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Profile of WuXi
Leading China-based contract research organization serving the
drug discovery
Has continuously been building capabilities and capacities along
manufacturing services
3
sciences industry
This engine offers a technology platform and integrated
service offerings that will enable anyone and any company to discover and develop medicines
China is rapidly becoming an important hub for
pharmaceutical R&D, in part because of the rapid growth of the large Chinese pharmaceutical market itself
WuXi will continue to lead the Chinese life-sciences industry
Compound Synthesis
Assay Development
Hit/Lead Identification
Discovery
ADME/ DMPK
Formulation
Research Manufacture
Toxicology
Preclinical
Commercial Manufacture
Bioanalytical Services
Clinical
Compound Synthesis
Assay Development
Hit/Lead Identification
Discovery
ADME/ DMPK
Formulation
Research Manufacturing
Toxicology
Preclinical
Commercial Manufacture
Bioanalytical Services
Clinical
~22%
$406+
Manufacturing
$253.5
$270.0
$402-$406 million
+14-15% + About 6% + At least 84% Approximately equal to 2010 level on GAAP basis, decline of about 1.5 percentage points on non-GAAP basis About 21% GAAP; about 24% non-GAAP
Exceeded
Achieved Achieved Achieved Achieved
Operating Margin
Achieved
About 18%
$60-65 million
Achieved
Achieved
Manufacturing Services
API manufacturing Advanced intermediates manufacturing Process scale-up Process validation
Cell therapy
Microbiology testing Lot release testing
Bioanalytical services
Analytical/stability testing
~251
58%
219.4
47%
185.8
258
171
2009
2010
Revenues ($ millions)
2011
2009
2010
2011
Number of Customers
10
24
and SFDA certified GLP facility for general toxicology and genetic toxicity studies
Contracts signed with Johnson
2009
2010
2011
Number of Customers
Suzhou site (tox and large animal DMPK) expected to break even by 4Q12
11
Manufacturing Services
(US$ in Millions)
~75
~88%
Research manufacturing
Driven by innovative work of ~310
99%
39.9
process chemists
Produces advanced intermediates and
20.1
2009
Phase II, and 75 Phase I/preclinical programs, some of which will feed toxicology and commercial manufacturing Commercial manufacturing
Produces advanced intermediates for a
2009
2010
2011
Number of Projects
~80
75.5
64.1
services for biologics and medical devices necessary for regulatory approval or product release
Excluding one tissue processing
2009
2010
2011
Revenues ($ millions)
13
areas:
New Wuhan site for chemistry laboratories Expanded and integrated drug discovery capabilities and
capacities
Biologics discovery and development laboratory in Shanghai and
manufacturing capacity
Clinical development capabilities Abgent marketing and sales capabilities and new reagent product
development capabilities
14
1,000
Allows WuXi to
15
Established a leading
peptides, and proteins for research, with catalog of about 20,000 antibodies
About 150 employees work in a 34,000 square-foot
laboratory in Suzhou and a 10,000 square-foot laboratory and office in San Diego
Expands our service offering to our existing customers and
to new customers in the life-sciences research community and taps into the rapidly growing Chinese life-sciences research market
In 2012, plan to develop new high-value-added products
and expanded sales and marketing capabilities in the U.S. and China to build a platform for strong growth in 2013 and beyond
17
management, and site management for multinational and Chinese pharmaceutical companies filing products in China
Has operations in 15 Chinese cities, with offices in Shanghai,
capability and infrastructure in China, launching us into this business faster than we could accomplish on our own
Will focus in 2012 on significantly expanding clinical teams and
building capabilities
Two multinational CROs have recently bought China-based
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$104.0
Revenues
$83.8
38.5%
34.7
37.1%
38.6
38.2 %
40.6
21.2%
19.8
21.2%
21.5
21.3 %
22.2
3Q10
4Q10
1Q11
2Q11
3Q11
19
(US$ in Millions)
$104.0
Revenues
$83.8
34.5 22.6
41.2% 27.0%
35.6
40.2% 25.3%
36.1 23.1
38.5% 24.7%
40.0
39.5%
41.8
22.4
25.0
24.7%
24.9
3Q10
4Q10
1Q11
2Q11
3Q11
20
Uses of Cash
WuXi has about $200 million of cash and a $29 million
bank loan
We see several good opportunities to use this cash and
our free cash flow for targeted investments, primarily in China, to continue to build our capabilities and capacity
A convertible note of $36 million will be redeemed on
February 9 if the stock price is below $12.60, reducing the share count for calculating diluted EPS similar to a share buyback
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integrated discovery and development capabilities in medicinal chemistry, CMC, toxicology, and IND services
Advance manufacturing project pipeline with our strong
development platform
Continue to drive U.S.-based Laboratory Services to broaden
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change and adopting a more collaborative and networked R&D model for drug discovery and development
WuXi is building an integrated open-access R&D services
platform as the industrys alternative R&D engine to enable anyone and any company to discover and develop new drugs
Outsourcing of R&D increases pharmaceutical companies
of the fast-growing Chinese pharmaceutical market and growing R&D capabilities in China
WuXi will work hard to become THE technology platform
Appendix
GAAP to Non-GAAP Reconciliations
24
3Q2011
(US$ in millions)
Net revenues Cost of revenues Selling & marketing expenses General & administrative expenses Other income/(expenses), net Income tax expenses Net income
104.0 (63.4) (2.7) (15.6) 3.0 (4.7) 20.6 2.3 (0.1) 0.3 1.4 0.9 0.4
25
9M2011
(US$ in millions)
Net revenues Cost of revenues Selling & marketing expenses General & administrative expenses Other income/(expenses), net Income tax expenses Net income
298.6 (184.8) (7.2) (43.0) 6.6 (12.7) 57.5 8.4 (0.4) 0.6 5.6 2.8 1.0
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