the electron, protons conductance, in the B-2 point generated low level of proton gradient, formed during electron, protons conductance due to their leakage and slip mecchanism, in the D-4 point is changed the speed of information - response reaction, diminished the concentration of cholesteols, protein, LPLD, the concentration of LPHD synthetized here, accumulated in the second compartment, increased the membrane leakage of all membrane structures due to antioxidand shortage, increased the quantity of deprotonized products in all membrane structures due to antioxidand shortage, increased the lysosome degradation activity due to elevated membrane leakage, in the H - 8 point occurredthe lowing of oxidation - reduction potentials capacity, in the I-9 point prevailed the intermediate, gamma state of membrane structures with low degree of oxidation - reduction potentials of membrane redoxy potentials 3 state lines, coded by rLung abstract thermin. 1.1.3. The statement and involvement a of lecturer, student, supporter, contributors, employers or health managers and graduates, interest and donor participating in formulating mission and objectives of the curriculum. The main principles are to implement and achieve the mission and objectives of the curriculum through the involvement and representation of students, employers or health managers and graduates in the curriculum management process along with harmonizing our mission and objectives to address the health needs of the public and also reflecting comments and opinions of graduates, employers when updating the mission and objectives by undertaking the following activities as joint meeting of graduates and
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employers, inter institute and professional teachers organizations joint workshops and meetings, conferences. It should stressed that the new medical education program Traditional medical education in the 21 century have been elobarated with involvement of contributors, teachers, students and appeared because of their demands and requists, comments and opinions. Their demands and requists are follows: 1. In connection with this that prevailed the imagination that human body consists of really existing rLung, mkhris, badgan, the conducting of training process of Traditional Medical doctors based in the X, G knowledge do not give positive result to implementation of the new medical education programTraditional medical education in the 21 century. 2. In connection with this that nevertheless, when changed the imagination that human body do not consist of really existing rLung, mkhris, badgan considered that the sympathic and parasympathic regulation are connected with abstract theory of rLung, mkhris, badgan, training process of Traditional Medical doctors based in the X, G knowledge separately and S knowledge separately without connection, also do not give positive result to implementation of the new medical education programTraditional medical education in the 21 century. 3. But when appeared the new conception - the coincidence of really existing living cell membrane redoxy potentials 3 state regulation is the substance of forming the theory of rLung, mkhris, badgan, training process of Traditional Medical doctors based in the X, G knowledge , in addition to it S knowledge, integrated through s-NCM knowledge, would give positive result to implementation of the new medical education programTraditional medical education in the 21 century. 1.1.4.The world tendency ofdevelopment traditional education medical system and our achievment. To make selfevaluation to new medical education program Traditional medical education in the 21 century we put the goal to evaluate our gained achievement since proposing a new conception as rlung, mkhris, badgan-three states of membrane structures and redoxy potentials, The one cell two medicine new conception in 1990 in comparision with analogical investigations, carried out around world by other researchers of forein countries. a. As other researchers,who are conducting a analogical investigations, by us choosen study of professor Prasher B, Institute of genomics and integrated Biology in the field of India-Aurveda medicine, study of professors Hyun-Ju Kim, Bu-Yeo Kim, Korea, Institute of Oriental Medicine in the field of Korea - Sa sang medicine, study of professor Yanrui Wu - Beijing University of Chinese Medicine in the field of Chinese traditional medicine -Yang-Ying theory. b.To evaluate the gained achievement in the field of elucidation of theorertical aspects of Oriental medicine, made by researchers, who are conducting a analogical investigations with attempts to find common language between basic theoretical aspects of Oriental and Modern medicine and build a scientific bridge between basic theoretical aspects of Oriental and Modern medicine we are used a following main parameters as: 1. A achievements in the direction of finding of corresponding Genome expression of individuals, belonging to three and four types of constitutions 2. A achievements in the direction of finding of corresponding Biochemical correlates of individuals, belonging to three and four types of constitutions, according to Modern medicine and Biology analogous findings 3. A achievements in the direction of proposing the new conception, comprising all aspects of basic theory of Oriental Traditional and Modern medicine 4. A achievements in the direction of finding of corresponding Morphofunctional correlates of individuals, belonging to three and four types of constitutions, which are existed in accordance with Modern medicine and Biology analogous findings
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5. A achievements in the direction of developing the new methodological approach, which could be used to find common language between basic theoretical aspects of Oriental and Modern medicine and build a scientific bridge between basic theoretical aspects of both medicines 6. A achievements in the direction of establishing the common language and bridges betweenbasic theoretical aspects of traditional and recent medicines 7. A achievements in the direction of Introduction of common language and builded bridge in to research works, diagnostic and treatment practice, training practice 8. A achievements in the direction of creation of independent third new medical system in the result of finding a common language between basic theoretical aspects of both medicines 9. A achievements in proposing absolutely new cognitive space in the science,which serves the role of common language and bridge of likage detween basic theoretical aspects of Oriental and Modern Medicine. In the result of summarizing and comparing the main achievements, made in the new scientific direction of proposing the new conception, comprising all aspects of basic theory of Traditional medicine, of developing the new methodological approach, which could be used to find common language between basic theoretical aspects of Oriental and Modern medicine and build a scientific bridge between basic theoretical aspects of Oriental and Modern medicine we are occupying a priority position, relating to 7 parameters from 8 main parameters, excluding the investigation aimed to finding of corresponding Genome expression of individuals, belonging to three and four types of constitutions. But, it is started the study aimed to find rlung, mkhris, badgan related genes by using new methodological approach, as abstraction( rlung, mkhris, badgan) five elements (fire, water, earth) - external patterns (hot, cool, hotoil, cold-oil, stupid, sharp) -corresponding substrates,enzymes,proteins- corresponding,responsible genes at example- may be postulate that the predominance of bette state of membrane structures and prevailance of high reduction ability of redoxy chain in badgan dominated type of people are accompanied with inducing the SCD gene enzyme activity and causing a remarkable increase in plasma lipid and very low density lipoprotein production . Findings Countries India-AurvedaKorea-Sa Chinese traditional Mongolia (Prasher B, sang medicine -Yang(M.Ambaga, professor, Institute of medicine Ying theory(Yanrui International cadeny , genomics and (Hyun-Ju Wu -Beijing of Eastern and Western Academy, integrated Kim, BuNew medicine (NCM) medical University of Biology) Yeo Kim, institute Chinese Medicine) Korea Institute of It is started the study aimed to Oriental find Medicine) rlung,mkhris, badgan related genes by using new methodological approach, as Kapha males So-Yang Normality, Yangabstraction ( rlung, mkhris, also had high type deficiency, Yinbadgan) levels of LDL, (Extroversi deficiency and 1. reduced on and Phlegm-wetness with five elements (fire, water, earth)-external patterns Genome prothrombin Perceiving) whom 23 single (hot, cool, hot-oil, cold-oil, stupid, expressio time and low - the nucleotide sharp)-corresponding substrates, n expression of genetic polymorphisms enzymes, proteinsgenes related to polymorphi (SNPs) in the three
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fibrinolysis (KRT1 and F2), Higher expression of genes which affects hemoglobin levels HBA1, HBB, NOV in Pitta compared to Vata and Kapha,also genes DPYD, ABCC1[32], FTL. In Kaphaoverall downregulation of genes of fibrinolysis involved in negative regulation of blood coagulation,Pitta exhibited significant over expression of genes related to immune response ,In Kapha-overall up-regulation of genes involved in cellular biosynthesis including ATP and cofactor biosynthesis and purine salvage pathway, Vata group- showed a distinct down regulation of genes involved in response to biotic stimulus sm of the MDR1 gene was thus shown to be an indicator that could distinguish So-yangin from other constitution s, Soyangin and So-eumin showed significant differences in the distribution of both 1236C2677G3435C and 1236T2677G3435T, haplotypes of MDR1SoEum type (Introversio n and Judging) Significant differences in MDR1 C1236T genotypes were found between So-yangin and Soeumin-an. Tae-Eum typeMDR1 G2677T/A
genes were genotyped. Biased distribution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotype13 (Hap13) of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hap14 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be groupassociated haplotypes. These results suggested that single SNP and haplotypes of PPARD, PPARG corresponding, responsible genes at example- may be postulate that the predominance of bette state of membrane structures and prevailance of high reduction bility of redoxy chain in badgan dominated type of people are accompanied with inducing the SCD gene enzyme activity and causing a remarkable increase in plasma lipid and very low density lipoprotein production .
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and inflammatory response, overexpression of genes of immune related pathways was observed in Pitta ,Vata (cell division and regulation of function of Kapha and Pitta), Pitta (host surveillance) and Kapha with anabolism, Complement -to be low in Kapha. Triglycerides (TG), total cholesterol, VLDL, LDL, LDL/HDL ratio, was higher in Kapha when compared to Pitta and Vata maes, Kapha had lower levels of HDL when compared to Vata. The levels of serum uric acidindependent predictor of cardiovascular mortality elevated in Kapha. Prothrombin time were high in Vata in genotype also showed significant differences in allele distribution between So-yangin and Taeeumin.
