Clinical Pharmacology

Hormonal Therapy
Mohanad AlBayati
Mohanad AbdulSattar Ali Al-Bayati, BVM&S, MS. Physiology, PhD. Assistant Professor of Pharmacology and Toxicology Department of Physiology and Pharmacology College of Veterinary Medicine University of Baghdad Al-Ameria, Baghdad Phone: 0964 7700766550 E. Mail: aumnmumu@covm.uobaghdad.edu.iq aumnmumu@yahoo.com

Hormonal Homeostasis
The coordinated Physiological Processes

which maintain most of the steady states in the organism are so complex and so peculiar to living beings that I have suggested a special designation for these states, homeostasis. The word dose not imply something immobile, a stagnation; it mean a condition which may vary, but which is relatively constant

Clinical Pharmacology

Hormonal Class
Chemical Class Hormone Major Source

Molecular weight 30 kd or less

Continue

Clinical Pharmacology

Hormonal Class
Chemical Class Hormone Major Source

Continue

Clinical Pharmacology

Hormonal Class
Chemical Class Hormone Major Source

Continue

Clinical Pharmacology

Hormonal Class
Chemical Class Hormone Major Source

Continue

Clinical Pharmacology

Clinical Pharmacology

Hormonal Class
Chemical Class Hormone Major Source

Continue

Clinical Pharmacology

Hormonal Class
Chemical Class Hormone Major Source

Clinical Pharmacology

Endocrine and Hormone

Greek: Endocrine mean to separate within Hormone mean I excite Non reproductive veterinary endocrinology Recently, Increase awareness of the endocrine disorder Endocrine disorders appear to be involved in about 10% - 20% of medical disease on small animals Largely been based on studies in large animal species

Clinical Pharmacology The Action of a Hormone at its Target Site is Dependent Upon Nine General Factor

10

Feedback Control of The Hypothalamic-Pituitary Axis

Continue

11

Clinical Pharmacology

Continue

12

Clinical Pharmacology

Variation in Chemical Communication With an Animal

Continue

13

Clinical Pharmacology

Feedback control Hormonal Homeostasis

Endocrine system that a balanced state of feedback regulation be maintained among the various glands in order to maintain Homeostasis Direct and indirect Feedback control 1. Ultra short loop 2. Short loop 3. Long loop
Chemical Regulator 1. Paracrain 2. Neurocraine and neuroendocraine 3. Endocraine 4. Paracraine 5. Autocraine

14

Clinical Pharmacology

Ligands Working intracellular Messenger Pathways

Continue

15

Clinical Pharmacology

Ligands Working intracellular Messenger Pathways

Continue

16

Clinical Pharmacology

Ligands Working intracellular Messenger Pathways

Continue

17

Clinical Pharmacology

Receptors Working and Short comes

1. High affinity: strong tendency , Small number of hormone. 2. High specificity: little tendency to bind other molecules 3. Low capacity: all receptor sites can be occupied (saturated) low hormone concentration. i. Down regulation: ii. Prolonged hormonal exposure. Desensitized iii. Destroyed after endocytosis iv. Internalized and remain stored in intracellular vesicales v. Remain on the cell surface but bind hormone inappropriately vi. Receptor-Hormones complexes; induce sub-optimal responese

18

Clinical Pharmacology

Cell receptors Cross-Communication and Drugs disorders

Intracellular receptor ligand Second messenger communication Inter-Receptor talker Hormonal communication disorders

19