2. Biochemi cal correlates
rLung-low ATP, NADPH, thermoregulation, low Cholesterol, TG, LPLD, LPHD, low oxidase, reductase, activity, low CD4,CD 8 activity, Badgan-high ATP, NADPH, low thermoregulation, high Cholesterol, TG, LPLD, low oxidase, high reductase activity, middle CD4, CD 8 activity, Mkhris-middle ATP, NADPH, high thermoregulation, middle Cholesterol, TG, LPLD, high LPHD, high oxidase, low reductase activity, high CD4, CD 8 activity.
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comparison to Kapha and/or Pitta. Pitta males showed high values of hematological parameters like hemoglobin, PCV, and RBC count In comparison to Vata and/or Kapha. Non 3. New conceptio n, comprisin g all aspects of basic theory of Tradition al medicine 1.Individuals who had thin and narrow body frame, weakly developed body build, with irregular appetite, food and bowel habits, difficulty in gaining weight, quick at physical activities, dry skin and hair, and less tolerance for cold temperature
The new conception of coincidence of theory rlung, mkhris, badgan with three states of membrane structures and redoxy potentials, located in first compartment and fourth compartment of living cell and reflected in the second, third compartments of human body.
4. Morphof unctional correlates
rLung-low visceral alpha-10%, low subcutaneous alpha-30%, low AO activity, high SPOL, mkhris middle visceral alpha-10%, high subcutaneous alpha-30%, high AO activity, middle SPOL, badgan high visceral alpha10%, middle subcutaneous alpha-30%, high AO activity, low SPOL.
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were considered as Vata Prakriti. 2.Individuals with moderately developed build, high frequency of appetite and thirst, good digestive power, perspiration tendency higher than normal, 3.tolerance for cold weather, moderately mobile with moderate physical strength were identified as Pitta Prakriti. Individuals who had broad body frames with well developed body build, tendency to gain weight, low appetite and digestion, preferred to be less mobile, less forgetful and with good healing power and cool temperament, were selected as Kapha individuals.
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Non 5. New methodol ogical approach
New methodological approaches: One cell-two medicine, substance-external properties-abstraction, Rlung, mkhris, badgan-three states of membrane structures and redoxy potentials
6. What is common language and bridges between traditiona l and recent medicine s
Vata contributes to manifestation of shape, cell division, signaling, movement, excretion of wastes, cognition and also regulates the activities of Kapha and Pitta. Kapha is responsible for anabolism, growth and maintenance of structure, storage and stability. Pitta is primarily responsible for metabolism, thermoregulation, energy homeostasis, pigmentation, vision, and host surveillance.
The common language and building bridges between traditional and recent medicines are the new scientific cognitive interpretation,so named s-NCM, comprising the new definition-new modelling system of living cells and human body, the 4 compartments,10 systems.
7.Introdu ction of common language and builded bridge in to
It is introduced in to research works, diagnostic and treatment, training practice new approach, described as g--S-s-NCM
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research works,dia gnostic and treatment practice,t raining practice 8.A new steps of creation of independ ent third new medical system 9. Proposin g absolutel y new cognitive space in the science,w hich serves the role of common language and bridge of likage detween basic theoretica l aspects of Oriental and Modern Medicine .
It is created the third new medical system,so named NCM medicine. 9. It is proposed a absolutely new cognitive space in the science,which serves the role of common language and bridge of likage detween basic theoretical aspects of Oriental and Modern Medicine.
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1.1.7.The establishment of connection with other education organisation and credit exchange, exchange by experience in the field of preparing of Traditional medical doctors. Why we should modify and modernize the education system of preparing of Traditional medical doctorsin the 21 century,this is because of that : 1.The history of teaching of of Traditional medical doctors had started since 13 century,when many Tibetan medical sutara-books translated in Mongolian language, through these translation inheritated the the tibetian style of medical training system, where prevailed the imagination that human body consists of really existing rLung, mkhris, badgan, training process of Traditional Medical doctors based in the X, G knowledge. In one hand we can say that Traditional medicine (TM) is full system, because TM has own phillosophy,own founder, TM has own theory, own methods of investigation, has own methods of prevention, diagnosis, treatment, own methods of using of all medicaments, own system of preparing of young generation within own X, G knowledge, but one shortage of TM is that, it have not S and s-NCM knowledge. 2. Frankly speaking in the 21 century the use of medicine, which only based in the X, G knowledge without S and s-NCM knowledge is impossible, in this case in every day prevention, diagnosis, treatment practice we would feel lack of these knowledges. In this connection we are elobarating new medical education program Traditional medical education in the 21 century in which X, G knowledge of Traditional medicine enriched by S and s-NCM knowledge i.e. X, G knowledge of Traditional medicine have been integrated with S and s-NCM knowledge, acquiring full character as X, G knowledge + S + s-NCM knowledge. Theoretical basis of new medical education program Traditional medical education in the 21 century and X, G knowledge + S + s-NCM knowledge based preparing of Traditional medical doctors are approved by by results of forein researchers, who are succeded to find rLung- related genes, mkhris - related genes, badgan - related genes. Professor Husted C et all (USA, Global Institute for Tibetan Medicine, Norwalk, California, USA. husted@globaltibetmed.org)-in own article as Tibetan medical interpretation of myelin lipids and multiple Sclerosis ( Annals of new York Academy of sciences, 2009, 1172, 278-296) stressed that ...A comparison of the three humor theory of Tibetan medicine and the three thermodynamic phase properties of myelin lipids exemplifies how integrating medical systems can increase understanding of complex chronic disabling conditionswith citation of our new conception Relationship between abstract theory of rlung, mkhris, badgan and membrane-redoxy potentials 3 state systems The thermin as integrating medical system, expressed by professor Husted C indicated the essence of our new medical education program Traditional medical education in the 21 century and X, G knowledge + S + s-NCM knowledge based preparing of Traditional medical doctors and gives to us further collobaration, information change and also possibility of credit change. Also established by Prasher B et all (Institute of genomics and integrated Biology) experimetal and clinical data as Triglycerides (TG), total cholesterol, VLDL, LDL, LDL/HDL ratio was higher in Kapha, who is prone to cardiovascular disease witnessed the rightness of our similar experimetal and clinical data during which we observed that the individuals, coded by Badgan abstract thermin - in the G-7 point is increased the solid, betta state of membrane structures with high degree of reduction potentials, because of this in the A-1 point is decreased the electron, protons conductance, in the B-2 point generated high level of proton gradient, formed during electron, protons conductance, in the C-3 point occurred high intensity of high energy phosphate-ATP, high energy electrons-NADPH and middle intensity of heat energy generation with participation of proton gradient, formed during electron,protons conductance, in the D-4 point is decreased the speed of information-response reaction,elevated the concentration and synthesis of biological active compounds with reduced functional groups, increased
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the amount of protonized products in all membrane structures, decreased the lysosome degradation activity, decreased the quantity of oxygen active forms, observed the high level of protein synthesis, increased the synthesis of LPLD, decreased the synthesis of LPHD, in the H -8 point predominated high reduction potentials state, in the I-9 point prevailed the solid 8 betta state of membrane structures with high degree of reduction potentials of membrane redoxy potentials 3 state lines, coded by Badgan abstract thermin. Now in ordr to introduce the new medical education program Traditional medical education in the 21 century and X, G knowledge + S + s-NCM knowledge based preparing of Traditional medical doctors in credit and information change with forein similar education and research organisations we are planning to establish connection with Bhushan Patwardhan, India, Director of Institute of Ayurveda and Integrative medicine, Charlie C. Hu*, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, Bhavana Prasher,#1 Sapna Negi,#1 Shilpi Aggarwal, Delhi, India 2Department of Statistics, University of Pune, 411007 Pune, India Bhavana Prasher: bhavana.p@igib.res.in; Sapna Negi: sapna.negi@igib.res.in; Shilpi Aggarwal: shilpi.aggarwal@igib.res.in; Amit K Mandal: amit491@gmail.com; Tav P Sethi: t.sethi@igib.res.in; Shailaja R Deshmukh: srd@stats.unipune.ernet.in; Sudha G Purohit: sgp@stats.unipune.ernet.in; Shantanu Sengupta: shantanus@igib.res.in; Sangeeta Khanna: skhanna@igib.res.in; Farhan Mohammad: farhan@mailhost.tifr.res.in; Gaurav Garg: gaurav.garg@igib.res.in; Samir K Brahmachari: skb@igib.res.in; Indian Genome Variation Consortium: skb@igib.res.in; Mitali Mukerji: mitali@igib.res.in, Sanjeev Rastogi ,Vatsala Hospital, Tulsi Das Marg, Lucknow - 226 004, India. E-mail: rastogisanjeev@rediffmail.com, Si-Woo Lee,1Republic of Korea. Tel: Phone: +82-42-868-9489; Fax: +82-42-868-9480; E-mail: ssmed@kiom.re.kr,Yanrui Wua,1, Beijing University of Chinese Medicine, Si-Woo Lee,1 1Korea Institute of Oriental Medicine (KIOM), Hyun-Ju Kim, Republic of Korea 4Department of Oriental Pharmacy, College of Pharmacy, Jong Yeol Kim1, National Hospital of Traditional Medicine of Vietnam, 29 Nguyen Binh Khiem St., Hai Ba Trung Dist., Hanoi, Vietnam and 4Kyunghee University, Department of Sasang Constitutional Medicine, Kyunghee University Medical Center, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-702, Republic of Korea, Bu-Yeo Kim, Seongwon Cha, Hee-Jeong Jin and Sangkyun Jeong Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine, 461-24, Jeonmin-dong, Yuseong-gu, Daejeon, 305-811, Korea , Some lecture of professor M.Ambaga,relating to new conception Relationship between abstract theory of rlung, mkhris, badgan and membrane-redoxy potentials 3 state systems, s-NCM new knowledge, and the new medical education program Traditional medical education in the 21 century and X,G knowledge + S + s-NCM knowledge based preparing of Traditional medical doctors now are conducted www.youtube.com/watch . Now we are informing through internet web site a some new scientific debated articles as The serious mistake revealed by Mongolian researcher professor Ambaga in one widely in the world used equation, Rlung, mkhris, badgan - three states of membrane structures and redoxy potentials, The one cell two medicine, new conception and achievements in the field of finding a common language between Modern and Oriental medicine, which at further may be open the way to extend our connection, credit exchange with foreign similar education and research organisation in framework of the new medical education program Traditional medical education in the 21 century and X, G knowledge + S + s-NCM knowledge based preparing of Traditional medical doctors . The graduates - Traditional medical doctors,trained by program Traditional medical education in the 21 century able to some analyze the some acute problems of modern biology and biochemistry by using s NCM knowledges and X+G+S+s-NCM full integrated knowledge and make the some modified and improved conclusion. Below we take some examples:
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Due to relatively limited scientific, cognitive capacity of all informations ,accumulated in Modern medicine and Biology, which is characterized by that as we could not overcome knowledge shortage, described as level S, we could not reach the level as s-NCM, we could not create unique theoretical basis, named as s-NCM,allowing to us the possibility explain a essence of more important biological processes, occurred in living cells from one general view point, we could not describe the new model of functioning a living cells, including memrane-redoxy line, existing inside living cell, harvesting energy from various H,e donators and H,e acceptors as oxygen, in last 50 years around the world had distributed completely incorrect formula as 6126 + 62 = energy + 620 + 602 in page of every textbook manuals, relating to Chemistry and Biology, beginning from 6 class of secondry school. Why we are saying that completely incorrect formula as 6126 + 6 2 = energy + 6 20 + 6 02, because in case of such reaction would not occurred a formation of such end products energy, 20, 02 instead them would be formed glucuronic acid in the result of autooxidation of glucose molecule.i.e. in the result direct contact of glucose molecule with oxygen. The right variant of this formila is 6126 + membrane-redoxy three state line + 62 = energy (, , heat energy) + 620 + 602 by putting the membrane-redoxy three state line between 6126 and 62, but only in this case would be formed 620 and 602, energy (TP, DP, heat energy), through formation of proton gradients-leading to generation of TP, DP, heat energy, formation of 620- inside of mitochondrial matrix, creation of 602-in the Krebs cycle.i.e. in the result of discovering the energy synthetizing line, consisting of 69 reaction stations, named as membrane redoxy chains we are revealed the more serious mistake in the one equation as 6126 + 62 = energy + 620 + 602. It was interesting that, the general features of abovementioned reaction was described by symbolic code as rlung, mkhris, badgan in Tibetian - Mongolian Traditional medicine, i.e. in case, if this reaction is occurred by first variant when H,e donator 6126 + 6 2 is slowly utilized because of shortage of H,e donator -62 under influence of betta state of membrane structures and prevailed reduction potentials,which lead to more conversion of proton gradients to ATP with less formation of heat energy happened the appearance of cold, heavy, cool-oil external patterns, whole reaction in the theory of Tibetian-Mongolian Traditional medicine described by symbolic code as Badgan-moon, water + earth elements. In case, if this reaction is occurred by second variant when H,e donator 6126 + 6 2 is more rapidly utilized because of sufficient supply of H,e donator - 6 2 under influence of alpha state of membrane structures and prevailed oxidation potentials, which lead to more conversion of proton gradients to heat energy, with middle formation of ATP - happened the appearance of hot, light, hot - oil external patterns, whole reaction in the theory of Tibetian-Mongolian Traditional medicine described by symbolic code as mkhris - moon, fire element. If, it is dominated third variant when contents of H,e donator 6126 are diminished and the concentration of 62 is also decreased under influence of gamma state of membrane structures and slow redoxy potentials, which lead to decrease of proton gradients,which are accompanied t with low formation of ATP, NADPH, heat energy - happened the appearance of mobile, light, nonfatty external patterns, whole reaction in the theory of Tibetian-Mongolian Traditional medicine described by symbolic code as rlung-wind, wind rlung element. Beside, by us have been revealedthat, rlung, mkhris, badgan code, formed due to three basic variants of membrane-redoxy three state line are exerted their influence in the three remaining 2, 3, 4 compartments of living cell and human body leading to appearance of external patterns of rlung, mkhris, badgan abstract code i.e.the prevailance of gamma state of MS with low redoxy potentials in the first compartment leads to decrease of ATP, NADPH, heat energy, in this connection in the fourth compartment inside living cells are diminished the intensity of gene-cell division, synthetic-resynthetic, biotransformation,
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bioenergetic functions and observed the instability of information-response reaction in the background of ATP, NADPH, heat energy deficiency,which are accompanied with decrease of contents of proteins, glucose, LPHD, LPLD and antioxidant pool, increase of acid: alkaline ratio in the second compartment, which also lead to decrease of visceral-alpha 10% fats and subcutaneous alpha 30% fats because of ATP, NADPH, heat energy shortage, which are accompanied by appearance of dry, light, mobile, nonfatty external patterns, belonging to symbolic code as rlung-wind, wind rlung element. The prevailance of alpha state of MS with high oxy potentials in the first compartment leads to increase of heat energy, oxygen diffusion ,in this connection in the fourth compartment inside living cells a synthetic-resynthetic, biotransformation, bioenergetic functions are enriched by oxygen comsumption, the ratio of oxidized: reduced form of functional groups in the newly syntethized proteins, lipoproteids, glycoproteids is increased in the second compartment a contents of proteins, glucose, LPHD, LPLD are decreased because of their utilization are intensified in the first compartment, ratio of LPHD:LPLD is increased in the in the second compartment, which also lead to decrease of visceral-alpha 10% fats and increase of subcutaneous alpha 30% fats, which are accompanied by appearance of hot, hot-oil external patterns, belonging to symbolic code as mkhris-sun, fire element. Meanwhile the predominance of betta state of MS with high red potentials in the first compartment leads to decrease of heat, oxygen diffusion, in this connection in the fourth compartment inside living cells a synthetic-resynthetic, biotransformation, bioenergetic functions are occurred in rhe circumstance of deficiency of oxygen comsumption, the ratio of oxidized: reduced form of functional groups in the newly syntethized proteins, lipoproteids, glycoproteids is decreased in the second compartment ,a contents of proteins, glucose, LPHD, LPLD are increased because the intensity of their utilization are diminished in the first compartment, ratio of LPHD:LPLD is decreased in the in the second compartment, which also lead to increase of visceral-alpha 10% fats and decrease of subcutaneous alpha 30% fats, which are accompanied by appearance of cool, cool-oil, heavy, stupid external patterns, belonging to symbolic code as mkhris-sun, fire element. In order to show what kind of educational and research activity we are conducting with purpose ,aimed connect a knowledge obtained from the new medical education program Traditional medical education in the 21 century and X, G knowledge + S + s-NCM knowledge based preparing of Traditional medical doctors with last time new information, appeared in a biological science drawn below examples. 1.Sibille B, Keriel C, Fontaine E, et all (Laboratoire de Thrapeutique, Universita Joseph Fourier, Grenoble, France) established that, Fatty acid addition to cells uncoupled with 2, 4-dinitrophenol appears to restore a mitochondrial membrane potential, probably by providing the respiratory chain with reduced cofactors directly in the matrix, thus allowing the transfer of reducing equivalents across the mitochondrial membrane. The restoration, to some extent, of a protonmotive force to uncoupled cells by fatty acid addition is also supported by an increase in ATP synthesis as evidenced by a glucose synthesis with dihydroxyacetone as gluconeogenic substrate (Octanoate affects 2, 4-dinitrophenol uncoupling in intact isolated rat hepatocytes). 2. Hamamoto,T; Hirata, H.; Kagawa, Y, Dept. of Biochem., Jichi Med. Sch, Tochigi also established that: Stable phospholipid bilayer membranes were made by polymerizing the phospholipid 1,2-di (2, 4octadecadienoyl) - 3-phosphatidylcholine (DODPC) by means of UV irradiation and used to measure proton translocation and ATP (adenosine triphosphate) synthesis by H+-ATPase from the thermophilic bacterium PS3. The polymerized membrane was much more tight and stable than the monomeric DODPC membrane, but not more stable than the soybean phospholipid bilayer membrane previously used for reconstruction of H+-ATPase (Membrane electronics of reconstituted thermophilic proteins: polymerization of planar phospholipid bilayer membranes)
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3. Basing in the results of abovementioned researchers as Sibille B, Keriel C, Fontaine E, et all and Hamamoto,T; Hirata, H; Kagawa, Y, please give a answers to following questions ( in case of giving a answers to following quiestions we should consider the fatty acids in the one hand as donators of electrons, protons, used in membrane-redoxy potentials 3 state systems, in another hand as phospholipid membrane components, from which formed a membrane-redoxy potentials 3 state systems) . First question and answer: a. Explain the results of abovementioned articles of foreign authors in connection with theory of Traditional medicine of 20 external patterns and 17 powers of medicaments as hot, hot oil, cool, cool oil, light, heavy, acute, stupid, mobile, unoilly patterns within G knowledge. b.Explain the results of abovementioned articles of foreign authors in connection with theory of Traditional medicine of 5 element (hot, hot oil pattern related fire element, cool, cool oil, heavy pattern related earth, water elements, mobile, unoilly pattern related wind element), rlung, mkhris, badgan (hot, hot oil patterns- fire element related sun like mkhris abstract thermin, cool, cool oil, heavy patterns earth, water elements related moon like Badgan abstract thermin, mobile, unoilly pattern - wind element related mobile-wind like rLung abstract thermin) within X knowledge. c. Explain the results of abovementioned articles of foreign authors in connection with theory of Modern medicine within S knowledge. d. Explain the results of abovementioned articles of foreign authors in connection with theory of NCM medicine within s-NCM knowledge. e. Explain the results of abovementioned articles of foreign authors in connection with new conception of existence of membrane-redoxy potentials 3 state line inside human body. f. Explain the reason of these processes, why could not functioned the membrane strucures without fatty acids component, why could not conducted the proton-electrons conductance, generation of proton gradient, formation of high energy phosphate-ATP, high energy electrons-NADPH, heat energy. When making answer to these quiestions should consider that: .Fatty acid addition providing the respiratory chain with reduced cofactors directly in the matrix . Fatty acid addition allowing the transfer of reducing equivalents across the mitochondrial membrane. .The inner mitochondrial compartment consists of gele like substance of water, named the matrix, which contains high concentrations of soluble enzymes of oxidative metabolism - citric acid cycle enzymes. At second: express your opinion how to create experimental model of regulation, coded by rlung, mkhris, badgan abstract thermin. At third: Connect the results of abovementioned articles of foreign authors with pathogenesis of diabetes, obesity, early ageing, atherosclerosis and liver cirrhosis, myocardial infarction, renal insufficiency. Beside below we are given some questions of state examination,which conducted within new medical education program Traditional medical education in the 21 century and X, G knowledge + S + sNCM knowledge based preparing of Traditional medical doctors. Assesment 11 1. Explain the relationship between Albert Einstein quotation as I like to think that the moon is there even if I am not looking at it and phillosophical - historical way of appearing of theory of rlung, mkhris, badgan and evolutionary - historical way of appearing of membrane - redoxy potentials 3 state line system in the universe, their links as the theory of rlung, mkhris, badgan and membrane - redoxy potentials 3 state line system related normal existince of human body by using s-NCM new knowledge. 2. Describe the coding of Krebs cycle reaction of electron-proton conductance by rlung, mkhris, badgan abstract thermin in Traditional medicine by using s-NCM new knowledge.
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3. Find the unknown functional-structural unit, which is ensured the normal existence of livind cells with participation of glucose and oxygen molecules, decribe the coding of these processes by rlung, mkhris, badgan abstract thermin in Traditional medicine by using s-NCM new knowledge. Assesment 26 1. Describe the mecchanism of all kinds of vitamins in the membrane-redoxy potentials 3 state line system by using s-NCM new knowledge. 2. Show gene variants, which play a fundamental roles in s-NCM new knowledge related explanation of essense of 6 steps of cognitive processes as Gene-enzyme-substrats-external patterns-their 5 element mediated coding- their rlung, mkhris, badgan abstract thermin mediated coding 3. Explain the reasons, why in Traditional medicine the lung considered as organ, coded by abstract badgan thermin with connection of UCP2, UCP3 gene-enzyme activation through s - s - NCM new knowledge. Beside, we are conducting every year among 3d, 4th and 5th year students the contest as Who good know and good use the new enriched definition of living cells since 2007, which are playing the significant roles in the improving theoretical and clinical thinking ability of students. Below are shown some variants of questions, which are used during this contest : 1. Explain the biological basis of that why plants growed in Mongolia exerted good effects to people, lived in our territory. 2. Explain the reason of insomnia and increased diuresis in compliance with with new conception of existence of membrane-redoxy potentials 3 state line inside human body by using new enriched definition of living cells . 3. Describe the Rlung, mkhris, badgan coding of events as proton, electron conductance-generation of ATP, NADPH, heat energy according to new enriched definition of living cells. 4. Describe the pathogenesis of Stomach ulcer disease in connection with pathological processes, provocated in first, second, third, fourth compartments of human body according to new enriched definition of living cells. 5. Describe the pathogenesis of Diabetes mellitis in connection with pathological processes, provocated in first, second, third, fourth compartments of human body according to new enriched definition of living cells. 1.2.4.Integration of teaching programs, included in the curriculum of preparing Traditional medical doctors and interdiscipline relationship,their inheritance. - -.49 Students should understand that: 1. Famous researchers of humanity during last 3000 years was engaged in obtaining the right answers to one very important questions as the key regulation of normal existence of human body-cause of pathological change their diagnostics-their treatment within 6 parameters gene - enzyme - substrate 20 external patterns - abstraction these by 5 element-abstraction these by rlung, mkhris, badgan with periodically disruption. The study of first 3 members of abovementionad equation was implemented by Modern medicine and disrupted the last 3 members of abovementionad equation, meanwhile study of last 3 members of abovementionad equation was implemented Traditional medicine 2. In the period of first disruption appeared X, G knowledge and subjects, disciplins as theory of 20 external patterns, theory of 5 element, theory of rlung, mkhris, badgan, pulse and urine diagnostics, acupuncture, massage therapy, food therapy, traditional inner disease, traditional hot disease et all. In the period of second disruption appeared S knowledge and subjects, disciplins as morphology, physiology, immunology, dermatology, surgery, cardiology et all. Theoretically can be say that all subjects, disciplins as theory of 20 external patterns, theory of 5 element, theory of rlung, mkhris, badgan, pulse and urine diagnostics, acupuncture, massage therapy, food therapy, traditional inner disease, traditional hot disease et all, appeared in the period of first disruption, as well as
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subjects, disciplins as morphology, physiology, immunology, dermatology, surgery, cardiology et all, appeared in the period of second disruption should not be remained disconnected. But in the result of conducting interdisciplin integration through s-NCM knowledge created the possibility to connect a all subjects, disciplins of X, G knowledge with all subjects, disciplins of S knowledge. 3. The rightness od our suggestion that gene enzyme substrate - 20 external patterns - abstraction these by 5 element-abstraction these by rlung, mkhris, badgan 6 steps cognitive line should be exist under regulation of genes are confirmed by results of investigation of foreign researchers as Chinese researchers established that in case Iyn deficiency prevailed PPARG Pro12Ala gene-enzyme forms, in a Phlegm-wetness individuals dominated PPARD rs2076167, APM1 rs 266729 and rs 7627128 forms , Yan deficiency individuals dominated APM1 gene, Hap25 of APM1 gene-enzyme forms, Indian researchers revealed that in Pitta people in comparision with Vata Kapha people dominated HBA1, HBB, NOV gene freqiuncy, Koren researchers established that in So-Eum type people distinguished by appearance of MDR1 gene 1236C-2677G-3435C and 1236T-2677G-3435T, haplotypes of MDR1 geneenzyme forms, in So-yangin and So-eumin individuals have MDR1 C1236T genotypes, Tae-Eum type have MDR1 G2677T/A gene-enzyme forms . The question of creating of experimental models of cell regulation, coded by abstract rlung, mkhris, badgan thermins in Traditional medicine is very important part of confirmation of scientific basis of new training technology Traditional medical education in the 21 century, because during which became clear the essence of the new conception and new knowledge as The coincidence of Rlung, Mkhris, Badgan abstract thermin with regulation occurred in membrane-redoxy potentials 3 state systems of living cells. In otherwise, the scientic based elimination of the cognitive uncoincidence - barrier existing between X + G medical knowledge based training of Traditional medicine and S knowledge based training of Modern medicine, relating to urgent quiestion of medicine as status of normal existince of human body - key cause of pathological change - their diagnostics - their treatment would be decided in case of using of experimental models of cell regulation, coded by abstract rlung, mkhris, badgan thermins in Traditional medicine. The results of these investigations should be give scientific - methodological basis to integrate all disciplins,belonging to Traditional and Modern medicine and to ensure their inheritance, to decide the integration between teaching programs,included in the curriculum of preparing Traditional medical doctors. Basic methods of investigation, conducted by us to creating of experimental models of cell regulation, coded by abstract rlung, mkhris, badgan thermins in Traditional medicine. Experimental justification of basic conception of NCM medicine, s-NCM knowledge and new training technology Traditional medical education in the 21 century, are conducted by using following methods. Subjects of our experimental works was rabbits aged 18-24 months, including male and female, ratio 50:50. A.Experimental inducing of fluid alpha states, consisting of unsaturated fatty acids with high levels of oxy potentials and with high levels of proton, electrons conductance and high levels heat energy release in a rabbits was caused by injection of Dinitrophenol 2- 4 (3,5 g/ kg, four days, under cutaneous ) B.Experimental inducing of solid betta state, consisting of mainly saturated fatty acids, conditioning a high levels of red potentials and with slow levels of proton, electrons conductance and low levels of heat energy release, high degree of energy accumulation and high degree of high energy phosphate-ATP, high energy electrons in a rabbits was caused by injection of Rotenon (2,5 g/ kg, four days,under cutaneous). Results of iour nvestigation
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First results: A. Change of oxidizing activity of hemaglobine molecules in the first compartment during of modelling of high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenol mediated proton loss process) and their relationship with abstract Mkhris code. We revealed that in the case of modelling of high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are increased the oxidizing activity of hemaglobine molecules in 3,0-7,67 times in comparision with control animals after 3, 7, 14 days of modelling,which is on of appearanse of a sun like hot,hot oil external characteristics, coded by abstract mkhris thermin. B.Change of reduction : oxidation ratio activity of second compartment (serum oxidase enzyme activity)during of modelling of membrane high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process ) and their relationship with abstract Mkhris code. By us established that in the case of modelling of high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process ) are increased the reduction : oxidation ratio activity of second compartment (serum oxidase enzyme activity) in 1,2-1,6 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearanse of a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. C. Change of the free radical protonizing activity of membrane - redoxy 3 state line systems ,existing in the first compartment) during of modelling of membrane high alpha state - high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenol mediated proton loss process) and their relationship with abstract Mkhris code. It was clear that in the case of modelling of high alpha state - high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are slowed the free radical protonizing activity of membrane - redoxy 3 state line systems ,existing in the first compartment) in 1,11,12 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearanse of a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. D.Change of the quantity of deprotonized products in the second compartment during of modelling of membrane high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process ) and their relationship with abstract Mkhris code. We revealed that in the case of modelling of high alpha state - high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are increased the quantity of deprotonized products in the second compartment in 1, 2 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearance of a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. E. Change of the quantity of deprotonized products in the fourth compartment during of modelling of membrane high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) and their relationship with abstract Mkhris code. It was clear that in the case of modelling of high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are increased the quantity of deprotonized products in the fourth compartment in 1, 2 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearanse of a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. I. Change of the quantity of deprotonized products in the fourth compartment during of modelling of membrane high alpha state-high oxy potential elevated situation in rabbits by
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dinitrophenol (dinitrophenolmediated proton loss process ) and their relationship with abstract Mkhris code. By us revealed that in the case of modelling of high alpha state - high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are increased the resistance of membrane structures, belonging to fourth compartment in 1, 18 times in comparision with control animals after 3, 7, 14 days of modelling,which is on of appearanse of a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. Second results: A. Change of oxidizing activity of hemaglobine molecules in the first compartment during of modelling of membrane high betta state-high reduction potential elevated situation in rabbits by rotenone(by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) and their relationship with abstract Badgan code. We revealed that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are decreased the oxidizing activity of hemaglobine molecules in 1,8-14,0 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. B. Change of oxidizing activity of hemaglobine molecules in the first compartment during of modelling of membrane high betta state-high reduction potential elevated situation in rabbits by rotenone(by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) and their relationship with abstract Badgan code. By us established that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone(by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are decreased the oxidizing activity of hemaglobine molecules in 1,8-14,0 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. C. Change of reduction :oxidation ratio activity of second compartment (serum oxidase enzyme activity) during modelling of membrane high betta state - high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH ) and their relationship with abstract Badgan code. It was clear that in the case of modelling of membrane high betta state - high reduction potential elevated situation in rabbits by rotenone(by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are decreased the reduction :oxidation ratio activity of second compartment (serum oxidase enzyme activity) in 1,6-7,25 times in comparision with control animals after 3, 7, 14 days of modelling,which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. D. Change of oxidizing activity of hemaglobine molecules in the second compartment during of modelling of membrane high betta state-high reduction potential elevated situation in rabbits by rotenone(by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH ) and their relationship with abstract Badgan code. We observed that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are decreased the the deprotonized products in the second compartment in 1,2 times in comparision with control animals after 3, 7, 14 days of modelling,which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin.
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E.Change of deprotonized products in the forth compartment during of modelling of membrane high betta state-high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH ) and their relationship with abstract Badgan code. By us established that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone(by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH ) are decreased the deprotonized products in the forth compartment in 1,3 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. I. Change of the free radical protonized activity of membrane - redoxy 3 state line systems in the first compartment and membrane structures in the forth compartment during of modelling of membrane high betta state - high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) and their relationship with abstract Badgan code. We observed that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are increased the free radical protonized activity of membraneredoxy 3 state line systems in the first compartment and membrane structures in the forth compartment in 1,3 times in comparision with control animals after 3, 7, 14 days of modelling, which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. L. Change of the resistance of membrane structures, belonging to the forth compartment during of modelling of membrane high betta state-high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH ) and their relationship with abstract Badgan code. It was clear that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are increased the resistance of membrane structures, belonging to the forth compartment in 1, 2 times in comparision with control animals after 3, 7, 14 days of modelling,which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. M. Change of some parameters in the all 4 compartments during of modelling of membrane high gamma state-slow redoxy potential situation in rabbits by long time use of rotenon (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) and their relationship with abstract Badgan code. By us established that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by long time use of rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are increased the contens of LPLD, cholesterols, triglycerids i.e.decline of dilution effect of LPHD in relation to LPLD, cholesterols, triglycerids and decreased the contens of LPHD in the the second compartment in 1,2 times in comparision with control animals after 28 days of modelling, which is on of appearance of a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. Third results:
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A. Change of some parameters in the all 4 compartments during of modelling of membrane high gamma state-slow redoxy potential situation in rabbits by long time use of dinitrophenol (dinitrophenolmediatedproton loss process) and their relationship with abstract Rlung code. We established that in the case of modelling of membrane high gamma state-slow redoxy potential situation in rabbits long time use of dinitrophenol (dinitrophenolmediated proton loss process) are decreased the ATP concentration by uncoupling process, because of this decreased the ATP-ase activity, leading to decline of slip redox potential, evidence of these was the decrease of glucose concentration in the second compartment, decline of concentration of LPLD, LPHD in 1,6 times in comparision with control animals after 14 days of modelling, which is on of appearance of a wind like unoilly, mobile, light external characteristics, coded by abstract rlung thermin. In such way: 1. We observed that in the case of modelling of high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are provocated the increase of body temperature, decrease of reduced form of NADPH contents, increase of oxidized form of NADP contents, oxidizing activity of hemaglobine molecules, decrease of reduction : oxidation ratio in a first and fourth compartments, also reduction activity of membrane-redoxy potentials three state line systems, decrease of membrane resistance of membrane structures of 1 compartment, elevation of quantity of LPHD in second compartment, increase of glucose utilization speed in second compartment with following decrease of glucose concentration in a second compartment, increase of oxidized deprotonized in a 5 membrane structures, belonging to fourth compartment, exhibiting a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. 2. We established that in the case of modelling of high alpha state-high oxy potential elevated situation in rabbits by dinitrophenol (dinitrophenolmediated proton loss process) are increased the quantity of LPHD in a second compartment, decrease of LPLD, cholesterols, triglycerids in the medium between cell membrane structures-serum, representing a second compartment, paralleled with a high alpha statehigh oxy potentials in membrane-redoxy potentials three state line systems, exhibiting a sun like hot, hot oil external characteristics, coded by abstract mkhris thermin. 3. We observed that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are provocated the decrease of body temperature, increase of reduced form of NADPH contents, decrease of oxidized form of NADP contents, deline of oxidizing activity of hemaglobine molecules, increase of reduction: oxidation ratio in a first and fourth compartments, elevation of reduction activity of membrane-redoxy potentials three state line systems, increase of membrane resistance of membrane structures of 1 compartment, decline of quantity of LPHD in second compartment, decrease of glucose utilization speed in second compartment with following increase of glucose concentration in a second compartment, decrease of oxidized - deprotonized products in a 5 membrane structures, belonging to fourth compartment, exhibiting a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. 4. We observed that in the case of modelling of high solid betta state mediated high reduction potential elevated situation in rabbits by rotenone (by blocking cytochrome oxidase in the complex 4 with elevation of reduced form of NADH) are decreased the quantity of LPHD in a second compartment, increase of LPLD, cholesterols, triglycerids in the medium between cell membrane structures-serum, representing a second compartment, paralleled with a high solid betta state - high reduction potentials in membrane -redoxy potentials three state line systems, exhibiting a moon like cold, cool oil external characteristics, coded by abstract badgan thermin. Definition of Mkhris abstract thermin. Abstract Mkhris thermin showed:
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a.Relatively high level of fluid alpha states, consisting of unsaturated fatty acids with high levels of oxy potentials and with high levels of proton, electrons conductance and high levels heat energy release, middle degree of energy accumulation and middle degree of high energy phosphate-ATP, high energy electrons NADPH, with middle ratio of donators: accceptors are associated with abstract theory of Mkhris, which is distinguished by hot, hot oil, acute external characteristics. b.The change of fourth compartment parameters, named as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems in the form of unregulated intensification of information - response functions are coded by abstract Mkhris code. c. The Change of fourth compartment parameters, named as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems in the form of slowing of information-response functions are coded by abstract Mkhris code in the Tibetian Mongolian Traditional medicine. d. The change of Third compartment parameters in the form of increase of unsaturated class of visceral and external under skin fatty acids, also decrease of donators, increase of acceptors are coded by abstract Mkhris code in the Tibetian Mongolian Traditional medicine. Definition of Badgan abstract thermin. Abstract Badgan thermin showed: a. Relatively high level of solid betta state,consisting of mainly saturated fatty acids, conditioning a high levels of red potentials and with slow levels of proton, electrons conductance and low levels of heat energy release, high degree of energy accumulation and high degree of high energy phosphate-ATP, high energy electrons NADPH, with increased ratio of donators :accceptors are associated with abstract theory of Badgan, which is distinguished by cool, cold oil, stupid external characteristics. b. The change of fourth compartment parameters consisting of serum and extracellular system, where donators, acceptors and some metabolites formed in the result of functioning of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions in the form of increase of contents of donators, decrease of acceptors and increase of AO - decrease of SPOL system are coded by abstract Badgan code in the Tibetian Mongolian Traditional medicine. c. The change of fourth compartment parameters consisting of serum and extracellular system,where donators, acceptors and some metabolites formed in the result of functioning of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions in the form of decrease of contents of donators, increase of acceptors and decrease of AO- increase of SPOL system are coded by abstract Badgan code in the Tibetian Mongolian Traditional medicine. d. The change of Third compartment parameters in the form of increase of saturated class of visceral and external under skin fatty acids, also increase of donators, decrease of acceptors are coded by abstract Badgan code in the Tibetian Mongolian Traditional medicine. Definition of Rlung abstract thermin. Abstract Rlung thermin showed : a. Relatively high level of gamma state, consisting of decreased contents of saturated-unsaturated fatty acids, conditioning a decreased levels of redoxy potentials and with slow levels of proton, electrons conductance and low levels of heat energy release and energy accumulation and low degree of high energy phosphate-ATP, high energy electrons NADPH, with decreased contents of donators:accceptors,
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increased significance of proton, electrons prior to generation of proton gradients, prevailed slip mecchanism are associated with abstract theory of rlung, which is distinguished by light, mobile, nonoil, cool external characteristics. b. The change of fourth compartment parameters, consisting of serum and extracellular system, where donators, acceptors and some metabolites formed in the result of functioning of 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions in the form of decrease of contents of donators, acceptors and some metabolites formed in the result of functioning of 5 of membrane structures-5 function systems, including synthetic, bioenergy, biotransformation functions are coded by abstract Rlung code in the Tibetian Mongolian Traditional medicine. c. The change of fourth compartment parameters, named as 5 membrane structures-5 function systems, ensuring normal genetic-cell division, information-response, biosynthetical, bioenergetical, biotransformation functions by using of high energy phosphate-ATP, high energy electrons NADPH and heat energy, generated in membrane-redoxy potentials three state line systems in the form of decrease of synthetic, bioenergy, biotransformation functions and of unregulated disturbance of informationresponse functions are coded by abstract Rlung code in the Tibetian Mongolian Traditional medicine. d. The change of third compartment parameters in the form of decrease of visceral and external under skin fatty acids, also donators, acceptors are coded by abstract Rlung code in the Tibetian Mongolian Traditional medicine. In such way, the investigation aimed to make the integration between training programs of curriculum of preparing Traditional medical doctors and interdiscipline relationship, their inheritance and issue the definition of Rlung, Mkhris, Badgan abstract thermin, by creating of experimental models of cell regulation, coded by abstract rlung, mkhris, badgan thermins in Traditional medicine is revealed and confirmed the scientific basis of new training technology Traditional medical education in the 21 century, because during which became clear the essence of the new conception and new knowledge as The coincidence of Rlung, Mkhris, Badgan abstract thermin with regulation occurred in membrane-redoxy potentials 3 state systems of living cells In our institute the consistency of lesson teaching program with mission, objectives of curriculum of preparing of Traditional Medical doctors and their continuous improvement and change appeared through constant correction, modernisation of training technology of medical education programm Traditional medical education in the 21 century and X + G + S + s-NCM full integrated knowledge relating preparing of Traditional medical doctors. Under the notion as of improvement teaching technology we understand the complex processes, conducted as entry of new knowledge - elobarating of new knowledge - fixation of new knowledge, which occurred between teacher and students. Meanwhile, entry of new knowledge depends from teaching ability of teachers, elobarating of new knowledge-fixation of new knowledge depend from previous fundamental, acquiring, accumulated knowledge of students. Beside the teaching ability of teachers and the level of previous fundamental, acquiring, accumulated knowledge of students depend from that, how the concrete education organisation is succeeded to establish the basic point of knowledge acquiring functions, since 2004 our institute started use of new enriched definition of living cells as basic point of knowledge acquiring functions Comparison between content of teacing program of our institute and other similar institute. New medicine (NCM) medical institute Other similar institute. 1 Pathological Pathological physiological basis of all disease Pathological
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physiology
are taught within G, X knowledges + S knowledge + s-NCM knowledge, including the new conception as 4 compartments of human body. physiological basis of all disease are taught within S knowledge without the new conception as 4 compartments of human body . Raw materials of Traditional Medicine, therminology, substitution, mecchanism of their treatment action, technology of obtaining from which medicinal forms as pilule, tablet, infusion, oil and ethanol solved forms are taught within G, X knowledges Traditional inner disease as disease of 5 solid, 6 hollow organs, disease of white vessels, poison disease, ageing disease, their cause, pathogenesis, diagnostics, treatment are taugt within traditional medical G, X knowledges .
Raw materials of Raw materials of Traditional Medicine, Traditional therminology, substitution, mecchanism of their Medicine treatment action, technology of obtaining from which medicinal forms as pilule, tablet, infusion, oil and ethanol solved forms are taught within G, X knowledges + S knowledge + s-NCM knowledge, including the new conception as 4 compartments of human body .
3 Traditional disease-2
Traditional inner disease as disease of 5 solid, 6 inner hollow organs,disease of white vessels, poison disease, ageing disease, their cause, pathogenesis, diagnostics, treatment are taugt within G, X knowledges + S knowledge + sNCM knowledge, including the new conception as 4 compartments of human body .
From abovementioned we should conclude that our institute is moving from G, X knowledge based teaching tecchnology to G, X knowledges + S knowledge + s-NCM knowledge based tecchology, including the new conception as 4 compartments of human body. In such way we are conducting the teaching technology which are existed in compliance with formulations, proposed by us and foreign authors as finding of common language and building of bridge between Oriental and Modern Medicine, finding of molecular correlates theory of Oriental Medicine, as theory vata, kapha, pitta. Below we are drawn the s-NCM new knowledge based definition of some lessons. 1. History of Traditional medicine (2-th course, 1- sem, 2 credir, lecture 32 hours ) Student will possess knowledge about: 1. The history of foundation and development of in X,G period of Traditional medicine when appeared the theory 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile)-abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin. Cold, heavy, cold oilly external patterns,
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symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin) - studied by Traditional medicine (alone X,G). 2. The history of foundation and development of in X, G + S + s-NCM period of Traditional medicine as S knowledge expressed by study of cell regulation within Gene enzymes substrates - external signs system + integration through s-NCM new knowledge + 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) - abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin, cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 2. Theory of Traditional medicine (2-th course, 1- sem, 3, 5 credit, lecture 32 hours, practice 80 hours ) Student will possess knowledge about basic theory of Traditional medicine (TM) in the level of X,G knowledge of TM : at first: the theory of 20 external patterns, 17 powers of medicaments (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile ) at second: theory of 5 element-abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by water and earth elements, unoilly, light, modile external patterns, symbolized by wind element) at third: theory of rlung, mkhris, badgan - abstraction by rlung, mkhris, badgan (appeared by symbolizing hot, hot oilly cold external patterns, symbolized by fire element under sun like mkhris abstract thermin, appeared by symbolizing cold, heavy, cold oilly external patterns, symbolized by water and earth elements under moon like badgan abstract thermin. appeared by symbolizing unoilly, light, modile external patterns, symbolized by wind element under wind like rlung abstract thermin) 3. Prevention of disease, basing Traditional medicine. (2-th course, 1- sem, 2credit, lecture 16 hours, seminar 32 hours ) Student will possess knowledge how to conduct the prevention of disease by using the theory of 20 external patterns, 17 powers of medicaments (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile), the theory of 5 element-abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns,symbolized by water and earth elements, unoilly, light, modile external patterns, symbolized by wind element), theory of rlung, mkhris, badgan - abstraction by rlung, mkhris, badgan (appeared by symbolizing hot, hot oilly cold external patterns, symbolized by fire element under sun like mkhris abstract thermin, appeared by symbolizing cold, heavy, cold oilly external patterns, symbolized by water and earth elements under moon like badgan abstract thermin. appeared by symbolizing unoilly, light, modile external patterns, symbolized by wind element under wind like rlung abstract thermin). 4. Raw materials of Traditional medicine (2 -th course , 2-th sem, 5 credit, lecture 48 hours, practice 64 hours) Student will gain knowledge about raw materials of Traditional Medicine, therminology, substitution, mecchanism of their treatment action, technology of obtaining from which medicinal forms as pilule, tablet, infusion, oil and ethanol solved forms are taught within G, X knowledges + S knowledge + sNCM knowledge, including the new conception as 4 compartments of human body . 5. Traditional massage therapy (5-th course, 1-th sem, 6 credit, lecture 48 hours, practice 96 hours)
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Student will possess knowledge, practical skills to conduct Traditional massage therapy within G, X knowledges + S knowledge + s-NCM knowledge, including the new conception as 4 compartments of human body, according to principle as Gene enzymes substrates - external signs regulation (S knowledge) + (integration through s-NCM new knowledge + new conception of 4 compartmentsof human body) + theory of 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) - abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin, cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin, unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 6. Acupuncture and Moxibustion (5-th course, 2-th sem, 8 credit, lecture 64 hours, practice 128 hours) Student will possess knowledge, practical skills to conduct Acupuncture and Moxibustion therapy within G, X knowledges + S knowledge + s-NCM knowledge, including the new conception as 4 compartments of human body, according to principle as Gene enzymes substrates - external signs regulation (S knowledge) + (integration through s-NCM new knowledge + new conception of 4 compartmentsof human body) + theory of 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) -abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin, cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin, unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 7.Traditional inner disease-2 (4,5 - th course, 1 - th sem, 13 credit, lecture 128 hours, practice 160 hours) Student will possess knowledge to understand a essence of Traditional inner disease as disease of 5 solid, 6 hollow organs, disease of white vessels, poison disease, ageing disease, their cause, pathogenesis, diagnostics, treatment within G, X knowledges + S knowledge + s-NCM knowledge, including the new conception as 4 compartments of human body, according to principle as Gene enzymes substrates - external signs regulation (S knowledge) + (integration through s-NCM new knowledge + new conception of 4 compartmentsof human body) + theory of 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) - abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin, cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 8. Hot disease (6-th course, 1-th sem, 2,5 credit, lecture 32 hours, practice 16 hours) Student will possess knowledge to understand a essence of the theory of hot disease as unripened, empty, hidden, chronic, turbid, spreading, disturbed, contagious, poisonning fevers (G, X knowledge), according to principle as Gene enzymes substrates - external signs regulation (S knowledge) + (integration through s-NCM new knowledge + new conception of 4 compartmentsof human body) + theory of 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly,
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mobile)-abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin, cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 9.Theoretical aspects of NCM medicine (4-th course, 1-th sem, 5 credit, lecture 48 hours, practice 64 hours) Student will possess knowledge to understand a essence of the theory of 20 external patterns, theory of 5 element, theory of rlung, mkhris, badgan (G, X knowledge), according to principle as Gene enzymes substrates - external signs regulation (S knowledge) + (integration through s-NCM new knowledge + new conception of 4 compartmentsof human body) + theory of 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) - abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns, symbolized by fire element and sun like mkhris abstract thermin. Cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 10. Clinical aspects of NCM medicine (6-th course, 2-th sem, 3 credit, lecture 32 hours, practice 32 hours) Student will possess knowledge to understand traditional G, X - knowledge related and modern medical S X - knowledge related diagnostics and treatment of all disease, according to principle as Gene enzymes substrates - external signs regulation + (integration through s-NCM new knowledge + new conception of 4 compartmentsof human body) + 20 external patterns (hot, cold, light, heavy, hot oilly, cold oilly, unoilly, mobile) - abstraction by 5 elements (hot, hot oilly cold external patterns, symbolized by fire element, cold, heavy, cold oilly external patterns, symbolized by waterand earth elements, unoilly, light, modile external patterns, symbolized by wind element) - abstraction by rlung, mkhris, badgan (hot, hot oilly cold external patterns,symbolized by fire element and sun like mkhris abstractt thermin. Cold, heavy, cold oilly external patterns, symbolized by water and earth elements and moon like badgan abstract thermin. Unoilly, light, modile external patterns, symbolized by wind element and wind like rlung abstract thermin). 11. Cardiology (4-th course, 1-th sem, 4 credit, lecture 32 hours, practice 64 hours) Student will possess knowledge about physiology, pathophysiology, diagnosis, treatment of cardiovascular pathology with using S knowledge, relating to Gene enzymes substrates level regulation system, integrated and systematized in the level of s-NCM new knowledge and, also the new conception about existing the human body in 4 compartments. 12. Gastro - enterology (4-th course, 1-th sem, 4 credit, lecture 80 hours, practice 64 hours) Student will possess knowledge about physiology, pathophysiology, diagnosis, treatment of gastro enteral pathology with using S knowledge, relating to Gene enzymes substrates level regulation system, integrated and systematized in the level of s-NCM new knowledge and, also the new conception about existing the human body in 4 compartments. 13. Pathophysiology (3-th course, 4, 5-th sem , 7 credit, lecture 32 hours, practice 64 hours) Student will possess knowledge about mecchanism of development of pathological processe of all organs and system with using S - knowledge, relating to Gene - enzymes - substrates - external signs level
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regulation system, integrated and systematized in the level of s-NCM new knowledge and, also the new conception about existing the human body in 4 compartments. Concretely speaking in the result of implementation of new training technology Traditional medical education in the 21 century we are succeeded to give full explanation to the new conception as gene enzyme - substrate - 20 external patterns - abstraction these by 5 element - abstraction these by rlung, mkhris, badgan. At last time prevaied two approaches to find the corresponding gene - enzyme - substrate , which lead to appearance of theory as 20 external patterns - abstraction these by 5 element - abstraction these by rlung, mkhris, badgan, first approach is investigation, aimed to reveal directly concrete gene, second approach is investigation, aimed not to reveal direct gene, but reveal correspondingthe biochemical and morpho - physiological correlates, belonging to membrane - redoxy line system, thereby find genes, which lead to theory of rlung, mkhris, badgan, now we are conducting research by following the second approach. Within new training technology Traditional medical education in the 21 century, implemented by us the ratio of all subjects as follows: subjects of G, X knowledge 40 %: s-NCM knowledge 5%:55% S - knowledges. The ratio as G, X knowledge 40 % : s-NCM knowledge 5% : 55% S - knowledges, recommended in the of new training technology Traditional medical education in the 21 century have some similarity with Curriculum of the Oriental medical School of Kyunghee University. Oriental medical unoversities have maintained a six long curriculum, two years of premedical course and four years of a regular course. Premed students learn introduction to the oriental medicine, medical history, orientalphillosophy, from the third year, oriental medical students learn primary subjects of oriental medicine and western medicine (pathology and experiment, pharmacy and experiment, internal medicine on hepatic, cardiac, digestive, pulmonary, urogenital diseases, clinic pathology, gynecology, pediatrics, radiology, emergency medicine, forensic medicine, dermatology, neuropsychiatry, opthalmology and otolaryngology,) and Sa Sang medicine. In addition to this, around Sa Sang medicine theory of practics conducted many investigations during which established that among MDR1 gene polymorphism in the So-Eum type (rlung similar type) people prevailed 1236C-2677G-3435C and 1236T-2677G-3435T haplotypes, in the So-yangin (mkhris similar type) more differences revealed in the MDR1 G2677T/A haplotype in comparision to So - eumin.
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ABSTRACTION IN THE FORM OF APPEARANCE OF THEORY OF RLUNG, MKHRIS, BADGAN (YANG-YIN)

WATER, EARTH ELEMENT

Cold, heavy characteristics

The prevalence of gamma state of MS with low redoxy potentials

Whole organisms level

The basic three states of membrane redoxy potential 3 state system

The theory rlung, Mkhris, Badgan

ABSTRACTI ON Hot Acute

The three states of MS with 3 state of redoxypotentials

Hot Cold Fluid Acute Heav Light Motile

Fluid Cold Heavy Stupid

Mkhris (yang) Badgan (yin)

Substance Stupid UnoillyLi Rlung g element Motile

Fire, water, earth, rlung, space, wood, iron elements

The step of cognition by the direct sensation

The step of abstract cognition

Unsaturated Fatty acids ratio (%)

Unsaturated Fatty acids ratio (%)

MEAT, OILS, MILKS

Alpha state of MS with high oxy potentials

Betta state of MS with high red potentials

Betta state of MS with high red potentials

Alpha state of MS with high oxy potentials

Healthy human body

The interaction between five elements of medicaments and human body

Fire element Rlung Rlung

The appearance of specific for liver pulse as taut, fast

Normal clockwise rules

Increase of resistance of MS to action of pathogenic factors

Decrease of adrenoreceptors activity and oxygen diffusion

Pathological counter clockwise rules

Normal clockwise rules

The disturbance of NPA in autumn season

Pathological counter clockwise rules

Decrease of lung cells

Before bloodletting therapy

After bloodletting therapy

The population of erythrocytes

2. Biochemi cal correlates

4. Morphof unctional correlates

7.Introdu ction of common language and builded bridge in to

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